Oroxylin A induces BDNF expression on cortical neurons through Adenosine A2 A receptor stimulation: A possible role in neuroprotection

Biomolecules and Therapeutics

Volumn 20, Issue 1, 2012, Pages 27-35

  Jeon, Se Jin ^a,d   Bak, Haerang ^a   Seo, Jungeun ^a   Han, So Min ^a   Lee, Sung Hoon ^d   Han, Seol Heui ^d   Kwon, Kyoung Ja ^d   Ryu, Jong Hoon ^b   Cheong, Jae Hoon ^c   Ko, Kwang Ho ^a   Yang, Sung IL ^e   Choi, Ji Woong ^f   Park, Seung Hwa ^d,e   Shin, Chan Young ^d,e  

^a Seoul National University   (South Korea)

^b Kyung Hee University   (South Korea)

^c Sahmyook University   (South Korea)

^d Neuroscience Research Center   (South Korea)

^e Konkuk University School of Medicine   (South Korea)

^f Gachon University College of Medicine   (South Korea)

Author keywords

Adenosine A2 A receptor; BDNF; CGS21680; CREB; Oroxylin A; ZM241385

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; ADENOSINE A2A RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; GLYCOGEN SYNTHASE KINASE 3BETA; OROXYLIN A; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; INTRACELLULAR SIGNALING; NERVE FIBER GROWTH; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN SYNTHESIS; RAT; SYNAPTOGENESIS;

EID: 84863159534     PISSN: 19769148     EISSN: 20054483     Source Type: Journal    
DOI: 10.4062/biomolther.2012.20.1.027     Document Type: Article

References (56)

