Antroquinonol from ethanolic extract of mycelium of Antrodia cinnamomea protects hepatic cells from ethanol-induced oxidative stress through Nrf-2 activation

Journal of Ethnopharmacology

Volumn 136, Issue 1, 2011, Pages 168-177

  Kumar, K J Senthil ^a   Chu, Fang Hua ^b   Hsieh, Han Wen ^a   Liao, Jiunn Wang ^a   Li, Wen Hsiung ^c   Lin, Johnson Chin Chung ^d   Shaw, Jei Fu ^a   Wang, Sheng Yang ^a,e  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c BIODIVERSITY RESEARCH CENTER   (Taiwan)

^d Taiwan Leader Biotech Company   (Taiwan)

^e AGRICULTURAL BIOTECHNOLOGY RESEARCH CENTER   (Taiwan)

Author keywords

Antrodia cinnamomea; Antroquinonol; Hepatoprotective activity; HO 1; Nrf 2

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ANTIOXIDANT; ANTRODIA CINNAMOMEA EXTRACT; ANTROQUINONOL; ASPARTATE AMINOTRANSFERASE; GLUTATHIONE; HEME OXYGENASE 1; LIVER PROTECTIVE AGENT; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; SILYMARIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL INTOXICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ANTRODIA CINNAMOMEA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL DEGENERATION; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; ENZYME ACTIVATION; GEL MOBILITY SHIFT ASSAY; GENE ACTIVATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIPID PEROXIDATION; LIVER CELL; LIVER HYPERTROPHY; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; ANTRODIA; BIOLOGICAL AGENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; ETHANOL; GLUTATHIONE; HEME OXYGENASE-1; HEP G2 CELLS; HEPATOCYTES; HUMANS; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; MICE; MICE, INBRED ICR; MITOGEN-ACTIVATED PROTEIN KINASES; MYCELIUM; NF-E2-RELATED FACTOR 2; NITRIC OXIDE; OXIDATIVE STRESS; PHYTOTHERAPY; REACTIVE OXYGEN SPECIES; TRANSAMINASES; UBIQUINONE;

ANTRODIA CINNAMOMEA; BASIDIOMYCOTA; MUS;

EID: 79958101248     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.04.030     Document Type: Article

References (33)

