-
1
-
-
84864437676
-
Androgen action and metabolism in prostate cancer
-
Green, S. M., and Mostaghel., E. A., and Nelson, P. S. (2012) Androgen action and metabolism in prostate cancer. Mol. Cell. Endocrinol. 360, 3-13
-
(2012)
Mol. Cell. Endocrinol.
, vol.360
, pp. 3-13
-
-
Green, S.M.1
Mostaghel, E.A.2
Nelson, P.S.3
-
2
-
-
84879127816
-
Targeting alternative sites on the androgen receptor to treat castration-resistant prostate cancer
-
Lallous, N., Dalal, K., Cherkasov, A., and Rennie, P. S. (2013) Targeting alternative sites on the androgen receptor to treat castration-resistant prostate cancer. Int. J. Mol. Sci. 14, 12496-12519
-
(2013)
Int. J. Mol. Sci.
, vol.14
, pp. 12496-12519
-
-
Lallous, N.1
Dalal, K.2
Cherkasov, A.3
Rennie, P.S.4
-
3
-
-
43149125406
-
Structural basis for the nuclear import of the human androgen receptor
-
Cutress, M. L., and Whitaker., H. C., Mills, I. G., Stewart, M., and Neal, D. E. (2008) Structural basis for the nuclear import of the human androgen receptor. J. Cell Sci. 121, 957-968
-
(2008)
J. Cell Sci.
, vol.121
, pp. 957-968
-
-
Cutress, M.L.1
Whitaker, H.C.2
Mills, I.G.3
Stewart, M.4
Neal, D.E.5
-
4
-
-
77951645885
-
Androgen regulation of gene expression
-
Lamont, K. R., and Tindall, D. J. (2010) Androgen regulation of gene expression. Adv. Cancer Res. 107, 137-162
-
(2010)
Adv. Cancer Res.
, vol.107
, pp. 137-162
-
-
Lamont, K.R.1
Tindall, D.J.2
-
5
-
-
84892557687
-
Treatment options in castration-resistant prostate cancer: Current therapies and emerging docetaxel-based regimens
-
Saad, F., and Miller, K. (2014) Treatment options in castration-resistant prostate cancer: current therapies and emerging docetaxel-based regimens. Urol. Oncol. 32, 70-79
-
(2014)
Urol. Oncol.
, vol.32
, pp. 70-79
-
-
Saad, F.1
Miller, K.2
-
6
-
-
0025935923
-
Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization
-
Jenster, G., van der Korput, H. A., van Vroonhoven, C., van der Kwast, T. H., Trapman, J., and Brinkmann, A. O. (1991) Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization. Mol. Endocrinol. 5, 1396-1404
-
(1991)
Mol. Endocrinol.
, vol.5
, pp. 1396-1404
-
-
Jenster, G.1
Van Der Korput, H.A.2
Van Vroonhoven, C.3
Van Der Kwast, T.H.4
Trapman, J.5
Brinkmann, A.O.6
-
7
-
-
17844376217
-
Structural basis for antagonism and resistance of bicalutamide in prostate cancer
-
Bohl, C. E., Gao, W., Miller, D. D., Bell, C. E., and Dalton, J. T. (2005) Structural basis for antagonism and resistance of bicalutamide in prostate cancer. Proc. Natl. Acad. Sci. U.S.A. 102, 6201-6206
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 6201-6206
-
-
Bohl, C.E.1
Gao, W.2
Miller, D.D.3
Bell, C.E.4
Dalton, J.T.5
-
8
-
-
10644220145
-
Identification of a novel class of androgen receptor antagonists based on the bicyclic-1H-isoindole-1, 3(2H)-dione nucleus
-
Salvati, M. E., Balog, A., Wei, D. D., Pickering, D., Attar, R. M., Geng, J., Rizzo, C.A., and Hunt., J. T., Gottardis, M. M., Weinmann, R., and Martinez, R. (2005) Identification of a novel class of androgen receptor antagonists based on the bicyclic-1H-isoindole-1, 3(2H)-dione nucleus. Bioorg. Med. Chem. Lett. 15, 389-393
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 389-393
-
-
Salvati, M.E.1
Balog, A.2
Wei, D.D.3
Pickering, D.4
Attar, R.M.5
Geng, J.6
Rizzo, C.A.7
Hunt, J.T.8
Gottardis, M.M.9
Weinmann, R.10
Martinez, R.11
-
9
-
-
79958077907
-
Unexpected binding orientation of bulky-B-ring anti-androgens and implications for future drug targets
-
Duke, C. B., Jones, A., Bohl, C. E., Dalton, J. T., and Miller, D. D. (2011) Unexpected binding orientation of bulky-B-ring anti-androgens and implications for future drug targets. J. Med. Chem. 54, 3973-3976
-
(2011)
