Expression of steroidogenic enzymes in human sebaceous glands

Journal of Endocrinology

Volumn 222, Issue 3, 2014, Pages 301-312

  Inoue, Takayoshi ^a,b   Miki, Yasuhiro ^a   Kakuo, Shingo ^b   Hachiya, Akira ^b   Kitahara, Takashi ^b   Aiba, Setsuya ^a   Zouboulis, Christos C ^c   Sasano, Hironobu ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KAO CORPORATION   (Japan)

^c DESSAU MEDICAL CENTER   (Germany)

Author keywords

17 HSD2; Androgen; Human skin; Sebaceous glands

Indexed keywords

17BETA HYDROXYSTEROID 18 OXIDOREDUCTASE 2; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ACYL COENZYME A DESATURASE; ANDROGEN RECEPTOR; ANDROSTANOLONE; ANDROSTENEDIONE; CARNITINE PALMITOYLTRANSFERASE I; EPITHELIAL MEMBRANE ANTIGEN; FAT DROPLET; GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE; HYDROXYSTEROID DEHYDROGENASE; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PERILIPIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PRASTERONE; SEX HORMONE; SOMATOMEDIN C; STEROID 5ALPHA REDUCTASE 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TESTOSTERONE; UNCLASSIFIED DRUG; ANDROGEN; ESTRADIOL 17BETA DEHYDROGENASE; HSD17B2 PROTEIN, HUMAN; MTOR PROTEIN, HUMAN; RECOMBINANT PROTEIN; TARGET OF RAPAMYCIN KINASE;

ACNE; ADOLESCENT; ADULT; AGED; ANDROGEN SYNTHESIS; ANDROGENESIS; ANIMAL TISSUE; ARTICLE; CELL IMMORTALIZATION; CHILD; CLINICAL ARTICLE; CORRELATION ANALYSIS; CYTOPLASM; DISEASE EXACERBATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIPOGENESIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SEBACEOUS CELL; SEBACEOUS GLAND; SEBUM SECRETION; SEX DIFFERENCE; STEROIDOGENESIS; VERY ELDERLY; ANIMAL; BIOSYNTHESIS; CELL LINE; CYTOLOGY; ENZYMOLOGY; FEMALE; GENE EXPRESSION; GENETIC TRANSFECTION; GENETICS; HAMSTER; LIPID METABOLISM; METABOLISM; MIDDLE AGED; SEBUM; SKIN; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANDROGENS; ANDROSTENEDIONE; ANIMALS; CELL LINE; CHILD; CRICETINAE; DIHYDROTESTOSTERONE; ESTRADIOL DEHYDROGENASES; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; LIPID METABOLISM; MALE; MIDDLE AGED; PPAR GAMMA; RECOMBINANT PROTEINS; SEBACEOUS GLANDS; SEBUM; SKIN; TESTOSTERONE; TOR SERINE-THREONINE KINASES; TRANSFECTION; YOUNG ADULT;

EID: 84907338613     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-14-0323     Document Type: Article

References (53)

