Mechanical stretch upregulates proteins involved in Ca2+ sensitization in urinary bladder smooth muscle hypertrophy

American Journal of Physiology - Cell Physiology

Volumn 307, Issue 6, 2014, Pages C542-C553

  Boopathi, Ettickan ^a   Gomes, Cristiano ^b   Zderic, Stephen A ^c   Malkowicz, Bruce ^a   Chakrabarti, Ranjita ^a   Patel, Darshan P ^a   Wein, Alan J ^a   Chacko, Samuel ^a,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Benign prostatic hyperplasia; Calcium sensitization; Cell stretch; Human bladder; Partial bladder outlet obstruction

Indexed keywords

CALCIUM ION; COLLAGEN TYPE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN KINASE C; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SILICONE; TRANSCRIPTION FACTOR GATA 6; GATA6 PROTEIN, HUMAN; PHOSPHOPROTEIN PHOSPHATASE; PPP1R14A PROTEIN, HUMAN; RHOA PROTEIN, HUMAN; RHOA PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER DISTENSION; BLADDER OBSTRUCTION; BLADDER WALL; CELL LEVEL; CONTROLLED STUDY; DETRUSOR MUSCLE; ELASTICITY; ENZYME REGULATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MALE; MICTURITION; MOUSE; MUSCLE HYPERTROPHY; NONHUMAN; PROMOTER REGION; PROSTATE HYPERTROPHY; PROTEIN CONTENT; PROTEIN EXPRESSION; SENSITIZATION; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; UPREGULATION; AGED; ANIMAL; BINDING SITE; BLADDER; CALCIUM SENSITIZATION; CALCIUM SIGNALING; CELL CULTURE; CELL PROLIFERATION; CELL STRETCH; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; HUMAN BLADDER; HYPERTROPHY; MECHANOTRANSDUCTION; METABOLISM; MIDDLE AGED; MUSCLE CONTRACTION; PARTIAL BLADDER OUTLET OBSTRUCTION; PATHOLOGY; PATHOPHYSIOLOGY; SMOOTH MUSCLE; TIME;

BENIGN PROSTATIC HYPERPLASIA; CALCIUM SENSITIZATION; CELL STRETCH; HUMAN BLADDER; PARTIAL BLADDER OUTLET OBSTRUCTION;

AGED; ANIMALS; BINDING SITES; CALCIUM SIGNALING; CELL PROLIFERATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GATA6 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; HUMANS; HYPERTROPHY; MALE; MECHANOTRANSDUCTION, CELLULAR; MICE; MIDDLE AGED; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; NF-KAPPA B; PHOSPHOPROTEIN PHOSPHATASES; PROMOTER REGIONS, GENETIC; PROSTATIC HYPERPLASIA; RHO GTP-BINDING PROTEINS; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION, GENETIC; URINARY BLADDER; URINARY BLADDER NECK OBSTRUCTION;

EID: 84907146871     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00033.2014     Document Type: Article

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