A systematic review of neurodevelopmental effects of prenatal and postnatal organophosphate pesticide exposure

Toxicology Letters

Volumn 230, Issue 2, 2014, Pages 104-121

  Gonzalez Alzaga B ^a   Lacasana M ^a,b   Aguilar Garduno C ^c   Rodriguez Barranco M ^a,b   Ballester, F ^b,c,d   Rebagliato, M ^b,e   Hernandez A F ^f  

^a ANDALUSIAN SCHOOL OF PUBLIC HEALTH   (Spain)

^b CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^c Center for Research in Public Health (CSISP)   (Spain)

^d UNIVERSITY OF VALENCIA   (Spain)

^e UNIVERSITAT JAUME I   (Spain)

^f UNIVERSITY OF GRANADA   (Spain)

Author keywords

Neurodevelopment; Organophosphorus pesticides; Postnatal exposure; Prenatal exposure

Indexed keywords

ORGANOPHOSPHATE PESTICIDE; ORGANOPHOSPHATE; PESTICIDE;

ARTICLE; ATTENTION DEFICIT DISORDER; AUTISM; ENVIRONMENTAL EXPOSURE; EPIGENETICS; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; MENTAL DEVELOPMENT; MOTOR DEVELOPMENT; NERVE CELL DIFFERENTIATION; POSTNATAL EXPOSURE; PRENATAL EXPOSURE; PSYCHOMOTOR DEVELOPMENT; RESPONSE TIME; SEX DIFFERENCE; SYSTEMATIC REVIEW; VERBAL MEMORY; WORKING MEMORY; BRAIN; CHILD; CHILD BEHAVIOR; CHILD DEVELOPMENT; DRUG EFFECTS; FEMALE; FETUS; MALE; PHYSIOLOGY; PREGNANCY; TOXICITY;

BRAIN; CHILD; CHILD BEHAVIOR; CHILD DEVELOPMENT; ENVIRONMENTAL EXPOSURE; FEMALE; FETUS; HUMANS; MALE; ORGANOPHOSPHATES; PESTICIDES; PREGNANCY;

EID: 84907172225     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.11.019     Document Type: Article

References (98)