J. Med. Chem.
, vol.54
, pp. 3973-3976
-
-
Duke, C.B.1
Jones, A.2
Bohl, C.E.3
Dalton, J.T.4
Miller, D.D.5
-
10
-
-
1842637389
-
Structural basis of androgen receptor binding toselective androgen response elements
-
Shaffer, P. L., Jivan, A., Dollins, D. E., Claessens, F., and Gewirth, D. T. (2004) Structural basis of androgen receptor binding toselective androgen response elements. Proc. Natl. Acad. Sci. U.S.A. 101, 4758-4763
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 4758-4763
-
-
Shaffer, P.L.1
Jivan, A.2
Dollins, D.E.3
Claessens, F.4
Gewirth, D.T.5
-
11
-
-
8344226282
-
Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance
-
He, B., and Gampe., R. T., Jr., Kole, A. J., Hnat, A. T., Stanley, T. B., An, G., Stewart, E. L., Kalman, R. I., Minges, J. T., and Wilson, E. M. (2004) Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance. Mol. Cell 16, 425-438
-
(2004)
Mol. Cell
, vol.16
, pp. 425-438
-
-
He, B.1
Gampe, R.T.2
Kole, A.J.3
Hnat, A.T.4
Stanley, T.B.5
An, G.6
Stewart, E.L.7
Kalman, R.I.8
Minges, J.T.9
Wilson, E.M.10
-
12
-
-
35348812462
-
A surface on the androgen receptor that allosterically regulates coactivator binding
-
Estébanez-Perpiñá, E., Arnold, L. A., Arnold, A. A., Nguyen, P., Rodrigues, E. D., Mar, E., Bateman, R., Pallai, P., Shokat, K. M., Baxter, J.D., Guy, R. K., Webb, P., and Fletterick, R. J. (2007) A surface on the androgen receptor that allosterically regulates coactivator binding. Proc. Natl. Acad. Sci. U.S.A. 104, 16074-16079
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 16074-16079
-
-
Estébanez-Perpiñá, E.1
Arnold, L.A.2
Arnold, A.A.3
Nguyen, P.4
Rodrigues, E.D.5
Mar, E.6
Bateman, R.7
Pallai, P.8
Shokat, K.M.9
Baxter, J.D.10
Guy, R.K.11
Webb, P.12
Fletterick, R.J.13
-
13
-
-
84055217577
-
Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening
-
Lack, N. A., Axerio-Cilies, P., Tavassoli, P., and Han., F. Q., Chan, K. H., Feau, C., LeBlanc, E., and Guns., E. T., Guy, R. K., Rennie, P. S., and Cherkasov, A. (2011) Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening. J. Med. Chem. 54, 8563-8573
-
(2011)
J. Med. Chem.
, vol.54
, pp. 8563-8573
-
-
Lack, N.A.1
Axerio-Cilies, P.2
Tavassoli, P.3
Han, F.Q.4
Chan, K.H.5
Feau, C.6
LeBlanc, E.7
Guns, E.T.8
Guy, R.K.9
Rennie, P.S.10
Cherkasov, A.11
-
14
-
-
48549089747
-
Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance
-
Dehm, S. M., and Schmidt., L. J., Heemers, H. V., Vessella, R. L., and Tindall, D. J. (2008) Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance. Cancer Res. 68, 5469-5477
-
(2008)
Cancer Res.
