메뉴 건너뛰기




Volumn 4, Issue 3, 2013, Pages 157-171

Demographics, treatment patterns, safety, and real-world effectiveness in patients aged 70 years and over with chronic lymphocytic leukemia receiving bendamustine with or without rituximab: A retrospective study

Author keywords

bendamustine; chart review; chemoimmunotherapy; chronic lymphocytic leukemia; retrospective; rituximab

Indexed keywords

ANTIBIOTIC AGENT; ANTIEMETIC AGENT; BENDAMUSTINE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RITUXIMAB;

EID: 84993683967     PISSN: 20406207     EISSN: 20406215     Source Type: Journal    
DOI: 10.1177/2040620713478629     Document Type: Article
Times cited : (6)

References (29)
  • 1
    • 0036337956 scopus 로고    scopus 로고
    • Bendamustine in the treatment of chronic lymphocytic leukemia: results and future perspectives
    • Aivado M. Schulte K. Henze L. Burger J. Finke J. Haas R. (2002) Bendamustine in the treatment of chronic lymphocytic leukemia: results and future perspectives. Semin Oncol 29(4 Suppl. 13): 19–22.
    • (2002) Semin Oncol , vol.29 , Issue.4 , pp. 19-22
    • Aivado, M.1    Schulte, K.2    Henze, L.3    Burger, J.4    Finke, J.5    Haas, R.6
  • 2
    • 79953072637 scopus 로고    scopus 로고
    • Fludarabine, cyclophosphamide and rituximab chemoimmunotherapy is highly effective treatment for relapsed patients with CLL
    • Badoux X. Keating M. Wang X. O'Brien S. Ferrajoli A. Faderl S. et al. (2011) Fludarabine, cyclophosphamide and rituximab chemoimmunotherapy is highly effective treatment for relapsed patients with CLL. Blood 117: 3016–3024.
    • (2011) Blood , vol.117 , pp. 3016-3024
    • Badoux, X.1    Keating, M.2    Wang, X.3    O'Brien, S.4    Ferrajoli, A.5    Faderl, S.6
  • 3
    • 27144548424 scopus 로고    scopus 로고
    • Efficacy of bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase I / II study of the German CLL Study Group
    • Bergmann M. Goebeler M. Herold M. Emmerich B. Wilhelm M. Ruelfs C. et al. (2005) Efficacy of bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase I / II study of the German CLL Study Group. Haematologica 90: 1357–1364.
    • (2005) Haematologica , vol.90 , pp. 1357-1364
    • Bergmann, M.1    Goebeler, M.2    Herold, M.3    Emmerich, B.4    Wilhelm, M.5    Ruelfs, C.6
  • 4
    • 0029981025 scopus 로고    scopus 로고
    • National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment
    • Cheson B. Bennett J. Grever M. Kay N. Keating M. O'Brien S. et al. (1996) National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 87: 4990–4997.
    • (1996) Blood , vol.87 , pp. 4990-4997
    • Cheson, B.1    Bennett, J.2    Grever, M.3    Kay, N.4    Keating, M.5    O'Brien, S.6
  • 5
    • 63049113411 scopus 로고    scopus 로고
    • Bendamustine: rebirth of an old drug
    • Cheson B. Rummel M. (2009) Bendamustine: rebirth of an old drug. J Clin Oncol 27: 1492–1501.
    • (2009) J Clin Oncol , vol.27 , pp. 1492-1501
    • Cheson, B.1    Rummel, M.2
  • 6
    • 77953670179 scopus 로고    scopus 로고
    • Optimal use of bendamustine in chronic lymphocytic leukemia, non-Hodgkin lymphomas, and multiple myeloma: treatment recommendations from an international consensus panel
    • Cheson B. Wendtner C. Pieper A. Dreyling M. Friedberg J. Hoelzer D. et al. (2010) Optimal use of bendamustine in chronic lymphocytic leukemia, non-Hodgkin lymphomas, and multiple myeloma: treatment recommendations from an international consensus panel. Clin Lymphoma Myeloma Leuk 10: 21–27.
    • (2010) Clin Lymphoma Myeloma Leuk , vol.10 , pp. 21-27
    • Cheson, B.1    Wendtner, C.2    Pieper, A.3    Dreyling, M.4    Friedberg, J.5    Hoelzer, D.6
  • 7
    • 77957743452 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial
    • Dreger P. Döhner H. Ritgen M. Böttcher S. Busch R. Dietrich S. et al. (2010) Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial. Blood 116: 2438–2447.
    • (2010) Blood , vol.116 , pp. 2438-2447
    • Dreger, P.1    Döhner, H.2    Ritgen, M.3    Böttcher, S.4    Busch, R.5    Dietrich, S.6
  • 8
    • 84866531516 scopus 로고    scopus 로고
    • Bendamustine in combination with rituximab for previously untreated patients with chronic lymphocytic leukemia: a multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group
