-
1
-
-
84874566782
-
European cancer mortality predictions for the year 2013
-
Malvezzi M, Bertuccio P, Levi F, et al. European cancer mortality predictions for the year 2013. Ann Oncol. 2013;24(3):792-800.
-
(2013)
Ann Oncol.
, vol.24
, Issue.3
, pp. 792-800
-
-
Malvezzi, M.1
Bertuccio, P.2
Levi, F.3
-
2
-
-
84872967522
-
Cancer statistics, 2013
-
Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63(1):11-30.
-
(2013)
CA Cancer J Clin.
, vol.63
, Issue.1
, pp. 11-30
-
-
Siegel, R.1
Naishadham, D.2
Jemal, A.3
-
4
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 2001;344(11):783-792.
-
(2001)
N Engl J Med.
, vol.344
, Issue.11
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
5
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-674.
-
(2011)
Cell.
, vol.144
, Issue.5
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
6
-
-
84875490185
-
Cancer genome landscapes
-
Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA Jr, Kinzler KW. Cancer genome landscapes. Science. 2013;339(6127): 1546-1558.
-
(2013)
Science.
, vol.339
, Issue.6127
, pp. 1546-1558
-
-
Vogelstein, B.1
Papadopoulos, N.2
Velculescu, V.E.3
Zhou, S.4
Diaz Jr., L.A.5
Kinzler, K.W.6
-
7
-
-
84884369881
-
Selection and adaptation during metastatic cancer progression
-
Klein CA. Selection and adaptation during metastatic cancer progression. Nature. 2013;501(7467):365-372.
-
(2013)
Nature.
, vol.501
, Issue.7467
, pp. 365-372
-
-
Klein, C.A.1
-
8
-
-
84884407337
-
Tumour heterogeneity in the clinic
-
Bedard PL, Hansen AR, Ratain MJ, Siu LL. Tumour heterogeneity in the clinic. Nature. 2013;501(7467):355-364.
-
(2013)
Nature.
, vol.501
, Issue.7467
, pp. 355-364
-
-
Bedard, P.L.1
Hansen, A.R.2
Ratain, M.J.3
Siu, L.L.4
-
9
-
-
77955626568
-
Beyond HER2 and trastuzumab: Heterogeneity, systems biology, and cancer origin research may guide the future for personalized treatment of very early but aggressive breast cancer
-
Roukos DH. Beyond HER2 and trastuzumab: heterogeneity, systems biology, and cancer origin research may guide the future for personalized treatment of very early but aggressive breast cancer. J Clin Oncol. 2010;28(17):e279-e280.
-
(2010)
J Clin Oncol.
, vol.28
, Issue.17
-
-
Roukos, D.H.1
-
10
-
-
84877028141
-
Comprehensive molecular portraits of human breast tumors
-
Cancer Genome Atlas Network
-
Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumors. Nature. 2012;490(7418):61-70.
-
(2012)
Nature.
, vol.490
, Issue.7418
, pp. 61-70
-
-
-
11
-
-
84865859048
-
What does our genome encode?
-
Stamatoyannopoulos JA. What does our genome encode? Genome Res. 2012;22(9):1602-1611.
-
(2012)
Genome Res.
, vol.22
, Issue.9
, pp. 1602-1611
-
-
Stamatoyannopoulos, J.A.1
-
12
-
-
84897137550
-
Novel next-generation sequencing and networks-based therapeutic targets: Realistic more effective drug design and discovery
-
Roukos DH, Baltogiannis GG, Katsouras CS, et al. Novel next-generation sequencing and networks-based therapeutic targets: realistic more effective drug design and discovery. Curr Pharm Des. 2014;20(1): 11-22.
-
(2014)
Curr Pharm Des.
, vol.20
, Issue.1
, pp. 11-22
-
-
Roukos, D.H.1
Baltogiannis, G.G.2
Katsouras, C.S.3
-
13
-
-
26844503270
-
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
-
Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med. 2005;353(16):1659-1672.
-
(2005)
N Engl J Med.
, vol.353
, Issue.16
, pp. 1659-1672
-
-
Piccart-Gebhart, M.J.1
Procter, M.2
Leyland-Jones, B.3
-
14
-
-
26844536978
-
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
-
Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med. 2005;353(16):1673-1684.
-
(2005)
N Engl J Med.
