Antibodies as an unlimited source of anti-infective, anti-tumour and immunomodulatory peptides

Science Progress

Volumn 97, Issue 3, 2014, Pages 215-233

  Ciociola, Tecla ^a   Magliani, Walter ^a   Giovati, Laura ^a   Sperindè, Martina ^a   Santinoli, Claudia ^a   Conti, Giorgio ^a   Conti, Stefania ^a   Polonelli, Luciano ^a  

^a UNIVERSITY OF PARMA   (Italy)

Author keywords

Anti infective peptides; Anti tumour pepetides; Antibodies; Immunomodulatory peptides

Indexed keywords

ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY; PEPTIDE FRAGMENT;

ANIMAL; ANTIBODY COMBINING SITE; APOPTOSIS; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; DRUG EFFECTS; DRUG INDUSTRY; HUMAN; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING SITES, ANTIBODY; CELL LINE, TUMOR; CIRCULAR DICHROISM; DRUG INDUSTRY; HUMANS; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84907084496     PISSN: 00368504     EISSN: 20477163     Source Type: Journal    
DOI: 10.3184/003685014X14049273183515     Document Type: Article

References (60)

1. Delves, P.J. and Roitt, I.M. (2000) The immune system. First of two parts. N. Engl. J. Med., 343, 37-49.
2. Torres, M. and Casadevall, A. (2008) The immunoglobulin constant region contributes to affinity and specificity. Trends Immunol., 29, 91-97.
3. von Behring, E. and Kitasato, S. (1890) Ueber das Zustandekommen der Diphtherie-Immunität und der Tetanus-Immunität bei Thieren. Dtsch. Med. Wochenschr., 16, 1113-1114.
4. Lindenmann, J. (1984) Origin of the terms 'antibody' and 'antigen'. Scand. J. Immunol., 19, 281-285.
5. Mahendra, A., Sharma, M., Rao, D.N., Peyron, I., Planchais, C., Dimitrov, J.D., Kaveri, S.V. and Lacroix-Desmazes, S. (2013) Antibody-mediated catalysis: induction and therapeutic relevance. Autoimmun. Rev., 12, 648-652.
6. Polonelli, L., Conti, S., Gerloni, M., Magliani, W., Castagnola, M., Morace, G. and Chezzi, C. (1991) 'Antibiobodies': antibiotic-like anti-idiotypic antibodies. J. Med. Vet. Mycol., 29, 235-242.
7. Carter, P.J. (2006) Potent antibody therapeutics by design. Nat. Rev. Immunol., 6, 343-357.
8. Li, J. and Zhu, Z. (2010) Research and development of next generation of antibody-based therapeutics. Acta Pharmacol. Sin., 31, 1198-1207.
9. Bellou, S., Pentheroudakis, G., Murphy, C. and Fotsis, T. (2013) Anti-angiogenesis in cancer therapy: Hercules and hydra. Cancer Lett., 338, 219-228.
10. Shah, P.S. and Kaufman, D.A. (2009) Antistaphylococcal immunoglobulins to prevent staphylococcal infection in very low birth weight infants. Cochrane Database Syst. Rev., CD006449.
11. Nagy, E., Giefing, C. and von Gabain, A. (2008) Anti-infective antibodies: a novel tool to prevent and treat nosocomial diseases. Expert Rev. Anti. Infect. Ther., 6, 21-30.
12. Dadachova, E. and Casadevall, A. (2008) Host and microbial cells as targets for armed antibodies in the treatment of infectious diseases. Curr. Opin. Investig. Drugs, 9, 184-188.
13. Sassoon, I. and Blanc, V. (2013) Antibody-drug conjugate (ADC) clinical pipeline: a review. Methods Mol. Biol., 1045, 1-27.
14. Lianos, G.D., Vlachos, K., Zoras, O., Katsios, C., Cho, W.C. and Roukos, D.H. (2014) Potential of antibodydrug conjugates and novel therapeutics in breast cancer management. Onco, Targets Ther, 7, 491-500.
15. Drake, C.G. (2012) Combination immunotherapy approaches. Ann. Oncol., 23 Suppl 8, viii41-46.
16. Najjar, V.A. and Nishioka, K. (1970) "Tuftsin": a natural phagocytosis stimulating peptide. Nature, 228, 672-673.
17. Veretennikova, N.I., Chipens, G.I., Nikiforovich, G.V. and Betinsh, Y.R. (1981) Rigin, another phagocytosisstimulating tetrapeptide isolated from human IgG. Confirmations of a hypothesis. Int. J. Pept. Protein Res., 17, 430-435.
