Brain anomalies in children exposed prenatally to a common organophosphate pesticide

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 20, 2012, Pages 7871-7876

  Rauh, Virginia A ^a   Perera, Frederica P ^a   Horton, Megan K ^a   Whyatt, Robin M ^a   Bansal, Ravi ^b   Hao, Xuejun ^b   Liu, Jun ^b   Barr, Dana Boyd ^c   Slotkin, Theodore A ^d   Peterson, Bradley S ^b,e  

^a Columbia University ^*  (United States)

^b Columbia University College of Physicians and Surgeons ^*  (United States)

^c EMORY UNIVERSITY   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

^e NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

Brain structure; Neurotoxicity

Indexed keywords

CHLORPYRIFOS; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; TOBACCO SMOKE;

ARTICLE; BRAIN DEVELOPMENT; BRAIN MALFORMATION; BRAIN SIZE; CHILD; CLINICAL ARTICLE; COGNITION; COHORT ANALYSIS; COMMUNITY; CONCENTRATION (PARAMETERS); CUNEUS; DOSE RESPONSE; FEMALE; FRONTAL CORTEX; FUSIFORM GYRUS; HUMAN; INFERIOR PARIETAL LOBULE; INTELLIGENCE QUOTIENT; INTERMETHOD COMPARISON; MALE; MIDDLE TEMPORAL GYRUS; NUCLEAR MAGNETIC RESONANCE IMAGING; ORBITAL CORTEX; PARIETAL CORTEX; POSTCENTRAL GYRUS; PRECUNEUS; PRENATAL EXPOSURE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RIGHT HEMISPHERE; SCHOOL CHILD; SEX DIFFERENCE; SUPERIOR FRONTAL GYRUS; SUPERIOR TEMPORAL GYRUS; SUPRAMARGINAL GYRUS; THICKNESS; UMBILICAL CORD BLOOD; WHITE MATTER;

ADULT; BRAIN; CHILD; CHLORPYRIFOS; COGNITION; COHORT STUDIES; FEMALE; FETAL BLOOD; HUMANS; INTELLIGENCE TESTS; MAGNETIC RESONANCE IMAGING; NERVOUS SYSTEM MALFORMATIONS; NEW YORK CITY; PESTICIDES; PHOSPHORIC ACID ESTERS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROSPECTIVE STUDIES;

ANIMALIA; NICOTIANA TABACUM;

EID: 84861219976     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1203396109     Document Type: Article

References (53)

