Stretch augments TGF-β1 expression through RhoA/ROCK1/2, PTK, and PI3K in airway smooth muscle cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 299, Issue 3, 2010, Pages

  Mohamed, Junaith Shaik ^a   Boriek, Aladin M ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

c Jun; Cyclic stretch; ERK1 2; RhoA GTPase

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; EXOENZYME C3; GENISTEIN; GUANOSINE TRIPHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OLIGONUCLEOTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN CDC42; PROTEIN TYROSINE KINASE; RAC1 PROTEIN; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA1; DNA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN C JUN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; ROCK1 PROTEIN, HUMAN; ROCK2 PROTEIN, HUMAN;

AIRWAY; ARTICLE; ASTHMA; BINDING SITE; CONTROLLED STUDY; DNA BINDING; ENZYME ASSAY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MECHANICAL STRESS; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; RNA SYNTHESIS; SITE DIRECTED MUTAGENESIS; SMOOTH MUSCLE FIBER; UPREGULATION; CELL CULTURE; CYTOLOGY; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; RESPIRATORY SYSTEM; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELLS, CULTURED; DNA; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-JUN; RESPIRATORY SYSTEM; RHO GTP-BINDING PROTEINS; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; TRANSCRIPTION FACTOR AP-1; TRANSFORMING GROWTH FACTOR BETA1;

EID: 77956670557     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.90628.2008     Document Type: Article

References (34)