, vol.68
, pp. 5469-5477
-
-
Dehm, S.M.1
Schmidt, L.J.2
Heemers, H.V.3
Vessella, R.L.4
Tindall, D.J.5
-
15
-
-
58249110391
-
Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer
-
Hu, R., and Dunn., T. A., Wei, S., Isharwal, S., Veltri, R. W., Humphreys, E., Han, M., and Partin., A. W., Vessella, R. L., Isaacs, W. B., Bova, G. S., and Luo, J. (2009) Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer. Cancer Res. 69, 16-22
-
(2009)
Cancer Res.
, vol.69
, pp. 16-22
-
-
Hu, R.1
Dunn, T.A.2
Wei, S.3
Isharwal, S.4
Veltri, R.W.5
Humphreys, E.6
Han, M.7
Partin, A.W.8
Vessella, R.L.9
Isaacs, W.B.10
Bova, G.S.11
Luo, J.12
-
16
-
-
65549168746
-
A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletionresistant growth
-
Guo, Z., Yang, X., Sun, F., Jiang, R., and Linn., D. E., Chen, H., Chen, H., Kong, X., Melamed, J., Tepper, C. G., Kung, H. J., Brodie, A. M., Edwards, J., and Qiu, Y. (2009) A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletionresistant growth. Cancer Res. 69, 2305-2313
-
(2009)
Cancer Res.
, vol.69
, pp. 2305-2313
-
-
Guo, Z.1
Yang, X.2
Sun, F.3
Jiang, R.4
Linn, D.E.5
Chen, H.6
Chen, H.7
Kong, X.8
Melamed, J.9
Tepper, C.G.10
Kung, H.J.11
Brodie, A.M.12
Edwards, J.13
Qiu, Y.14
-
17
-
-
77955296562
-
Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant
-
Sun, S., and Sprenger., C. C., Vessella, R. L., Haugk, K., Soriano, K., and Mostaghel., E. A., Page, S. T., Coleman, I. M., Nguyen, H. M., Sun, H., Nelson, P. S., and Plymate, S. R. (2010) Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant. J. Clin. Invest. 120, 2715-2730
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 2715-2730
-
-
Sun, S.1
Sprenger, C.C.2
Vessella, R.L.3
Haugk, K.4
Soriano, K.5
Mostaghel, E.A.6
Page, S.T.7
Coleman, I.M.8
Nguyen, H.M.9
Sun, H.10
Nelson, P.S.11
Plymate, S.R.12
-
18
-
-
78049280194
-
Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor
-
Watson, P.A., Chen, Y. F., and Balbas., M. D., Wongvipat, J., Socci, N. D., Viale, A., Kim, K., and Sawyers, C. L. (2010) Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor. Proc. Natl. Acad. Sci. U.S.A. 107, 16759-16765
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 16759-16765
-
-
Watson, P.A.1
Chen, Y.F.2
Balbas, M.D.3
Wongvipat, J.4
Socci, N.D.5
Viale, A.6
Kim, K.7
Sawyers, C.L.8
-
19
-
-
84861728843
-
Androgen receptor splice variants activate androgen receptor target genes and support aberrant prostate cancer cell growth independent of canonical androgen receptor nuclear localization signal
-
Chan, S. C., Li, Y., and Dehm, S. M. (2012) Androgen receptor splice variants activate androgen receptor target genes and support aberrant prostate cancer cell growth independent of canonical androgen receptor nuclear localization signal. J. Biol. Chem. 287, 19736-19749
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 19736-19749
-
-
Chan, S.C.1
Li, Y.2
Dehm, S.M.3
-
20
-
-
84872534568
-
Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines
-
Li, Y., and Chan., S. C., Brand, L. J., Hwang, T. H., Silverstein, K. A., and Dehm, S. M. (2013) Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines. Cancer Res. 73, 483-489
-
(2013)
Cancer Res.
