β-actin-binding complementarity-determining region 2 of variable heavy chain from monoclonal antibody C7 induces apoptosis in several human tumor cells and is protective against metastatic melanoma

Journal of Biological Chemistry

Volumn 287, Issue 18, 2012, Pages 14912-14922

  Arruda, Denise C ^a   Santos, Luana C P ^a   Melo, Filipe M ^a   Pereira, Felipe V ^a   Figueiredo, Carlos R ^a   Matsuo, Alisson L ^a,c   Mortara, Renato A ^a   Juliano, Maria A ^a   Rodrigues, Elaine G ^a   Dobroff, Andrey S ^b   Polonelli, Luciano ^d   Travassos, Luiz R ^a,b  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b Recepta Biopharma   (Brazil)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d UNIVERSITY OF PARMA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN POLYMERIZATION; ANNEXINS; ANTI-TUMOR ACTIVITIES; ANTICANCER DRUG; CANDIDA ALBICANS; CASPASES; CHROMATIN CONDENSATION; COLONY FORMATION; COMPLEMENTARITY-DETERMINING REGIONS; CYTOSKELETONS; CYTOTOXIC; DERIVATIZATIONS; DNA FRAGMENTATION; F-ACTIN; HEAVY CHAIN; HIGH DOSE; HUMAN TUMOR CELLS; IN-VITRO; INDUCED APOPTOSIS; LUNG METASTASIS; MASS SPECTROMETRY ANALYSIS; MELANOMA CELLS; METASTATIC MELANOMA; NONTUMORIGENIC CELLS; PEPTIDE BINDING; SUPEROXIDE ANIONS; SYNTHETIC PEPTIDE; TUMOR CELL LINES; TUMOR CELLS;

AMIDES; BIOLOGICAL ORGANS; CELL CULTURE; CELL MEMBRANES; CYTOTOXICITY; DERMATOLOGY; DRUG PRODUCTS; MAMMALS; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; ONCOLOGY; OXYGEN; PEPTIDES; TUMORS;

CELL DEATH;

BETA ACTIN; CASPASE 3; CASPASE 8; DNA; F ACTIN; LAMIN; LIPOCORTIN 5; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY C7H2; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING KINETICS; CANCER CELL; CANCER CELL CULTURE; CELL INTERACTION; CELL ORGANELLE; CELL SURFACE; CHROMATIN CONDENSATION; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; CYTOSKELETON; DERIVATIZATION; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG EFFICACY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TIME; INTERNALIZATION; LUNG METASTASIS; MALE; MASS SPECTROMETRY; MELANOMA; METASTASIS POTENTIAL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN POLYMERIZATION; PROTEIN STABILITY;

ACTINS; ANIMALS; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTIBODIES, NEOPLASM; ANTINEOPLASTIC AGENTS; APOPTOSIS; CANDIDA ALBICANS; CASPASE 3; CASPASE 8; CELL LINE, TUMOR; DNA FRAGMENTATION; DNA, NEOPLASM; FUNGAL PROTEINS; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MALE; MELANOMA; MEMBRANE GLYCOPROTEINS; MICE; NEOPLASM METASTASIS; NEOPLASM PROTEINS;

CANDIDA ALBICANS; MUS;

EID: 84860381346     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.322362     Document Type: Article

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