Aggregation of MHC class I molecules on a CD8+ αβ T cell clone specifically inhibitis non-antigen-specific lysis of targel cells

European Journal of Immunology

Volumn 34, Issue 1, 2004, Pages 47-55

  Caparrós, Esther ^a   de Heredia, A Beltrán ^a   Carpio, Emilio ^a,c   Sancho, David ^b   Aguado, Enrique ^a   Aparicio, Pedro ^a  

^a UNIVERSITY OF MURCIA   (Spain)

^b HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^c Facultad de Ciencias Medicas   (Cuba)

Author keywords

CD94; Inhibitory receptors; MHC class I molecules; Redirected lysis

Indexed keywords

CD8 ANTIGEN; CD94 ANTIGEN; FC RECEPTOR; HLA ANTIGEN CLASS 1; INTERLEUKIN 2 RECEPTOR; LECTIN; LEUKOCYTE ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; APOPTOSIS; ARTICLE; CELL CLONE; CELL INTERACTION; CELL MEDIATED CYTOTOXICITY; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; EFFECTOR CELL; GENE CLUSTER; GENETIC CODE; HUMAN; HUMAN CELL; IMMUNOLOGY; METABOLISM; MICROTUBULE ORGANIZING CENTER; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN INTERACTION; RECEPTOR UPREGULATION; TARGET CELL DESTRUCTION; UPREGULATION;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD94; APOPTOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IMMUNITY, CELLULAR; LECTINS, C-TYPE; MICROTUBULE-ORGANIZING CENTER; RECEPTORS, IGG; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTES, CYTOTOXIC; UP-REGULATION;

EID: 1642554825     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200324462     Document Type: Article

References (35)

