-
1
-
-
0033583824
-
Chemotherapeutic options in chronic lymphocytic leukemia: A meta-analysis of the randomized trials-CLL Trialists' Collaborative Group
-
Chemotherapeutic options in chronic lymphocytic leukemia: A meta-analysis of the randomized trials-CLL Trialists' Collaborative Group. J Natl Cancer Inst 91:861-868, 1999
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 861-868
-
-
-
2
-
-
83055186737
-
AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia
-
Motiwala T, Zanesi N, Datta J, et al.: AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia. Blood 118:6132-6140, 2011
-
(2011)
Blood
, vol.118
, pp. 6132-6140
-
-
Motiwala, T.1
Zanesi, N.2
Datta, J.3
-
3
-
-
33644847307
-
Select high-risk genetic features predict earlier progression following chemoimmunotherapy with fludarabine and rituximab in chronic lymphocytic leukemia: Justification for risk-adapted therapy
-
Byrd JC, Gribben JG, Peterson BL, et al.: Select high-risk genetic features predict earlier progression following chemoimmunotherapy with fludarabine and rituximab in chronic lymphocytic leukemia: Justification for risk-adapted therapy. J Clin Oncol 24:437-443, 2006
-
(2006)
J Clin Oncol
, vol.24
, pp. 437-443
-
-
Byrd, J.C.1
Gribben, J.G.2
Peterson, B.L.3
-
4
-
-
80054853285
-
B-cell receptor signaling in chronic lymphocytic leukemia
-
Stevenson FK, Krysov S, Davies AJ, et al.: B-cell receptor signaling in chronic lymphocytic leukemia. Blood 118:4313-4320, 2011
-
(2011)
Blood
, vol.118
, pp. 4313-4320
-
-
Stevenson, F.K.1
Krysov, S.2
Davies, A.J.3
-
5
-
-
84865176364
-
The B-cell receptor signaling pathway as a therapeutic target in CLL
-
Woyach JA, Johnson AJ, Byrd JC: The B-cell receptor signaling pathway as a therapeutic target in CLL. Blood 120:1175-1184, 2012
-
(2012)
Blood
, vol.120
, pp. 1175-1184
-
-
Woyach, J.A.1
Johnson, A.J.2
Byrd, J.C.3
-
6
-
-
70349237504
-
B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: Specific targeting with a novel spleen tyrosine kinase inhibitor, R406
-
Quiroga MP, Balakrishnan K, Kurtova AV, et al.: B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: Specific targeting with a novel spleen tyrosine kinase inhibitor, R406. Blood 114:1029-1037, 2009
-
(2009)
Blood
, vol.114
, pp. 1029-1037
-
-
Quiroga, M.P.1
Balakrishnan, K.2
Kurtova, A.V.3
-
7
-
-
84858636448
-
The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia
-
de Rooij MF, Kuil A, Geest CR, et al.: The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia. Blood 119:2590-2594, 2012
-
(2012)
Blood
, vol.119
, pp. 2590-2594
-
-
De Rooij, M.F.1
Kuil, A.2
Geest, C.R.3
-
8
-
-
78751549662
-
-
Herishanu Y, Pérez-Galán P, Liu D, et al.: The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia Blood 117:563-574, 2011
-
(2011)
The Lymph Node Microenvironment Promotes B-cell Receptor Signaling, NF-kappaB Activation, and Tumor Proliferation in Chronic Lymphocytic Leukemia Blood
, vol.117
, pp. 563-574
-
-
Herishanu, Y.1
Pérez-Galán, P.2
Liu, D.3
-
9
-
-
0030662472
-
A re-evaluation of the effects of X-linked immunodeficiency (xid) mutation on B cell differentiation and function in the mouse
-
Klaus GG, Holman M, Johnson-Léger C, et al.: A re-evaluation of the effects of X-linked immunodeficiency (xid) mutation on B cell differentiation and function in the mouse. Eur J Immunol 27:2749-2756, 1997
-
(1997)
Eur J Immunol
, vol.27
, pp. 2749-2756
-
-
Klaus, G.G.1
Holman, M.2
Johnson-Léger, C.3
