Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs

Veterinary Parasitology

Volumn 201, Issue 3-4, 2014, Pages 179-189

  Shoop, Wesley L ^a   Hartline, Eric J ^a   Gould, Brandon R ^a   Waddell, Molly E ^a   McDowell, Richard G ^a   Kinney, John B ^a   Lahm, George P ^a   Long, Jeffrey K ^a   Xu, Ming ^a   Wagerle, Ty ^a   Jones, Gail S ^a   Dietrich, Robert F ^a   Cordova, Daniel ^a   Schroeder, Mark E ^a   Rhoades, Daniel F ^a   Benner, Eric A ^a   Confalone, Pat N ^a  

^a DUPONT COMPANY   (United States)

Author keywords

Afoxolaner; Dogs; Ectoparasiticide; Fleas; Isoxazoline; Ticks

Indexed keywords

4 AMINOBUTYRIC ACID; AFOXOLANER; CHEMICAL COMPOUND; CHLORIDE CHANNEL; DIELDRIN; ISOXAZOLINE DERIVATIVE; PARASITICIDE; UNCLASSIFIED DRUG;

ACARICIDAL ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CROSS RESISTANCE; CTENOCEPHALIDES; DERMACENTOR VARIABILIS; DOG; DROSOPHILA; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SAFETY; EXPERIMENTAL STUDY; FEMALE; GENE MUTATION; INSECTICIDAL ACTIVITY; MALE; NONHUMAN; REPEATED DRUG DOSE; SINGLE DRUG DOSE;

CANIS FAMILIARIS; CTENOCEPHALIDES FELIS; DERMACENTOR VARIABILIS; HEXAPODA; IXODIDA; SIPHONAPTERA (FLEAS);

AFOXOLANER; DOGS; ECTOPARASITICIDE; FLEAS; ISOXAZOLINE; TICKS;

ANIMALS; ANTIPARASITIC AGENTS; CHLORIDE CHANNELS; COCKROACHES; DOG DISEASES; DOGS; DROSOPHILA MELANOGASTER; ELECTROPHYSIOLOGICAL PHENOMENA; FEMALE; FLEA INFESTATIONS; ISOXAZOLES; MALE; NAPHTHALENES; OOCYTES; PROTEIN BINDING; RANDOM ALLOCATION; SIPHONAPTERA; TICK INFESTATIONS; TICKS; XENOPUS LAEVIS;

EID: 84898057267     PISSN: 03044017     EISSN: 18732550     Source Type: Journal    
DOI: 10.1016/j.vetpar.2014.02.020     Document Type: Article

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