Bendamustine can severely impair T-cell immunity against cytomegalovirus

Leukemia and Lymphoma

Volumn 54, Issue 6, 2013, Pages 1327-1328

  Hosoda, Toru ^a   Yokoyama, Akihiro ^a   Yoneda, Mie ^a   Yamamoto, Ryusuke ^a   Ohashi, Kota ^a   Kagoo, Toshiya ^a   Ueno, Hironori ^a   Boku, Saigen ^a   Yano, Takahiro ^a  

^a NATIONAL HOSPITAL ORGANIZATION TOKYO MEDICAL CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BENDAMUSTINE; CYCLOPHOSPHAMIDE; CYTOMEGALOVIRUS ANTIGEN PP65; DEXAMETHASONE; DOXORUBICIN; FLUDARABINE; FOSCARNET; GANCICLOVIR; IMMUNOGLOBULIN G; MITOXANTRONE; PREDNISOLONE; RITUXIMAB; VALGANCICLOVIR; VINCRISTINE;

ABNORMAL LABORATORY RESULT; ACUTE KIDNEY FAILURE; ACUTE RESPIRATORY FAILURE; ADULT; AGED; ANOREXIA; CANCER COMBINATION CHEMOTHERAPY; CANCER RECURRENCE; CANCER REGRESSION; CASE REPORT; CD4 CD8 RATIO; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CELLULAR IMMUNODEFICIENCY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; CYTOTOXIC T LYMPHOCYTE; DIARRHEA; FEMALE; FOLLICULAR LYMPHOMA; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMOPHAGOCYTIC SYNDROME; HUMAN; LARGE CELL LYMPHOMA; LETTER; LEUKOCYTE COUNT; LYMPHOMA CELL; MALE; MULTIPLE CYCLE TREATMENT; MULTIPLE ORGAN FAILURE; NAUSEA; PNEUMOCYSTIS PNEUMONIA; PRIORITY JOURNAL; REDUCED INTENSITY CONDITIONING; RESUSCITATION; SIDE EFFECT; SUDDEN CARDIAC DEATH; T LYMPHOCYTE; WEIGHT REDUCTION;

AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS, ALKYLATING; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; FEMALE; HUMANS; LYMPHOMA, B-CELL; MALE; MIDDLE AGED; NITROGEN MUSTARD COMPOUNDS; T-LYMPHOCYTES;

EID: 84877751454     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2012.739285     Document Type: Letter

References (4)

1. Gratama J W, v an Esser J W, L amers C H, et a l. T etramer-based quantifi cation of cytomegalovirus-specifi c CD8 - T lymphocytes in T-cell-depleted stem cell grafts and after transplantation may identify patients at risk for progressive CMV infection . Blood 2001; 98 : 1358 - 1364.
2. Robinsin KS, Williams ME, van der Jagt RH, et al . Phase II multicenter study of bendamustine plus rituximab in patients with relapsed B-cell and mantle cell non-Hodgkin ' s lymphoma . J Clin Oncol 2008; 26 : 4473 - 4479.
3. Kahl BS, Bartlett NL, Leonard JP, et al . Bendamustine is eff ective therapy in patients with rituximab-refractory, indolent B-cell non- Hodgkin ' s lymphoma: Results from a multicenter study . Cancer 2010; 116 : 106 - 114.
4. L im S H, P athapati S, L angevin J, et a l. S evere CMV reactivation and gastritis during treatment of follicular lymphoma with bendamustine. Ann Hematol 2012; 91 : 643 - 644.