18. Morgan, E.L., Hugli, T.E. and Weigle, W.O. (1982) Isolation and identification of a biologically active peptide derived from the CH3 domain of human IgG1. Proc. Natl. Acad. Sci. USA, 79, 5388-5391.
19. Mitin, Y.V., Navolotskaya, E.V., Vasilenko, R.N., Abramov, V.M. and Zav'Yalov, V.P. (1993) Synthesis and properties of the peptide corresponding to the ACTH-like sequence of human immunoglobulin G1. Int. J. Pept. Protein Res., 41, 517-521.
20. Zav'yalov, V.P., Zaitseva, O.R., Navolotskaya, E.V., Abramov, V.M., Volodina, E. and Mitin, Y.V. (1996) Receptor-binding properties of the peptides corresponding to the beta-endorphin-like sequence of human immunoglobulin G. Immunol. Lett., 49, 21-26.
21. Jarrin, A., Andrieux, A., Chapel, A., Buchou, T. and Marguerie, G. (1994) A synthetic peptide with anti-platelet activity derived from a CDR of an anti-GPIIb-IIIa antibody. FEBS Lett., 354, 169-172.
22. Bourgeois, C., Bour, J.B., Aho, L.S. and Pothier, P. (1998) Prophylactic administration of a complementaritydetermining region derived from a neutralising monoclonal antibody is effective against respiratory syncytial virus infection in BALB/c mice. J. Virol., 72, 807-810.
23. Monnet, C., Laune, D., Laroche-Traineau, J., Biard-Piechaczyk, M., Briant, L., Bes, C., Pugniere, M., Mani, J.C., Pau, B., Cerutti, M., Devauchelle, G., Devaux, C., Granier, C. and Chardes, T. (1999) Synthetic peptides derived from the variable regions of an anti-CD4 monoclonal antibody bind to CD4 and inhibit HIV-1 promoter activation in virus-infected cells. J. Biol. Chem., 274, 3789-3796.
24. Park, B.W., Zhang, H.T., Wu, C., Berezov, A., Zhang, X., Dua, R., Wang, Q., Kao, G., O'Rourke, D.M., Greene, M.I. and Murali, R. (2000) Rationally designed anti-HER2/neu peptide mimetic disables P185HER2/neu tyrosine kinases in vitro and in vivo. Nat. Biotechnol., 18, 194-198.
25. Moskal, J.R., Kuo, A.G., Weiss, C., Wood, P.L., O'Connor Hanson, A., Kelso, S., Harris, R.B. and Disterhoft, J.F. (2005) GLYX-13: a monoclonal antibody-derived peptide that acts as an N-methyl-D-aspartate receptor modulator. Neuropharmacology, 49, 1077-1087.
26. Heap, C.J., Wang, Y., Pinheiro, T.J., Reading, S.A., Jennings, K.R. and Dimmock, N.J. (2005) Analysis of a 17-amino acid residue, virus-neutralising microantibody. J. Gen. Virol., 86, 1791-1800.
27. Dorfman, T., Moore, M.J., Guth, A.C., Choe, H. and Farzan, M. (2006) A tyrosine-sulfated peptide derived from the heavy-chain CDR3 region of an HIV-1-neutralising antibody binds gp120 and inhibits HIV-1 infection. J. Biol. Chem., 281, 28529-28535.
28. Qiu, X.Q., Wang, H., Cai, B., Wang, L.L. and Yue, S.T. (2007) Small antibody mimetics comprising two complementarity-determining regions and a framework region for tumour targeting. Nat. Biotechnol., 25, 921-929.
29. Mozes, E., Sela, U. and Sharabi, A. (2008) A novel synthetic peptide for the specific treatment of lupus: clinical effects and mechanism of action. Isr. Med. Assoc. J., 10, 40-42.
30. Okarvi, S.M. and Jammaz, I.A. (2009) Design, synthesis, radiolabeling and in vitro and in vivo characterization of tumour-antigen-and antibody-derived peptides for the detection of breast cancer. Anticancer Res., 29, 1399-1409.
31. Jerne, N.K. (1974) Towards a network theory of the immune system. Ann. Immunol. (Paris), 125C, 373-389.
32. Magliani, W., Conti, S., Travassos, L.R. and Polonelli, L. (2008) From yeast killer toxins to antibiobodies and beyond. FEMS Microbiol. Lett., 288, 1-8.