1. Angelucci, F., Brenè, S. and Mathé, A. A. (2005) BDNF in schizophrenia, depression and corresponding animal models. Mol. Psychiatry. 10, 345-352.
2. Bartrup, J. T., Moorman, J. M. and Newberry, N. R. (1997) BDNF enhances neuronal growth and synaptic activity in hippocampal cell cultures. Neuroreport. 8, 3791-3794
3. Canals, M., Angulo, E., Casadó, V., Canela, E. I., Mallol, J., Viñals, F., Staines, W., Tinner, B., Hillion, J., Agnati, L., Fuxe, K., Ferré, S., Lluis, C. and Franco, R. (2005) Molecular mechanisms involved in the adenosine A and A receptor-induced neuronal differentiation in neuroblastoma cells and striatal primary cultures. J. Neurochem. 92, 337-348.
4. Chen, Y., Yang, L. and Lee, T. J. (2000) Oroxylin A inhibition of lipopolysaccharide- induced iNOS and COX-2 gene expression via suppression of nuclear factor-kappaB activation. Biochem. Pharmacol. 59, 1445-1457.
5. Chen, Y. C., Shen, S. C., Chen, L. G., Lee, T. J. and Yang, L. L. (2001) Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide. Biochem. Pharmacol. 61, 1417-1427.
6. Cheng, H. C., Shih, H. M. and Chern, Y. (2002) Essential role of cAMPresponse element-binding protein activation by A2A adenosine receptors in rescuing the nerve growth factor-induced neurite outgrowth impaired by blockage of the MAPK cascade. J. Biol. Chem. 277, 33930-33942.
7. Cheng, Y., Gidday, J. M., Yan, Q., Shah, A. R. and Holtzman, D. M. (1997) Marked age-dependent neuroprotection by brain-derived neurotrophic factor against neonatal hypoxic-ischemic brain injury. Ann. Neurol. 41, 521-529.
8. Choi, S. H., Li, Y., Parada, L. F. and Sisodia, S. S. (2009) Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF. Mol. Neurodegener. 4, 52.
9. Chou, S. Y., Lee, Y. C., Chen, H. M., Chiang, M. C., Lai, H. L., Chang, H. H., Wu, Y. C., Sun, C. N., Chien, C. L., Lin, Y. S., Wang, S. C., Tung, Y. Y., Chang, C. and Chern, Y. (2005) CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model. J. Neurochem. 93, 310-320.
10. Cowansage, K. K., LeDoux, J. E. and Monfils, M. H. (2010) Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity. Curr. Mol. Pharmacol. 3, 12-29.
11. Croll, S. D., Wiegand, S. J., Anderson, K. D., Lindsay, R. M. and Nawa, H. (1994) Regulation of neuropeptides in adult rat forebrain by the neurotrophins BDNF and NGF. Eur. J. Neurosci. 6, 1343-1353.
12. Cunha, R. A., Ferré, S., Vaugeois, J. M. and Chen, J. F. (2008) Potential therapeutic interest of adenosine A2A receptors in psychiatric disorders. Curr. Pharm. Des. 14, 1512-1524.
13. Diógenes, M. J., Fernandes, C. C., Sebastião, A. M. and Ribeiro, J. A. (2004) Activation of adenosine A2A receptor facilitates brainderived neurotrophic factor modulation of synaptic transmission in hippocampal slices. J. Neurosci. 24, 2905-2913.
14. Flajolet, M., Wang, Z., Futter, M., Shen, W., Nuangchamnong, N., Bendor, J., Wallach, I., Nairn, A. C., Surmeier, D. J. and Greengard, P. (2008) FGF acts as a co-transmitter through adenosine A(2A) receptor to regulate synaptic plasticity. Nat. Neurosci. 11, 1402-1409.
15. Fontinha, B. M., Diógenes, M. J., Ribeiro, J. A. and Sebastião, A. M. (2008) Enhancement of long-term potentiation by brain-derived neurotrophic factor requires adenosine A2A receptor activation by endogenous adenosine. Neuropharmacology. 54, 924-933.
16. Francesco, A. L., Diego, G., Susanna, G., Giuseppina, L., Amina, W. S., Sergi, F., Rafael, F. and Kjell, F. (2008) Integrative action of receptor mosaics: relevance of receptor topology and allosteric modulators. J. Recept. Signal. Transduct. Res. 28, 543-565.
17. Gasiorowski, K., Lamer-Zarawska, E., Leszek, J., Parvathaneni, K., Yendluri, B. B., Błach-Olszewska, Z. and Aliev, G. (2011) Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? CNS. Neurol. Disord. Drug. Targets. 10, 184-191.
18. Han, B. H. and Holtzman, D. M. (2000) BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway. J. Neurosci. 20, 5775-5781.