, vol.353
, Issue.16
, pp. 1673-1684
-
-
Romond, E.H.1
Perez, E.A.2
Bryant, J.3
-
15
-
-
84877302244
-
Trastuzumab-DM1: A clinical update of the novel antibody-drug conjugate for HER2-overexpressing breast cancer
-
Barginear MF, John V, Budman DR. Trastuzumab-DM1: a clinical update of the novel antibody-drug conjugate for HER2-overexpressing breast cancer. Mol Med. 2012;18:1473-1479.
-
(2012)
Mol Med.
, vol.18
, pp. 1473-1479
-
-
Barginear, M.F.1
John, V.2
Budman, D.R.3
-
16
-
-
74949107560
-
Antibody-drug conjugates: Linking cytotoxic payloads to monoclonal antibodies
-
Ducry L, Stump B. Antibody-drug conjugates: linking cytotoxic payloads to monoclonal antibodies. Bioconjug Chem. 2010;21:5-13.
-
(2010)
Bioconjug Chem.
, vol.21
, pp. 5-13
-
-
Ducry, L.1
Stump, B.2
-
17
-
-
67649886201
-
Potent antibody drug conjugates for cancer therapy
-
Senter PD. Potent antibody drug conjugates for cancer therapy. Curr Opin Chem Biol. 2009;13:235-244.
-
(2009)
Curr Opin Chem Biol.
, vol.13
, pp. 235-244
-
-
Senter, P.D.1
-
18
-
-
84862752215
-
The effect of different linkers on target cell catabolism and pharmacokinetics/pharmacodynamics of trastuzumab-maytansinoid conjugates
-
Erickson HK, Lewis Phillips GD, Leipold DD, et al. The effect of different linkers on target cell catabolism and pharmacokinetics/pharmacodynamics of trastuzumab-maytansinoid conjugates. Mol Cancer Ther. 2012;11(5):1133-1142.
-
(2012)
Mol Cancer Ther.
, vol.11
, Issue.5
, pp. 1133-1142
-
-
Erickson, H.K.1
Lewis Phillips, G.D.2
Leipold, D.D.3
-
19
-
-
84863678237
-
Brentuximab vedotin (SGN-35) in patients with relapsed or refractory systemic anaplastic large-cell lymphoma: Results of a Phase II study
-
Pro B, Advani R, Brice P, et al. Brentuximab vedotin (SGN-35) in patients with relapsed or refractory systemic anaplastic large-cell lymphoma: results of a Phase II study. J Clin Oncol. 2012;30:2190-2196.
-
(2012)
J Clin Oncol.
, vol.30
, pp. 2190-2196
-
-
Pro, B.1
Advani, R.2
Brice, P.3
-
20
-
-
84897136419
-
-
US Food and Drug Administration (FDA) [homepage on the Internet]. [updated June 21, 2010; cited January 11, 2013]. Available from:. Accessed January 27, 2014
-
US Food and Drug Administration (FDA) [homepage on the Internet]. Mylotarg (gemtuzumab ozogamicin): market withdrawal. Silver Spring, MD: FDA; 2010 [updated June 21, 2010; cited January 11, 2013]. Available from: http://www.fda.gov/safety/medwatch/safetyinformation/safetyalertsforhumanmedicalproducts/ucm216458.htm. Accessed January 27, 2014.
-
(2010)
Mylotarg (gemtuzumab ozogamicin): Market withdrawal. Silver Spring, MD: FDA
-
-
-
21
-
-
79952232216
-
Global cancer statistics
-
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69-90.
-
(2011)
CA Cancer J Clin.
, vol.61
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
22
-
-
79952711587
-
Reduced dose and intermittent treatment with lapatinib and trastuzumab for potent blockade of the HER pathway in HER2/neu-overexpressing breast tumor xenografts
-
Rimawi MF, Wiechmann LS, Wang YC, et al. Reduced dose and intermittent treatment with lapatinib and trastuzumab for potent blockade of the HER pathway in HER2/neu-overexpressing breast tumor xenografts. Clin Cancer Res. 2011;17:1351-1361.
-
(2011)
Clin Cancer Res.
, vol.17
, pp. 1351-1361
-
-
Rimawi, M.F.1
Wiechmann, L.S.2
Wang, Y.C.3
-
23
-
-
84871809195
-
The potential for trastuzumab emtansine in human epidermal growth factor receptor 2 positive metastatic breast cancer: Latest evidence and ongoing studies
-
Hurvitz SA, Kakkar R. The potential for trastuzumab emtansine in human epidermal growth factor receptor 2 positive metastatic breast cancer: latest evidence and ongoing studies. Ther Adv Med Oncol. 2012;4(5):235-245.