, vol.73
, pp. 483-489
-
-
Li, Y.1
Chan, S.C.2
Brand, L.J.3
Hwang, T.H.4
Silverstein, K.A.5
Dehm, S.M.6
-
21
-
-
84874426546
-
Interplay between genomic alterations and androgen receptor signaling during prostate cancer development and progression
-
Nyquist, M. D., and Dehm, S. M. (2013) Interplay between genomic alterations and androgen receptor signaling during prostate cancer development and progression. Horm. Cancer 4, 61-69
-
(2013)
Horm. Cancer
, vol.4
, pp. 61-69
-
-
Nyquist, M.D.1
Dehm, S.M.2
-
22
-
-
84886447413
-
TALEN-engineered AR gene rearrangements reveal endocrine uncoupling of androgen receptor in prostate cancer
-
Nyquist, M. D., Li, Y., Hwang, T. H., Manlove, L. S., Vessella, R. L., Silverstein, K. A., Voytas, D. F., and Dehm, S. M. (2013) TALEN-engineered AR gene rearrangements reveal endocrine uncoupling of androgen receptor in prostate cancer. Proc. Natl. Acad. Sci. U.S.A. 110, 17492-17497
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 17492-17497
-
-
Nyquist, M.D.1
Li, Y.2
Hwang, T.H.3
Manlove, L.S.4
Vessella, R.L.5
Silverstein, K.A.6
Voytas, D.F.7
Dehm, S.M.8
-
23
-
-
84873912697
-
Targeting the binding function3(BF3) site of the androgen receptor through virtual screening. 2. Development of2-((2-phenoxyethyl) thio)-1H-benzimidazole derivatives
-
Munuganti, R. S., Leblanc, E., Axerio-Cilies, P., Labriere, C., Frewin, K., Singh, K., Hassona, M. D., Lack, N. A., Li, H., Ban, F., Tomlinson Guns, E., Young, R., Rennie, P. S., and Cherkasov, A. (2013) Targeting the binding function3(BF3) site of the androgen receptor through virtual screening. 2. Development of2-((2-phenoxyethyl) thio)-1H-benzimidazole derivatives. J. Med. Chem. 56, 1136-1148
-
(2013)
J. Med. Chem.
, vol.56
, pp. 1136-1148
-
-
Munuganti, R.S.1
Leblanc, E.2
Axerio-Cilies, P.3
Labriere, C.4
Frewin, K.5
Singh, K.6
Hassona, M.D.7
Lack, N.A.8
Li, H.9
Ban, F.10
Tomlinson Guns, E.11
Young, R.12
Rennie, P.S.13
Cherkasov, A.14
-
24
-
-
84873040206
-
Identification of novel androgen receptor antagonists using structure- and ligand-based methods
-
Li, H., Ren, X., Leblanc, E., Frewin, K., and Rennie., P. S., and Cherkasov, A. (2013) Identification of novel androgen receptor antagonists using structure- and ligand-based methods. J. Chem. Inf. Model. 53, 123-130
-
(2013)
J. Chem. Inf. Model.
, vol.53
, pp. 123-130
-
-
Li, H.1
Ren, X.2
Leblanc, E.3
Frewin, K.4
Rennie, P.S.5
Cherkasov, A.6
-
25
-
-
84906080748
-
Discovery of small-molecule inhibitors selectively targeting the DNA-binding domain of the human androgen receptor
-
Li, H., Ban, F., Dalal, K., Leblanc, E., Frewin, K., Ma, D., Adomat, H., and Rennie., P. S., and Cherkasov, A. (2014) Discovery of small-molecule inhibitors selectively targeting the DNA-binding domain of the human androgen receptor. J. Med. Chem. 10.1021/jm500802j
-
(2014)