-
10
-
-
0029792213
-
Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage
-
Hendriks RW, de Bruijn MF, Maas A, et al.: Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage. Embo J 15:4862-4872, 1996
-
(1996)
Embo J
, vol.15
, pp. 4862-4872
-
-
Hendriks, R.W.1
De Bruijn, M.F.2
Maas, A.3
-
11
-
-
0037047590
-
Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice
-
Okkenhaug K, Bilancio A, Farjot G, et al.: Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice. Science 297: 1031-1034, 2002
-
(2002)
Science
, vol.297
, pp. 1031-1034
-
-
Okkenhaug, K.1
Bilancio, A.2
Farjot, G.3
-
12
-
-
77957201023
-
Phosphatidylinositol 3-kinase-delta inhibitor CAL- 101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
-
Herman SE, Gordon AL, Wagner AJ, et al.: Phosphatidylinositol 3-kinase-delta inhibitor CAL- 101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood 116:2078- 2088, 2010
-
(2010)
Blood
, vol.116
, pp. 2078-2088
-
-
Herman, S.E.1
Gordon, A.L.2
Wagner, A.J.3
-
13
-
-
80053345977
-
The phosphoinositide 3-kinase delta inhibitor, CAL- 101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
-
Hoellenriegel J, Meadows SA, Sivina M, et al.: The phosphoinositide 3-kinase delta inhibitor, CAL- 101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia. Blood 118:3603-3612, 2011
-
(2011)
Blood
, vol.118
, pp. 3603-3612
-
-
Hoellenriegel, J.1
Meadows, S.A.2
Sivina, M.3
-
14
-
-
78751553221
-
CAL-101, a p110delta selective phosphatidylinositol- 3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
-
Lannutti BJ, Meadows SA, Herman SE, et al.: CAL-101, a p110delta selective phosphatidylinositol- 3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Blood 117:591-594, 2011
-
(2011)
Blood
, vol.117
, pp. 591-594
-
-
Lannutti, B.J.1
Meadows, S.A.2
Herman, S.E.3
-
15
-
-
84863011553
-
The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo
-
Ponader S, Chen SS, Buggy JJ, et al.: The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo. Blood 119:1182- 1189, 2012
-
(2012)
Blood
, vol.119
, pp. 1182-1189
-
-
Ponader, S.1
Chen, S.S.2
Buggy, J.J.3
-
16
-
-
79959404661
-
Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI- 32765
-
Herman SE, Gordon AL, Hertlein E, et al.: Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI- 32765. Blood 117:6287-6296, 2011
-
(2011)
Blood
, vol.117
, pp. 6287-6296
-
-
Herman, S.E.1
Gordon, A.L.2
Hertlein, E.3
-
17
-
-
77955625479
-
The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
-
Honigberg LA, Smith AM, Sirisawad M, et al.: The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A 107:13075-13080, 2010
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 13075-13080
-
-
Honigberg, L.A.1
Smith, A.M.2
Sirisawad, M.3
-
18
-
-
43449109584
-
Management of infectious complications in patients with chronic lymphocytic leukemia
-
Morrison VA: Management of infectious complications in patients with chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program 2007:332-338, 2007
-
(2007)
Hematology Am Soc Hematol Educ Program
, vol.2007
, pp. 332-338
-
-
Morrison, V.A.1
-
19
-
-
0031952390
-
The infectious complications of chronic lymphocytic leukemia
-
Morrison VA: The infectious complications of chronic lymphocytic leukemia. Semin Oncol 25:98-106, 1998
-
(1998)
Semin Oncol
, vol.25
, pp. 98-106
-
-
Morrison, V.A.1
-
20
-
-
33645982603
-
Infectious complications of chronic lymphocytic leukemia
-