1. Altamirano F, Oyarce C, Silva P, Toyos M, Wilson C, Lavandero S, Uhlén P & Estrada M. 2009 Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway. Journal of Endocrinology 202 299-307.
2. Bakan I & Laplante M. 2012 Connecting mTORC1 signaling to SREBP-1 activation. Current Opinion in Lipidology 23 226-234.
3. Beilstein F, Bouchoux J, Rousset M & Demignot S. 2013 Proteomic analysis of lipid droplets from Caco-2/TC7 enterocytes identifies novel modulators of lipid secretion. PLoS ONE 8 e53017.
4. Belanger C, Luu-The V, Dupont P & Tchernof A. 2002 Adipose tissue intracrinology: potential importance of local androgen/estrogen metabolism in the regulation of adiposity. Hormone and Metabolic Research 34 737-745.
5. Bhate K & Williams HC. 2013 Epidemiology of acne vulgaris. British Journal of Dermatology 168 474-485.
6. Blanchard PG, Festuccia WT, Houde VP, St-Pierre P, Brûlé S, Turcotte V, Côté M, Bellmann K, Marette A & Deshaies Y. 2012 Major involvement of mTOR in the PPARg-induced stimulation of adipose tissue lipid uptake and fat accretion. Journal of Lipid Research 53 1117-1125.
7. Chen W, Tsai SJ, Sheu HM, Tsai JC & Zouboulis CC. 2010 Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone. Experimental Dermatology 19 470-472.
8. Eisinger M, Li WH, Anthonavage M, Pappas A, Zhang L, Rossetti D, Huang Q & Seiberg. M 2011 A melanocortin receptor 1 and 5 antagonist inhibits sebaceous gland differentiation and the production of sebum-specific lipids. Journal of Dermatological Science 63 23-32.
9. Fluhr JW, Mao-Qiang M, Brown BE, Wertz PW, Crumrine D, Sundberg JP, Feingold KR & Elias PM. 2003 Glycerol regulates stratum corneum hydration in sebaceous gland deficient (Asebia) mice. Journal of Investigative Dermatology 120 728-737.
10. Fritsch M, Orfanos CE & Zouboulis CC. 2001 Sebocytes are the key regulators of androgen homeostasis in human skin. Journal of Investigative Dermatology 116 793-800.
11. George R, Clarke S & Thiboutot D. 2008 Hormonal therapy for acne. Seminars in Cutaneous Medicine and Surgery 27 188-196.
12. Georgel P, Crozat K, Lauth X, Makrantonaki E, Seltmann H, Sovath S, Hoebe K, Du X, Rutschmann S, Beutler B et al.. 2005 A TLR2-responsive lipid effector pathway protects mammals against Gram-positive bacterial skin infections. Infection and Immunity 73 4512-4521.
13. Ghodsi SZ, Orawa H & Zouboulis CC. 2009 Prevalence, severity and severity risk factors of acne in high school pupils: a community-based study. Journal of Investigative Dermatology 129 2136-2141.
14. Harris HH, Downing DT, Stewart ME & Strauss JS. 1983 Sustainable rates of sebum secretion in acne patients andmatched normal control subjects. Journal of the American Academy of Dermatology 8 200-203.
15. Harrison WJ, Bull JJ, Seltmann H, Zouboulis CC & Philpott MP. 2007 Expression of lipogenic factors galectin-12, resistin, SREBP-1 and SCD in human sebaceous glands and cultured sebocytes. Journal of Investigative Dermatology 127 1309-1317.
16. Inoue T, Miki Y, Abe K, Hatori M, Hosaka M, Kariya Y, Kakuo S, Fujimura T, Hachiya A, Honma S et al. 2012 Sex steroid synthesis in human skin in situ: the roles of aromatase and steroidogenic acute regulatory protein in the homeostasis of human skin. Molecular and Cellular Endocrinology 362 19-22.
17. Labrie F. 1991 Intracrinology. Molecular and Cellular Endocrinology 78 C113-C118.
18. Labrie F, Luu-The V, Labrie C, Pelletier G & El-Alfy M. 2000a Intracrinology and the skin. Hormone Research 54 218-229.
