The NF-κB subunit c-Rel stimulates cardiac hypertrophy and fibrosis

American Journal of Pathology

Volumn 180, Issue 3, 2012, Pages 929-939

  Gaspar Pereira, Silvia ^a   Fullard, Nicola ^a   Townsend, Paul A ^c   Banks, Paul S ^a   Ellis, Elizabeth L ^a   Fox, Christopher ^a   Maxwell, Aidan G ^a   Murphy, Lindsay B ^a   Kirk, Adam ^c   Bauer, Ralf ^b   Caamao, Jorge H ^d   Figg, Nichola ^e   Foo, Roger S ^e   Mann, Jelena ^a   Mann, Derek A ^a   Oakley, Fiona ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P50; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR REL; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOPLASM; GENE DELETION; GENE EXPRESSION; HEART DISEASE; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HUMAN; HUMAN TISSUE; MALE; MOUSE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANGIOTENSINS; ANIMALS; BLOOD PRESSURE; CARDIOMEGALY; FIBROSIS; GENE DELETION; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIUM; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; PROTO-ONCOGENE PROTEINS C-REL; SIGNAL TRANSDUCTION; VENTRICULAR REMODELING;

EID: 84857217526     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.11.007     Document Type: Article

References (50)

1. M. Franco, R.S. Cooper, U. Bilal, V. Fuster Challenges and opportunities for cardiovascular disease prevention Am J Med 124 2011 95 102
2. S.P. Barry, S.M. Davidson, P.A. Townsend Molecular regulation of cardiac hypertrophy Int J Biochem Cell Biol 40 2008 2023 2039
3. K.R. Chien Stress pathways and heart failure Cell 98 1999 555 558
4. N. Frey, E.N. Olson Cardiac hypertrophy: the good, the bad, and the ugly Annu Rev Physiol 65 2003 45 79
5. B. Chevalier, F. Callens-el Amrani, C. Heymes, B. Swynghedauw Molecular basis of regression of cardiac hypertrophy Am J Cardiol 73 1994 10C 17C
6. C. Perrino, H.A. Rockman Reversal of cardiac remodeling by modulation of adrenergic receptors: a new frontier in heart failure Curr Opin Cardiol 22 2007 443 449
7. J. Wohlschlaeger, K.J. Schmitz, C. Schmid, K.W. Schmid, P. Keul, A. Takeda, S. Weis, B. Levkau, H.A. Baba Reverse remodeling following insertion of left ventricular assist devices (LVAD): a review of the morphological and molecular changes Cardiovasc Res 68 2005 376 386
8. M.S. Hayden, S. Ghosh Signaling to NF-kappaB Genes Dev 18 2004 2195 2224
9. S. Gupta, S. Sen Role of the NF-kappaB signaling cascade and NF-kappaB-targeted genes in failing human hearts J Mol Med (Berl) 83 2005 993 1004
10. Y. Li, T. Ha, X. Gao, J. Kelley, D.L. Williams, I.W. Browder, R.L. Kao, C. Li NF-kappaB activation is required for the development of cardiac hypertrophy in vivo Am J Physiol Heart Circ Physiol 287 2004 H1712 H1720
11. K. Van der Heiden, S. Cuhlmann, A. Luong le, M. Zakkar, P.C. Evans Role of nuclear factor kappaB in cardiovascular health and disease Clin Sci (Lond) 118 2010 593 605
12. L. Zelarayan, A. Renger, C. Noack, M.P. Zafiriou, C. Gehrke, R. van der Nagel, R. Dietz, L. de Windt, M.W. Bergmann NF-kappaB activation is required for adaptive cardiac hypertrophy Cardiovasc Res 84 2009 416 424
13. J.W. Gordon, J.A. Shaw, L.A. Kirshenbaum Multiple facets of NF-kappaB in the heart: to be or not to NF-kappaB Circ Res 108 2011 1122 1132
14. S. Frantz, D. Fraccarollo, H. Wagner, T.M. Behr, P. Jung, C.E. Angermann, G. Ertl, J. Bauersachs Sustained activation of nuclear factor kappa B and activator protein 1 in chronic heart failure Cardiovasc Res 57 2003 749 756
15. T. Saito, A. Giaid Cyclooxygenase-2 and nuclear factor-kappaB in myocardium of end stage human heart failure Congest Heart Fail 5 1999 222 227
