A randomized, blinded, controlled and multi-centered field study comparing the efficacy and safety of Bravecto™ (fluralaner) against Frontline™ (fipronil) in flea- and tick-infested dogs

Parasites and Vectors

Volumn 7, Issue 1, 2014, Pages

  Rohdich, Nadja ^a   Roepke, Rainer Ka ^a   Zschiesche, Eva ^a  

^a Intervet Innovation GmbH   (Germany)

Author keywords

Bravecto (fluralaner); Dog; Efficacy; Field study; Fleas; Frontline (fipronil); Isoxazoline; Ticks

Indexed keywords

BRAVECTO; FIPRONIL; FLURALANER; FRONTLINE; UNCLASSIFIED DRUG; A1443 COMPOUND; ACARICIDE; INSECTICIDE; ISOXAZOLE DERIVATIVE; PYRAZOLE DERIVATIVE; TABLET;

ANIMAL EXPERIMENT; ARTICLE; CHEWABLE TABLET; CLINICAL ASSESSMENT; CONTROLLED STUDY; DOG; DRUG EFFICACY; DRUG SAFETY; FLEA; FLEA ALLERGY DERMATITIS; FLEA INFESTATION; HOUSEHOLD; INSECT CONTROL; MULTICENTER STUDY (TOPIC); NONHUMAN; PARASITE CONTROL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK REDUCTION; SINGLE DRUG DOSE; SKIN ALLERGY; TICK; TICK INFESTATION; TREATMENT DURATION; TREATMENT OUTCOME; ANIMAL; CLINICAL TRIAL; DOG DISEASES; DRUG EFFECTS; FEMALE; FLEA INFESTATIONS; FRANCE; GERMANY; MALE; MULTICENTER STUDY; ORAL DRUG ADMINISTRATION; PARASITOLOGY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SPAIN; TABLET; TICK INFESTATIONS; TOPICAL DRUG ADMINISTRATION; VETERINARY;

ACARICIDES; ADMINISTRATION, ORAL; ADMINISTRATION, TOPICAL; ANIMALS; DOG DISEASES; DOGS; FEMALE; FLEA INFESTATIONS; FRANCE; GERMANY; INSECTICIDES; ISOXAZOLES; MALE; PYRAZOLES; SINGLE-BLIND METHOD; SIPHONAPTERA; SPAIN; TABLETS; TICK INFESTATIONS; TICKS; TREATMENT OUTCOME;

EID: 84897988613     PISSN: None     EISSN: 17563305     Source Type: Journal    
DOI: 10.1186/1756-3305-7-83     Document Type: Article

References (7)

1. Insecticide/acaricide resistance in fleas and ticks infesting dogs and cats. Coles TB, Dryden MW, Parasit Vectors 2014 7 8 10.1186/1756-3305-7-8 24393426
2. Tick infestation and tick prophylaxis in dogs in the area of Berlin/Brandenburg-results of a questionnaire study. Beck S, Schein E, Baldermann C, von Samson-Himmelstjerna G, Kohn B, Berl Munch Tierarztl Wochenschr 2013 126 69 76 23367671
3. The antiparasitic isoxazoline A1443 is a potent blocker of insect ligand-gated chloride channels. Ozoe Y, Asahi M, Ozoe F, Nakahira K, Mita T, Biochem Biophys Res Commun 2010 391 744 749 10.1016/j.bbrc.2009.11.131 19944072
4. European Commission, Community register of veterinary medicinal products, Product information Bravecto, Annex 1 Summary of product characteristics Bruxelles 2014 http://ec.europa.eu/health/documents/community-register/html/ v158.htm
5. The novel isoxazoline ectoparasiticide fluralaner: Selective inhibition of arthropod γ-aminobutyric acid- and L-glutamate-gated chloride channels and insecticidal/acaricidal activity. Gassel M, Wolf C, Noack S, Williams H, Ilg T, Insect Biochem Mol Biol 2014 45 111 124 24365472
6. World Association for the Advancement of Veterinary Parasitology (WAAVP) guidelines for evaluating the efficacy of parasiticides for the treatment, prevention and control of flea and tick infestation on dogs and cats. Marchiondo AA, Holdsworth PA, Green P, Blagburn BL, Jacobs DE, Vet Parasitol 2007 145 332 344 10.1016/j.vetpar.2006.10.028 17140735 (Pubitemid 46442771)
7. Test statistics and sample size formulae for comparative binomial trials with null hypothesis of non-zero risk difference or non-unity relative risk. Farrington CP, Manning G, Stat Med 2009 9 1447 1454