J. Med. Chem.
-
-
Li, H.1
Ban, F.2
Dalal, K.3
Leblanc, E.4
Frewin, K.5
Ma, D.6
Adomat, H.7
Rennie, P.S.8
Cherkasov, A.9
-
26
-
-
0022458855
-
Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA
-
Miesfeld, R., Rusconi, S., Godowski, P.J., Maler, B.A., Okret, S., Wikström, A. C., Gustafsson, J. A., and Yamamoto, K. R. (1986) Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA. Cell 46, 389-399
-
(1986)
Cell
, vol.46
, pp. 389-399
-
-
Miesfeld, R.1
Rusconi, S.2
Godowski, P.J.3
Maler, B.A.4
Okret, S.5
Wikström, A.C.6
Gustafsson, J.A.7
Yamamoto, K.R.8
-
27
-
-
41149148236
-
Combining the polymerase incomplete primer extension method for cloning and mutagenesis with microscreening to accelerate structural genomics efforts
-
Klock, H. E., and Koesema., E. J., Knuth, M. W., and Lesley, S. A. (2008) Combining the polymerase incomplete primer extension method for cloning and mutagenesis with microscreening to accelerate structural genomics efforts. Proteins 71, 982-994
-
(2008)
Proteins
, vol.71
, pp. 982-994
-
-
Klock, H.E.1
Koesema, E.J.2
Knuth, M.W.3
Lesley, S.A.4
-
28
-
-
84863111874
-
Stepwise androgen receptor dimerization
-
van Royen, M.E., van Cappellen, W. A., de Vos, C., Houtsmuller, A.B., and Trapman, J. (2012) Stepwise androgen receptor dimerization. J. Cell Sci. 125, 1970-1979
-
(2012)
J. Cell Sci.
, vol.125
, pp. 1970-1979
-
-
Van Royen, M.E.1
Van Cappellen, W.A.2
De Vos, C.3
Houtsmuller, A.B.4
Trapman, J.5
-
29
-
-
84896974375
-
Ligand-independent and tissue-selective androgen receptor inhibition by pyrvinium
-
Lim, M., Otto-Duessel, M., He, M., Su, L., Nguyen, D., Chin, E., Alliston, T., and Jones, J. O. (2014) Ligand-independent and tissue-selective androgen receptor inhibition by pyrvinium. ACS Chem. Biol. 9, 692-702
-
(2014)
ACS Chem. Biol.
, vol.9
, pp. 692-702
-
-
Lim, M.1
Otto-Duessel, M.2
He, M.3
Su, L.4
Nguyen, D.5
Chin, E.6
Alliston, T.7
Jones, J.O.8
-
30
-
-
0031838203
-
Differential transactivation by the androgen receptor in prostate cancer cells
-
Snoek, R., Bruchovsky, N., Kasper, S., Matusik, R. J., Gleave, M., Sato, N., and Mawji., N. R., and Rennie, P. S. (1998) Differential transactivation by the androgen receptor in prostate cancer cells. Prostate 36, 256-263
-
(1998)
Prostate
, vol.36
, pp. 256-263
-
-
Snoek, R.1
Bruchovsky, N.2
Kasper, S.3
Matusik, R.J.4
Gleave, M.5
Sato, N.6
Mawji, N.R.7
Rennie, P.S.8
-
31
-
-
1842532337
-
Chemogenomics: An emerging strategy for rapid target and drug discovery
-
Bredel, M., and Jacoby, E. (2004) Chemogenomics: an emerging strategy for rapid target and drug discovery. Nat. Rev. Genet. 5, 262-275
-
(2004)
Nat. Rev. Genet.