    • Fischer K. Cramer P. Busch R. Böttcher S. Bahlo J. Schubert J. et al. (2012) Bendamustine in combination with rituximab for previously untreated patients with chronic lymphocytic leukemia: a multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group. J Clin Oncol 30: 3209–3216.
    • (2012) J Clin Oncol , vol.30 , pp. 3209-3216
    • Fischer, K.1    Cramer, P.2    Busch, R.3    Böttcher, S.4    Bahlo, J.5    Schubert, J.6
  • 9
    • 80053020928 scopus 로고    scopus 로고
    • Bendamustine combined with rituximab in patients with relapsed and / or refractory chronic lymphocytic leukemia: a multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group
    • Fischer K. Cramer P. Busch R. Stilgenbauer S. Bahlo J. Schweighofer C. et al. (2011) Bendamustine combined with rituximab in patients with relapsed and / or refractory chronic lymphocytic leukemia: a multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group. J Clin Oncol 29: 3559–3566.
    • (2011) J Clin Oncol , vol.29 , pp. 3559-3566
    • Fischer, K.1    Cramer, P.2    Busch, R.3    Stilgenbauer, S.4    Bahlo, J.5    Schweighofer, C.6
  • 10
    • 77949424964 scopus 로고    scopus 로고
    • Changing paradigms in the treatment of chronic lymphocytic leukemia
    • Foon K. Hallek M. (2010) Changing paradigms in the treatment of chronic lymphocytic leukemia. Leukemia 24: 500–511.
    • (2010) Leukemia , vol.24 , pp. 500-511
    • Foon, K.1    Hallek, M.2
  • 11
    • 75649140955 scopus 로고    scopus 로고
    • How I treat CLL up front
    • Gribben J. (2010) How I treat CLL up front. Blood 115: 187–197.
    • (2010) Blood , vol.115 , pp. 187-197
    • Gribben, J.1
  • 12
    • 28844483804 scopus 로고    scopus 로고
    • Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia
    • Gribben J. Zahrieh D. Stephans K. Bartlett-Pandite L. Alyea E. Fisher D. et al. (2005) Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia. Blood 106: 4389–4396.
    • (2005) Blood , vol.106 , pp. 4389-4396
    • Gribben, J.1    Zahrieh, D.2    Stephans, K.3    Bartlett-Pandite, L.4    Alyea, E.5    Fisher, D.6
  • 13
    • 77949479415 scopus 로고    scopus 로고
    • State-of-the-art treatment of chronic lymphocytic leukemia
    • Hallek M. (2009) State-of-the-art treatment of chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program 440–449.
    • (2009) Hematology Am Soc Hematol Educ Program , pp. 440-449
    • Hallek, M.1
  • 14
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines
    • Hallek M. Cheson B. Catovsky D. Caligaris-Cappio F. Dighiero G. Döhner H. et al. (2008) Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 111: 5446–5456.
    • (2008) Blood , vol.111 , pp. 5446-5456
    • Hallek, M.1    Cheson, B.2    Catovsky, D.3    Caligaris-Cappio, F.4    Dighiero, G.5    Döhner, H.6
  • 15
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial
    • Hallek M. Fischer K. Fingerle-Rowson G. Fink A. Busch R. Mayer J. et al. (2010) Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet 376: 1164–1174.
    • (2010) Lancet , vol.376 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3    Fink, A.4    Busch, R.5    Mayer, J.6
  • 16
    • 84867330981 scopus 로고    scopus 로고
    • Treatment option of bendamustine in combination with rituximab in elderly and frail patients with aggressive B-non-Hodgkin lymphoma: rational, efficacy, and tolerance
    • Horn J. Kleber M. Hieke S. Schmitt-Gräff A. Wäsch R. Engelhardt M. (2012) Treatment option of bendamustine in combination with rituximab in elderly and frail patients with aggressive B-non-Hodgkin lymphoma: rational, efficacy, and tolerance. Ann Hematol 91: 1579–1586.
    • (2012) Ann Hematol , vol.91 , pp. 1579-1586
    • Horn, J.1    Kleber, M.2    Hieke, S.3    Schmitt-Gräff, A.4    Wäsch, R.5    Engelhardt, M.6
  • 18
    • 0034744322 scopus 로고    scopus 로고
    • Bendamustine monotherapy in advanced and refractory chronic lymphocytic leukemia
    • Kath R. Blumenstengel K. Fricke H. Höffken K. (2001) Bendamustine monotherapy in advanced and refractory chronic lymphocytic leukemia. J Cancer Res Clin Oncol 127: 48–54.
    • (2001) J Cancer Res Clin Oncol , vol.127 , pp. 48-54
    • Kath, R.1    Blumenstengel, K.2    Fricke, H.3    Höffken, K.4
  • 19
    • 78650272415 scopus 로고    scopus 로고
    • Evidences showing wide presence of small genomic aberrations in chronic lymphocytic leukemia
    • Kim Y. Jung Y. Chen J. Alhasan A. Kaewsaard P. Zhang Y. et al. (2010) Evidences showing wide presence of small genomic aberrations in chronic lymphocytic leukemia. BMC Res Notes 3: 341.