1. Abdel Rasoul G.M., Abou Salem M.E., Mechael A.A., Hendy O.M., Rohlman D.S., Ismail A.A. Effects of occupational pesticide exposure on children applying pesticides. Neurotoxicology 2008, 29:833-838.
2. Achenbach T.M., Rescorla L.A. Manual for the ASEBA Preschool Forms and Profiles 2000, University of Vermont Department of Psychiatry, Burlington, VT.
3. Androutsopoulos V.P., Hernandez A.F., Liesivuori J., Tsatsakis A.M. A mechanistic overview of health associated effects of low levels of organochlorine and organophosphorous pesticides. Toxicology 2013, 307:89-94.
4. Aprea C., Strambi M., Novelli M.T., Lunghini L., Bozzi N. Biologic monitoring of exposure to organophosphorus pesticides in 195 italian children. Environ. Health Perspect. 2000, 108:521-525.
5. Arbuckle T.E. Are there sex and gender differences in acute exposure to chemicals in the same setting. Environ. Res. 2006, 101:195-204.
6. Barr D.B., Bravo R., Weerasekera G., Caltabiano L.M., Whitehead R.D., Olsson A.O., et al. Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population. Environ. Health Perspect. 2004, 112:186-200.
7. Beamer P., Key M.E., Ferguson A.C., Canales R.A., Auyeung W., Leckie J.O. Quantified activity pattern data from 6 to 27-month-old farmworker children for use in exposure assessment. Environ. Res. 2008, 108:239-246.
8. Bearer C.F., Lee S., Salvator A.E., Minnes S., Swick A., Yamashita T., et al. Ethyl linoleate in meconium: a biomarker of prenatal ethanol exposure. Alcohol Clin. Exp. Res. 1999, 23:487-493.
9. Bird A. DNA methylation patterns and epigenetic memory. Genes Dev. 2002, 16:6-21.
10. Bouchard M.F., Bellinger D.C., Wright R.O., Weisskopf M.G. Attention-deficit/hyperactivity disorder and urinary metabolites of organophosphate pesticides. Pediatrics 2010, 125:1270-1277.
11. Bouchard M.F., Chevrier J., Harley K.G., Kogut K., Vedar M., Calderon N., Trujillo C., Johnson C., Bradman A., Barr D.B., Eskenazi B. Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children. Environ. Health Perspect. 2011, 119:1189-1195.
12. Bradman A., Eskenazi B., Barr D.B., Bravo R., Castorina R., Chevrier J., Kogut K., Harnly M.E., McKone T.E. Organophosphate urinary metabolite levels during pregnancy and after delivery in women living in an agricultural community. Environ. Health Perspect. 2005, 113:1802-1807.
13. Cheung P., Lau P. Epigenetic regulation by histone methylation and histone variants. Mol. Endocrinol. 2005, 19:563-573.
14. Clougherty J.E. A growing role for gender analysis in air pollution epidemiology. Environ. Health Perspect. 2010, 118:167-176.
15. Cole T.B., Fisher J.C., Burbacher T.M., Costa L.G., Furlong C.E. Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon. Neurotoxicol. Teratol. 2012, 34:311-322.
16. Costa L.G., Cole T.B., Vitalone A., Furlong C.E. Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity. Clin. Chim. Acta 2005, 352:37-47.
17. Costa L.G., Richter R.J., Li W.-F., Cole T., Guizzetti M., Furlong C.E. Paraoxonase (PON 1) as a biomarker of susceptibility for organophosphate toxicity. Biomarkers 2003, 8:1-12.
18. Costa L.G., Vitalone A., Cole T.B., Furlong C.E. Modulation of paraoxonase (PON1) activity. Biochem. Pharmacol. 2005, 69:541-550.
19. Costello J.F., Plass C. Methylation matters. J. Med. Genet. 2001, 38:285-303.
20. Curl C.L., Fenske R.A., Kissel J.C., Shirai J.H., Moate T.F., Griffith W., Coronado G., Thompson B. Evaluation of take-home organophosphorus pesticide exposure among agricultural workers and their children. Environ. Health Perspect. 2002, 110:787-792.
21. Curl C.L., Fenske R.A., Elgethun K. Organophosphorus pesticide exposure of urban and suburban preschool children with organic and conventional diets. Environ. Health Perspect. 2003, 111:377-382.
22. Eaton D.L., Farin F., Omiecinski C.J., Omenn G.S. Genetic susceptibility. Environmental and Occupational Medicine 1998, 209-221. Lippincott-Raven, Philadelphia. W.N. Rom (Ed.).