Wadhwa PD, Morrison VA: Infectious complications of chronic lymphocytic leukemia. Semin Oncol 33:240-249, 2006
-
(2006)
Semin Oncol
, vol.33
, pp. 240-249
-
-
Wadhwa, P.D.1
Morrison, V.A.2
-
21
-
-
0027302504
-
Immunosuppressive effects and clinical response of fludarabine in refractory chronic lymphocytic leukemia
-
Bergmann L, Fenchel K, Jahn B, et al.: Immunosuppressive effects and clinical response of fludarabine in refractory chronic lymphocytic leukemia. Ann Oncol 4:371-375, 1993
-
(1993)
Ann Oncol
, vol.4
, pp. 371-375
-
-
Bergmann, L.1
Fenchel, K.2
Jahn, B.3
-
22
-
-
0027283739
-
Severe immunodeficiency in patients treated with fludarabine monophosphate
-
Wijermans PW, Gerrits WB, Haak HL: Severe immunodeficiency in patients treated with fludarabine monophosphate. Eur J Haematol 50:292-296, 1993
-
(1993)
Eur J Haematol
, vol.50
, pp. 292-296
-
-
Wijermans, P.W.1
Gerrits, W.B.2
Haak, H.L.3
-
23
-
-
0034744322
-
Bendamustine monotherapy in advanced and refractory chronic lymphocytic leukemia
-
Kath R, Blumenstengel K, Fricke HJ, et al.: Bendamustine monotherapy in advanced and refractory chronic lymphocytic leukemia. J Cancer Res Clin Oncol 127:48-54, 2001
-
(2001)
J Cancer Res Clin Oncol
, vol.127
, pp. 48-54
-
-
Kath, R.1
Blumenstengel, K.2
Fricke, H.J.3
-
24
-
-
84877751454
-
Bendamustine can severely impair T-cell immunity against cytomegalovirus
-
Hosoda T, Yokoyama A, Yoneda M, et al.: Bendamustine can severely impair T-cell immunity against cytomegalovirus. Leuk Lymphoma 54:1327- 1328, 2013
-
(2013)
Leuk Lymphoma
, vol.54
, pp. 1327-1328
-
-
Hosoda, T.1
Yokoyama, A.2
Yoneda, M.3
-
25
-
-
84892576029
-
Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells
-
Krönke J, Udeshi ND, Narla A, et al: Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. Science 343:301-305, 2014
-
(2014)
Science
, vol.343
, pp. 301-305
-
-
Krönke, J.1
Udeshi, N.D.2
Narla, A.3
-
26
-
-
67349107194
-
The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells
-
Galustian C, Meyer B, Labarthe MC, et al.: The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells. Cancer Immunol Immunother 58:1033-1045, 2009
-
(2009)
Cancer Immunol Immunother
, vol.58
, pp. 1033-1045
-
-
Galustian, C.1
Meyer, B.2
Labarthe, M.C.3
-
27
-
-
46749132717
-
Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug
-
Ramsay AG, Johnson AJ, Lee AM, et al.: Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug. J Clin Invest 118:2427-2437, 2008
-
(2008)
J Clin Invest
, vol.118
, pp. 2427-2437
-
-
Ramsay, A.G.1
Johnson, A.J.2
Lee, A.M.3
-
28
-
-
84880276168
-
Long-term repair of T-cell synapse activity in a phase II trial of chemoimmunotherapy followed by lenalidomide consolidation in previously untreated chronic lymphocytic leukemia (CLL)
-
Shanafelt TD, Ramsay AG, Zent CS, et al.: Long-term repair of T-cell synapse activity in a phase II trial of chemoimmunotherapy followed by lenalidomide consolidation in previously untreated chronic lymphocytic leukemia (CLL). Blood 121: 4137-4141, 2013
-
(2013)
Blood
, vol.121
, pp. 4137-4141
-
-
Shanafelt, T.D.1
Ramsay, A.G.2
Zent, C.S.3
-
29
-
-
79954435811
-
Chemoimmunotherapy with fludarabine and rituximab produces extended overall survival and progression-free survival in chronic lymphocytic leukemia: Long-term follow-up of CALGB study 9712
-
Woyach JA, Ruppert AS, Heerema NA, et al.: Chemoimmunotherapy with fludarabine and rituximab produces extended overall survival and progression-free survival in chronic lymphocytic leukemia: Long-term follow-up of CALGB study 9712. J Clin Oncol 29:1349-1355, 2013