-
(2012)
Ther Adv Med Oncol.
, vol.4
, Issue.5
, pp. 235-245
-
-
Hurvitz, S.A.1
Kakkar, R.2
-
24
-
-
80053539103
-
Adjuvant trastuzumab in HER2-positive breast cancer
-
Slamon D, Eiermann W, Robert N, et al. Adjuvant trastuzumab in HER2-positive breast cancer. N Engl J Med. 2011;365(14):1273-1283.
-
(2011)
N Engl J Med.
, vol.365
, Issue.14
, pp. 1273-1283
-
-
Slamon, D.1
Eiermann, W.2
Robert, N.3
-
25
-
-
84886737613
-
Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer
-
Canonici A, Gijsen M, Mullooly M, et al. Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer. Oncotarget. 2013;4(10):1592-1605.
-
(2013)
Oncotarget.
, vol.4
, Issue.10
, pp. 1592-1605
-
-
Canonici, A.1
Gijsen, M.2
Mullooly, M.3
-
26
-
-
79960980007
-
Strategies for subtypes-dealing with the diversity of breast cancer: Highlights of the St Gallen international expert consensus on the primary therapy of early breast cancer 2011
-
Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thórlimann B, Senn HJ. Strategies for subtypes-dealing with the diversity of breast cancer: highlights of the St Gallen international expert consensus on the primary therapy of early breast cancer 2011. Ann Oncol. 2011;22:1736-1747.
-
(2011)
Ann Oncol.
, vol.22
, pp. 1736-1747
-
-
Goldhirsch, A.1
Wood, W.C.2
Coates, A.S.3
Gelber, R.D.4
Thórlimann, B.5
Senn, H.J.6
-
27
-
-
73949090721
-
Prognosis of women with metastatic breast cancer by HER2 status and trastuzumab treatment: An institutional-based review
-
Dawood S, Broglio K, Buzdar AU, Hortobagyi GN, Giordano SH. Prognosis of women with metastatic breast cancer by HER2 status and trastuzumab treatment: an institutional-based review. J Clin Oncol. 2010;28:92-98.
-
(2010)
J Clin Oncol.
, vol.28
, pp. 92-98
-
-
Dawood, S.1
Broglio, K.2
Buzdar, A.U.3
Hortobagyi, G.N.4
Giordano, S.H.5
-
28
-
-
79953066553
-
Trastuzumab and beyond: Sequencing cancer genomes and predicting molecular networks
-
Roukos DH. Trastuzumab and beyond: sequencing cancer genomes and predicting molecular networks. Pharmacogenomics J. 2011;11(2): 81-92.
-
(2011)
Pharmacogenomics J.
, vol.11
, Issue.2
, pp. 81-92
-
-
Roukos, D.H.1
-
29
-
-
79952041937
-
Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: A 4-year follow-up of a randomised controlled trial
-
Gianni L, Dafni U, Gelber RD, et al. Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: a 4-year follow-up of a randomised controlled trial. Lancet Oncol. 2011;12:236-244.
-
(2011)
Lancet Oncol.
, vol.12
, pp. 236-244
-
-
Gianni, L.1
Dafni, U.2
Gelber, R.D.3
-
30
-
-
84884418164
-
2 years versus 1 year of adjuvant trastuzumab for HER2-positive breast cancer (HERA): An open-label, randomised controlled trial
-
Goldhirsch A, Gelber RD, Piccart-Gebhart MJ, et al. 2 years versus 1 year of adjuvant trastuzumab for HER2-positive breast cancer (HERA): an open-label, randomised controlled trial. Lancet. 2013;382(9897):1021-1028.
-
(2013)
Lancet.
, vol.382
, Issue.9897
, pp. 1021-1028
-
-
Goldhirsch, A.1
Gelber, R.D.2
Piccart-Gebhart, M.J.3
-
32
-
-
84879780559
-
6 months versus 12 months of adjuvant trastuzumab for patients with HER2-positive early breast cancer (PHARE): A randomized Phase 3 trial
-
Pivot X, Romieu G, Deblet M, et al. 6 months versus 12 months of adjuvant trastuzumab for patients with HER2-positive early breast cancer (PHARE): a randomized Phase 3 trial. Lancet Oncol. 2013;14(8):741-748.
-
(2013)
Lancet Oncol.