23. Ecobichon D.J. Pesticide use in developing countries. Toxicology 2001, 160:27-33.
24. Engel S.M., Berkowitz G.S., Barr D.B., Teitelbaum S.L., Siskind J., Meisel S.J., et al. Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort. Am. J. Epidemiol. 2007, 165:1397-1404.
25. Engel S.M., Wetmur J., Chen J., Zhu C., Barr D.B., Canfield R.L., et al. Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in childhood. Environ. Health Perspect. 2011, 119:1182-1188.
26. Eskenazi B., Harley K., Bradman A., Weltzien E., Jewell N.P., Barr D.B., et al. Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population. Environ. Health Perspect. 2004, 112:1116-1124.
27. Eskenazi B., Huen K., Marks A., Harley K.G., Bradman A., Barr D.B., et al. PON1 and neurodevelopment in children from the CHAMACOS study exposed to organophosphate pesticides in utero. Environ. Health Perspect. 2010, 118:1775-1781.
28. Eskenazi B., Marks A.R., Bradman A., Harley K., Barr D.B., Johnson C., et al. Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children. Environ. Health Perspect. 2007, 115:792-798.
29. Filipowicz W., Bhattacharyya S.N., Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight. Nat. Rev. Genet. 2008, 9:102-114.
30. Flanagan D.P., Kaufman A.S. Essentials of WISC-IV Assessment 2004, John Wiley&Sons, New Jersey, USA.
31. Flaskos J. The developmental neurotoxicity of organophosphorus insecticides: a direct role for the oxon metabolites. Toxicol. Lett. 2012, 209:86-93.
32. Forns J., Aranbarri a, Grellier J., Julvez J., Vrijheid M., Sunyer J. A conceptual framework in the study of neuropsychological development in epidemiological studies. Neuroepidemiology 2012, 38:203-208.
33. Furlong C.E., Holland N., Richter R.J., Bradman A., Ho A., Eskenazi B. PON1 status of farmworker mothers and children asa predictor of organophosphate sensitivity. Pharmacogenet. Genom. 2006, 16:183-190.
34. Furlong C.E. Genetic variability in the cytochrome P450-paraoxonase 1 (PON1) pathway for detoxication of organophosphorus compounds. J. Biochem. Mol. Toxicol. 2007, 21:197-205.
35. Grandjean P., Harari R., Barr D.B., Debes F. Pesticide exposure and stunting as independent predictors of neurobehavioral deficits in Ecuadorian school children. Pediatrics 2006, 117:e546-e556.
36. Grandjean P., Landrigan P.J. Developmental neurotoxicity of industrial chemicals. Lancet 2006, 368:2167-2178.
37. Griffith W., Curl C.L., Fenske R.A., Lu C.A., Vigoren E.M., Faustman E.M. Organophosphate pesticide metabolite levels in pre-school children in an agricultural community: within- and between-child variability in a longitudinal study. Environ. Res. 2011, 111:751-756.
38. Guo Y., Zhang J., Yu R., Zhu K.Y., Guo Y., Ma E. Identification of two new cytochrome P450 genes and RNA interference to evaluate their roles in detoxification of commonly used insecticides in Locusta migratoria. Chemosphere 2012, 87:709-717.
39. Guodong D., Pei W., Ying T., Jun Z., Yu G., Xiaojin W., et al. Organophosphate pesticide exposure and neurodevelopment in young Shanghai children. Environ. Sci. Technol. 2012, 46:2911-2917.
40. Handal A.J., Harlow S.D., Breilh J., Lozoff B. Occupational exposure to pesticides during pregnancy and neurobehavioral development of infants and toddlers. Epidemiology 2008, 19:851-859.
41. Harari R., Julvez J., Murata K., Barr D., Bellinger D.C., Debes F., et al. Neurobehavioral deficits and increased blood pressure in school-age children prenatally exposed to pesticides. Environ. Health Perspect. 2010, 118:890-896.
42. Hayashi K., Chuva de Sousa Lopes S.M., Kaneda M., Tang F., Hajkova P., Lao K., O'Carroll D., Das P.P., Tarakhovsky A., Miska E.A., Surani M.A. MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis. PLoS One 2008, 3:e1738.
