Quantification of valproic acid and its metabolite 2-propyl-4-pentenoic acid in human plasma using HPLC-MS/MS

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 850, Issue 1-2, 2007, Pages 206-212

  Cheng, Hao ^a   Liu, Zhongfa ^a   Blum, William ^a   Byrd, John C ^a   Klisovic, Rebecca ^a   Grever, Michael R ^a   Marcucci, Guido ^a   Chan, Kenneth K ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Clinical application; Derivatization; LC MS MS; Metabolites; Valproic acid

Indexed keywords

CLINICAL APPLICATION; DERIVATIZATION; LC-MS/MS; VALPROIC ACID;

ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PATIENT TREATMENT; PLASMA (HUMAN); REACTION KINETICS;

ORGANIC ACIDS;

2 PROPYL 4 PENTENOIC ACID; 4 DIMETHYLAMINOBENZYLAMINE DIHYDROCHLORIDE; 5 AZA 2' DEOXYCYTIDINE; BENZYLAMINE DERIVATIVE; UNCLASSIFIED DRUG; VALPROIC ACID;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; ELECTROSPRAY; ELUTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; STEADY STATE; VALIDATION STUDY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FATTY ACIDS, MONOUNSATURATED; HUMANS; LEUKEMIA, MYELOID, CHRONIC; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; VALPROIC ACID;

EID: 34247268647     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.11.027     Document Type: Article

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