    • (2010) BMC Res Notes , vol.3 , pp. 341
    • Kim, Y.1    Jung, Y.2    Chen, J.3    Alhasan, A.4    Kaewsaard, P.5    Zhang, Y.6
  • 20
    • 70349330220 scopus 로고    scopus 로고
    • Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia
    • Knauf W. Lissitchkov T. Aldaoud A. Liberati A. Loscertales J. Herbrecht R. et al. (2009) Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia. J Clin Oncol 27: 4378–4384.
    • (2009) J Clin Oncol , vol.27 , pp. 4378-4384
    • Knauf, W.1    Lissitchkov, T.2    Aldaoud, A.3    Liberati, A.4    Loscertales, J.5    Herbrecht, R.6
  • 21
    • 40749085662 scopus 로고    scopus 로고
    • Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents
    • Leoni L. Bailey B. Reifert J. Bendall H. Zeller R. Corbeil J. et al. (2008) Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res 14: 309–317.
    • (2008) Clin Cancer Res , vol.14 , pp. 309-317
    • Leoni, L.1    Bailey, B.2    Reifert, J.3    Bendall, H.4    Zeller, R.5    Corbeil, J.6
  • 22
    • 28644433498 scopus 로고    scopus 로고
    • Phase-I/II study to evaluate dose limiting toxicity, maximum tolerated dose, and tolerability of bendamustine HCl in pre-treated patients with B-chronic lymphocytic leukaemia (Binet stages B and C) requiring therapy
    • Lissitchkov T. Arnaudov G. Peytchev D. Merkle K. (2006) Phase-I/II study to evaluate dose limiting toxicity, maximum tolerated dose, and tolerability of bendamustine HCl in pre-treated patients with B-chronic lymphocytic leukaemia (Binet stages B and C) requiring therapy. J Cancer Res Clin Oncol 132: 99–104.
    • (2006) J Cancer Res Clin Oncol , vol.132 , pp. 99-104
    • Lissitchkov, T.1    Arnaudov, G.2    Peytchev, D.3    Merkle, K.4
  • 23
    • 84993733942 scopus 로고    scopus 로고
    • NCCN (National Comprehensive Cancer Network)
    • Version 3.2012. Available at (accessed 4 December 2012).
    • NCCN (National Comprehensive Cancer Network) (2012) NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines™): Non-Hodgkin's Lymphomas. Version 3.2012. Available at: http://www.nccn.org/professionals/physician_gls/pdf/nhl.pdf (accessed 4 December 2012).
    • (2012) NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines™): Non-Hodgkin's Lymphomas
  • 24
    • 77950478885 scopus 로고    scopus 로고
    • Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia
    • Robak T. Dmoszynska A. Solal-Céligny P. Warzocha K. Loscertales J. Catalano J. et al. (2010 a) Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia. J Clin Oncol 10: 1756–1765.
    • (2010) J Clin Oncol , vol.10 , pp. 1756-1765
    • Robak, T.1    Dmoszynska, A.2    Solal-Céligny, P.3    Warzocha, K.4    Loscertales, J.5    Catalano, J.6
  • 25
    • 77958061246 scopus 로고    scopus 로고
    • Rituximab plus fludarabine and cyclophosphamide or other agents in chronic lymphocytic leukemia
    • Robak T. Lech-Maranda E. Robak P. (2010 b) Rituximab plus fludarabine and cyclophosphamide or other agents in chronic lymphocytic leukemia. Expert Rev Anticancer Ther 10: 1529–1543.
    • (2010) Expert Rev Anticancer Ther , vol.10 , pp. 1529-1543
    • Robak, T.1    Lech-Maranda, E.2    Robak, P.3
  • 26
    • 0036340530 scopus 로고    scopus 로고
    • In vitro studies with bendamustine: enhanced activity in combination with rituximab
    • Rummel M. Chow K. Hoelzer D. Mitrou P. Weidmann E. (2002) In vitro studies with bendamustine: enhanced activity in combination with rituximab. Semin Oncol 29(4 Suppl. 13): 12–14.
    • (2002) Semin Oncol , vol.29 , Issue.4 , pp. 12-14
    • Rummel, M.1    Chow, K.2    Hoelzer, D.3    Mitrou, P.4    Weidmann, E.5
  • 27
    • 77954663766 scopus 로고    scopus 로고
    • Bendamustine: something old, something new
    • Tageja N. Nagi J. (2010) Bendamustine: something old, something new. Cancer Chemother Pharmacol 66: 413–423.
    • (2010) Cancer Chemother Pharmacol , vol.66 , pp. 413-423
    • Tageja, N.1    Nagi, J.2
  • 28
    • 51649093353 scopus 로고    scopus 로고
    • Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia
    • Tam C. O'Brien S. Wierda W. Kantarjian H. Wen S. Do K. et al. (2008) Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia. Blood 112: 975–980.
    • (2008) Blood , vol.112 , pp. 975-980
    • Tam, C.1    O'Brien, S.2    Wierda, W.3    Kantarjian, H.4    Wen, S.5    Do, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.