CCAAT/enhancer binding protein β mediates expression of matrix metalloproteinase 13 in human articular chondrocytes in inflammatory arthritis

Arthritis and Rheumatism

Volumn 60, Issue 3, 2009, Pages 708-716

  Hayashida, Mitsumasa ^a   Okazaki, Ken ^a,b   Fukushi, Junichi ^a   Sakamoto, Akio ^a   Iwamoto, Yukihide ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CCAAT ENHANCER BINDING PROTEIN BETA; COLLAGENASE 3; INTERLEUKIN 1BETA; LUCIFERASE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; ARTICULAR CARTILAGE; BINDING SITE; CARTILAGE; CARTILAGE CELL; CELL STIMULATION; CHROMATIN IMMUNOPRECIPITATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME LOCALIZATION; GENE ACTIVITY; GENE DELETION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MUTATIONAL ANALYSIS; ORGAN CULTURE; OSTEOARTHRITIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; WESTERN BLOTTING;

AGED; AGED, 80 AND OVER; ARTHRITIS, RHEUMATOID; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELLS, CULTURED; CHONDROCYTES; HUMANS; INTERLEUKIN-1BETA; KNEE JOINT; MATRIX METALLOPROTEINASE 13; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 61649113489     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24332     Document Type: Article

References (44)