33. Polonelli, L., Magliani, W., Conti, S., Bracci, L., Lozzi, L., Neri, P., Adriani, D., De Bernardis, F. and Cassone, A. (2003) Therapeutic activity of an engineered synthetic killer antiidiotypic antibody fragment against experimental mucosal and systemic candidiasis. Infect. Immun., 71, 6205-6212.
34. Manfredi, M., McCullough, M.J., Conti, S., Polonelli, L., Vescovi, P., Al-Karaawi, Z.M. and Porter, S.R. (2005) In vitro activity of a monoclonal killer anti-idiotypic antibody and a synthetic killer peptide against oral isolates of Candida spp. differently susceptible to conventional antifungals. Oral Microbiol. Immunol., 20, 226-232.
35. Cenci, E., Bistoni, F., Mencacci, A., Perito, S., Magliani, W., Conti, S., Polonelli, L. and Vecchiarelli, A. (2004) A synthetic peptide as a novel anticryptococcal agent. Cell. Microbiol., 6, 953-961.
36. Travassos, L.R., Silva, L.S., Rodrigues, E.G., Conti, S., Salati, A., Magliani, W. and Polonelli, L. (2004) Therapeutic activity of a killer peptide against experimental paracoccidioidomycosis. J. Antimicrob. Chemother., 54, 956-958.
37. Conti, S., Magliani, W., Giovati, L., Libri, I., Maffei, D.L., Salati, A. and Polonelli, L. (2008) Screening of a Saccharomyces cerevisiae nonessential gene deletion collection for altered susceptibility to a killer peptide. New Microbiol., 31, 143-145.
38. Cafarchia, C., Immediato, D., Paola, G.D., Magliani, W., Ciociola, T., Conti, S., Otranto, D. and Polonelli, L. (2014) In vitro and in vivo activity of a killer peptide against Malassezia pachydermatis causing otitis in dogs. Med. Mycol., 52, 350-355.
39. Donini, M., Lico, C., Baschieri, S., Conti, S., Magliani, W., Polonelli, L. and Benvenuto, E. (2005) Production of an engineered killer peptide in Nicotiana benthamiana by using a potato virus X expression system. Appl. Environ. Microbiol., 71, 6360-6367.
40. Savoia, D., Scutera, S., Raimondo, S., Conti, S., Magliani, W. and Polonelli, L. (2006) Activity of an engineered synthetic killer peptide on Leishmania major and Leishmania infantum promastigotes. Exp. Parasitol., 113, 186-192.
41. Fiori, P.L., Mattana, A., Dessi, D., Conti, S., Magliani, W. and Polonelli, L. (2006) In vitro acanthamoebicidal activity of a killer monoclonal antibody and a synthetic peptide. J. Antimicrob. Chemother., 57, 891-898.
42. Casoli, C., Pilotti, E., Perno, C.F., Balestra, E., Polverini, E., Cassone, A., Conti, S., Magliani, W. and Polonelli, L. (2006) A killer mimotope with therapeutic activity against AIDS-related opportunistic micro-organisms inhibits ex-vivo HIV-1 replication. AIDS, 20, 975-980.
43. Conti, G., Magliani, W., Conti, S., Nencioni, L., Sgarbanti, R., Palamara, A.T. and Polonelli, L. (2008) Therapeutic activity of an anti-idiotypic antibody-derived killer peptide against influenza A virus experimental infection. Antimicrob. Agents Chemother., 52, 4331-4337.
44. Omaetxebarria, M.J., Moragues, M.D., Elguezabal, N., Rodriguez-Alejandre, A., Brena, S., Schneider, J., Polonelli, L. and Ponton, J. (2005) Antifungal and antitumour activities of a monoclonal antibody directed against a stress mannoprotein of Candida albicans. Curr. Mol. Med., 5, 393-401.
45. Brena, S., Omaetxebarria, M.J., Elguezabal, N., Cabezas, J., Moragues, M.D. and Ponton, J. (2007) Fungicidal monoclonal antibody C7 binds to Candida albicans Als3. Infect. Immun., 75, 3680-3682.
46. Polonelli, L., Ponton, J., Elguezabal, N., Moragues, M.D., Casoli, C., Pilotti, E., Ronzi, P., Dobroff, A.S., Rodrigues, E.G., Juliano, M.A., Maffei, D.L., Magliani, W., Conti, S. and Travassos, L.R. (2008) Antibody complementarity-determining regions (CDRs) can display differential antimicrobial, antiviral and antitumour activities. PLoS ONE, 3, e2371.