-
(2013)
J Clin Oncol
, vol.29
, pp. 1349-1355
-
-
Woyach, J.A.1
Ruppert, A.S.2
Heerema, N.A.3
-
30
-
-
51649093353
-
Longterm results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia
-
Tam CS, O'Brien S, Wierda W, et al.: Longterm results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia. Blood 112:975-980, 2008
-
(2008)
Blood
, vol.112
, pp. 975-980
-
-
Tam, C.S.1
O'brien, S.2
Wierda, W.3
-
31
-
-
77957664665
-
Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
-
Hallek M, Fischer K, Fingerle-Rowson G, et al.: Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial. Lancet 376:1164-1174, 2010
-
(2010)
Lancet
, vol.376
, pp. 1164-1174
-
-
Hallek, M.1
Fischer, K.2
Fingerle-Rowson, G.3
-
32
-
-
33750807672
-
Cutting edge: The phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells
-
Patton DT, Garden OA, Pearce WP, et al.: Cutting edge: The phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells. J Immunol 177:6598-6602, 2006
-
(2006)
J Immunol
, vol.177
, pp. 6598-6602
-
-
Patton, D.T.1
Garden, O.A.2
Pearce, W.P.3
-
33
-
-
84888216911
-
Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes
-
Dubovsky JA, Beckwith KA, Natarajan G, et al.: Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes. Blood 122:2539-2549, 2013
-
(2013)
Blood
, vol.122
, pp. 2539-2549
-
-
Dubovsky, J.A.1
Beckwith, K.A.2
Natarajan, G.3
-
34
-
-
84863116430
-
Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: Results of a phase i study of navitoclax in patients with relapsed or refractory disease
-
Roberts AW, Seymour JF, Brown JR, et al.: Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: Results of a phase I study of navitoclax in patients with relapsed or refractory disease. J Clin Oncol 30:488-496, 2013
-
(2013)
J Clin Oncol
, vol.30
, pp. 488-496
-
-
Roberts, A.W.1
Seymour, J.F.2
Brown, J.R.3
-
35
-
-
84873540049
-
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
-
Souers AJ, Leverson JD, Boghaert ER, et al.: ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med 19:202-208, 2013
-
(2013)
Nat Med
, vol.19
, pp. 202-208
-
-
Souers, A.J.1
Leverson, J.D.2
Boghaert, E.R.3
-
36
-
-
84881399114
-
Emerging drug profile: Cyclin-dependent kinase inhibitors
-
Blachly JS, Byrd JC: Emerging drug profile: Cyclin-dependent kinase inhibitors. Leuk Lymphoma 54:2133-2143, 2013
-
(2013)
Leuk Lymphoma
, vol.54
, pp. 2133-2143
-
-
Blachly, J.S.1
Byrd, J.C.2
-
37
-
-
84896619061
-
A phase 1 study evaluating the safety and tolerability of otlertuzumab (TRU-016), an anti-CD37 mono-specific ADAPTIRTM therapeutic protein in chronic lymphocytic leukemia
-
Byrd JC, Pagel JM, Awan FT, et al.: A phase 1 study evaluating the safety and tolerability of otlertuzumab (TRU-016), an anti-CD37 mono-specific ADAPTIRTM therapeutic protein in chronic lymphocytic leukemia. Blood 123:1302-1308, 2014
-
(2014)
Blood
, vol.123
, pp. 1302-1308
-
-
Byrd, J.C.1
Pagel, J.M.2
Awan, F.T.3
-
38
-
-
84861415717
-
Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals
-
Lapalombella R, Yeh YY, Wang L, et al.: Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals. Cancer Cell 21:694- 708, 2012
-
(2012)
Cancer Cell
, vol.21
, pp. 694-708
-
-
Lapalombella, R.1
Yeh, Y.Y.2
Wang, L.3
-
39
-
-
84866531516
-
Bendamustine in combination with rituximab for previously untreated patients with chronic lymphocytic leukemia: A multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group