1. US Environmental Protection Agency (2000) Chlorpyrifos Revised Risk Assessment and Agreement with Registrants (US Environmental Protection Agency, Washington, DC).
2. Berkowitz GS, et al. (2003) Exposure to indoor pesticides during pregnancy in a multiethnic, urban cohort. Environ Health Perspect 111:79-84.
3. Whyatt RM, et al. (2002) Residential pesticide use during pregnancy among a cohort of urban minority women. Environ Health Perspect 110:507-514. (Pubitemid 34546511)
4. Slotkin TA (2004) Guidelines for developmental neurotoxicity and their impact on organophosphate pesticides: A personal view from an academic perspective. Neurotoxicology 25:631-640.
5. Mauro RE, Zhang L (2007) Unique insights into the actions of CNS agents: Lessons from studies of chlorpyrifos and other common pesticides. Central Nerv Syst Agents Med Chem 7(3):183-199. (Pubitemid 47364636)
6. Bradman A, et al. (2003) Measurement of pesticides and other toxicants in amniotic fluid as a potential biomarker of prenatal exposure: A validation study. Environ Health Perspect 111:1779-1782. (Pubitemid 37407940)
7. Whyatt RM, et al. (2005) Biomarkers in assessing residential insecticide exposures during pregnancy and effects on fetal growth. Toxicol Appl Pharmacol 206:246-254. (Pubitemid 40828245)
8. Berkowitz GS, et al. (2004) In utero pesticide exposure, maternal paraoxonase activity, and head circumference. Environ Health Perspect 112:388-391. (Pubitemid 38351405)
9. Whyatt RM, et al. (2004) Prenatal insecticide exposures and birth weight and length among an urban minority cohort. Environ Health Perspect 112:1125-1132. (Pubitemid 39029170)
10. Engel SM, et al. (2007) Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort. Am J Epidemiol 165:1397-1404. (Pubitemid 47234308)
11. Young JG, et al. (2005) Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates. Neurotoxicology 26:199-209. (Pubitemid 40248438)
12. Marks AR, et al. (2010) Organophosphate pesticide exposure and attention in young Mexican-American children: The CHAMACOS study. Environ Health Perspect 118:1768-1774.
13. Rauh VA, et al. (2006) Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children. Pediatrics 118(6):e1845-e1859.
14. Eskenazi B, et al. (2007) Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children. Environ Health Perspect 115:792-798. (Pubitemid 46785051)
15. BouchardMF, et al. (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children. Environ Health Perspect 119:1189-1195.
16. Engel SM, et al. (2011) Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in childhood. Environ Health Perspect 119:1182-1188.
17. Rauh V, et al. (2011) Seven-year neurodevelopmental scores and prenatal exposure to chlorpyrifos, a common agricultural pesticide. Environ Health Perspect 119:1196-1201.
18. Roy TS, Seidler FJ, Slotkin TA (2004) Morphologic effects of subtoxic neonatal chlorpyrifos exposure in developing rat brain: regionally selective alterations in neurons and glia. Brain Res Dev Brain Res 148:197-206. (Pubitemid 38177430)
19. Roy TS, Sharma V, Seidler FJ, Slotkin TA (2005) Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats. Brain Res Dev Brain Res 155:71-80. (Pubitemid 40347309)
20. Garcia SJ, Seidler FJ, Qiao D, Slotkin TA (2002) Chlorpyrifos targets developing glia: Effects on glial fibrillary acidic protein. Brain Res Dev Brain Res 133:151-161. (Pubitemid 34212000)
21. Aldridge JE, Seidler FJ, Slotkin TA (2004) Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: Critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. Environ Health Perspect 112:148-155. (Pubitemid 38195822)
22. Levin ED, et al. (2001) Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats. Dev Brain Res 130:83-89. (Pubitemid 32830975)
23. Rauh VA, et al. (2004) Developmental effects of exposure to environmental tobacco smoke and material hardship among inner-city children. Neurotoxicol Teratol 26:373-385. (Pubitemid 38534470)
24. Adler CM, et al. (2001) Changes in neuronal activation with increasing attention demand in healthy volunteers: An fMRI study. Synapse 42:266-272. (Pubitemid 33027300)
25. Forbes CE, Grafman J (2010) The role of the human prefrontal cortex in social cognition and moral judgment. Annu Rev Neurosci 33:299-324.
26. Bigler ED, et al. (2007) Superior temporal gyrus, language function, and autism. Dev Neuropsychol 31:217-238. (Pubitemid 46598264)