19. Labrie F, Luu-The V, Lin SX, Simard J, Labrie C, El-Alfy M, Pelletier G & Belanger A. 2000b Intracrinology: role of the family of 17β-hydroxysteroid dehydrogenases in human physiology and disease. Journal of Molecular Endocrinology 25 1-16.
20. Li L, Tang L, Baranov E, Yang M, Amoh Y, Katsuoka K & Hoffman RM. 2010 Selective induction of apoptosis in the hamster flank sebaceous gland organ by a topical liposome 5-α-reductase inhibitor: a treatment strategy for acne. Journal of Dermatology 37 156-162.
21. Louet JF, Le May C, Pégorier JP, Decaux JF & Girard J. 2001 Regulation of liver carnitine palmitoyltransferase I gene expression by hormones and fatty acids. Biochemical Society Transactions 29 310-316.
22. Makrantonaki E & Zouboulis CC. 2007 Testosterone metabolism to 5α-dihydrotestosterone and synthesis of sebaceous lipids is regulated by the peroxisome proliferator-activated receptor ligand linoleic acid in human sebocytes. British Journal of Dermatology 156 428-432.
23. Melnik BC. 2012 Dietary intervention in acne: attenuation of increased mTORC1 signaling promoted by Western diet. Dermato-Endocrinology 4 20-32.
24. Melnik BC & Schmitz G. 2009 Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris. Experimental Dermatology 18 833-841.
25. Melnik BC & Zouboulis CC. 2013 Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne. Experimental Dermatology 22 311-315.
26. Montagna W. 1974 An introduction to sebaceous glands. Journal of Investigative Dermatology 62 120-123.
27. Nikkari T. 1974 Comparative chemistry of sebum. Journal of Investigative Dermatology 62 257-267.
28. Ntambi JM, Miyazaki M, Stoehr JP, Lan H, Kendziorski CM, Yandell BS, Song Y, Cohen P, Friedman JM & Attie AD. 2002 Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. PNAS 99 11482-11486.
29. Perkins AC, Cheng CE, Hillebrand GG, Miyamoto K & Kimball. AB 2011 Comparison of the epidemiology of acne vulgaris among Caucasian, Asian, Continental Indian and African American women. Journal of the European Academy of Dermatology and Venereology 25 1054-1060.
30. Pochi PE & Strauss JS. 1974 Endocrinologic control of the development and activity of the human sebaceous gland. Journal of Investigative Dermatology 62 191-201.
31. Puranen TJ, Kurkela RM, Lakkakorpi JT, Poutanen MH, Itäranta PV, Melis JP, Ghosh D, Vihko RK & Vihko PT. 1999 Characterization of molecular and catalytic properties of intact and truncated human β-hydroxysteroid dehydrogenase type 2 enzymes: intracellular localization of the wild-type enzyme in the endoplasmic reticulum. Endocrinology 140 3334-3441.
32. Rosignoli C, Nicolas JC, Jomard A & Michel S. 2003 Involvement of the SREBP pathway in the mode of action of androgens in sebaceous glands in vivo. Experimental Dermatology 12 480-489.
33. Sasano H, Suzuki T, Miki Y & Moriya T. 2008 Intracrinology of estrogen and androgens in breast carcinoma. Journal of Steroid Biochemistry and Molecular Biology 108 181-185.
34. Sato H, Sugai H, Kurosaki H, Ishikawa M, Funaki A, Kimura Y & Ueno K. 2013 The effect of sex hormones on peroxisome proliferatoractivated receptor γ expression and activity in mature adipocytes. Biological & Pharmaceutical Bulletin 36 564-573.
35. Shen Z, Peng Z, Sun Y, Vaananen HK & Poutanen M. 2008 Overexpression of human hydroxysteroid (17β) dehydrogenase 2 induces disturbance in skeletal development in young malemice. Journal of Bone and Mineral Research 23 1217-1226.
36. Shen Z, Saloniemi T, Rönnblad A, Järvensivu P, Pakarinen P & Poutanen M. 2009 Sex steroid-dependent and -independent action of hydroxysteroid (17β) dehydrogenase 2: evidence from transgenic female mice. Endocrinology 150 4941-4949.