-
Fischer K, Cramer P, Busch R, et al.: Bendamustine in combination with rituximab for previously untreated patients with chronic lymphocytic leukemia: A multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group. J Clin Oncol 30:3209-3216, 2012
-
(2012)
J Clin Oncol
, vol.30
, pp. 3209-3216
-
-
Fischer, K.1
Cramer, P.2
Busch, R.3
-
40
-
-
84993683967
-
Demographics, treatment patterns, safety, and realworld effectiveness in patients aged 70 years and over with chronic lymphocytic leukemia receiving bendamustine with or without rituximab: A retrospective study
-
Kolibaba KS, Sterchele JA, Joshi AD, et al.: Demographics, treatment patterns, safety, and realworld effectiveness in patients aged 70 years and over with chronic lymphocytic leukemia receiving bendamustine with or without rituximab: A retrospective study. Ther Adv Hematol 4:157-171, 2013
-
(2013)
Ther Adv Hematol
, vol.4
, pp. 157-171
-
-
Kolibaba, K.S.1
Sterchele, J.A.2
Joshi, A.D.3
-
41
-
-
84904818973
-
Rituximab plus chlorambucil as first-line treatment for chronic lymphocytic leukemia: Final analysis of an open-label phase II study
-
Hillmen P, Gribben JG, Follows GA, et al.: Rituximab plus chlorambucil as first-line treatment for chronic lymphocytic leukemia: Final analysis of an open-label phase II study. J Clin Oncol 32:1236- 1241, 2014
-
(2014)
J Clin Oncol
, vol.32
, pp. 1236-1241
-
-
Hillmen, P.1
Gribben, J.G.2
Follows, G.A.3
-
42
-
-
84898486579
-
Chlorambucil plus rituximab with or without maintenance rituximab as first-line treatment for elderly chronic lymphocytic leukemia patients
-
Foà R, Del Giudice I, Cuneo A, et al: Chlorambucil plus rituximab with or without maintenance rituximab as first-line treatment for elderly chronic lymphocytic leukemia patients. Am J Hematol 89: 480-486, 2014
-
(2014)
Am J Hematol
, vol.89
, pp. 480-486
-
-
Foà, R.1
Del Giudice, I.2
Cuneo, A.3
-
43
-
-
84874835426
-
Comparative assessment of clinically utilized CD20-directed antibodies in chronic lymphocytic leukemia cells reveals divergent NK cell, monocyte, and macrophage properties
-
Rafiq S, Butchar JP, Cheney C, et al.: Comparative assessment of clinically utilized CD20-directed antibodies in chronic lymphocytic leukemia cells reveals divergent NK cell, monocyte, and macrophage properties. J Immunol 190:2702-2711, 2013
-
(2013)
J Immunol
, vol.190
, pp. 2702-2711
-
-
Rafiq, S.1
Butchar, J.P.2
Cheney, C.3
-
44
-
-
84896480883
-
Ofatumumab + chlorambucil versus chlorambucil alone in patients with untreated chronic lymphocytic leukemia (CLL): Results of the phase III study Complement
-
528
-
Hillmen PR, Janssens A, Govindbabu K, et al.: Ofatumumab + chlorambucil versus chlorambucil alone in patients with untreated chronic lymphocytic leukemia (CLL): Results of the phase III study Complement. Blood 122, 2013 (abstr 528)
-
(2013)
Blood
, vol.122
-
-
Hillmen, P.R.1
Janssens, A.2
Govindbabu, K.3
-
45
-
-
84894552888
-
Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions
-
Goede V, Fischer K, Busch R, et al.: Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions. N Engl J Med 370:1101-1110, 2014
-
(2014)
N Engl J Med
, vol.370
, pp. 1101-1110
-
-
Goede, V.1
Fischer, K.2
Busch, R.3
-
46
-
-
84891373281
-
Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: An open-label, multicentre, phase 1b/2 trial
-
