Neurobehavioral deficits and increased blood pressure in school-age children prenatally exposed to pesticides

Environmental Health Perspectives

Volumn 118, Issue 6, 2010, Pages 890-896

  Harari, Raul ^a   Julvez, Jordi ^b   Murata, Katsuyuki ^c   Barr, Dana ^d   Bellinger, David C ^b,e   Debes, Frodi ^f   Grandjean, Philippe ^b,f  

^a Corporación para el Desarrollo de la Producción y el Medio Ambiente Laboral ^*  (Ecuador)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c AKITA UNIVERSITY   (Japan)

^d NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

^e BOSTON CHILDREN S HOSPITAL   (United States)

^f UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Acetylcholinesterase; Blood pressure; Maternal exposure; Neurotoxicity syndromes; Occupational exposure; Organophosphorus compounds; Pesticides; Prenatal exposure delayed effects

Indexed keywords

PESTICIDE; ORGANOPHOSPHATE;

APTITUDE TEST; ARTICLE; BODY MASS; CHILD; COGNITIVE DEFECT; CONTROLLED STUDY; DEPTH PERCEPTION; DEVELOPMENTAL DISORDER; DISEASE ASSOCIATION; ENVIRONMENTAL EXPOSURE; FEMALE; GREENHOUSE; HEALTH HAZARD; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MOTOR COORDINATION; MOTOR PERFORMANCE; OCCUPATIONAL EXPOSURE; PRENATAL EXPOSURE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SYSTOLIC BLOOD PRESSURE; VISUAL MEMORY; WEIGHT REDUCTION; ADULT; ATTENTION; BLOOD PRESSURE; CHEMICALLY INDUCED; CROSS-SECTIONAL STUDY; DRUG EFFECTS; ECUADOR; NEUROPSYCHOLOGICAL TEST; OCCUPATIONAL DISEASE; PREGNANCY; PSYCHOMOTOR PERFORMANCE; TOXICITY; URINE;

ADULT; AGRICULTURAL WORKERS' DISEASES; ATTENTION; BLOOD PRESSURE; CHILD; CROSS-SECTIONAL STUDIES; DEVELOPMENTAL DISABILITIES; ECUADOR; FEMALE; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; OCCUPATIONAL EXPOSURE; PESTICIDES; PHOSPHORIC ACID ESTERS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PSYCHOMOTOR PERFORMANCE; ORGANOPHOSPHATES;

EID: 77953249502     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.0901582     Document Type: Article

References (53)