19. Hashimoto, K., Shimizu, E. and Iyo, M. (2004) Critical role of brainderived neurotrophic factor in mood disorders. Brain. Res. Brain. Res. Rev. 45, 104-114.
20. Huang, N. K., Lin, Y. W., Huang, C. L., Messing, R. O. and Chern, Y. (2001) Activation of protein kinase A and atypical protein kinase C by A(2A) adenosine receptors antagonizes apoptosis due to serum deprivation in PC12 cells. J. Biol. Chem. 276, 13838-13846.
21. Huen, M. S., Leung, J. W., Ng, W., Lui, W. S., Chan, M. N., Wong, J. T. and Xue, H. 5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties. Biochem. Pharmacol. 66, 125-132.
22. Ip, N.Y., Li, Y., Yancopoulos, G.D. and Lindsay, R.M. (1993) Cultured hippocampal neurons show response to BDNF, NT-3 and NT-4, but not NGF. J. Neurosci. 13, 3394-3405.
23. Jeon, S. J., Rhee, S. Y., Seo, J. E., Bak, H. R., Lee, S. H., Ryu, J. H., Cheong, J. H., Shin, C. Y., Kim, G. H., Lee, Y. S. and Ko, K. H. (2011) Oroxylin A increases BDNF production by activation of MAPK-CREB pathway in rat primary cortical neuronal culture. Neurosci. Res. 69, 214-222.
24. Jiwajinda, S., Santisopasri, V., Murakami, A., Kim, O. K., Kim, H. W., and Ohigashi, H. (2002) Suppressive effects of edible thai plants on superoxide and nitric oxide generation. Asian. Pac. J. Cancer. Prev. 3, 215-223.
25. Kim, D. H., Jeon, S. J., Son, K. H., Jung, J. W., Lee, S., Yoon, B. H., Choi, J. W., Cheong, J. H., Ko, K. H. and Ryu, J. H. (2006) Effect of the flavonoid, oroxylin A, on transient cerebral hypoperfusioninduced memory impairment in mice. Pharmacol. Biochem. Behav. 85, 658-668.
26. Kim, D. H., Jeon, S. J., Son, K. H., Jung, J. W., Lee, S., Yoon, B. H., Lee, J. J., Cho, Y. W., Cheong, J. H., Ko, K. H. and Ryu, J. H. (2007) The ameliorating effect of oroxylin A on scopolamineinduced memory impairment in mice. Neurobiol. Learn. Mem. 87, 536-546.
27. Kim, D. H., Kim, S., Jeon, S. J., Son, K. H., Lee, S., Yoon, B. H., Cheong, J. H., Ko, K. H. and Ryu, J. H. (2008) The effects of acute and repeated oroxylin A treatments on Abeta(25-35)-induced memory impairment in mice. Neuropharmacology. 55, 639-647.
28. Kobayashi, H., Yokoyama, M., Matsuoka, Y., Omori, M., Itano, Y., Kaku, R., Morita, K. and Ichikawa, H. (2008) Expression changes of multiple brain-derived neurotrophic factor transcripts in selective spinal nerve ligation model and complete Freund's adjuvant model. Brain. Res. 1206, 13-19.
29. Lee, E. and Son, H. (2009) Adult hippocampal neurogenesis and related neurotrophic factors. BMB. Rep. 42, 239-244.
30. Lewin, G. R. (1996) Neurotrophins and the specification of neuronal phenotype. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 351, 405-411.
31. Lindholm, D., Dechant, G., Heisenberg, C. P. and Thoenen, H. (1993) Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamateinduced neurotoxicity. Eur. J. Neurosci. 5, 1455-1464.
32. Lynch, G., Rex, C. S., Chen, L. Y. and Gall, C. M. (2008) The substrates of memory: defects, treatments, and enhancement. Eur. J. Pharmacol. 585, 2-13.
33. Mai, L., Jope, R. S. and Li, X. (2002) BDNF-mediated signal transduction is modulated by GSK3beta and mood stabilizing agents. J. Neurochem. 82, 75-83.
34. Marty, S., Carroll, P., Cellerino, A., Castrén, E., Staiger, V., Thoenen, H. and Lindholm, D. (1996) Brain-derived neurotrophic factor promotes the differentiation of various hippocampal nonpyramidal neurons, including Cajal-Retzius cells, in organotypic slice cultures. J. Neurosci. 16, 675-687.
35. Moser, A., Liebetrau, A. and Cramer, H. (1991) Adenosine receptorcoupled adenylate cyclase in the caudate nucleus of the rat brain. Neuropharmacology. 30, 769-773.
36. Nawa, H., Pelleymounter, M. A. and Carnahan, J. (1994) Intraventricular administration of BDNF increases neuropeptide expression in newborn rat brain. J. Neurosci. 14, 3751-3765.
37. Noble, E. E., Billington, C. J., Kotz, C.M. and Wang, C. (2011) The lighter side of BDNF. Am. J. Physiol. Regul. Integr. Comp. Physiol. 300, R1053-1069.