, vol.5
, pp. 262-275
-
-
Bredel, M.1
Jacoby, E.2
-
32
-
-
0037015040
-
The program of androgen-responsive genes in neoplastic prostate epithelium
-
Nelson, P. S., Clegg, N., Arnold, H., Ferguson, C., Bonham, M., White, J., Hood, L., and Lin, B. (2002) The program of androgen-responsive genes in neoplastic prostate epithelium. Proc. Natl. Acad. Sci. U.S.A. 99, 11890-11895
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 11890-11895
-
-
Nelson, P.S.1
Clegg, N.2
Arnold, H.3
Ferguson, C.4
Bonham, M.5
White, J.6
Hood, L.7
Lin, B.8
-
33
-
-
29344467436
-
Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element
-
Magee, J. A., and Chang., L. W., Stormo, G. D., and Milbrandt, J. (2006) Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element. Endocrinology 147, 590-598
-
(2006)
Endocrinology
, vol.147
, pp. 590-598
-
-
Magee, J.A.1
Chang, L.W.2
Stormo, G.D.3
Milbrandt, J.4
-
34
-
-
67650742283
-
Characterization and interlaboratory comparison of a gene expression signature for differentiating genotoxic mechanisms
-
Ellinger-Ziegelbauer, H., Fostel, J. M., Aruga, C., Bauer, D., Boitier, E., Deng, S., Dickinson, D., Le Fevre, A. C., Fornace, A. J., Jr., Grenet, O., Gu, Y., Hoflack, J. C., Shiiyama, M., Smith, R., Snyder, R. D., Spire, C., Tanaka, G., and Aubrecht, J. (2009) Characterization and interlaboratory comparison of a gene expression signature for differentiating genotoxic mechanisms. Toxicol. Sci. 110, 341-352
-
(2009)
Toxicol. Sci.
, vol.110
, pp. 341-352
-
-
Ellinger-Ziegelbauer, H.1
Fostel, J.M.2
Aruga, C.3
Bauer, D.4
Boitier, E.5
Deng, S.6
Dickinson, D.7
Le Fevre, A.C.8
Fornace, A.J.9
Grenet, O.10
Gu, Y.11
Hoflack, J.C.12
Shiiyama, M.13
Smith, R.14
Snyder, R.D.15
Spire, C.16
Tanaka, G.17
Aubrecht, J.18
-
35
-
-
84873025061
-
Abiraterone and novel antiandrogens: Overcoming castration resistance in prostate cancer
-
Ferraldeschi, R., Pezaro, C., Karavasilis, V., and de Bono, J. (2013) Abiraterone and novel antiandrogens: overcoming castration resistance in prostate cancer. Annu. Rev. Med. 64, 1-13
-
(2013)
Annu. Rev. Med.
, vol.64
, pp. 1-13
-
-
Ferraldeschi, R.1
Pezaro, C.2
Karavasilis, V.3
De Bono, J.4
-
36
-
-
84873861022
-
Androgen receptor antagonists in castration-resistant prostate cancer
-
Rathkopf, D., and Scher, H. I. (2013) Androgen receptor antagonists in castration-resistant prostate cancer. Cancer J. 19, 43-49
-
(2013)
Cancer J.
, vol.19
, pp. 43-49
-
-
Rathkopf, D.1
Scher, H.I.2
-
37
-
-
0034192382
-
Acquisition of chemoresistant phenotype by overexpression of the antiapoptotic gene testosterone-repressed prostate message-2 in prostate cancer xenograft models
-
Miyake, H., Nelson, C., Rennie, P. S., and Gleave, M. E. (2000) Acquisition of chemoresistant phenotype by overexpression of the antiapoptotic gene testosterone-repressed prostate message-2 in prostate cancer xenograft models. Cancer Res. 60, 2547-2554
-
(2000)
Cancer Res.
, vol.60
, pp. 2547-2554
-
-
Miyake, H.1
Nelson, C.2
Rennie, P.S.3
Gleave, M.E.4
-
38
-
-
0030152008
-
Intermittent androgen suppression delays progression to androgen-independent regulation of prostate-specific antigen gene in the LNCaP prostate tumour model
-
Sato, N., and Gleave., M. E., Bruchovsky, N., Rennie, P. S., Goldenberg, S. L., Lange, P. H., and Sullivan, L. D. (1996) Intermittent androgen suppression delays progression to androgen-independent regulation of prostate-specific antigen gene in the LNCaP prostate tumour model. J. Steroid Biochem. Mol. Biol. 58, 139-146
-
(1996)