43. Horton M.K., Kahn L.G., Perera F., Barr D.B., Rauh V. Does the home environment and the sex of the child modify the adverse effects of prenatal exposure to chlorpyrifos on child working memory?. Neurotoxicol. Teratol. 2012, 34:534-541.
44. Huen K., Harley K., Brooks J., Hubbard A., Bradman A., Eskenazi B., Holland N. Developmental changes in PON1 enzyme activity in young children and effects of PON1polymorphisms. Environ. Health Perspect. 2009, 117:1632-1638.
45. Jedrychowski W., Perera F., Jankowski J., Mrozek-Budzyn D., Mroz E., Flak E., et al. Gender specific differences in neurodevelopmental effects of prenatal exposure to very low-lead levels: the prospective cohort study in three-year olds. Early Hum. Dev. 2009, 85:503-510.
46. Jurewicz J., Hanke W. Prenatal and childhood exposure to pesticides and neurobehavioral development: review of epidemiological studies. Int. J. Occup. Med. Environ. Health 2008, 21:121-132.
47. Kofman O., Berger A., Massarwa A., Friedman A., Jaffar A.A. Motor inhibition and learning impairments in school-aged children following exposure to organophosphate pesticides in infancy. Pediatric Res. 2006, 60:88-92.
48. Koureas M., Tsakalof A., Tsatsakis A., Hadjichristodoulou C. Systematic review of biomonitoring studies to determine the association between exposure to organophosphorus and pyrethroid insecticides and human health outcomes. Toxicol. Lett. 2012, 210:155-168.
49. Lacasaña M., Va´zquez-Grameix H., Borja-Aburto V.H., Blanco-Muñoz J., Romieu I., Aguilar-Garduño C., Garci´a A.M. Maternal and paternal occupational exposure to agricultural work and the risk of anencephaly. Occup. Environ. Med. 2006, 63:649-656.
50. Lizardi P.S., O'Rourke M.K., Morris R.J. The effects of organophosphate pesticide exposure on Hispanic children's cognitive and behavioral functioning. J. Pediatr. Psycholol. 2008, 33:91-101.
51. Lee D.H., Jacobs D.R., Porta M. Hypothesis: a unifying mechanism for nutrition and chemicals as lifelong modulators of DNA hypomethylation. Environ. Health Perspect. 2009, 117:1799-1802.
52. Lu C., Essig C., Root C., Rohlman D.S., McDonald T., Sulzbacher S. Assessing the association between pesticide exposure and cognitive development in rural Costa Rican children living in organic and conventional coffee farms. Int. J. Adolesc. Med. Health 2009, 21:609-621.
53. Lu C., Barr D.B., Pearson M.A., Waller L.A. Dietary intake and its contribution to longitudinal organophosphorus pesticide exposure in urban/suburban children. Environ. Health Perspect. 2008, 116:537-542.
54. Lu C., Toepel K., Irish R., Fenske R.A., Barr D.B., Bravo R. Organic diets significantly lower children's dietary exposure to organophosphorus pesticides. Environ. Health Perspect. 2006, 114:260-263.
55. Marks A.R., Harley K., Bradman A., Kogut K., Barr D.B., Johnson C., et al. Organophosphate pesticide exposure and attention in young Mexican-American children: the CHAMACOS study. Environ. Health Perspect. 2010, 118:1768-1774.
56. Maroni M., Colosio C., Ferioli A., Fait A. Biological monitoring of pesticide exposure: a review. Introduction. Toxicology 2000, 143:1-118.
57. Marti´nez-Fri´as M.L. Can our understanding of epigenetics assist with primary prevention of congenital defects. J. Med. Genet. 2010, 47:73-80.
58. Martino S., Girolamo I.di, Orlacchio A., Datti A., Orlacchio A. MicroRNA implications across neurodevelopment and neuropathology. J. Biomed. Biotechnol. 2009, 2009:654346.
59. Maurissen J.P., Hoberman a M., Garman R.H., Hanley T.R. Lack of selective developmental neurotoxicity in rat pups from dams treated by gavage with chlorpyrifos. Toxicol. Sci. 2000, 57:250-263.
60. Molinero O., Castro-Piñero J., Ruiz J.R., Gonza´lez Montesinos J.L., Mora J., Ma´rquez S. Health behaviour of school children at the province of Ca´diz. Nutr. Hosp. 2010, 25:280-289.
61. Olmos M., Antelo M., Vazquez H., Smecuol E., Maurino E., Bai J.C. Systematic review and meta-analysis of observational studies on the prevalence of fractures in coeliac disease. Dig. Liver Dis. 2008, 40:46-53.