16. D.G. Santos, M.F. Resende, J.G. Mill, A.J. Mansur, J.E. Krieger, A.C. Pereira Nuclear factor (NF) kappaB polymorphism is associated with heart function in patients with heart failure BMC Med Genet 11 2010 89
17. B. Zhou, L. Rao, Y. Peng, Y. Wang, Y. Li, L. Gao, Y. Chen, H. Xue, Y. Song, M. Liao, L. Zhang Functional polymorphism of the NFKB1 gene promoter is related to the risk of dilated cardiomyopathy BMC Med Genet 10 2009 47
18. S. Gupta, D. Young, S. Sen Inhibition of NF-kappaB induces regression of cardiac hypertrophy, independent of blood pressure control, in spontaneously hypertensive rats Am J Physiol Heart Circ Physiol 289 2005 H20 H29
19. S. Kawano, T. Kubota, Y. Monden, N. Kawamura, H. Tsutsui, A. Takeshita, K. Sunagawa Blockade of NF-kappaB ameliorates myocardial hypertrophy in response to chronic infusion of angiotensin II [Erratum appeared in Cardiovasc Res 2006;69:556] Cardiovasc Res 67 2005 689 698
20. S. Kawano, T. Kubota, Y. Monden, T. Tsutsumi, T. Inoue, N. Kawamura, H. Tsutsui, K. Sunagawa Blockade of NF-kappaB improves cardiac function and survival after myocardial infarction Am J Physiol Heart Circ Physiol 291 2006 H1337 H1344
21. L. Timmers, J.K. van Keulen, I.E. Hoefer, M.F. Meijs, B. van Middelaar, K. den Ouden, C.J. van Echteld, G. Pasterkamp, D.P. de Kleijn Targeted deletion of nuclear factor kappaB p50 enhances cardiac remodeling and dysfunction following myocardial infarction Circ Res 104 2009 699 706
22. P. Kratsios, M. Huth, L. Temmerman, E. Salimova, M. Al Banchaabouchi, A. Sgoifo, M. Manghi, K. Suzuki, N. Rosenthal, F. Mourkioti Antioxidant amelioration of dilated cardiomyopathy caused by conditional deletion of NEMO/IKKgamma in cardiomyocytes Circ Res 106 2010 133 144
23. S. Hikoso, O. Yamaguchi, Y. Nakano, T. Takeda, S. Omiya, I. Mizote, M. Taneike, T. Oka, T. Tamai, J. Oyabu, Y. Uno, Y. Matsumura, K. Nishida, K. Suzuki, M. Kogo, M. Hori, K. Otsu The I{kappa}B kinase {beta}/nuclear factor {kappa}B signaling pathway protects the heart from hemodynamic stress mediated by the regulation of manganese superoxide dismutase expression Circ Res 105 2009 70 79
24. J.B. Chakraborty, D.A. Mann NF-kappaB signalling: embracing complexity to achieve translation J Hepatol 52 2010 285 291
25. T.H. Leung, A. Hoffmann, D. Baltimore One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers Cell 118 2004 453 464
26. N.D. Perkins Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway Oncogene 25 2006 6717 6730
27. H. Zhong, M.J. May, E. Jimi, S. Ghosh The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1 Mol Cell 9 2002 625 636
28. I.K. Campbell, S. Gerondakis, K. O'Donnell, I.P. Wicks Distinct roles for the NF-kappaB1 (p50) and c-Rel transcription factors in inflammatory arthritis J Clin Invest 105 2000 1799 1806
29. S.J. Campbell, D.C. Anthony, F. Oakley, H. Carlsen, A.M. Elsharkawy, R. Blomhoff, D.A. Mann Hepatic nuclear factor kappa B regulates neutrophil recruitment to the injured brain J Neuropathol Exp Neurol 67 2008 223 230
30. S. Gerondakis, R. Grumont, R. Gugasyan, L. Wong, I. Isomura, W. Ho, A. Banerjee Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models Oncogene 25 2006 6781 6799
31. R.G. Gieling, A.M. Elsharkawy, J.H. Caamano, D.E. Cowie, M.C. Wright, M.R. Ebrahimkhani, A.D. Burt, J. Mann, P. Raychaudhuri, H.C. Liou, F. Oakley, D.A. Mann The c-Rel subunit of nuclear factor-kappaB regulates murine liver inflammation, wound-healing, and hepatocyte proliferation Hepatology 51 2010 922 931
32. S.G. Pereira, F. Oakley Nuclear factor-kappaB1: regulation and function Int J Biochem Cell Biol 40 2008 1425 1430
