-
2
-
-
80051580618
-
Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
-
Siegel R, Ward E, Brawley O, et al: Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 61: 212-236, 2011.
-
(2011)
CA Cancer J Clin
, vol.61
, pp. 212-236
-
-
Siegel, R.1
Ward, E.2
Brawley, O.3
-
3
-
-
27644476353
-
Clinical factors predictive of outcome with bortezomib in patients with relapsed, refractory multiple myeloma
-
Richardson PG, Barlogie B, Berenson J, et al: Clinical factors predictive of outcome with bortezomib in patients with relapsed, refractory multiple myeloma. Blood 106: 2977-2981, 2005.
-
(2005)
Blood
, vol.106
, pp. 2977-2981
-
-
Richardson, P.G.1
Barlogie, B.2
Berenson, J.3
-
4
-
-
77954618168
-
Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma
-
Richardson PG, Weller E, Lonial S, et al: Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma. Blood 116: 679-686, 2010.
-
(2010)
Blood
, vol.116
, pp. 679-686
-
-
Richardson, P.G.1
Weller, E.2
Lonial, S.3
-
5
-
-
2642551522
-
Structure and function of eukaryotic DNA methyltransferases
-
Chen T and Li E: Structure and function of eukaryotic DNA methyltransferases. Curr Top Dev Biol 60: 55-89, 2004.
-
(2004)
Curr Top Dev Biol
, vol.60
, pp. 55-89
-
-
Chen, T.1
Li, E.2
-
6
-
-
22844457491
-
DNA methylation and human disease
-
Robertson KD: DNA methylation and human disease. Nat Rev Genet 6: 597-610, 2005.
-
(2005)
Nat Rev Genet
, vol.6
, pp. 597-610
-
-
Robertson, K.D.1
-
7
-
-
17144441661
-
A microassay for measuring cytosine DNA methyltransferase activity during tumor progression
-
Belinsky SA, Nikula KJ, Baylin SB, et al: A microassay for measuring cytosine DNA methyltransferase activity during tumor progression. Toxicol Lett 82-83: 335-340, 1995.
-
(1995)
Toxicol Lett
, vol.82-83
, pp. 335-340
-
-
Belinsky, S.A.1
Nikula, K.J.2
Baylin, S.B.3
-
8
-
-
0029973718
-
De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase
-
Vertino PM, Yen RW, Gao J and Baylin SB: De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase. Mol Cell Biol 16: 4555-4565, 1996.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4555-4565
-
-
Vertino, P.M.1
Yen, R.W.2
Gao, J.3
Baylin, S.B.4
-
9
-
-
0030940091
-
Frequent hypermethylation of p16 and p15 genes in multiple myeloma
-
Ng MH, Chung YF, Lo KW, et al: Frequent hypermethylation of p16 and p15 genes in multiple myeloma. Blood 89: 2500-2506, 1997.
-
(1997)
Blood
, vol.89
, pp. 2500-2506
-
-
Ng, M.H.1
Chung, Y.F.2
Lo, K.W.3
-
10
-
-
18544379572
-
Methylation is an inactivating mechanism of the p16 gene in multiple myeloma associated with high plasma cell proliferation and short survival
-
Mateos MV, García-Sanz R, Lopez-Perez R, et al: Methylation is an inactivating mechanism of the p16 gene in multiple myeloma associated with high plasma cell proliferation and short survival. Br J Haematol 118: 1034-1040, 2002.
-
(2002)
Br J Haematol
, vol.118
, pp. 1034-1040
-
-
Mateos, M.V.1
García-Sanz, R.2
Lopez-Perez, R.3
-
11
-
-
34250827855
-
Epigenetic dysregulation of the death-associated protein kinase/p14/HDM2/p53/Apaf-1 apoptosis pathway in multiple myeloma
-
Chim CS, Liang R, Fung TK, et al: Epigenetic dysregulation of the death-associated protein kinase/p14/HDM2/p53/Apaf-1 apoptosis pathway in multiple myeloma. J Clin Pathol 60: 664-669, 2007.
-
(2007)
J Clin Pathol
, vol.60
, pp. 664-669
-
-
Chim, C.S.1
Liang, R.2
Fung, T.K.3
-
12
-
-
0345392554
-
Alterations of RAS signalling in Chinese multiple myeloma patients: Absent BRAF and rare RAS mutations, but frequent inactivation of RASSF1A by transcriptional silencing or expression of a non-functional variant transcript
-
Ng MH, Lau KM, Wong WS, et al: Alterations of RAS signalling in Chinese multiple myeloma patients: absent BRAF and rare RAS mutations, but frequent inactivation of RASSF1A by transcriptional silencing or expression of a non-functional variant transcript. Br J Haematol 123: 637-645, 2003.