O'Brien S, Furman RR, Coutre SE, et al.: Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: An open-label, multicentre, phase 1b/2 trial. Lancet Oncol 15:48-58, 2014
-
(2014)
Lancet Oncol
, vol.15
, pp. 48-58
-
-
O'brien, S.1
Furman, R.R.2
Coutre, S.E.3
-
47
-
-
84884523966
-
Ibrutinib in relapsed chronic lymphocytic leukemia
-
Byrd JC, O'Brien S, James DF: Ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med 369:1278-1279, 2013
-
(2013)
N Engl J Med
, vol.369
, pp. 1278-1279
-
-
Byrd, J.C.1
O'brien, S.2
James, D.F.3
-
48
-
-
80053350801
-
Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia
-
Badoux XC, Keating MJ, Wen S, et al.: Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia. Blood 118:3489- 3498, 2011
-
(2011)
Blood
, vol.118
, pp. 3489-3498
-
-
Badoux, X.C.1
Keating, M.J.2
Wen, S.3
-
49
-
-
79952769640
-
Singleagent lenalidomide in the treatment of previously untreated chronic lymphocytic leukemia
-
Chen CI, Bergsagel PL, Paul H, et al.: Singleagent lenalidomide in the treatment of previously untreated chronic lymphocytic leukemia. J Clin Oncol 29:1175-1181, 2011
-
(2011)
J Clin Oncol
, vol.29
, pp. 1175-1181
-
-
Chen, C.I.1
Bergsagel, P.L.2
Paul, H.3
-
50
-
-
84889096434
-
A phase II study of the selective phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitor idelalisib (GS- 1101) in combination with rituximab (R) in treatment-naive patients (pts) ≥ 65 years with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)
-
7005
-
O'Brien SM, Lamanna N, Kipps TJ, et al.: A phase II study of the selective phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitor idelalisib (GS- 1101) in combination with rituximab (R) in treatment-naive patients (pts) ≥ 65 years with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). J Clin Oncol 31, 2013 (suppl 15s; abstr 7005)
-
(2013)
J Clin Oncol
, vol.31
-
-
O'brien, S.M.1
Lamanna, N.2
Kipps, T.J.3
-
51
-
-
19944429446
-
Addition of rituximab to fludarabine may prolong progressionfree survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: An updated retrospective comparative analysis of CALGB 9712 and CALGB 9011
-
Byrd JC, Rai K, Peterson BL, et al.: Addition of rituximab to fludarabine may prolong progressionfree survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: An updated retrospective comparative analysis of CALGB 9712 and CALGB 9011. Blood 105:49-53, 2005
-
(2005)
Blood
, vol.105
, pp. 49-53
-
-
Byrd, J.C.1
Rai, K.2
Peterson, B.L.3
-
52
-
-
84903201129
-
Chemoimmunotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) versus bendamustine and rituximab (BR) in previously untreated and physically fit patients (pts) with advanced chronic lymphocytic leukemia (CLL): Results of a planned interim analysis of the CLL10 trial, an international, randomized study of the German CLL Study Group (GCLLSG)
-
21
-
Eichhorst B, Fink AM, Busch R, et al.: Chemoimmunotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) versus bendamustine and rituximab (BR) in previously untreated and physically fit patients (pts) with advanced chronic lymphocytic leukemia (CLL): Results of a planned interim analysis of the CLL10 trial, an international, randomized study of the German CLL Study Group (GCLLSG). Blood 122, 2013 (abstr 21)
-
(2013)
Blood
, vol.122
-
-
Eichhorst, B.1
Fink, A.M.2
Busch, R.3
-
53
-
-
84863769805
-
Alemtuzumab in combination with methylprednisolone is a highly effective induction regimen for patients with chronic lymphocytic leukemia and deletion of TP53: Final results of the National Cancer