, vol.14
, Issue.8
, pp. 741-748
-
-
Pivot, X.1
Romieu, G.2
Deblet, M.3
-
33
-
-
84884413983
-
Duration of adjuvant trastuzumab: Shorter beats longer
-
Joensuu H. Duration of adjuvant trastuzumab: shorter beats longer. Lancet. 2013;382(9897):1010-1011.
-
(2013)
Lancet.
, vol.382
, Issue.9897
, pp. 1010-1011
-
-
Joensuu, H.1
-
34
-
-
33845886440
-
Lapatinib plus capecitabine for HER2-positive advanced breast cancer
-
Geyer CE, Forster J, Lindquist D, et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med. 2006;355(26): 2733-2743.
-
(2006)
N Engl J Med.
, vol.355
, Issue.26
, pp. 2733-2743
-
-
Geyer, C.E.1
Forster, J.2
Lindquist, D.3
-
35
-
-
84880441014
-
Temporal regulation of EGF signalling networks by the scaffold protein Shc1
-
Zheng Y, Zhang C, Croucher D, et al. Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Nature. 2013;499(7457):166-171.
-
(2013)
Nature.
, vol.499
, Issue.7457
, pp. 166-171
-
-
Zheng, Y.1
Zhang, C.2
Croucher, D.3
-
36
-
-
84893848111
-
Preclinical and clinical pharmacokinetic/pharmacodynamic considerations for antibody-drug conjugates
-
Sapra P, Betts A, Boni J. Preclinical and clinical pharmacokinetic/pharmacodynamic considerations for antibody-drug conjugates. Expert Rev Clin Pharmacol. 2013;6(5):541-555.
-
(2013)
Expert Rev Clin Pharmacol.
, vol.6
, Issue.5
, pp. 541-555
-
-
Sapra, P.1
Betts, A.2
Boni, J.3
-
37
-
-
79959700509
-
Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer
-
Junttila TT, Li G, Parsons K, Phillips GL, Sliwkowski MX. Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer. Breast Cancer Res Treat. 2011;128:347-356.
-
(2011)
Breast Cancer Res Treat.
, vol.128
, pp. 347-356
-
-
Junttila, T.T.1
Li, G.2
Parsons, K.3
Phillips, G.L.4
Sliwkowski, M.X.5
-
38
-
-
84934444640
-
Antibody-drug conjugate (ADC) clinical pipeline: A review
-
Sassoon I, Blanc V. Antibody-drug conjugate (ADC) clinical pipeline: a review. Methods Mol Biol. 2013;1045:1-27.
-
(2013)
Methods Mol Biol.
, vol.1045
, pp. 1-27
-
-
Sassoon, I.1
Blanc, V.2
-
39
-
-
84880128705
-
Antibodies to watch in 2013. Mid-year update
-
Reichert JM. Antibodies to watch in 2013. Mid-year update. MAbs. 2013;5(4):513-517.
-
(2013)
MAbs.
, vol.5
, Issue.4
, pp. 513-517
-
-
Reichert, J.M.1
-
40
-
-
84877310777
-
Maturing antibody-drug conjugate pipeline hits 30
-
Mullard A. Maturing antibody-drug conjugate pipeline hits 30. Nat Rev Drug Discov. 2013;12:329-332.
-
(2013)
Nat Rev Drug Discov.
, vol.12
, pp. 329-332
-
-
Mullard, A.1
-
41
-
-
84902549490
-
The success story of trastuzumab emtansine, a targeted therapy in HER2-positive breast cancer
-
Epub July 14
-
Diéras V, Bachelot T. The success story of trastuzumab emtansine, a targeted therapy in HER2-positive breast cancer. Target Oncol. Epub July 14, 2013.
-
(2013)
Target Oncol.
-
-
Diéras, V.1
Bachelot, T.2
-
42
-
-
79952092706
-
Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy
-
Burris HA 3rd, Rugo HS, Vukelja SJ, et al. Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy. J Clin Oncol. 2011;29:398-405.
-
(2011)
J Clin Oncol.
, vol.29
, pp. 398-405
-
-
Burris III, H.A.1
Rugo, H.S.2
Vukelja, S.J.3
-
43
-
-
78651447411
-
A Phase II study of trastuzumab-DM1 (T-DM1), a novel HER2 antibody-drug conjugate, in patients with HER2+ metastatic breast cancer who were previously treated with an anthracycline, a taxane, capecitabine, lapatinib, and trastuzumab. Poster presented at: Annual San Antonio Breast Cancer Symposium
-
abstract
-
Krop IE, Lo Russo P, Miller K, et al. A Phase II study of trastuzumab-DM1 (T-DM1), a novel HER2 antibody-drug conjugate, in patients with HER2+ metastatic breast cancer who were previously treated with an anthracycline, a taxane, capecitabine, lapatinib, and trastuzumab. Poster presented at: Annual San Antonio Breast Cancer Symposium. Cancer Res. 2009;70(Suppl):abstract 710.