-
(2003)
Br J Haematol
, vol.123
, pp. 637-645
-
-
Ng, M.H.1
Lau, K.M.2
Wong, W.S.3
-
13
-
-
0038784365
-
SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma
-
Galm O, Yoshikawa H, Esteller M, et al: SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma. Blood 101: 2784-2788, 2003.
-
(2003)
Blood
, vol.101
, pp. 2784-2788
-
-
Galm, O.1
Yoshikawa, H.2
Esteller, M.3
-
14
-
-
6344229983
-
DNA methylation changes in multiple myeloma
-
Galm O, Wilop S, Reichelt J, et al: DNA methylation changes in multiple myeloma. Leukemia 18: 1687-1692, 2004.
-
(2004)
Leukemia
, vol.18
, pp. 1687-1692
-
-
Galm, O.1
Wilop, S.2
Reichelt, J.3
-
15
-
-
33644846509
-
Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?
-
Baylin SB and Ohm JE: Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat Rev Cancer 6: 107-116, 2006.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 107-116
-
-
Baylin, S.B.1
Ohm, J.E.2
-
16
-
-
0033753779
-
The DNA methyltransferases of mammals
-
Bestor TH: The DNA methyltransferases of mammals. Hum Mol Genet 9: 2395-2402, 2000.
-
(2000)
Hum Mol Genet
, vol.9
, pp. 2395-2402
-
-
Bestor, T.H.1
-
18
-
-
77956661140
-
Reduction of pancreatic cancer cell viability and induction of apoptosis mediated by siRNA targeting DNMT1 through suppression of total DNA methyltransferase activity
-
Xu M, Gao J, Du YQ, et al: Reduction of pancreatic cancer cell viability and induction of apoptosis mediated by siRNA targeting DNMT1 through suppression of total DNA methyltransferase activity. Mol Med Rep 3: 699-704, 2010.
-
(2010)
Mol Med Rep
, vol.3
, pp. 699-704
-
-
Xu, M.1
Gao, J.2
Du, Y.Q.3
-
19
-
-
0034054673
-
DNA methyltransferase inhibition induces the transcription of the tumor suppressor p21 (WAF1/CIP1/sdi1)
-
Milutinovic S, Knox JD and Szyf M: DNA methyltransferase inhibition induces the transcription of the tumor suppressor p21 (WAF1/CIP1/sdi1). J Biol Chem 275: 6353-6359, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 6353-6359
-
-
Milutinovic, S.1
Knox, J.D.2
Szyf, M.3
-
20
-
-
34547799171
-
DNA methyltransferases as targets for cancer therapy
-
Ghoshal K and Bai S: DNA methyltransferases as targets for cancer therapy. Drugs Today (Barc) 43: 395-422, 2007.
-
(2007)
Drugs Today (Barc)
, vol.43
, pp. 395-422
-
-
Ghoshal, K.1
Bai, S.2
-
21
-
-
29244453281
-
Methylation of tumor suppressor genes p16(INK4a), p27(Kip1) and E-cadherin in carcinogenesis
-
Auerkari EI: Methylation of tumor suppressor genes p16(INK4a), p27(Kip1) and E-cadherin in carcinogenesis. Oral Oncol 42: 5-13, 2006.
-
(2006)
Oral Oncol
, vol.42
, pp. 5-13
-
-
Auerkari, E.I.1
-
22
-
-
0346025548
-
Disruption of INK4/CDK/Rb cell cycle pathway by gene hypermethylation in multiple myeloma and MGUS
-
Chim CS, Fung TK and Liang R: Disruption of INK4/CDK/Rb cell cycle pathway by gene hypermethylation in multiple myeloma and MGUS. Leukemia 17: 2533-2535, 2003.
-
(2003)
Leukemia
, vol.17
, pp. 2533-2535
-
-
Chim, C.S.1
Fung, T.K.2
Liang, R.3
-
23
-
-
18344415251
-
Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers
-
Komazaki T, Nagai H, Emi M, et al: Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers. Jpn J Clin Oncol 34: 191-194, 2004.
-
(2004)
Jpn J Clin Oncol
, vol.34
, pp. 191-194
-
-
Komazaki, T.1
Nagai, H.2
Emi, M.3
-
24
-
-
67349239320
-
Epigenetic dysregulation of secreted Frizzled-related proteins in multiple myeloma
-
Jost E, Gezer D, Wilop S, et al: Epigenetic dysregulation of secreted Frizzled-related proteins in multiple myeloma. Cancer Lett 281: 24-31, 2009.
-
(2009)
Cancer Lett
, vol.281
, pp. 24-31
-
-
Jost, E.1
Gezer, D.2
Wilop, S.3
-
25
-
-
55549112534
-
Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma
-
Tshuikina M, Jernberg-Wiklund H, Nilsson K, et al: Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma. Exp Hematol 36: 24-31, 2008.