1. Ahlbom J, Fredriksson A, Eriksson P. 1995. Exposure to an organophosphate (DFP) during a defined period in neonatal life induces permanent changes in brain muscarinic receptors and behaviour in adult mice. Brain Res 677(1):13-19.
2. Andersen HR, Nielsen JB, Grandjean P. 2000. Toxicologic evidence of developmental neurotoxicity of environmental chemicals. Toxicology 144(1-3):121-127.
3. Bardin PG, van Eeden SF, Moolman JA, Foden AP, Joubert JR. 1994. Organophosphate and carbamate poisoning. Arch Intern Med 154(13):1433-1441.
4. Berkowitz GS, Wetmur JG, Birman-Deych E, Obel J, Lapinski RH, Godbold JH, et al. 2004. In utero pesticide exposure, maternal paraoxonase activity, and head circumference. Environ Health Perspect 112:388-391.
5. Bjørling-Poulsen M, Andersen HR, Grandjean P. 2008. Potential developmental neurotoxicity of pesticides used in Europe. Environ Health 7:50; doi:10.1186/1476-069X-7-50 [Online 22 October 2008].
6. Bravo R, Driskell WJ, Whitehead RD Jr, Needham LL, Barr DB. 2002. Quantitation of dialkyl phosphate metabolites of organophosphate pesticides in human urine using GC-MS-MS with isotopic internal standards. J Anal Toxicol 26(5):245-252.
7. Brion MJ, Leary SD, Lawlor DA, Smith GD, Ness AR. 2008. Modifiable maternal exposures and offspring blood pressure: a review of epidemiological studies of maternal age, diet, and smoking. Pediatr Res 63(6):593-598.
8. Brucker-Davis F. 1998. Effects of environmental synthetic chemicals on thyroid function. Thyroid 8(9):827-856.
9. Chevrier C, Sullivan K, White RF, Comtois C, Cordier S, Grandjean P. 2009. Qualitative assessment of visuospatial errors in mercury-exposed Amazonian children. Neurotoxicology 30(1):37-46.
10. Chiappa KH. 1997. Evoked Potentials in Clinical Medicine. 3rd ed. Philadelphia:Lippencott-Raven.
11. Choi AL, Weihe P, Budtz-Jorgensen E, Jorgensen PJ, Salonen JT, Tuomainen TP, et al. 2009. Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men. Environ Health Perspect 117:367-372.
12. Colosio C, Harari R, Birindelli S, Fustinoni S, Harari H, Minoia C, et al. 2004. Exposición profesional a plaguicidas en floricultoras del Ecuador. In: Seguridad, Salud y Ambiente en la Floricultura (Harari R, ed). Quito:IFA-PROMSA, 36-55.
13. Conners CK. (2001). Conners' Kiddie Continuous Performance Test. Toronto:Multi-Health Systems Inc.
14. de Onis M, Frongillo EA, Blossner M. 2000. Is malnutrition declining? An analysis of changes in levels of child malnutrition since 1980. Bull WHO 78(10):1222-1233.
15. Debes F, Budtz-Jørgensen E, Weihe P, White RF, Grandjean P. 2006. Impact of prenatal methylmercury toxicity on neurobehavioral function at age 14 years. Neurotoxicol Teratol 28(3):363-375.
16. Engel SM, Berkowitz GS, Barr DB, Teitelbaum SL, Siskind J, Meisel SJ, et al. 2007. Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort. Am J Epidemiol 165(12):1397-1404.
17. Eskenazi B, Marks AR, Bradman A, Harley K, Barr DB, Johnson C, et al. 2007. Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children. Environ Health Perspect 115:792-798.
18. Grandjean P, Harari R, Barr DB, Debes F. 2006. Pesticide exposure and stunting as independent predictors of neurobehavioral deficits in Ecuadorian school children. Pediatrics 117(3):e546-e556.
19. Grandjean P, Landrigan PJ. 2006. Developmental neurotoxicity of industrial chemicals. Lancet 368(9553):2167-2178.
20. Grandjean P, Weihe P, White RF, Debes F, Araki S, Yokoyama K, et al. 1997. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol 19(6):417-428.
21. Grandjean P, White RF, Nielsen A, Cleary D, de Oliveira Santos EC. 1999. Methylmercury neurotoxicity in Amazonian children downstream from gold mining. Environ Health Perspect 107:587-591.
22. Guillette EA, Meza MM, Aquilar MG, Soto AD, Garcia IE. 1998. An anthropological approach to the evaluation of preschool children exposed to pesticides in Mexico. Environ Health Perspect 106:347-353.
23. Handal AJ, Harlow SD, Breilh J, Lozoff B. 2008. Occupational exposure to pesticides during pregnancy and neurobehavioral development of infants and toddlers. Epidemiology 19(6):851-859.
24. Handal AJ, Lozoff B, Breilh J, Harlow SD. 2007. Neurobehavioral development in children with potential exposure to pesticides. Epidemiology 18(3):312-320.
25. ILO (International Labour Organization). 2000. Maternity protection convention. Available: http://www.ilo.org/ilolex/cgi-lex/convde.pl?C183 [accessed 16 February 2010].
26. Julvez J, Grandjean P. 2009. Neurodevelopmental toxicity risks due to occupational exposure to industrial chemicals during pregnancy. Ind Health 47(5):459-468.