27. Elliott R, Deakin B (2005) Role of the orbitofrontal cortex in reinforcement processing and inhibitory control: Evidence from functional magnetic resonance imaging studies in healthy human subjects. Int Rev Neurobiol 65:89-116. (Pubitemid 43624179)
28. Garcia SJ, Seidler FJ, Crumpton TL, Slotkin TA (2001) Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells. Brain Res 891:54-68. (Pubitemid 32115495)
29. O'Callaghan JP, Miller DB (1993) Quantification of reactive gliosis as an approach to neurotoxicity assessment. NIDA Res Monogr 136:188-212.
30. Slotkin TA (2005) Developmental neurotoxicity of organophosphates: A case study of chlorpyrifos. Toxicity of Organophosphate and Carbamate Pesticides, ed Gupta RC (Elsevier Academic, San Diego), pp 293-314.
31. Harasty J, Double KL, Halliday GM, Kril JJ, McRitchie DA (1997) Language-associated cortical regions are proportionally larger in the female brain. Arch Neurol 54:171-176. (Pubitemid 27078724)
32. Nopoulos P, Flaum M, O'Leary D, Andreasen NC (2000) Sexual dimorphism in the human brain: Evaluation of tissue volume, tissue composition and surface anatomy using magnetic resonance imaging. Psychiatry Res 98:1-13. (Pubitemid 30119884)
33. Cahill L (2006) Why sex matters for neuroscience. Nat Rev Neurosci 7:477-484.
34. Aldridge JE, Levin ED, Seidler FJ, Slotkin TA (2005) Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animalmodels of depression. Environ Health Perspect 113:527-531. (Pubitemid 40711339)
35. Slotkin TA, Seidler FJ (2005) The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent. Brain Res Dev Brain Res 158:115-119. (Pubitemid 41116641)
36. Barr DB, et al. (2002) A multi-analyte method for the quantification of contemporary pesticides in human serum and plasma using high-resolution mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 778:99-111.
37. Casida JE, Quistad GB (2004) Organophosphate toxicology: Safety aspects of non-acetylcholinesterase secondary targets. Chem Res Toxicol 17:983-998. (Pubitemid 39108669)
38. Perera FP, et al. (2002) The challenge of preventing environmentally related disease in young children: Community-based research in New York City. Environ Health Perspect 110:197-204. (Pubitemid 34163039)
39. Whyatt RM, et al. (2003) Contemporary-use pesticides in personal air samples during pregnancy and blood samples at delivery among urban minority mothers and newborns. Environ Health Perspect 111:749-756. (Pubitemid 36621607)
40. Perera FP, et al. (2003) Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population. Environ Health Perspect 111:201-205. (Pubitemid 36305318)
41. Sled JG, Zijdenbos AP, Evans AC (1998) A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans Med Imaging 17:87-97. (Pubitemid 128742012)
42. Shattuck DW, Leahy RM (2002) BrainSuite: An automated cortical surface identification tool. Med Image Anal 6:129-142. (Pubitemid 35282822)
43. Marr D, Hildreth E (1980) Theory of edge detection. Proc R Soc Lond B Biol Sci 207:187-217. (Pubitemid 10103608)
44. Shrout PE, Fleiss JL (1979) Intraclass correlations: Uses in assessing rater reliability. Psychol Bull 86:420-428.
45. Bansal R, Staib LH, Whiteman R, Wang YM, Peterson BS (2005) ROC-based assessments of 3D cortical surface-matching algorithms. Neuroimage 24:150-162. (Pubitemid 39611035)
46. Plessen KJ, et al. (2006) Hippocampus and amygdala morphology in attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 63:795-807.
47. Haralick R, Shapiro L (1992) Computer and Robot Vision (Addison-Wesley, Reading, MA), Vol 1, Chap 5.
48. Rosenfeld A, Pfaltz J (1968) Distance functions in digital pictures. Pattern Recognit 1:33-61.
49. Mazziotta J, et al. (2001) A probabilistic atlas and reference system for the human brain: International Consortium for Brain Mapping (ICBM). Philos Trans R Soc Lond B Biol Sci 356:1293-1322. (Pubitemid 32876067)
50. Wechsler D (2003) Wechsler Intelligence Scale for Children. Administration and Scoring Manual (Harcourt Assessment, Inc., San Antonio, TX), 4th Ed.
51. Chiodo LM, Jacobson SW, Jacobson JL (2004) Neurodevelopmental effects of postnatal lead exposure at very low levels. Neurotoxicol Teratol 26:359-371. (Pubitemid 38534469)
52. Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: A practical and powerful approach to multiple testing. J Royal Stat Soc B 57:289-300.
53. Brown L, Sherbenou RJ, Johnson SK (1997) Test of Nonverbal Intelligence (Pro-Ed, Austin, TX), 3rd Ed.