MHC-I molecules selectively inhibit cell-mediated cytotoxicity triggered by ITAM-coupled activating receptors and 2B4

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Corral San Miguel, Rubén ^a   Hernández Caselles, Trinidad ^a   Ruiz Alcaraz, Antonio José ^a   Martínez Esparza, María ^a   García Peñarrubia, Pilar ^a  

^a UNIVERSITY OF MURCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; CD16 ANTIGEN; CD56 ANTIGEN; CD94 ANTIGEN; CYTOCHROME P450 2B4; HLA A ANTIGEN; HLA B ANTIGEN; HLA C ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; KILLER ACTIVATING RECEPTOR; LYMPHOCYTE RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; NATURAL KILLER CELL RECEPTOR NKG2A; NATURAL KILLER CELL RECEPTOR NKG2D; UNCLASSIFIED DRUG; CD244 PROTEIN, HUMAN; CYTOKINE; GAMMA INTERFERON; HLA ANTIGEN CLASS 1; IMMUNOGLOBULIN RECEPTOR; LEUKOCYTE ANTIGEN; NATURAL KILLER CELL RECEPTOR; PROTEIN BINDING;

ANTIGEN EXPRESSION; ARTICLE; CELL MATURATION; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOLYSIS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; INHIBITION KINETICS; INTRACELLULAR SIGNALING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE ACTIVATION; TUMOR ESCAPE; UPREGULATION; BIOLOGICAL MODEL; BIOSYNTHESIS; CYTOTOXICITY; IMMUNOLOGY; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; METABOLISM; T LYMPHOCYTE;

ANTIGENS, CD; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IMMUNOPHENOTYPING; INTERFERON-GAMMA; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MODELS, IMMUNOLOGICAL; PROTEIN BINDING; RECEPTORS, IMMUNOLOGIC; RECEPTORS, NATURAL KILLER CELL; T-LYMPHOCYTES;

EID: 84907212398     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107054     Document Type: Article

References (40)

