Derivatization of the tricarboxylic acid intermediates with O-benzylhydroxylamine for liquid chromatography-tandem mass spectrometry detection

Analytical Biochemistry

Volumn 465, Issue , 2014, Pages 134-147

  Tan, Bo ^a   Lu, Zhaohai ^a   Dong, Sucai ^a   Zhao, Genshi ^a   Kuo, Ming Shang ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Derivatization; LC MS MS; O benzylhydroxylamine; Tricarboxylic acid cycle intermediates

Indexed keywords

CELLS; DISEASES; HISTOLOGY; MASS SPECTROMETRY; METABOLISM; METABOLITES; TUMORS;

AMINO ACID METABOLISM; DERIVATIZATIONS; LC-MS/MS; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (LC MS/MS); LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; PHARMACOLOGICAL INHIBITORS; PHOSPHORIBOSYL TRANSFERASE; TRICARBOXYLIC ACID CYCLE;

LIQUID CHROMATOGRAPHY;

2 HYDROXYGLUTARIC ACID; 2 OXOGLUTARIC ACID; CITRIC ACID; FUMARIC ACID; HYDROXYLAMINE; ISOCITRIC ACID; LACTIC ACID; MALIC ACID; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; O BENZYLHYDROXYLAMINE; OXALOACETIC ACID; PYRUVIC ACID; SUCCINIC ACID; TRICARBOXYLIC ACID; UNCLASSIFIED DRUG; BENZYLOXYAMINE; CYTOKINE; ENZYME INHIBITOR; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE, HUMAN; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CANCER CELL; CANCER TISSUE; CITRIC ACID CYCLE; CONTROLLED STUDY; DERIVATIZATION; LIQUID CHROMATOGRAPHY; MOUSE; NONHUMAN; TANDEM MASS SPECTROMETRY; ANTAGONISTS AND INHIBITORS; CHEMISTRY; HUMAN; MASS SPECTROMETRY; METABOLISM; NEOPLASM; PATHOLOGY; PROCEDURES; TUMOR CELL LINE;

CELL LINE, TUMOR; CHROMATOGRAPHY, LIQUID; CITRIC ACID CYCLE; CYTOKINES; ENZYME INHIBITORS; HUMANS; HYDROXYLAMINES; MASS SPECTROMETRY; NEOPLASM PROTEINS; NEOPLASMS; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; TRICARBOXYLIC ACIDS;

EID: 84907211039     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2014.07.027     Document Type: Article

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