38. O'Driscoll, C. M. and Gorman, A. M. (2005) Hypoxia induces neurite outgrowth in PC12 cells that is mediated through adenosine A2A receptors. Neuroscience. 131, 321-329.
39. Pardon, M. C. (2010) Role of neurotrophic factors in behavioral processes: implications for the treatment of psychiatric and neurodegenerative disorders. Vitam. Horm. 82, 185-200.
40. Pezet, S. and Malcangio, M. (2004) Brain-derived neurotrophic factor as a drug target for CNS disorders. Expert. Opin. Ther. Targets. 8, 391-399.
41. Pousinha, P. A., Diogenes, M. J., Ribeiro, J. A. and Sebastião, A. M. (2006) Triggering of BDNF facilitatory action on neuromuscular transmission by adenosine A2A receptors. Neurosci. Lett. 404, 143-147.
42. Proll, M. A., Clark, R. B. and Butcher, R. W. (1986) A1 and A2 adenosine receptors regulate adenylate cyclase in cultured human lung fibroblasts. Mol. Cell. Endocrinol. 44, 211-217.
43. Rebola, N., Lujan, R., Cunha, R.A. and Mulle, C. (2008) Adenosine A2A receptors are essential for long-term potentiation of NMDAEPSCs at hippocampal mossy fiber synapses. Neuron. 57, 121-134.
44. Sasaki, Y., Welshhans, K., Wen, Z., Yao, J., Xu, M., Goshima, Y., Zheng, J. Q. and Bassell, G. J. (2010) Phosphorylation of zipcode binding protein 1 is required for brain-derived neurotrophic factor signaling of local beta-actin synthesis and growth cone turning. J. Neurosci. 30, 9349-9358.
45. Scemes, E., Duval, N. and Meda, P. (2003) Reduced expression of P2Y1 receptors in connexin43-null mice alters calcium signaling and migration of neural progenitor cells. J. Neurosci. 23, 11444-11452.
46. Schmidt, H. D. and Duman, R. S. (2007) The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior. Behav. Pharmacol. 18, 391-418.
47. Sebastião, A. M. and Ribeiro, J. A. (2009) Triggering neurotrophic factor actions through adenosine A2A receptor activation: implications for neuroprotection. Br. J. Pharmacol. 158, 15-22.
48. Shen, W., Wu, B., Zhang, Z., Dou, Y., Rao, Z. R., Chen, Y. R. and Duan, S. (2006) Activity-induced rapid synaptic maturation mediated by presynaptic cdc42 signaling. Neuron. 50, 401-414.
49. Shih, H. C., Hsu, C. S. and Yang, L. L. (2009) In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root. J. Biomed. Sci. 16, 27.
50. Stafford, M. R., Bartlett, P. F. and Adams, D. J. (2007) Purinergic receptor activation inhibits mitogen-stimulated proliferation in primary neurospheres from the adult mouse subventricular zone. Mol. Cell. Neurosci. 35, 535-548.
51. Tebano, M. T., Martire, A., Potenza, R. L., Grò, C., Pepponi, R., Armida, M., Domenici, M. R., Schwarzschild, M. A., Chen, J. F. and Popoli, P. (2008) Adenosine A(2A) receptors are required for normal BDNF levels and BDNF-induced potentiation of synaptic transmission in the mouse hippocampus. J. Neurochem. 104, 279-286.
52. Tebano, M. T., Martire, A., Rebola, N., Pepponi, R., Domenici, M. R., Grò, M. C., Schwarzschild, M. A., Chen, J. F., Cunha, R. A. and Popoli, P. (2005) Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized and functionally interact in the hippocampus: a possible key mechanism in the modulation of Nmethyl- D-aspartate effects. J. Neurochem. 95, 1188-1200.
53. Terashima, M., Kobayashi, M., Motomiya, M., Inoue, N., Yoshida, T., Okano, H., Iwasaki, N., Minami, A. and Matsuoka, I. (2010) Analysis of the expression and function of BRINP family genes during neuronal differentiation in mouse embryonic stem cell-derived neural stem cells. J. Neurosci. Res. 88, 1387-1393.
54. Tucker, A. L. and Linden, J. (1993) Cloned receptors and cardiovascular responses to adenosine. Cardiovasc. Res. 27, 62-67.
55. Wiese, S., Jablonka, S., Holtmann, B., Orel, N., Rajagopal, R., Chao, M. V. and Sendtner, M. (2007) Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB. Proc. Natl. Acad. Sci. USA. 104, 17210-17215.
56. Winckler, B. (2007) BDNF instructs the kinase LKB1 to grow an axon. Cell. 129, 459-460.