1. Aikawa R, Komuro I, Yamazaki T, Zou Y, Kudoh S, Zhu W, Kadowaki T, Yazaki Y. Rho family small G proteins play critical roles in mechanical stress-induced hypertrophic responses in cardiac myocytes. Circ Res 84: 458-466, 1999.
2. Aubert JD, Dalal BI, Bai TR, Roberts CR, Hayashi S, Hogg JC. Transforming growth factor-beta 1 gene in human airways. Thorax 49: 225-232, 1994.
3. Bielinska A, Shivdasani RA, Zhang LQ, Nabel GJ. Regulation of gene expression with double-stranded phosphorothioate oligonucleotides. Science 250: 997-1000, 1990.
4. Birchenall-Roberts MC, Ruscetti FW, Kasper J, Lee HD, Friedman R, Geiser A, Sporn MB, Roberts AB, Kim SJ. Transcriptional regulation of the transforming growth factor beta 1 promoter by v-src gene products is mediated through the ap-1 complex. Mol Cell Biol 10: 4978-4983, 1990.
5. Black PN, Young PG, Skinner SJ. Response of airway smooth muscle cells to TGF-β1: effects on growth and synthesis of glycosaminoglycans. Am J Physiol Lung Cell Mol Physiol 271: L910-L917, 1996. (Pubitemid 126815127)
6. Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor-β1 in human disease. N Engl J Med 342: 1350-1358, 2000.
7. Chang L, Karin M. Mammalian MAP kinase signaling cascades. Nature 410: 37-40, 2001.
8. Cox D, Chang P, Zhang Q, Reddy PG, Bokoch GM, Greenberg S. Requirements for both Rac1 and Cdc 42 in membrane ruffling and phagocytosis in leukocytes. J Exp Med 186: 1487-1494, 1997. (Pubitemid 27479808)
9. Dhandapani KM, Khan MM, Wade FM, Wakade C, Mahesh VB, Brann DW. Induction of transforming growth factor-beta1 by basic fibroblast growth factor in glioma and astrocytes is medicated by MEK/ERK signaling and AP-1 activation. J Neurosci Res 85: 1033-1045, 2007.
10. Gillespie PG, Walker RG. Molecular basis of mechanosensory transduction. Nature 413: 194-202, 2007.
11. Goldsmith AM, Bentley JK, Zhou L, Jia Y, Bitar KN, Fingar DC, Hershenson MB. Transforming growth factor-beta induces airway smooth muscle hypertrophy. Am J Respir Cell Mol Biol 34: 247-254, 2006.
12. Hughes JMB, Hoppin FG Jr, Mead J. Effects of lung inflation on bronchial length and diameter in excised lungs. J Appl Physiol 32: 25-35, 1972.
13. Ingber DE. Cellular basis of mechanotransduction. Biol Bull 194: 323-327, 1998.
14. Kawamura S, Miyamoto S, Brown JH. Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae: cytoskeletal regulation of ERK translocation. J Biol Chem 278: 31111-31117, 2003. (Pubitemid 36994626)
15. Kim SJ, Glick A, Sporn MB, Roberts AB. Characterization of the promoter region of the human transforming growth factor-beta 1 gene. J Biol Chem 264: 402-408, 1989.
16. Kumar A, Chaudhry I, Reid MB, Boriek AM. Distinct signaling pathways are activated in response to mechanical stress applied axially and transversely to skeletal muscle fibers. J Biol Chem 277: 46493-46503, 2002.
17. Kumar A, Knox AJ, Boriek AM. CCAAT/enhancer-binding protein and activator protein-1 transcription factors regulate the expression of interleukin-8 through the mitogen-activated protein kinase pathways in response to mechanical stretch of human airway smooth muscle cells. J Biol Chem 278: 18868-18876, 2003. (Pubitemid 36799269)
18. Lee KY, Ito K, Hayashi R, Jazrawi EPI, Barnes PJ, Adcock IM. NF-κB and activator protein 1 response elements and the role of histone modifications in IL-1β-induced TGF-β1 gene transcription. J Immunol 176: 603-615, 2006.
19. Minshall EM, Leung DY, Martin RJ, Song YL, Cameron L, Ernst P, Hamid Q. Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma. Am J Respir Cell Mol Biol 17: 326-333, 1997.
20. Nobes CD, Hall A. Rho GTPases control polarity, protrusion, and adhesion during cell movement. J Cell Biol 144: 1235-1244, 1999. (Pubitemid 29157301)
21. Nomura A, Uchida Y, Sakamoto T, Ishii Y, Masuyama K, Morishima Y, Hirano K, Sekizawa K. Increases in collagen type I synthesis in asthma: the role of eosinophils and transforming growth factor-β. Clin Exp Allergy 32: 860-865, 2002.
22. Ohno I, Nitta Y, Yamauchi K, Hoshi H, Honma M, Woolley K, O'Byrne P, Tamura G, Jordana M, Shirato K. Transforming growth factor beta 1 (TGF beta 1) gene expression by eosinophils in asthmatic airway inflammation. Am J Respir Cell Mol Biol 15: 404-409, 1996.
23. Pan J, Singh US, Takahashi T, Oka Y, Palm-Leis A, Herbelin BS, Baker KM. PKC mediates cyclic stretch-induced cardiac hypertrophy through Rho family GTPases and mitogen-activated protein kinases in cardiomyocytes. J Cell Physiol 202: 536-553, 2005.
24. Qi M, Elion EA. MAP kinase pathways. J Cell Sci 118: 3569-3572, 2005.
25. Redington AE, Madden J, Frew AJ, Djukanovic R, Roche WR, Holgate ST, Howarth PH. Transforming growth factor-beta 1 in asthma. Measurement in bronchoalveolar lavage fluid. Am J Respir Crit Care Med 156: 642-647, 1997.
26. Sadoshima J, Takahashi T, Jahn L, Izumo S. Roles of mechano-sensitive ion channels, cytoskeleton, and contractile activity in stretchinduced immediate-early gene expression and hypertrophy of cardiac myocytes. Proc Natl Acad Sci USA 89: 9905-9909, 1992.
27. Seow Chun Y, Schellenberg RR, Pare Peter D. Structural and functional changes in the airway smooth muscle of asthmatic subjects. Am J Respir Crit Care Med 158: 179S-186S, 1998.
28. Smith PG, Garcia R, Kogerman L. Mechanical strain increases protein tyrosine phosphorylation in airway smooth muscle cells. Exp Cell Res 239: 353-360, 1998. (Pubitemid 28366635)
29. Smith PG, Janiga KE, Bruce MC. Strain increases airway smooth muscle cell proliferation. Am J Respir Cell Mol Biol 10: 85-90, 1994.
30. Takizawa H, Tanaka M, Takami K, Ohtoshi T, Ito K, Satoh M, Okada Y, Yamasawa F, Nakahara K, Umeda A. Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med 163: 1476-1483, 2001.
31. Tillie-Leblond I, Pugin J, Marquette CH, Lamblin C, Saulnier F, Brichet A, Wallaert B, Tonnel AB, Gosset P. Balance between proin-flammatory cytokines and their inhibitors in bronchial lavage from patients with status asthmaticus. Am J Respir Crit Care Med 159: 487-494, 1999.
32. Vignola AM, Chanez P, Chiappara G, Merendino A, Pace E, Rizzo A, la Rocca Antonio M, Bellia V, Bonsignore G, Bousquet J. Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med 156: 591-599, 1997.
33. Weigert C, Brodbeck K, Klopfer K, Häring H, Schleicher E. Angiotensin II induces human TGF-β1 promoter activation: similarity to hyperglycaemia. Diabetologia 45: 890-898, 2002.
34. Wiggs BR, Hrousis CA, Drazen JM, Kamm RD. On the mechanism of mucosal folding in normal and asthmatic airways. J Appl Physiol 83: 1814-1821, 1997.