Targeting the binding function 3 (BF3) site of the androgen receptor through virtual screening. 2. Development of 2-((2-phenoxyethyl) thio)-1H-benzimidazole derivatives

Journal of Medicinal Chemistry

Volumn 56, Issue 3, 2013, Pages 1136-1148

  Munuganti, Ravi Shashi Nayana ^a   Leblanc, Eric ^a   Axerio Cilies, Peter ^a   Labriere, Christophe ^b   Frewin, Kate ^a   Singh, Kriti ^a   Hassona, Mohamed D H ^a   Lack, Nathan A ^c   Li, Huifang ^a   Ban, Fuqiang ^a   Tomlinson Guns, Emma ^a   Young, Robert ^b   Rennie, Paul S ^a   Cherkasov, Artem ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b SIMON FRASER UNIVERSITY   (Canada)

^c KOÇ UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

1 ALLYL 2 [(2 PHENOXYETHYL)THIO] 1H BENZIMIDAZOLE; 1 ETHYL 2 [(PHENOXYETHYL)THIO] 1H BENZIMIDAZOLE; 2 ((2 PHENOXYETHYL) THIO) 1H BENZIMIDAZOLE DERIVATIVE; 2 ((2 PHENOXYETHYL)THIO) 1H BENZIMIDAZOLE; 2 [(2 PHENOXYETHYL)SULFINYL] 1H BENZIMIDAZOLE; 2 [(2 PHENOXYETHYL)SULFONYL] 1H BENZIMIDAZOLE; 2 [(2 PHENOXYETHYL)THIO] 1,3 BENZOXAZOLE; 2 [(2 PHENOXYETHYL)THIO] 1H INDOLE; 2 [(3 PHENYLPROPYL)THIO] 1H BENZIMIDAZOLE; 2 [2 [(PHENOXYETHYL)THIO] 1H BENZIMIDAZO 1 YL] ETHANOL; 2 [[2 (P TOLYLOXY)ETHYL]THIO] 1H BENZIMIDAZOLE; 2[[2 (2,6 DIMETHYLPHENOXY)ETHYL]THIO] 1H BENZIMIDAZOLE; 2[[2 (O TOLYLOXY)ETHYL]THIO] 1H BENZIMIDAZOLE; 3 [2 [(2 PHENOXYETHYL)THIO] 1H BENZIMIDAZOL 1 YL] PROPANOIC ACID; ANDROGEN RECEPTOR; BENZIMIDAZOLE DERIVATIVE; BINDING FUNCTION 3; ENZALUTAMIDE; LIGAND; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CANCER RESISTANCE; CELL GROWTH; CONTROLLED STUDY; DRUG DEVELOPMENT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MALE; MOLECULAR DOCKING; PROSTATE CANCER; STRUCTURE ACTIVITY RELATION; VIRTUAL REALITY;

BENZIMIDAZOLES; BINDING SITES; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; HUMANS; MALE; MOLECULAR STRUCTURE; PROSTATE-SPECIFIC ANTIGEN; RECEPTORS, ANDROGEN;

EID: 84873912697     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3015712     Document Type: Article

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