33. Y. Wang, B.H. Rickman, T. Poutahidis, K. Schlieper, E.A. Jackson, S.E. Erdman, J.G. Fox, B.H. Horwitz c-Rel is essential for the development of innate and T cell-induced colitis J Immunol 180 2008 8118 8125
34. H.C. Liou, Z. Jin, J. Tumang, S. Andjelic, K.A. Smith, M.L. Liou c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function Int Immunol 11 1999 361 371
35. W.C. Sha, H.C. Liou, E.I. Tuomanen, D. Baltimore Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses Cell 80 1995 321 330
36. C.G. Nebigil, P. Hickel, N. Messaddeq, J.L. Vonesch, M.P. Douchet, L. Monassier, K. Gyorgy, R. Matz, R. Andriantsitohaina, P. Manivet, J.M. Launay, L. Maroteaux Ablation of serotonin 5-HT(2B) receptors in mice leads to abnormal cardiac structure and function Circulation 103 2001 2973 2979
37. N.D. Perkins, R.M. Schmid, C.S. Duckett, K. Leung, N.R. Rice, G.J. Nabel Distinct combinations of NF-kappa B subunits determine the specificity of transcriptional activation Proc Natl Acad Sci USA 89 1992 1529 1533
38. J. Mann, F. Oakley, F. Akiboye, A. Elsharkawy, A.W. Thorne, D.A. Mann Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis Cell Death Differ 14 2007 275 285
39. J. Mann, D.C. Chu, A. Maxwell, F. Oakley, N.L. Zhu, H. Tsukamoto, D.A. Mann MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis Gastroenterology 138 2010 705 714 714.e14
40. I.M. Kim, S. Ramakrishna, G.A. Gusarova, H.M. Yoder, R.H. Costa, V.V. Kalinichenko The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature J Biol Chem 280 2005 22278 22286
41. X. Wang, D. Bhattacharyya, M.B. Dennewitz, V.V. Kalinichenko, Y. Zhou, R. Lepe, R.H. Costa Rapid hepatocyte nuclear translocation of the forkhead box M1B (FoxM1B) transcription factor caused a transient increase in size of regenerating transgenic hepatocytes Gene Expr 11 2003 149 162
42. F.J. Naya, B.L. Black, H. Wu, R. Bassel-Duby, J.A. Richardson, J.A. Hill, E.N. Olson Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor Nat Med 8 2002 1303 1309
43. T. Nishikimi, N. Maeda, H. Matsuoka The role of natriuretic peptides in cardioprotection Cardiovasc Res 69 2006 318 328
44. N. Kawamura, T. Kubota, S. Kawano, Y. Monden, A.M. Feldman, H. Tsutsui, A. Takeshita, K. Sunagawa Blockade of NF-kappaB improves cardiac function and survival without affecting inflammation in TNF-alpha-induced cardiomyopathy Cardiovasc Res 66 2005 520 529
45. J. Zhang, P. Ping, T.M. Vondriska, X.L. Tang, G.W. Wang, E.M. Cardwell, R. Bolli Cardioprotection involves activation of NF-kappa B via PKC-dependent tyrosine and serine phosphorylation of I kappa B-alpha Am J Physiol Heart Circ Physiol 285 2003 H1753 H1758
46. M.W. Bergmann, P. Loser, R. Dietz, R. von Harsdorf Effect of NF-kappa B Inhibition on TNF-alpha-induced apoptosis and downstream pathways in cardiomyocytes J Mol Cell Cardiol 33 2001 1223 1232
47. R.J. Grumont, I.B. Richardson, C. Gaff, S. Gerondakis rel/NF-kappa B nuclear complexes that bind kB sites in the murine c-rel promoter are required for constitutive c-rel transcription in B-cells Cell Growth Differ 4 1993 731 743
48. R.J. Grumont, S. Gerondakis The murine c-rel proto-oncogene encodes two mRNAs the expression of which is modulated by lymphoid stimuli Oncogene Res 5 1990 245 254
49. J. Xu, N.L. Gong, I. Bodi, B.J. Aronow, P.H. Backx, J.D. Molkentin Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice J Biol Chem 281 2006 9152 9162
50. M.J. Potthoff, E.N. Olson MEF2: a central regulator of diverse developmental programs Development 134 2007 4131 4140