37. Stocco DM. 2001 StAR protein and the regulation of steroid hormone biosynthesis. Annual Review of Physiology 63 193-213.
38. 5→4-isomerase activity associated with the human 17β-hydroxysteroid dehydrogenase type 2 isoform. Journal of Clinical Endocrinology and Metabolism 85 3669-3672.
39. Suzuki T, Miki Y, Moriya T, Akahira J, Ishida T, Hirakawa H, Yamaguchi Y, Hayashi S & Sasano H. 2007 5α-Reductase type 1 and aromatase in breast carcinoma as regulators of in situ androgen production. International Journal of Cancer 120 285-291.
40. Tansey JT, Sztalryd C, Gruia-Gray J, Roush DL, Zee JV, Gavrilova O, Reitman ML, Deng CX, Li C, Kimmel AR et al. 2001 Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. PNAS 22 6494-6499.
41. Thiboutot D, Martin P, Volikos L & Gilliland K. 1998 Oxidative activity of the type 2 isozyme of 17β-hydroxysteroid dehydrogenase (17β-HSD) predominates in human sebaceous glands. Journal of Investigative Dermatology 111 390-395.
42. Thiboutot D, Jabara S, McAllister JM, Sivarajah A, Gilliland K, Cong Z & Clawson G. 2003 Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1). Journal of Investigative Dermatology 120 905-914.
43. Trivedi NR, Cong Z, Nelson AM, Albert AJ, Rosamilia LL, Sivarajah S, Gilliland KL, Liu W, Mauger DT, Gabbay RA et al. 2006 Peroxisome proliferator-activated receptors increase human sebum production. Journal of Investigative Dermatology 126 2002-2009.
44. Wille JJ & Kydonieus A. 2003 Palmitoleic acid isomer (C16:1Δ6) in human skin sebum is effective against Gram-positive bacteria. Skin Pharmacology and Physiology 16 176-187.
45. Wróbel A, Seltmann H, Fimmel S, Müller-Decker K, Tsukada M, Bogdanoff B, Mandt N, Blume-Peytavi U, Orfanos CE & Zouboulis CC. 2003 Differentiation and apoptosis in human immortalized sebocytes. Journal of Investigative Dermatology 120 175-181.
46. Wu L, Einstein M, Geissler WM, Chan HK, Elliston KO & Andersson S. 1993 Expression cloning and characterization of human 17β-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20α-hydroxysteroid dehydrogenase activity. Journal of Biological Chemistry 268 12964-12969.
47. Yanase T, Suzuki S, Goto K & Nomura M. 2003 Aromatase in bone: roles of vitamin D3 and androgens. Journal of Steroid Biochemistry and Molecular Biology 86 393-397.
48. Zhenhuan Z, Hiroko Y, Tatsuya T, Yasuo H, Yoko O, Hiroshi S, Shunzo K, Nobuhiro H & Hirotaka I. 2002 Semi-quantitative immunohistochemical analysis of aromatase expression in ductal carcinoma in situ of the breast. Breast Cancer Research and Treatment 74 47-53.
49. Zhongyi S, Rantakari P, Lamminen T, Toppari J & Poutanen M. 2007 Transgenic male mice expressing human hydroxysteroid dehydrogenase 2 indicate a role for the enzyme independent of its action on sex steroids. Endocrinology 148 3827-3836.
50. Zhu L,Gong B, Bisgaier CL, Aviram M&Newton RS. 1998 Induction of PPARg1 expressioninhumanTHP-1monocytic leukemiacellsby9-cis-retinoic acid is associated with cellular growth suppression. Biochemical and Biophysical Research Communications 251 842-848.
51. Zouboulis CC. 2004 The human skin as a hormone target and an endocrine gland. Hormones 3 9-26.
52. Zouboulis CC, Xia L, Akamatsu H, Seltmann H, Fritsch M, Hornemann S, Ruhl R, Chen W, Nau H&Orfanos CE. 1998 The human sebocyte culture model provides new insights into development and management of seborrhoea and acne. Dermatology 196 21-31.
53. Zouboulis CC, Seltmann H, Neitzel H & Orfanos CE. 1999 Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95). Journal of Investigative Dermatology 113 1011-1020.