J. Steroid Biochem. Mol. Biol.
, vol.58
, pp. 139-146
-
-
Sato, N.1
Gleave, M.E.2
Bruchovsky, N.3
Rennie, P.S.4
Goldenberg, S.L.5
Lange, P.H.6
Sullivan, L.D.7
-
39
-
-
33751270698
-
Short hairpin RNA knockdown of the androgen receptor attenuates ligand-in-dependent activation and delays tumor progression
-
Cheng, H., Snoek, R., Ghaidi, F., Cox, M. E., and Rennie, P. S. (2006) Short hairpin RNA knockdown of the androgen receptor attenuates ligand-in-dependent activation and delays tumor progression. Cancer Res. 66, 10613-10620
-
(2006)
Cancer Res.
, vol.66
, pp. 10613-10620
-
-
Cheng, H.1
Snoek, R.2
Ghaidi, F.3
Cox, M.E.4
Rennie, P.S.5
-
40
-
-
58949101975
-
In vivo knockdown of the androgen receptor results in growth inhibition and regression of well established, castration-resistant prostate tumors
-
Snoek, R., Cheng, H., Margiotti, K., Wafa, L. A., Wong, C. A., Wong, E. C, Fazli, L., Nelson, C. C, Gleave, M. E., and Rennie, P. S. (2009) In vivo knockdown of the androgen receptor results in growth inhibition and regression of well established, castration-resistant prostate tumors. Clin. Cancer Res. 15, 39-47
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 39-47
-
-
Snoek, R.1
Cheng, H.2
Margiotti, K.3
Wafa, L.A.4
Wong, C.A.5
Wong, E.C.6
Fazli, L.7
Nelson, C.C.8
Gleave, M.E.9
Rennie, P.S.10
-
41
-
-
84877686260
-
A novel antiandrogen, compound 30, suppresses castration-resistant and MDV3100-resistant prostate cancer growth in vitro and in vivo
-
Kuruma, H., Matsumoto, H., Shiota, M., Bishop, J., Lamoureux, F., Thomas, C, Briere, D., Los, G., Gleave, M., Fanjul, A., and Zoubeidi, A. (2013) A novel antiandrogen, compound 30, suppresses castration-resistant and MDV3100-resistant prostate cancer growth in vitro and in vivo. Mol. Cancer Ther. 12, 567-576
-
(2013)
Mol. Cancer Ther.
, vol.12
, pp. 567-576
-
-
Kuruma, H.1
Matsumoto, H.2
Shiota, M.3
Bishop, J.4
Lamoureux, F.5
Thomas, C.6
Briere, D.7
Los, G.8
Gleave, M.9
Fanjul, A.10
Zoubeidi, A.11
-
42
-
-
70350098239
-
Lentiviruses with trastuzumab bound to their envelopes can target and kill prostate cancer cells
-
Zhang, K. X., Moussavi, M., Kim, C., Chow, E., and Chen., I. S., Fazli, L., Jia, W., and Rennie, P. S. (2009) Lentiviruses with trastuzumab bound to their envelopes can target and kill prostate cancer cells. Cancer Gene Ther. 16, 820-831
-
(2009)
Cancer Gene Ther.
, vol.16
, pp. 820-831
-
-
Zhang, K.X.1
Moussavi, M.2
Kim, C.3
Chow, E.4
Chen, I.S.5
Fazli, L.6
Jia, W.7
Rennie, P.S.8
-
43
-
-
84881229056
-
Beyond the ligand-binding pocket: Targeting alternate sites in nuclear receptors
-
Caboni, L., and Lloyd, D. G. (2012) Beyond the ligand-binding pocket: targeting alternate sites in nuclear receptors. Med. Res. Rev. 33, 1081-1118
-
(2012)
Med. Res. Rev.