1. Colucci, F., Di Santo, J. P. and Leibson, P. J., Natural killer cell activation in mice and men: different triggers for similar weapons. Nat. Immuno. 2002. 3: 807-813.
2. Trowsdale, J., Genetic and functional relationships between MHC and NK receptors. Immunity 2001. 15: 363-374.
3. Moretta, A., Bottino, C., Mingari, M. C., Biassoni, R. and Moretta, L., What is a natural killer? Nat. Immunol. 2002. 3: 6-8.
4. + T cells. Curr. Opin. Immunol. 2001. 13: 465-470.
5. Lanier, L. L., Turning on natural killer cells. J. Exp. Med. 2000. 191: 1259-1262.
6. Shibuya, K., Lanier, L. L., Phillips, J. H., Ochs, H. D., Shimizu, K., Nakayama. E., Nakauchi, H. and Shibuya, A., Physical and functional association of LFA-1 with DNAM-1 adhesion molecule. Immunity 1999. 11: 615-623.
7. Saverino, D., Tenca, C., Zarcone, D., Merlo, A., Megiovanni, A. M., Valle, M. T., Manca, F, Grossi, C. E. and Ciccone, E., CTLA-4 (CD152) inhibits the specific lysis mediated by human cytolytic T lymphocytes in a clonally distributed fashion. J. Immunol. 1999. 162: 651-658
8. Orengo, A. M., Cantoni, C., Neglia, F., Biassoni, R. and Ferrini, S., Reciprocal expression of CD70 and of its receptor, CD27, in human long term-activated T and natural killer (NK) cells: inverse regulation by cytokines and role in induction of cytotoxicity. Clin. Exp. Immunol. 1997.107: 608-613.
9. + T cell clone upon the aggregation of an activatory CD94/kp39 heterodimer. J. Immunol. 1999. 162: 3996-4002.
10. Fleischer, B., Sturm, E., De Vries, J. E. and Spits, H., Triggering of cytotoxic T lymphocytes and NK cells via the Tp103 pathway is dependent on the expression of the T cell receptor/CD3 complex. J. Immunol. 1988. 141: 1103-1107.
11. Cesano, A., Visonneau, S., Deaglio, S., Malavasi, F. and Santoli, D., Role of CD38 and its ligand in the regulation of MHC-nonrestricted cytotoxic T cells. J. Immunol.1998. 160:1106-1115.
12. Freitas, A. A. and Rocha, B., Population biology of lymphocytes: The flight for survival. Annu. Rev. Immunol. 2000. 18: 83-111.
13. Navarro, F., Llano, M., Bellón, T., Colonna, M., Geraghty, D. E. and López-Botet, M., The ILT2 (LIR1) and CD94/NKG2A NK cell receptors, respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells. Eur. J. Immunol. 1999. 29: 277-283.
14. Ellis, S. A., Taylor, C. and McMichael, A., Recognition of HLA-B27 and related antigen by a monoclonal antibody. Hum. Immunol. 1982 5: 49-59.
15. Genestier, L., Paillot, R., Bonnefoy- Berard, N., Meffre, G., Flacher, M., Fevre, D., Liu, Y. J., Le Bouteiller, P., Waldmann, H., Engelhard, V. H., Banchereau, J., Revillard, J. P., Fas-independent apoptosis of activated T cells induced by antibodies to the HLA class I alpha1 domain. Blood 1997. 90: 3629-3639.
16. Sancho, D., Nieto, M., Llano, M., Rodríguez-Fernández, J. L., Tejedor, R., Avraham, S., Cabañas, C., López-Botet, M. and Sánchez-Madrid, F., The tyrosine kinase PYK-2/RAFTK regulates Natural killer (NK) cell cytotoxic response, and is translocated and activated upon specific target cell recognition and killing. J. Cell. Biol. 2000. 149: 1249-1261.
17. Kuhné, M. R.,Lin, J., Yablonski, D., Mollenauer, M. N., Ehrlich, L. I. R., Huppa, J., Davis, M. M. and Weiss, A., Linker for activation of T cells, ξ-associated protein-70 and Src homology 2 domain-containing leucocyte protein-76 are required for TCR-induced microtubule-organizing center polarization. J. Immunol. 2003. 171: 860-866.
18. Skov, S., Intracellular signal transduction mediated by ligation of MHC class I molecules. Tissue Antigen 1998. 51: 215-223
19. Wagner, N., Engel, P., Vega, M. A. and Tedder, T. F., Ligation of MHC class I and class II molecules can lead to heterologous desensitization of signal transduction pathways that regulate homotypic adhesion in human lymphocytes. J. Immunol. 1994. 152: 5275-5287.
20. + cytotoxic effector T cells. Peptide-induced paralysis affects the peptide-MHC-recognizing cytotoxic T lymphocytes and is independent of Fas/Fas ligand interactions. Eur. J. Immunol. 1998. 28: 1911-1922.
21. Vyas, Y. M., Mehta, K. M., Morgan, M., Maniar, H., Butros, L., Jung, S., Burkhardt, J. K. and Dupont, B., Spatial organization of signal transduction molecules in the NK cell immune synapses during MHC class I-regulated noncytolytic and cytolytic interactions. J. Immunol. 2001. 167: 4358-4367.
22. + CTLs as potent veto cells: coexpression of CD8 and FasL is a prerequisite. Immunity 2000. 13: 507-515.
23. Colonna, M., Samaridis, J., Celia, M., Angman, L., Allen, R. L., O'Callaghan, C. A., Dunbar, R., Ogg, G. S., Cerundolo, V. and Rolink, A., Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules. J. Immunol. 1998. 160: 3096-3100.
24. Colonna, M., Navarro, F., Bellón, T., Llano, M., Garcia, P., Samaridis, J., Angman, L., Celia, M. and Lopez-Botet, M., A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J. Exp. Med. 1997. 186: 1809-1818.
25. Kavanagh, D. G., Koszinowski, U. H. and Hill, A. B., The murine cytomegalovirus immune evasion protein m4/gp34 forms biochemically distinct complexes with class I MHC at the cell surface and in a pre-Golgi compartment. J. Immunol. 2001. 167: 3894-3902.
26. Barber, D. L., Wherry, E. J. and Ahmed, R., Cutting Edge: Rapid in vivo killing by memory CD8 T cells. J. Immunol. 2003. 171: 27-31.
27. Ronchese, F. and Hermans, F., Killing of dendritic cells: a life cut short or a purposeful death? J. Exp. Med. 2001. 194: F23-F26.
28. + T cells. J. Exp Med. 2001. 194: 1711-1719.
29. Wong, P. and Pamer, E. G. CD8 T cell responses to infectious pathogens. Annu. Rev. Immunol. 2003. 21: 29-70.
30. Dong-Gyun, L., Slavic, J. M., Bourcier, K., Smith, K. J. and Hafler, D. A., Allelic variation of MHC structure alters peptide ligand to induce atypical partial agonistic CD8+ T cell function. J. Exp. Med. 2003. 198: 99-109.
31. Rajagopalan, S., Fu, J. and Long, E. O., Induction of IFN-γ production but not cytotoxicity by the killer cell Ig-like receptor KIR2DL4 (CD158d) in resting NK cells. J. Immunol. 2001. 167: 1877-1881
32. Leishman, A. J., Naidenko, O. V., Attinger, A., Koning, F., Lena, C. J., Xiong, Y., Chang, H. C., Reinherz, E., Kronenberg, M. and Cheroutre, H. T., Cell responses modulated through interaction between CD8αα and the nonclassical MHC class I molecule, TL. Science 2001. 294: 1936-1939.
33. Gerosa, F., Baldani-Guerra, B., Nisii, C., Marchesini, V., Carra, G. and Trinchieri, G., Reciprocal activating interaction between natural killer cells and dendritic cells. J. Exp. Med. 2002. 195: 327-333.
34. Aramburu, J., Balboa, M. A., Ramírez, A., Silva, A., Acevedo, A., Sánchez-Madrid, F., De Landázuri, M. O. and López-Botet, M., A novel functional cell surface climer (Kp43) expressed by natural killer and T cell receptor γδ T lymphocytes. J. Immunol. 1990. 144: 3238-3247.
35. Sancho, D., Montoya, M. C., Monjas, A., Gordon-Alonso, M., Katagiri, T., Gil, D., Tejedor, R., Alarcon, B. and Sánchez-Madrid, F., TCR engagement induces proline-rich tyrosine kinase-2 (Pyk2) translocation to the T cell-APC interface independently of Pyk2 activity and in an immunoreceptor tyrosine-based activation motif-mediated fashion. J. Immunol. 2002. 169: 292-300.