1. Ao, Z.H., Xu, Z.H., Lu, Z.M., Xu, H.Y., Zhang, X.M., Dou, W.F., 2009. Niuchangchih (Antrodia camphorata) and its potential in treating liver diseases. Journal of Ethnopharmacology 121, 194-212.
2. Bao, W., Rong, S., Yao, P., Hao, L., Ying, C., Zhang, X., Nussler, A., Liu, L., 2010. Curcumin alleviates ethanol-induced hepatocytes oxidative damage involving heme oxygenase-1 induction. Journal of Ethnopharmacology 128, 549-553.
3. Carson, E.J., Pruett, S.B., 1996. Development and characterization of a binge drinking model in mice for evaluation of the immunological effects of ethanol. Alcoholism, Clinical and Experimental Research 20, 132-138. (Pubitemid 26074662)
4. Chang, J.M., Lee, Y.R., Hung, L.M., Liu, S.Y., Kuo, M.T., Wen, W.C., Chen, P., 2008. An extract of Antrodia camphorata mycelia attenuates the progression of nephritis in systemic lupus erythematosus-prone NZB/WF1 mice. Evidence-based Complementary and Alternative Medicine, doi:10.1093/ecam/nen057.
5. Chiang, P.C., Lin, S.C., Pan, S.L., Kuo, C.H., Tsai, I.L., Kuo, M.T., Wen, W.C., Chen, P., Guh, J.H., 2010. Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathway. Biochemical Pharmacology 79, 162-171.
6. Dai, Y.Y., Chuang, C.H., Tsai, C.C., Sio, H.M., Huang, S.S., Chen, J.C., Hu, M.L., 2003. The protection of Antrodia camphorata against acute hepatotoxicity of alcohol in rats. Journal of Food and Drug Analysis 11, 177-185.
7. Das, S.K., Vasudevan, D.M., 2007. Alcohol-induced oxidative stress. Life Sciences 81, 177-187. (Pubitemid 46978376)
8. De, B.K., Gangopadyay, S., Dutta, D., Baksi, S.O., Pani, A., Gosh, P., 2009. Pentoxifylline versus prednisolone for severe alcoholic hepatitis: a randomized controlled trail. World Journal of Gastroenterology 15, 1613-1619.
9. Farombi, E.O., Surh, Y.J., 2006. Heme oxygenase-1 as potential therapeutic target for hepatoprotection. Journal of Biochemistry and Molecular Biology 39, 479-491. (Pubitemid 44714527)
10. Geethangili, M., Tzeng, Y.M., 2009. Review of pharmacological effects of Antrodia camphorata and its bioactive compounds. Evidence-based Complementary and Alternative Medicine, doi:10.1093/ecam/nep108.
11. Guitierrez-Ruiz, M.C., Quiroz, S.C., Souza, V., Bucio, L., Hernandez, E., Olivares, I.P., Llorente, L., Vargas-Vorackova, F., Kershenobich, D., 1999. Cytokines, growth factors, and oxidative stress in HepG2 cells treated with ethanol, acetaldehyde and LPS. Toxicology 134, 197-207. (Pubitemid 29248891)
12. Huang, J.S., Chang, H.C., Li, E.I.C., Huang, T.M., Su, Y.H., Wang, K.C., 2006. Enhancement of hepatoprotective efficacy of Antrodia camphorata by Chinese tradition medicine. Journal of Gastroenterology and Hepatology 21, A234.
13. Kanbak, G., Inal, M., Baycu, C., 2001. Ethanol-induced hepatotoxicity and hepatoprotective effects of betaine. Cell Biochemistry and Function 19, 281-285. (Pubitemid 33097885)
14. Kaur, G., Meena, C., Veeranjaneyulu, A., Agrawal, S.S, 2009. Evaluation of hepatoprotective activity of Ocimum scantum in HepG2 cell line. Archives of Pharmaceutical Science and Research 1, 25-30.
15. Kumar, K.J.S., Shei, H.W., Wang, S.Y., 2010. Anti-inflammatory effect of lucidone in mice via inhibition of NF-κB/MAP kinase pathway. International Immunopharmacology 10, 385-392.
16. Kumar, K.J.S., Wang, S.Y., 2009. Lucidone inhibits iNOS and COX-2 expression in LPS-induced RAW264.7 murine macrophage cells via NF-κB and MAPKs signaling pathway. Planta Medica 75, 494-500.
17. LeBouton, A.V., 1982. Routine overnight starvation and immunocytochemistry of hepatocyte albumin content. Cell and Tissue Research 227, 423-427.
18. Lee, T.H., Lee, C.K., Tsou, W.L., Liu, S.Y., Kuo, M.T., Wen, W.C., 2007. A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata. Planta Medica 73, 1412-1414.
19. Liu, S.Y., Kuo, M.T., Wen, W.C., 2008. Compounds from Antrodia camphorata. US Patent 7,385,088.
20. Lu, Z.M., Tao, W.Y., Zou, X.L., Fu, H.Z., Ao, Z.H., 2007. Protective effects of mycelia of Antrodia camphorata and Armillariella tabescens in submerged culture against ethanol-induced hepatic toxicity in rats. Journal of Ethnopharmacology 110, 160-164.
21. Majano, P.L., Medina, J., Zubia, I., Sunyer, L., Pezzi, E.L., Rodriguez, A.M., Cabrera, M.L., Otero, R.M., 2004. N-Acetyl-cysteine modulates inducible nitric oxide synthase gene expression in human Hepatoma cells. Journal of Hepatology 40, 632-637. (Pubitemid 38367785)
22. Nah, H.Y., Lee, W.S., Joo, Y.E., Kim, H.S., Choi, S.K., Rew, J.S., Kim, S.J., Jung, Y.D., Ahn, B.W., Park, J.S., Shin, B.A., 2005. Resveratrol protects HepG2 and Chang liver cells from oxidative stress. Chonnam Medical Journal 41, 243-252.
23. Ogny, J., Mathews, R., Anni, H., Shanon, K., Ercal, N., 2008. The mechanism of elevated toxicity in HepG2 cells due to the combined exposure of ethanol and ionizing radiation. Journal of Applied Toxicology 28, 345-355. (Pubitemid 351518122)
24. Qi, H., Siu, S.O., Chen, Y., Chu, I.K., Tong, Y., Lau, A.S.Y., Rong, J., 2010. Senkyunolides reduce hydrogen peroxide-induced oxidative damage in human liver HepG2 cells via induction of heme oxygenase-1. Chemico-Biological Interactions 183, 380-389.
25. Shen, C.C., Huang, R.L., Lin, L.C., Don, M.J., Chang, T.T., Chou, C.J., 2003. New ergostane and lanostane from Antrodia camphorata. Journal of Chinese Medicine 14, 247-258.
26. Song, Z., Deaciuc, I., Song, M., Lee, D.Y., Liu, Y., Ji, X., McClain, C., 2006. Silymarin protects against acute ethanol-induced hepatotoxicity in mice. Alcoholism, Clinical and Experimental Research 30, 407-413. (Pubitemid 43341346)
27. Su, C.H., 2002. Health Guardian Angel: Antrodia camphorata, 1st edn. EKS Book Publishing Co., Taipei, Taiwan.
28. Surh, Y.J., 2003. Cancer chemoprevention with dietary phytochemicals. Nature Review of Cancer 3, 768-778.
29. 2+NO-cGMP pathway. Life Sciences 73, 2769-2783.
30. Yang, S.S., Wang, G.J., Wang, S.Y., Lin, Y.Y., Kuo, Y.H., Lee, T.H., 2009.Newconstituents with iNOS inhibitory activity from mycelium of Antrodia camphorata. Planta Medica 75, 512-516.
31. Yao, P., Nussler, A., Liu, L., Hao, L., Song, F., Schirmeier, A., Nussler, N., 2007. Quercetin protects human hepatoma cells from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf-2 pathway. Journal of Hepatology 47, 253-261. (Pubitemid 47023137)
32. Younossi, Z.M., 1998. Epidemiology of alcohol-induced liver diseases. Clinics in Liver Disease 2, 661-671.
33. Zhao, J., Chen, H., Li, Y., 2008. Protective effect of bicyclol on acute alcohol-induced liver injury in mice. European Journal of Pharmacology 586, 322-331.