, vol.33
, pp. 1081-1118
-
-
Caboni, L.1
Lloyd, D.G.2
-
44
-
-
77953280591
-
Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor
-
Andersen, R. J., and Mawji., N. R., Wang, J., Wang, G., Haile, S., and Myung., J. K., Watt, K., Tam, T., Yang, Y. C, Bañuelos, C. A., Williams, D. E., McEwan, I. J., Wang, Y., and Sadar, M. D. (2010) Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor. Cancer Cell 17, 535-546
-
(2010)
Cancer Cell
, vol.17
, pp. 535-546
-
-
Andersen, R.J.1
Mawji, N.R.2
Wang, J.3
Wang, G.4
Haile, S.5
Myung, J.K.6
Watt, K.7
Tam, T.8
Yang, Y.C.9
Bañuelos, C.A.10
Williams, D.E.11
McEwan, I.J.12
Wang, Y.13
Sadar, M.D.14
-
45
-
-
34547496561
-
Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide
-
Nickols, N. G., and Dervan, P. B. (2007) Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide. Proc. Natl. Acad. Sci. U.S.A. 104, 10418-10423
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 10418-10423
-
-
Nickols, N.G.1
Dervan, P.B.2
-
46
-
-
0029011116
-
Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer
-
Taplin, M. E., and Bubley., G. J., Shuster, T. D., Frantz, M. E., Spooner, A. E., Ogata, G. K., Keer, H. N., and Balk, S. P. (1995) Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer. N Engl. J. Med. 332, 1393-1398
-
(1995)
N Engl. J. Med.
, vol.332
, pp. 1393-1398
-
-
Taplin, M.E.1
Bubley, G.J.2
Shuster, T.D.3
Frantz, M.E.4
Spooner, A.E.5
Ogata, G.K.6
Keer, H.N.7
Balk, S.P.8
-
47
-
-
65649090203
-
Development of a second-generation antiandrogen for treatment of advanced prostate cancer
-
Tran, C, Ouk, S., Clegg, N. J., Chen, Y., Watson, P. A., Arora, V., Wongvipat, J., Smith-Jones, P.M., Yoo, D., Kwon, A., Wasielewska, T., Welsbie, D., Chen, C D., Higano, C. S., Beer, T. M., Hung, D. T., Scher, H. I., Jung, M. E., and Sawyers, C. L. (2009) Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 324, 787-790
-
(2009)
Science
, vol.324
, pp. 787-790
-
-
Tran, C.1
Ouk, S.2
Clegg, N.J.3
Chen, Y.4
Watson, P.A.5
Arora, V.6
Wongvipat, J.7
Smith-Jones, P.M.8
Yoo, D.9
Kwon, A.10
Wasielewska, T.11
Welsbie, D.12
Chen, C.D.13
Higano, C.S.14
Beer, T.M.15
Hung, D.T.16
Scher, H.I.17
Jung, M.E.18
Sawyers, C.L.19
-
48
-
-
77958171338
-
Small-molecule inhibition of wnt signaling through activation of casein kinase 1α
-
Thorne, C. A., and Hanson., A. J., Schneider, J., Tahinci, E., Orton, D., and Cselenyi., C. S., Jernigan, K. K., Meyers, K. C, Hang, B. I., Waterson, A. G., Kim, K., Melancon, B., Ghidu, V. P., Sulikowski, G. A., La Fleur, B., Salic, A., Lee, L. A., Miller, D. M., 3rd, and Lee, E. (2010) Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α. Nat. Chem. Biol. 6, 829-836
-
(2010)
Nat. Chem. Biol.
, vol.6
, pp. 829-836
-
-
Thorne, C.A.1
Hanson, A.J.2
Schneider, J.3
Tahinci, E.4
Orton, D.5
Cselenyi, C.S.6
Jernigan, K.K.7
Meyers, K.C.8
Hang, B.I.9
Waterson, A.G.10
Kim, K.11
Melancon, B.12
Ghidu, V.P.13
Sulikowski, G.A.14
La Fleur, B.15
Salic, A.16
Lee, L.A.17
Miller, D.M.18
Lee, E.19
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