Clinical field study of the safety and efficacy of spinosad chewable tablets for controlling fleas on dogs

Veterinary Therapeutics

Volumn 9, Issue 1, 2008, Pages 26-36

  Robertson Plouch, Carol ^a,b   Baker, Keith A ^a   Hozak, Rebecca R ^a,b   Zimmermann, Alan G ^a,b   Parks, S Craig ^a,c   Herr, Cory ^a   Hart, Liane M ^a   Jay, Jeff ^a   Hutchens, Douglas E ^a   Snyder, Daniel E ^a  

^a ELANCO ANIMAL HEALTH   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c Virbac Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSECTICIDE; MACROLIDE; SPINOSAD;

ANIMAL; ANIMAL DISEASE; ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOG; DOG DISEASE; DRUG COMBINATION; FLEA INFESTATION; ORAL DRUG ADMINISTRATION; PARASITOLOGY; RANDOMIZED CONTROLLED TRIAL; TABLET;

ADMINISTRATION, ORAL; ANIMALS; DOG DISEASES; DOGS; DRUG COMBINATIONS; FLEA INFESTATIONS; INSECTICIDES; MACROLIDES; TABLETS;

CANIS FAMILIARIS; SIPHONAPTERA (FLEAS);

EID: 42149187577     PISSN: 15283593     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. McCall JW, Alva R, Irwin JP, et al. Comparative efficacy of a combination of fipronil/(S)-methoprene, a combination of imidacloprid/ permethrin, and imidacloprid against fleas and ticks when administered topically to dogs. J Appl Res Vet Med 2004;2:74-77.
2. McTier TL, Jones RL, Holbert MS, et al. Efficacy of selamectin against adult flea infestations (Ctenocephalides felis felis and Ctenocephalides canis) on dogs and cats. Vet Parasitol 2000;91:187-199.
3. Jennings KA, Canerdy TO, Keller RJ, et al. Human exposure to fipronil from dogs treated with Frontline. Vet Human Toxicol 2002;44:301-304.
4. Das PC, Cao Y, Cherrington N, Hodgson E, et al. Fipronil induces CYP isoforms and cytotoxicity in human hepatocytes. Chem Biol Interact 2006;164:200-214.
5. Gupta RC, Masthay MB, Canerdy TD, et al. Human exposure to selamectin from dogs treated with Revolution™: methodological consideration for selamectin isolation. Toxicol Mech Meth 2005;15:317-321.
6. Mackley CL, Anderson BE. Contact dermatitis from Frontline Top Spot. Dermatitis 2005;149-150.
7. Dryden MW, Denenberg TM, Bunch S. Control of fleas on naturally infested dogs and cars and in private residences with topical spot applications of fipronil or imidacloprid. Vet Parasitol 2000;93:69-75.
8. Rust MK. Advances in the control of Ctenocephalides felis (cat flea) on cats and dogs. Trends Parasitol 2005; 21:232-236.
9. Mertz FP, Yao RC. Saccharopolyspora spinosa sp.nov. isolated from soil collected in a sugar mill rum still. Int J Syst Bacteriol 1990;40:34-39.
10. Salgado VL. Studies on the mode of action of spinosad: insect symptoms and physiological correlates. Pest Biochem Physiol 1998;60:91-102.
11. Sparks TC, Crouse GD, Durst G. Natural products as insecticides: the biology, biochemistry and quantitative structure-activity relationships of spinosyns and spinosoids. Pest Manag Sci 2001;57:896-905.
12. Snyder DE, Meyer J, Zimmermann AG, et al. Preliminary studies on the effectiveness of the novel pulicide, spinosad, for the treatment and control of fleas on dogs. Vet Parasitol 2007;150(4):345-351.
13. Dryden MW, Perez HR, Ulitchny DM. Control of fleas on pets in homes by use of imidacloprid or lufenuron and a pyrethrin spray. JAVMA 1999;215: 36-39.
14. Benchaoui HA, Clemence RG, Clements PJM, et al. Efficacy and safety of selamectin against fleas on dogs and cats presented as veterinary patients in Europe. Vet Parasitol 2000;91:223-232.
15. Boy MG, Six RH, Thomas CA, et al. Efficacy and safety of selamectin against fleas and heartworms in dogs and cats presented as veterinary patients in North America. Vet Parasitol 2000;91:233-250.
16. Soll MD, Plue RE, Alva R, et al. Field safety, efficacy, and acceptability of ivermectin in a chewable formulation for dogs. Can Pract 1991;16:5-8.
17. Plue RE, Jernigan AD, Acre KE, et al. Field efficacy. safety and acceptability of ivermectin plus pyrantel in growing and adult dogs. In: Soll MD, ed. Proceedings of the Heartworm Symposium '92. Batavia, IL: American Heartworm. Society; 1992:205-208.
18. Rust MK, Rugg D, Rock D. Metaflumizone - a new ectoparasiticide for dogs and cats. Vet Parasitol 2007;150:175-176.