47. Polonelli, L., Ciociola, T., Magliani, W., Zanello, P.P., D'Adda, T., Galati, S., De Bernardis, F., Arancia, S., Gabrielli, E., Pericolini, E., Vecchiarelli, A., Arruda, D.C., Pinto, M.R., Travassos, L.R., Pertinhez, T.A., Spisni, A. and Conti, S. (2012) Peptides of the constant region of antibodies display fungicidal activity. PLoS ONE, 7, e34105.
48. Arruda, D.C., Santos, L.C., Melo, F.M., Pereira, F.V., Figueiredo, C.R., Matsuo, A.L., Mortara, R.A., Juliano, M.A., Rodrigues, E.G., Dobroff, A.S., Polonelli, L. and Travassos, L.R. (2012) beta-Actin-binding complementarity-determining region 2 of variable heavy chain from monoclonal antibody C7 induces apoptosis in several human tumour cells and is protective against metastatic melanoma. J. Biol. Chem., 287, 14912-14922.
49. Dobroff, A.S., Rodrigues, E.G., Juliano, M.A., Friaca, D.M., Nakayasu, E.S., Almeida, I.C., Mortara, R.A., Jacysyn, J.F., Amarante-Mendes, G.P., Magliani, W., Conti, S., Polonelli, L. and Travassos, L.R. (2010) Differential Antitumour Effects of IgG and IgM Monoclonal Antibodies and Their Synthetic Complementarity-Determining Regions Directed to New Targets of B16F10-Nex2 Melanoma Cells. Transl. Oncol., 3, 204-217.
50. Navolotskaya, E.V. (2014) The second life of antibodies. Biochemistry (Mosc.), 79, 1-7.
51. Cenci, E., Pericolini, E., Mencacci, A., Conti, S., Magliani, W., Bistoni, F., Polonelli, L. and Vecchiarelli, A. (2006) Modulation of phenotype and function of dendritic cells by a therapeutic synthetic killer peptide. J. Leukoc. Biol., 79, 40-45.
52. Gabrielli, E., Pericolini, E., Cenci, E., Ortelli, F., Magliani, W., Ciociola, T., Bistoni, F., Conti, S., Vecchiarelli, A. and Polonelli, L. (2009) Antibody complementarity-determining regions (CDRs): a bridge between adaptive and innate immunity. PLoS ONE, 4, e8187.
53. Gabrielli, E., Pericolini, E., Cenci, E., Monari, C., Magliani, W., Ciociola, T., Conti, S., Gatti, R., Bistoni, F., Polonelli, L. and Vecchiarelli, A. (2012) Antibody constant region peptides can display immunomodulatory activity through activation of the Dectin-1 signalling pathway. PLoS ONE, 7, e43972.
54. Pertinhez, T.A., Conti, S., Ferrari, E., Magliani, W., Spisni, A. and Polonelli, L. (2009) Reversible self-assembly: a key feature for a new class of autodelivering therapeutic peptides. Mol. Pharm., 6, 1036-1039.
55. Magliani, W., Conti, S., Ciociola, T., Giovati, L., Zanello, P.P., Pertinhez, T., Spisni, A. and Polonelli, L. (2011) Killer peptide: a novel paradigm of antimicrobial, antiviral and immunomodulatory auto-delivering drugs. Future Med. Chem., 3, 1209-1231.
56. Magliani, W., Conti, S., Giovati, L., Zanello, P.P., Sperinde, M., Ciociola, T. and Polonelli, L. (2012) Antibody Peptide based antifungal immunotherapy. Front. Microbiol., 3, 190.
57. Magliani, W., Conti, S., Giovati, L., Maffei, D.L. and Polonelli, L. (2008) Anti-beta-glucan-like immunoprotective candidacidal antiidiotypic antibodies. Front. Biosci., 13, 6920-6937.
58. Cutuli, M., Cristiani, S., Lipton, J.M. and Catania, A. (2000) Antimicrobial effects of alpha-MSH peptides. J. Leukoc. Biol., 67, 233-239.
59. Sforca, M.L., Machado, A., Figueredo, R.C., Oyama, S., Jr., Silva, F.D., Miranda, A., Daffre, S., Miranda, M.T., Spisni, A. and Pertinhez, T.A. (2005) The micelle-bound structure of an antimicrobial peptide derived from the alpha-chain of bovine hemoglobin isolated from the tick Boophilus microplus. Biochemistry (Mosc.), 44, 6440-6451.
60. Magliani, W., Conti, S., Cunha, R.L., Travassos, L.R. and Polonelli, L. (2009) Antibodies as crypts of antiinfective and antitumour peptides. Curr. Med. Chem., 16, 2305-2323.