27. Larrea C, Kawachi I. 2005. Does economic inequality affect child malnutrition? The case of Ecuador. Soc Sci Med 60(1):165-178.
28. Lezak MD. 1995. Neuropsychological Assessment. 3rd ed. Oxford, UK:Oxford University Press.
29. Lotti M. 1995. Cholinesterase inhibition: complexities in interpretation. Clin Chem 41(12 pt 2):1814-1818.
30. Mage DT, Allen RH, Kodali A. 2008. Creatinine corrections for estimating children's and adult's pesticide intake doses in equilibrium with urinary pesticide and creatinine concentrations. J Expo Sci Environ Epidemiol 18(4):360-368.
31. Morley R, Leeson Payne C, Lister G, Lucas A. 1995. Maternal smoking and blood pressure in 7.5 to 8 year old offspring. Arch Dis Child 72(2):120-124.
32. Morreale de Escobar G, Obregon MJ, Escobar del Rey F. 2000. Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia? J Clin Endocrinol Metab 85(11):3975-3987.
33. Murata K, Weihe P, Renzoni A, Debes F, Vasconcelos R, Zino F, et al. 1999. Delayed evoked potentials in children exposed to methylmercury from seafood. Neurotoxicol Teratol 21(4):343-348.
34. Murata K, Yano E, Hashimoto H, Karita K, Dakeishi M. 2005. Effects of shift work on QTc interval and blood pressure in relation to heart rate variability. Int Arch Occup Environ Health 78(4):287-292.
35. Nakao M, Barsky AJ, Nishikitani M, Yano E, Murata K. 2007. Somatosensory amplification and its relationship to somatosensory, auditory, and visual evoked and event-related potentials (P300). Neurosci Lett 415(2):185-189.
36. Rauh VA, Garfinkel R, Perera FP, Andrews HF, Hoepner L, Barr DB, et al. 2006. Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children. Pediatrics 118(6):e1845-e1859.
37. Raven JC, Court JH, Raven J. 1979. Manual for Raven's Progressive Matrices and vocabulary scales. London:H.K. Lewis.
38. Rice D, Barone S Jr. 2000. Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ Health Perspect 108(suppl 3):511-533.
39. Rothenberg SJ, Poblano A, Schnaas L. 2000. Brainstem auditory evoked response at five years and prenatal and postnatal blood lead. Neurotoxicol Teratol 22(4):503-510.
40. Ruckart PZ, Kakolewski K, Bove FJ, Kaye WE. 2004. Long-term neurobehavioral health effects of methyl parathion exposure in children in Mississippi and Ohio. Environ Health Perspect 112:46-51.
41. Semba R, Bloem M. 2001. Nutrition and Health in Developing Countries. Totowa, NJ:Humana Press.
42. Slotkin TA. 2004. Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates. Toxicol Appl Pharmacol 198(2):132-151.
43. Spiegelman D, Hertzmark E. 2005. Easy SAS calculations for risk or prevalence ratios and differences. Am J Epidemiol 162(3):199-200.
44. Sullivan K. 1999. Neurodevelopmental Aspects of Methylmercury Exposure: Neuropsychological Consequences and Cultural Issues. Boston:Boston University.
45. Thorndike RL, Hagen EP, Sattler JM. 1986. Stanford-Binet Intelligence Scale. 4th ed. Chicago:Riverside.
46. Walker SP, Gaskin P, Powell CA, Bennett FI, Forrester TE, Grantham-McGregor S. 2001. The effects of birth weight and postnatal linear growth retardation on blood pressure at age 11-12 years. J Epidemiol Community Health 55(6):394-398.
47. Wechsler D. 1974. Wechsler Intelligence Scale for Children Revised. New York:Psychological Corporation.
48. White RF, Debes F, Dahl R, Grandjean P. Developmental and field testing of a neuropsychological test battery to assess the effects of methylmercury exposure in the Faroe Islands. In: Proceedings of the International Symposium on Assessment of Environmental Pollution and Health Effects from Methylmercury, 1994. Minamata:National Institute of Minamata Disease, 127-140.
49. WHO (World Health Organization). 2006. WHO Global Database on Child Growth and Malnutrition. Available: http://www.who.int/nutgrowthdb/en/ [accessed 16 February 2010].
50. Whyatt RM, Rauh V, Barr DB, Camann DE, Andrews HF, Garfinkel R, et al. 2004. Prenatal insecticide exposures and birth weight and length among an urban minority cohort. Environ Health Perspect 112:1125-1132.
51. Wigle DT, Turner MC, Krewski D. 2009. A systematic review and meta-analysis of childhood leukaemia and parental occupational pesticide exposure. Environ Health Perspect 117:1505-1513.
52. Wilson AC, Forsyth JS, Greene SA, Irvine L, Hau C, Howie PW. 1998. Relation of infant diet to childhood health: seven year follow up of cohort of children in Dundee infant feeding study. BMJ 316(7124):21-25.
53. Young JG, Eskenazi B, Gladstone EA, Bradman A, Pedersen L, Johnson C, et al. 2005. Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates. Neurotoxicology 26(2):199-209.