-
(2008)
Exp Hematol
, vol.36
, pp. 24-31
-
-
Tshuikina, M.1
Jernberg-Wiklund, H.2
Nilsson, K.3
-
26
-
-
33846111256
-
Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer
-
Lin RK, Hsu HS, Chang JW, et al: Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer. Lung Cancer 55: 205-213, 2007.
-
(2007)
Lung Cancer
, vol.55
, pp. 205-213
-
-
Lin, R.K.1
Hsu, H.S.2
Chang, J.W.3
-
27
-
-
0034898120
-
DNA methylation in ovarian cancer. II. Expression of DNA methyltransferases in ovarian cancer cell lines and normal ovarian epithelial cells
-
Ahluwalia A, Hurteau JA, Bigsby RM, et al: DNA methylation in ovarian cancer. II. Expression of DNA methyltransferases in ovarian cancer cell lines and normal ovarian epithelial cells. Gynecol Oncol 82: 299-304, 2001.
-
(2001)
Gynecol Oncol
, vol.82
, pp. 299-304
-
-
Ahluwalia, A.1
Hurteau, J.A.2
Bigsby, R.M.3
-
28
-
-
0037224722
-
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells
-
Robert MF, Morin S, Beaulieu N, et al: DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Nat Genet 33: 61-65, 2003.
-
(2003)
Nat Genet
, vol.33
, pp. 61-65
-
-
Robert, M.F.1
Morin, S.2
Beaulieu, N.3
-
29
-
-
23044507007
-
Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation
-
Ting AH, Schuebel KE, Herman JG, et al: Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation. Nat Genet 37: 906-910, 2005.
-
(2005)
Nat Genet
, vol.37
, pp. 906-910
-
-
Ting, A.H.1
Schuebel, K.E.2
Herman, J.G.3
-
30
-
-
0037114636
-
Human myeloma cells stimulate the receptor activator of nuclear factor-kappa B ligand (RANKL) in T lymphocytes: A potential role in multiple myeloma bone disease
-
Giuliani N, Colla S, Sala R, et al: Human myeloma cells stimulate the receptor activator of nuclear factor-kappa B ligand (RANKL) in T lymphocytes: a potential role in multiple myeloma bone disease. Blood 100: 4615-4621, 2002.
-
(2002)
Blood
, vol.100
, pp. 4615-4621
-
-
Giuliani, N.1
Colla, S.2
Sala, R.3
-
31
-
-
21244489945
-
NF-kappaB activates IL-6 expression through cooperation with c-Jun and IL6-AP1 site, but is independent of its IL6-NFkappaB regulatory site in autocrine human multiple myeloma cells
-
Xiao W, Hodge DR, Wang L, et al: NF-kappaB activates IL-6 expression through cooperation with c-Jun and IL6-AP1 site, but is independent of its IL6-NFkappaB regulatory site in autocrine human multiple myeloma cells. Cancer Biol Ther 3: 1007-1017, 2004.
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 1007-1017
-
-
Xiao, W.1
Hodge, D.R.2
Wang, L.3
-
32
-
-
78650176111
-
NF-κB localization in multiple myeloma plasma cells and mesenchymal cells
-
Conticello C, Giuffrida R, Adamo L, et al: NF-κB localization in multiple myeloma plasma cells and mesenchymal cells. Leuk Res 35: 52-60, 2004.
-
(2004)
Leuk Res
, vol.35
, pp. 52-60
-
-
Conticello, C.1
Giuffrida, R.2
Adamo, L.3
-
33
-
-
80054024030
-
Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells
-
Kannaiyan R, Hay HS, Rajendran P, et al: Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells. Br J Pharmacol 164: 1506-1521, 2011.
-
(2011)
Br J Pharmacol
, vol.164
, pp. 1506-1521
-
-
Kannaiyan, R.1
Hay, H.S.2
Rajendran, P.3
-
34
-
-
0036087028
-
Role of Bcl-2 family of proteins in malignancy
-
Baliga BC and Kumar S: Role of Bcl-2 family of proteins in malignancy. Hematol Oncol 20: 63-74, 2002.
-
(2002)
Hematol Oncol
, vol.20
, pp. 63-74
-
-
Baliga, B.C.1
Kumar, S.2
-
35
-
-
0038662972
-
Role of Apo2L/TRAIL and Bcl-2-family proteins in apoptosis of multiple myeloma
-
Chen Q, Ray S, Hussein MA, et al: Role of Apo2L/TRAIL and Bcl-2-family proteins in apoptosis of multiple myeloma. Leuk Lymphoma 44: 1209-1214, 2003
-
(2003)
Leuk Lymphoma
, vol.44
, pp. 1209-1214
-
-
Chen, Q.1
Ray, S.2
Hussein, M.A.3
|