1. Long EO, Kim HS, Liu D, Peterson ME, Rajagopalan S (2013) Controlling natural killer cell responses: integration of signals for activation and inhibition. Annu Rev Immunol 31: 227-58.
2. Lanier LL (2008) Up to the tightrope: natural killer cell activation and inhibition. Nat Immunol 9 (5): 495-502.
3. Yokoyama WM, Kim S (2006) How do Natural Killer cells find self to achieve tolerance? Immunity 24: 249-257.
4. Höglund P, Brodin P (2010) Current perspectives of natural killer cell education by MHC class I molecules. Nat Rev Immunol 10 (10): 724-34.
5. Fernandez NC, Treiner E, Vance RE, Jamieson AM, Lemieux S, et al. (2005) Subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules. Blood 105: 4416-4423.
6. Liao N, Bix M, Zijlstra M, Jaenisch R, Raulet D (1991) MHC class I deficiency: susceptibility to natural killer (NK) cells and impaired NK activity. Science 253: 199-202.
7. Tscherning T, Claesson MH (1994) Signal transduction via MHC class-I molecules in T cells. Scand J Immunol 39: 117-121.
8. Skov S (1998) Intracellular signal transduction mediated by ligation of MHC class I molecules. Tissue Antigens 51: 215-223.
9. Pedersen AE, Skov S, Bregenholt S, Ruhwald M, Claesson MH (1999) Signal transduction by the major histocompatibility complex class I molecule. APMIS 107: 887-895.
10. Rubio G, Férez X, Sánchez-Campillo M, Gálvez J, Martí S, et al. (2004) Cross-linking of MHC class I molecules on human NK cells inhibits NK cell function, segregates MHC I from the NK cell synapse, and induces intracellular phosphotyrosines. J Leukoc Biol 76: 116-124.
11. Caparros E, de Heredia AB, Carpio E, Sancho D, Aguado E, et al. (2004) Aggregation of MHC class I molecules on a CD8+ alphabeta T cell clone specifically inhibits non-antigen-specific lysis of target cells. Eur J Immunol 34: 47-55.
12. Aparicio Alonso P, Rubio Pedraza G, Caparrós Cayuela E, Férez X, Beltrán de Heredia A, et al. (2004) Inhibition of non MHC-restricted cytotoxicity of human NK cells and a CD8+αβ T cell clone by MHC class I cross-linking. Inmunología 23 (3): 284-292.
13. Xu S, Liu X, Bao Y, Zhu X, Han C, et al. (2012) Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway. Nat Immunol 13: 551-60.
14. Robertson MJ, Cochran KJ, Cameron C, Le JM, Tantravahi R, et al. (1996) Characterization of a cell line, NKL, derived from an aggressive human natural killer cell leukemia. Exp Hematol 24: 406-415.
15. Hernández-Caselles T, Martínez-Esparza M, Pérez-Oliva AB, Quintanilla-Cecconi AM, García-Alonso A, et al. (2006) A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing. J Leukoc Biol 79: 46-58.
16. Bauer S, Groh V, Wu J, Steinle A, Phillips JH, et al. (1999) Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285: 727-729.
17. Sivori S, Vitale M, Morelli L, Sanseverino L, Augugliaro R, et al. (1997) p46, a novel natural killer cell-specific surface molecule that mediates cell activation. J Exp Med 186 (7): 1129-1136.
18. Cooper MA, Fehniger TA, Caligiuri MA (2001) The biology of human natural killer-cell subsets. Trends Immunol 22(11): 633-640.
19. André P, Castriconi R, Espéli M, Anfossi N, Juarez T, et al. (2004) Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors. Eur J Immunol 34: 961-971.
20. Bryceson YT, March ME, Ljunggren HG, Long EO (2006) Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion. Blood 107: 159-166.
21. Dasgupta JD, Granja CB, Yunis EJ, Relias V (1993) MHC class I antigens regulate CD3-induced tyrosine phosphorylation of proteins in T cells. Int Immunol 6: 481-489.
22. lck tyrosine kinases, leads to an alternative phenotype of the TcR/CD3fchain, and induces apoptosis. J Immunol 158: 3189-3196.
23. Gilliland LK, Norris NA, Grosmaire LS, Ferrone S, Gladstone P, et al. (1989) Signal transduction in lymphocyte activation through crosslinking of HLA class I molecules. Human Immunol 25: 269-289.
24. Gepper TD, Wacholtz MC, Patel SS, Lightfoot E, Lipsky PE (1989) Activation of human T cells clones and Jurkat cells by cross-linking class I MHC molecules. J Immunol 142: 3763-3772.
25. Woodle ES, Smith DM, Bluestone JA, Kirkman WM III, Green DR, et al. (1997) Anti-Human Class I MHC antibodies induce apoptosis by a pathway that is distinct from the Fas antigen-mediated pathway. J Immunol 158: 2156-2164.
26. Smith DM, Bluestone JA, Jeyarajah DR, Newberger MH, Engelhard VH, et al. (1994) Inhibition of T cell activation by a monoclonal antibody reactive against the α3 domain of human MHC class I molecules. J Immunol 153: 1054-1067.
27. Taylor DS, Nowell PC, Kornbluth J (1987) Anti-HLA class I antibodies inhibit the T cell-independent proliferation of human B lymphocytes. J Immunol 139: 1792-1796.
28. Petersson MGE, Gronberg A, Kiessling R, Ferm MT (1995) Engagement of MHC I proteins on natural killer cells inhibits their killing capacity. Scand J Immunol 42: 34-38.
29. García-Peñarrubia P, Férez X, Gálvez J (2005) Quantitative analysis of the factors that affect the determination of colocalization coefficients in dual-color confocal images. IEEE T Image Processing 14(8): 1151-1158.
30. Gur H, el-Zaatari F, Geppert TD, Wacholtz MC, Taurog JD, et al. (1990) Analysis of T cell signaling by class I MHC molecules: the cytoplasmic domain is not required for signal transduction. J Exp Med 172: 1267-1270.
31. Held W, Mariuzza RA (2008) Cis interactions of immunoreceptors with MHC and non-MHC ligands. Nat Rev Immunol 8: 269-279.
32. Doucey MA, Scarpellino L, Zimmer J, Guillaume P, Luescher IF, et al. (2004) Cis-association of Ly49A with MHC class I restricts natural killer cell inhibition. Nat Immunol 5: 328-336.
33. Raine T, Allen R (2005) MHC-I recognition by receptors on myelomonocytic cells: new tricks for old dogs? BioEssays 27: 542-550.
34. Arosa FA, Santos SG, Powis SJ (2007) Open conformers: the hidden face of MHC-I molecules. Trends Immunol 28(3): 115-23.
35. Goodridge JP, Burian A, Lee N, Geraghty DE (2010) HLA-F Complex without Peptide Binds to MHC Class I Protein in the Open Conformer Form. J Immunol 184: 6199-6208.
36. Santos SG, Powis SJ, Arosa FA (2004) Misfolding of Major Histocompatibility Complex Class I Molecules in Activated T Cells Allows cis-Interactions with Receptors and Signaling Molecules and Is Associated with Tyrosine Phosphorylation. J Biol Chem 279: (51) 53062-53070.
37. Andersson KE, Williams GS, Davis DM, Höglund P (2007) Quantifying the reduction in accessibility of the inhibitory NK cell receptor Ly49A caused by binding MHC class I proteins in cis. Eur J Immunol 37: 516-527.
38. Bessoles S, Angelov GS, Back J, Leclercq G, Vivier E, et al. (2013) Education of Murine NK Cells Requires Both cis and trans Recognition of MHC Class I Molecules. J Immunol 191(10): 5044-5051.
39. Li NL, Fu L, Uchtenhagen H, Achour A, Burshtyn DN (2013) Cis association of leukocyte Ig-like receptor 1 with MHC class I modulates accessibility to antibodies and HCMV UL18. Eur J Immunol 43: 1042-1052.
40. Ferlazzo G, Tsang ML, Moretta L, Melioli G, Steinman RM, et al. (2002) Human Dendritic Cells Activate Resting Natural Killer (NK) Cells and Are Recognized via the NKp30 Receptor by Activated NK Cells. J Exp Med 195: 343-351.