62. Ostrea E.M Testing for exposure to illicit drugs and other agents in the neonate: a review of laboratory methods and the role of meconium analysis. Curr. Prob. Pediatr. 1999, 29:37-56.
63. Padilla S., Buzzard J., Moser V.C. Comparison of the role of esterases in the differential age-related sensitivity to chlorpyrifos and methamidophos. Neurotoxicology 2000, 21:49-56.
64. Paus T., Zijdenbos A., Worsley K., Collins D.L., Blumenthal J., Giedd J.N., Rapoport J.L., Evans A.C. Structural maturation of neuralpathways in children and adolescents: in vivo study. Science 1999, 283:1908-1911.
65. Perera F., Herbstman J. Prenatal environmental exposures, epigenetics, and disease. Reprod. Toxicol. 2011, 31:363-373.
66. Persico A.M., Bourgeron T. Searching for ways out of the autism maze: genetic, epigenetic and environmental clues. Trends Neurosci. 2006, 29:349-358.
67. Pope C., Karanth S., Liu J. Pharmacology and toxicology of cholinesterase inhibitors: uses and misuses of a common mechanism of action. Environ. Toxicol. Pharmacol. 2005, 19:433-446.
68. Rauch S.A., Braun J.M., Barr D.B., Calafat A.M., Khoury J., Montesano M.A., Yolton K., Lanphear B.P. Associations of prenatal exposure to organophosphate pesticide metabolites with gestational age and birth weight. Environ. Health Perspect. 2012, 120:1055-1060.
69. Rauh V., Perera F.P., Horton M.K., Whyatt R.M., Bansal R., Hao X., Liu J., Barr D.B., Slotkin T.A., Peterson B.S. Brain anomalies in children exposed prenatally to a common organophosphate pesticide. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:7871-7876.
70. Rauh V., Arunajadai S., Horton M., Perera F., Hoepner L., Barr D.B., Whyatt R. Seven-year neurodevelopmental scores and prenatal exposure to chlorpyrifos, a common agricultural pesticide. Environ. Health Perspect. 2011, 119:1196-1201.
71. Rauh V.A., Garfinkel R., Perera F.P., Andrews H.F., Hoepner L., Barr D.B., Whitehead R., Tang D., Whyatt R.W. Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children. Pediatrics 2006, 118:e1845-e1859.
72. Ricci-Cabello I., Ruiz-Perez I., Olry de Labry-Lima A., Marquez-Calderon S. Do social inequalities exist in terms of the prevention, diagnosis, treatment, control and monitoring of diabetes?. A systematic review. Health Soc. Care Commun. 2010, 18:572-587.
73. Rice D., Barone S. Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models birth. Environ. Health Perspect. 2000, 108:511-533.
74. Rodri´guez-Barranco M., Lacasaña M., Aguilar-Garduño C., Alguacil J., Gil F., Gonza´lez-Alzaga B., Rojas-Garci´a A. Association of arsenic, cadmium and manganese exposure with neurodevelopment and behavioural disorders in children: A systematic review and meta-analysis. Sci. Total Environ. 2013, 454-455:562-577.
75. Rodri´guez-Milord D, Castillo P del, Aguilar-Garduño C, 1990. Glosario de te´rminos en salud ambiental: con especial e´nfasis en los efectos relacionados con las sustancias qui´micas. Mexico: PanAmerican Center for Human Ecology and Health, ECO/PAHO/WHO. http://www.bvsde.ops-oms.org/bvsacd/eco/030494/030494.htm.
76. Rohlman D.S., Arcury T.A., Quandt S.A., Lasarev M., Rothlein J., Travers R., et al. Neurobehavioral performance in preschool children from agricultural and non-agricultural communities in Oregon and North Carolina. Neurotoxicology 2005, 26:589-598.
77. Ruckart P.Z., Kakolewski K., Bove F.J., Kaye W.E. Long-term neurobehavioral health effects of methyl parathion exposure in children in Mississippi and Ohio. Environ. Health Perspect. 2004, 112:46-51.
78. Schuh R.A., Lein P.J., Beckles R.A., Jett D.A. Noncholinesterase mechanism of chlorpyrifos neurotoxicity: altered phosphorylation of Ca2+/cAMP response element binding protein in cultured neurons. Toxicol. Appl. Pharmacol. 2002, 182:176-185.