1. Firestein GS. Evolving concepts of rheumatoid arthritis. Nature 2003;423:356-61.
2. Murphy G, Lee MH. What are the roles of metalloproteinases in cartilage and bone damage? Ann Rheum Dis 2005;64 Suppl IV:iv44-7.
3. Kamekura S, Hoshi K, Shimoaka T, Chung U, Chikuda H, Yamada T, et al. Osteoarthritis development in novel experimental mouse models induced by knee joint instability. Osteoarthritis Cartilage 2005;13:632-41.
4. Goldring MB, Goldring SR. Osteoarthritis [review]. J Cell Physiol 2007;213:626-34.
5. Knauper V, Lopez-Otin C, Smith B, Knight G, Murphy G. Biochemical characterization of human collagenase-3. J Biol Chem 1996;271:1544-50.
6. Fosang AJ, Last K, Knauper V, Murphy G, Neame PJ. Degradation of cartilage aggrecan by collagenase-3 (MMP-13). FEBS Lett 1996;380:17-20.
7. Mengshol JA, Mix KS, Brinckerhoff CE. Matrix metalloproteinases as therapeutic targets in arthritic diseases: bull's-eye or missing the mark? [review]. Arthritis Rheum 2002;46:13-20.
8. Fukui N, McAlinden A, Zhu Y, Crouch E, Broekelmann TJ, Mecham RP, et al. Processing of type II procollagen amino propeptide by matrix metalloproteinases. J Biol Chem 2002;277:2193-201.
9. Knauper V, Murphy G, Tschesche H. Activation of human neutrophil procollagenase by stromelysin 2. Eur J Biochem 1996;235:187-91.
10. Neuhold LA, Killar L, Zhao W, Sung ML, Warner L, Kulik J, et al. Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice. J Clin Invest 2001;107:35-44.
11. Mengshol JA, Vincenti MP, Coon CI, Barchowsky A, Brinckerhoff CE. Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor κB: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum 2000;43:801-11.
12. Liacini A, Sylvester J, Li WQ, Huang W, Dehnade F, Ahmad M, et al. Induction of matrix metalloproteinase-13 gene expression by TNF-α is mediated by MAP kinases, AP-1, and NF-κB transcription factors in articular chondrocytes. Exp Cell Res 2003;288:208-17.
13. Tan L, Peng H, Osaki M, Choy BK, Auron PE, Sandell LJ, et al. Egr-1 mediates transcriptional repression of COL2A1 promoter activity by interleukin-1β. J Biol Chem 2003;278:17688-700.
14. Okazaki K, Li J, Yu H, Fukui N, Sandell LJ. CCAAT/enhancer-binding proteins β and δ mediate the repression of gene transcription of cartilage-derived retinoic acid-sensitive protein induced by interleukin-1β. J Biol Chem 2002;277:31526-33.
15. Akira S, Isshiki H, Sugita T, Tanabe O, Kinoshita S, Nishio Y, et al. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J 1990;9:1897-906.
16. Descombes P, Schibler U. A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell 1991;67:569-79.
17. Tanaka T, Akira S, Yoshida K, Umemoto M, Yoneda Y, Shirafuji N, et al. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell 1995;80:353-61.
18. Akira S, Kishimoto T. NF-IL6 and NF-κB in cytokine gene regulation. Adv Immunol 1997;65:1-46.
19. Thomas B, Berenbaum F, Humbert L, Bian H, Bereziat G, Crofford L, et al. Critical role of C/EBPδ and C/EBPβ factors in the stimulation of the cyclooxygenase-2 gene transcription by interleukin-1β in articular chondrocytes. Eur J Biochem 2000;267:6798-809.
20. 2 gene transcription by interleukin-1β: role of C/EBP factors. J Biol Chem 2000;275:22686-94.
21. Jones PL, Ping D, Boss JM. Tumor necrosis factor α and interleukin-1β regulate the murine manganese superoxide dismutase gene through a complex intronic enhancer involving C/EBP-β and NF-κB. Mol Cell Biol 1997;17:6970-81.
22. Saunders MA, Sansores-Garcia L, Gilroy DW, Wu KK. Selective suppression of CCAAT/enhancer-binding protein β binding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human fibroblasts. J Biol Chem 2001;276:18897-904.
23. Greenwel P, Tanaka S, Penkov D, Zhang W, Olive M, Moll J, et al. Tumor necrosis factor α inhibits type I collagen synthesis through repressive CCAAT/enhancer-binding proteins. Mol Cell Biol 2000;20:912-8.
24. Gutierrez S, Javed A, Tennant DK, van Rees M, Montecino M, Stein GS, et al. CCAAT/enhancer-binding proteins (C/EBP) β and δ activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression. J Biol Chem 2002;277:1316-23.
25. Raymond L, Eck S, Mollmark J, Hays E, Tomek I, Kantor S, et al. Interleukin-1β induction of matrix metalloproteinase-1 transcription in chondrocytes requires ERK-dependent activation of CCAAT enhancer-binding protein-β. J Cell Physiol 2006;207:683-8.
26. Kellgren JH, Lawrence JS. Radiological assessment of osteoarthrosis. Ann Rheum Dis 1957;16:494-502.
27. Van der Sluijs JA, Geesink RG, van der Linden AJ, Bulstra SK, Kuyer R, Drukker J. The reliability of the Mankin score for osteoarthritis. J Orthop Res 1992;10:58-61.
28. Finger F, Schorle C, Zien A, Gebhard P, Goldring MB, Aigner T. Molecular phenotyping of human chondrocyte cell lines T/C-28a2, T/C-28a4, and C-28/I2. Arthritis Rheum 2003;48:3395-403.
29. Hirai Y, Radisky D, Boudreau R, Simian M, Stevens ME, Oka Y, et al. Epimorphin mediates mammary luminal morphogenesis through control of C/EBPβ. J Cell Biol 2001;153:785-94.
30. Nakabeppu Y, Oda S, Sekiguchi M. Proliferative activation of quiescent Rat-1A cells by ΔFosB. Mol Cell Biol 1993;13:4157-66.
31. Sakaue H, Konishi M, Ogawa W, Asaki T, Mori T, Yamasaki M, et al. Requirement of fibroblast growth factor 10 in development of white adipose tissue. Genes Dev 2002;16:908-12.
32. Osada S, Yamamoto H, Nishihara T, Imagawa M. DNA binding specificity of the CCAAT/enhancer-binding protein transcription factor family. J Biol Chem 1996;271:3891-6.
33. Kamekura S, Kawasaki Y, Hoshi K, Shimoaka T, Chikuda H, Maruyama Z, et al. Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. Arthritis Rheum 2006;54:2462-70.
34. Tardif G, Pelletier JP, Dupuis M, Hambor JE, Martel-Pelletier J. Cloning, sequencing and characterization of the 5′-flanking region of the human collagenase-3 gene. Biochem J 1997;323(Pt 1):13-6.
35. Mengshol JA, Vincenti MP, Brinckerhoff CE. IL-1 induces collagenase-3 (MMP-13) promoter activity in stably transfected chondrocytic cells: requirement for Runx-2 and activation by p38 MAPK and JNK pathways. Nucleic Acids Res 2001;29:4361-72.
36. Pendas AM, Balbin M, Llano E, Jimenez MG, Lopez-Otin C. Structural analysis and promoter characterization of the human collagenase-3 gene (MMP13). Genomics 1997;40:222-33.
37. Jimenez MJ, Balbin M, Lopez JM, Alvarez J, Komori T, Lopez-Otin C. Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. Mol Cell Biol 1999;19:4431-42.
38. Selvamurugan N, Chou WY, Pearman AT, Pulumati MR, Partridge NC. Parathyroid hormone regulates the rat collagenase-3 promoter in osteoblastic cells through the cooperative interaction of the activator protein-1 site and the runt domain binding sequence. J Biol Chem 1998;273:10647-57.
39. Hess J, Porte D, Munz C, Angel P. AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element. J Biol Chem 2001;276:20029-38.
40. Imamura T, Imamura C, Iwamoto Y, Sandell LJ. Transcriptional co-activators CREB-binding protein/p300 increase chondrocyte Cd-rap gene expression by multiple mechanisms including sequestration of the repressor CCAAT/enhancer-binding protein. J Biol Chem 2005;280:16625-34.
41. Wang H, Larris B, Peiris TH, Zhang L, Le Lay J, Gao Y, et al. C/EBPβ activates E2F-regulated genes in vivo via recruitment of the coactivator CREB-binding protein/P300. J Biol Chem 2007;282:24679-88.
42. Vallejo M, Ron D, Miller CP, Habener JF. C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements. Proc Natl Acad Sci U S A 1993;90:4679-83.
43. LeClair KP, Blanar MA, Sharp PA. The p50 subunit of NF-κB associates with the NF-IL6 transcription factor. Proc Natl Acad Sci U S A 1992;89:8145-9.
44. Hsu W, Kerppola TK, Chen PL, Curran T, Chen-Kiang S. Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region. Mol Cell Biol 1994;14:268-76.