-
Research Institute CLL206 trial
-
Pettitt AR, Jackson R, Carruthers S, et al.: Alemtuzumab in combination with methylprednisolone is a highly effective induction regimen for patients with chronic lymphocytic leukemia and deletion of TP53: Final results of the National Cancer Research Institute CLL206 trial. J Clin Oncol 30: 1647-1655, 2012
-
(2012)
J Clin Oncol
, vol.30
, pp. 1647-1655
-
-
Pettitt, A.R.1
Jackson, R.2
Carruthers, S.3
-
54
-
-
84879748062
-
Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia
-
Byrd JC, Furman RR, Coutre SE, et al.: Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med 369:32-42, 2013
-
(2013)
N Engl J Med
, vol.369
, pp. 32-42
-
-
Byrd, J.C.1
Furman, R.R.2
Coutre, S.E.3
-
55
-
-
84875888445
-
Non-Hodgkin's lymphomas, version 1.2013
-
quiz 273
-
Zelenetz AD, Wierda WG, Abramson JS, et al.: Non-Hodgkin's lymphomas, version 1.2013. J Natl Compr Canc Netw 11:257-272, 2013; quiz 273
-
(2013)
J Natl Compr Canc Netw
, vol.11
, pp. 257-272
-
-
Zelenetz, A.D.1
Wierda, W.G.2
Abramson, J.S.3
-
56
-
-
84871806385
-
Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/ refractory B-cell malignancies
-
Advani RH, Buggy JJ, Sharman JP, et al.: Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/ refractory B-cell malignancies. J Clin Oncol 31:88- 94, 2013
-
(2013)
J Clin Oncol
, vol.31
, pp. 88-94
-
-
Advani, R.H.1
Buggy, J.J.2
Sharman, J.P.3
-
57
-
-
45149100665
-
Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute Working Group 1996 guidelines
-
Hallek M, Cheson BD, Catovsky D, et al.: Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute Working Group 1996 guidelines. Blood 111:5446- 5456, 2008
-
(2008)
Blood
, vol.111
, pp. 5446-5456
-
-
Hallek, M.1
Cheson, B.D.2
Catovsky, D.3
-
58
-
-
84897069190
-
Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy
-
Woyach JA, Smucker K, Smith LL, et al.: Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy. Blood 123:1810-1817, 2014
-
(2014)
Blood
, vol.123
, pp. 1810-1817
-
-
Woyach, J.A.1
Smucker, K.2
Smith, L.L.3
-
59
-
-
33750604779
-
Bruton tyrosine kinase is essential for botrocetin/VWFinduced signaling and GPIb-dependent thrombus formation in vivo
-
Liu J, Fitzgerald ME, Berndt MC, et al.: Bruton tyrosine kinase is essential for botrocetin/VWFinduced signaling and GPIb-dependent thrombus formation in vivo. Blood 108:2596-2603, 2006
-
(2006)
Blood
, vol.108
, pp. 2596-2603
-
-
Liu, J.1
Fitzgerald, M.E.2
Berndt, M.C.3
-
60
-
-
0032497629
-
A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen
-
Quek LS, Bolen J, Watson SP: A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen. Curr Biol 8:1137-1140, 1998
-
(1998)
Curr Biol
, vol.8
, pp. 1137-1140
-
-
Quek, L.S.1
Bolen, J.2
Watson, S.P.3
-
61
-
-
0034938535
-
Bruton's tyrosine kinase is present in normal platelets and its absence identifies patients with X-linked agammaglobulinaemia and carrier females
-
Futatani T, Watanabe C, Baba Y, et al.: Bruton's tyrosine kinase is present in normal platelets and its absence identifies patients with X-linked agammaglobulinaemia and carrier females. Br J Haematol 114:141-149, 2001
-
(2001)
Br J Haematol
, vol.114
, pp. 141-149
-
-
Futatani, T.1
Watanabe, C.2
Baba, Y.3
-
62
-
-
84896484537
-
Ibrutinib in combination with rituximab (iR) is well tolerated and induces a high rate of durable remissions in patients with high-risk chronic lymphocytic leukemia (CLL): New, updated results of a phase II trial in 40 patients