79. Selemon L.D. A role for synaptic plasticity in the adolescent development of executive function. Trans. Psychiatry 2013, 3:e238.
80. Shahbazian M.D., Grunstein M. Functions of site-specific histone acetylation and deacetylation. Annu. Rev. Biochem. 2007, 76:75-100.
81. Slotkin T.A., Bodwell B.E., Levin E.D., Seidler F.J. Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems. Environ. Health Perspect. 2008, 116:340-348.
82. Sudakin D.L., Stone D.L. Dialkyl phosphates as biomarkers of organophosphates: the current divide between epidemiology and clinical toxicology. Clin. Toxicol. 2011, 49:771-781.
83. Tam O.H., Aravin A.A., Stein P., Girard A., Murchison E.P., Cheloufi S., Hodges E., Anger M., Sachidanandam R., Schultz R.M., Hannon G.J. Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature 2008, 453:534e8.
84. Tian Y., Ishikawa H., Yamauchi T., Yokoyama K. Teratogenicity and developmental toxicity of chlorpyrifos. Maternal exposure during organogenesis in mice. Reprod. Toxicol. 2005, 20:267-270.
85. Tsatsakis A.M., Barbounis M.G., Kavalakis M., Kokkinakis M., Terzi I., Tzatzarakis M.N. Determination of dialkyl phosphates in human hair for the biomonitoring of exposure to organophosphate pesticides. J. Chromatogr. 2010, 878:1246-1252.
86. Tsatsakis A.M., Tzatzarakis M.N., Koutroulakis D., Toutoudaki M., Sifakis S. Dyalkyl phosphates in meconium as a biomarker of prenatal exposure to organophosphate pesticides: a study on pregnant women or rural areas in Crete, Greece. Xenobiotica 2009, 39:364-373.
87. Tsatsakis A.M., Tzatzarakis M.N., Tutudaki M., Babatsikou F., Alegakis A.K., Koutis C. Assessment of levels of organochlorine pesticides and their metabolites in the hair of a Greek rural human population. Hum. Exp. Toxicol. 2008, 27:933-940.
88. van Wendel et al., 2011. Personal communication, unpublished.
89. Varga-Weisz P.D., Becker P.B-I.I. Regulation of higher-order chromatin structures by nucleosome-remodelling factors. Curr. Opin. Genet. Dev. 2006, 16:151-156.
90. Venerosi A., Ricceri L., Tait S., Calamandrei G. Sex dimorphic behaviors as markers of neuroendocrine disruption by environmental chemicals: The case of chlorpyrifos. Neurotoxicology 2012 August 29, 10.1016/j.neuro.2012.08.009.
91. von Elm E., Altman D.G., Egger M., Pocock S.J., Gøtzsche P.C., Vandenbroucke J.P. STROBE initiative the strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. J. Clin. Epidemiol. 2008, 61:344-349.
92. White R.F., Campbell R., Echeverria D., Knox S.S., Janulewicz P. Assessment of neuropsychological trajectories in longitudinal population-based studies of children. J. Epidemiol. Commun. Health 2009, 63:15-26.
93. WHO, Biological Monitoring of Chemical Exposure in the Workplace Fourth National Report on Human Exposure to Environmental Chemicals, Department of Health and Human Services Centers for Disease Control and Prevention 2009 1996, vol. 1. World Health Organization, Geneva.
94. Weinhold B. Epigenetics: the science of change. Environ. Health Perspect. 2006, 114:A160-A167.
95. Whyatt R.M., Barr D.B. Measurement of organophosphate metabolites in postpartum meconium as a potential biomarker of prenatal exposure: a validation study. Environ. Health Perspect. 2001, 109:417-420.
96. Young J.G., Eskenazi B., Gladstone E., Bradman A., Pedersen L., Johnson C., et al. Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates. Neurotoxicology 2005, 26:199-209.
97. Zhang X., Wallace A.D., Du P., Kibbe W.A., Jafari N., Xie H., Lin S., Baccarelli A.A., Jiang H., Jafari N., Zheng Y., Xie H., Soares M.B., Hou L. DNA methylation alterations in response to pesticide exposure in vitro. Environ. Mol. Mutagen. 2012, 53:542-549.
98. Zhang X., Wallace A.D., Du P., Lin S., Baccarelli A.A., Jiang H., Jafari N., Zheng Y., Xie Hh Soares M.B., Kibbe W.A., Hou L. Genome wide study of DNA methylation alterations in response to diazinon exposure in vitro. Environ. Toxicol. Pharmacol. 2012, 34:959-968.