16α-Hydroxycleroda-3,13 (14)Z-dien-15,16-olide from Polyalthia longifolia: A safe and orally active antileishmanial agent

British Journal of Pharmacology

Volumn 159, Issue 5, 2010, Pages 1143-1150

  Misra, Pragya ^a   Sashidhara, Koneni V ^a   Singh, Suriya Pratap ^a   Kumar, Awanish ^a   Gupta, Reema ^a   Chaudhaery, Shailendra S ^a   Gupta, Souvik Sen ^b   Majumder, H K ^b   Saxena, Anil K ^a   Dube, Anuradha ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b NATIONAL CHEMICAL LABORATORY   (India)

Author keywords

Antileishmanial activity; Apoptosis; L. donovani topoisomerase I; Leishmania donovani; Molecular docking; Polyalthia longifolia

Indexed keywords

16ALPHA HYDROXYCLERODA 3,13 (14)DIEN 15,16 OLIDE; ANTILEISHMANIAL AGENT; CLERODANE DERIVATIVE; DITERPENE; DNA TOPOISOMERASE INHIBITOR; GREEN FLUORESCENT PROTEIN; NATURAL PRODUCT; PLANT EXTRACT; UNCLASSIFIED DRUG; 16 HYDROXYCLERODA 3,13(14) DIEN 15,16 OLIDE; 16-HYDROXYCLERODA-3,13(14)-DIEN-15,16-OLIDE; ANTIPROTOZOAL AGENT; DNA TOPOISOMERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; APOPTOSIS; ARTICLE; BIOASSAY; CELL DEATH; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SAFETY; DRUG TARGETING; EVALUATION; FRACTIONATION; HAMSTER; HYDROGEN BOND; IN VITRO STUDY; LEISHMANIA DONOVANI; MALE; MEDICINAL PLANT; MOLECULAR DOCKING; MOLECULAR MODEL; MOUSE; NONHUMAN; POLYALTHIA LONGIFOLIA; PRIORITY JOURNAL; PROTEIN INTERACTION; SURVIVAL; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DELIVERY SYSTEM; DRUG EFFECT; ENZYMOLOGY; HYDROPHOBICITY; ISOLATION AND PURIFICATION; ORAL DRUG ADMINISTRATION; POLYALTHIA; VISCERAL LEISHMANIASIS;

ADMINISTRATION, ORAL; ANIMALS; ANTIPROTOZOAL AGENTS; APOPTOSIS; CRICETINAE; DITERPENES; DNA TOPOISOMERASES, TYPE I, EUKARYOTIC; DRUG DELIVERY SYSTEMS; HYDROGEN BONDING; HYDROPHOBICITY; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; MALE; MODELS, MOLECULAR; POLYALTHIA;

EID: 77949394141     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00609.x     Document Type: Article

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