FoxO proteins' nuclear retention and BH3-only protein Bim induction evoke mitochondrial dysfunction-mediated apoptosis in berberine-treated HepG2 cells

Free Radical Biology and Medicine

Volumn 76, Issue , 2014, Pages 185-199

  Shukla, Shatrunajay ^a,c   Rizvi, Fatima ^a,b   Raisuddin, Sheikh ^c   Kakkar, Poonam ^a,b  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^b ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

^c HAMDARD UNIVERSITY   (India)

Author keywords

Apoptosis; Berberine; Bim; FoxO1; FoxO3a; HepG2

Indexed keywords

BERBERINE; BIM PROTEIN; CATALASE; GLUTATHIONE; LIPID; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SERINE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR FOXO; ANTIOXIDANT; APOPTOSIS REGULATORY PROTEIN; BCL-2-LIKE PROTEIN 11; CASPASE; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, HUMAN; FOXO3 PROTEIN, HUMAN; MEMBRANE PROTEIN; MTOR PROTEIN, HUMAN; ONCOPROTEIN; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; GENE SILENCING; HEPATOMA CELL; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MEDIATOR; MITOCHONDRION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; TRANSCRIPTION INITIATION; TUMOR SUPPRESSOR GENE; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL NUCLEUS; DRUG EFFECTS; ENZYME IMMUNOASSAY; GENETICS; LIVER NEOPLASMS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANTIOXIDANTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BERBERINE; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CASPASES; CELL CYCLE; CELL NUCLEUS; CELL PROLIFERATION; FORKHEAD TRANSCRIPTION FACTORS; IMMUNOENZYME TECHNIQUES; LIVER NEOPLASMS; MEMBRANE PROTEINS; MITOCHONDRIA; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUMOR CELLS, CULTURED;

EID: 84907202875     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.07.039     Document Type: Article

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