-
Burger JA, Keating MJ, Wierda WG, et al.: Ibrutinib in combination with rituximab (iR) is well tolerated and induces a high rate of durable remissions in patients with high-risk chronic lymphocytic leukemia (CLL): New, updated results of a phase II trial in 40 patients. Blood 122, 2013 (abstr 675)
-
(2013)
Blood
, vol.122
-
-
Burger, J.A.1
Keating, M.J.2
Wierda, W.G.3
-
63
-
-
84867853067
-
A phase Ib/II study evaluating activity and tolerability of BTK inhibitor PCI-32765 and ofatumumab in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and related diseases
-
6508
-
Jaglowski SM, Jones JA, Flynn JM, et al.: A phase Ib/II study evaluating activity and tolerability of BTK inhibitor PCI-32765 and ofatumumab in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and related diseases. J Clin Oncol 30:418s, 2012 (suppl; abstr 6508)
-
(2012)
J Clin Oncol
, vol.30
, pp. 418
-
-
Jaglowski, S.M.1
Jones, J.A.2
Flynn, J.M.3
-
64
-
-
84902316391
-
Ibrutinib in combination with bendamustine and rituximab is active and tolerable in patients with relapsed/refractory CLL/SLL: Final results of a phase 1b study
-
525
-
Brown JR, Barrientos JC, Barr PM, et al.: Ibrutinib in combination with bendamustine and rituximab is active and tolerable in patients with relapsed/refractory CLL/SLL: Final results of a phase 1b study. Blood 122, 2013 (abstr 525)
-
(2013)
Blood
, vol.122
-
-
Brown, J.R.1
Barrientos, J.C.2
Barr, P.M.3
-
65
-
-
84889100379
-
Final results of a phase i study of idelalisib (GS-1101) a selective inhibitor of PI3Kδ, in patients with relapsed or refractory CLL
-
7003
-
Brown JR, Furman RR, Flinn I, et al.: Final results of a phase I study of idelalisib (GS-1101) a selective inhibitor of PI3Kδ, in patients with relapsed or refractory CLL. J Clin Oncol 31, 2013 (suppl 15s; abstr 7003)
-
(2013)
J Clin Oncol
, vol.31
-
-
Brown, J.R.1
Furman, R.R.2
Flinn, I.3
-
66
-
-
84889100529
-
Update on a phase i study of the selective PI3Kδ inhibitor idelalisib (GS-1101) in combination with rituximab and/or bendamustine in patients with relapsed or refractory CLL
-
7017
-
Barrientos JC, Furman RR, Leonard J, et al.: Update on a phase I study of the selective PI3Kδ inhibitor idelalisib (GS-1101) in combination with rituximab and/or bendamustine in patients with relapsed or refractory CLL. J Clin Oncol 31, 2013 (suppl 15s; abstr 7017)
-
(2013)
J Clin Oncol
, vol.31
-
-
Barrientos, J.C.1
Furman, R.R.2
Leonard, J.3
-
67
-
-
84896692766
-
Idelalisib and rituximab in relapsed chronic lymphocytic leukemia
-
Furman RR, Sharman JP, Coutre SE, et al.: Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. N Engl J Med 370:997-1007, 2014
-
(2014)
N Engl J Med
, vol.370
, pp. 997-1007
-
-
Furman, R.R.1
Sharman, J.P.2
Coutre, S.E.3
-
68
-
-
80051720194
-
Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
-
Porter DL, Levine BL, Kalos M, et al.: Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med 365:725-733, 2011
-
(2011)
N Engl J Med
, vol.365
, pp. 725-733
-
-
Porter, D.L.1
Levine, B.L.2
Kalos, M.3
-
69
-
-
84902183019
-
Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib
-
Woyach JA, Furman RR, Liu TM, et al.: Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib. N Engl J Med 370:2286-2294, 2014
-
(2014)
N Engl J Med
, vol.370
, pp. 2286-2294
-
-
Woyach, J.A.1
Furman, R.R.2
Liu, T.M.3
|