-
(2009)
Cancer Res.
, vol.70
, Issue.SUPPL.
, pp. 710
-
-
Krop, I.E.1
Lo Russo, P.2
Miller, K.3
-
44
-
-
84876011018
-
Phase II randomized study of trastuzumab emtansine versus trastuzumab plus docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer
-
Hurvitz SA, Dirix L, Kocsis J, et al. Phase II randomized study of trastuzumab emtansine versus trastuzumab plus docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer. J Clin Oncol. 2013;31(9):1157-1163.
-
(2013)
J Clin Oncol.
, vol.31
, Issue.9
, pp. 1157-1163
-
-
Hurvitz, S.A.1
Dirix, L.2
Kocsis, J.3
-
45
-
-
84868520609
-
Trastuzumab emtansine for HER2-positive advanced breast cancer
-
Verma S, Miles D, Gianni L, et al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med. 2012;367(19): 1783-1791.
-
(2012)
N Engl J Med.
, vol.367
, Issue.19
, pp. 1783-1791
-
-
Verma, S.1
Miles, D.2
Gianni, L.3
-
46
-
-
84867842898
-
MARIANNE: A Phase III, randomized study of trastuzumab-DM1 (T-DM1) with or without pertuzumab (P) compared with trastuzumab (H) plus taxane for first-line treatment of HER2-positive, progressive, or recurrent locally advanced or metastatic breast cancer (MBC)
-
abstract
-
Ellis PA, Barrios CH, Im Y, Patre M, Branle F, Perez EA. MARIANNE: a Phase III, randomized study of trastuzumab-DM1 (T-DM1) with or without pertuzumab (P) compared with trastuzumab (H) plus taxane for first-line treatment of HER2-positive, progressive, or recurrent locally advanced or metastatic breast cancer (MBC). J Clin Oncol. 2011;29(Suppl 15):abstract TPS102.
-
(2011)
J Clin Oncol.
, vol.29
, Issue.SUPPL. 15
-
-
Ellis, P.A.1
Barrios, C.H.2
Im, Y.3
Patre, M.4
Branle, F.5
Perez, E.A.6
-
49
-
-
77949903478
-
Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
-
Baselga J, Gelmon KA, Verma S, et al. Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. J Clin Oncol. 2010;28:1138-1144.
-
(2010)
J Clin Oncol.
, vol.28
, pp. 1138-1144
-
-
Baselga, J.1
Gelmon, K.A.2
Verma, S.3
-
50
-
-
84862914692
-
Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
-
Baselga J, Cortés J, Kim SB, et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med. 2012;366: 109-119.
-
(2012)
N Engl J Med.
, vol.366
, pp. 109-119
-
-
Baselga, J.1
Cortés, J.2
Kim, S.B.3
-
51
-
-
84883179862
-
Targeting the ERBB family in cancer: Couples therapy
-
Tebbutt N, Pedersen MW, Johns TG. Targeting the ERBB family in cancer: couples therapy. Nat Rev Cancer. 2013;13(9):663-673.
-
(2013)
Nat Rev Cancer.
, vol.13
, Issue.9
, pp. 663-673
-
-
Tebbutt, N.1
Pedersen, M.W.2
Johns, T.G.3
-
52
-
-
77949884661
-
Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer
-
Blackwell KL, Burstein HJ, Storniolo AM, et al. Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer. J Clin Oncol. 2010;28:1124-1130.
-
(2010)
J Clin Oncol.
, vol.28
, pp. 1124-1130
-
-
Blackwell, K.L.1
Burstein, H.J.2
Storniolo, A.M.3
-
53
-
-
84857236823
-
Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): A randomised, open-label, multicentre, phase 3 trial
-
Baselga J, Bradbury I, Eidtmann H, et al. Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial. Lancet. 2012;379:633-640.
-
(2012)
Lancet.
, vol.379
, pp. 633-640
-
-
Baselga, J.1
Bradbury, I.2
Eidtmann, H.3
-
54
-
-
84871970956
-
From next-generation sequencing to nanopore sequencing technology: Paving the way to personalized genomic medicine
-
Ku CS, Roukos DH. From next-generation sequencing to nanopore sequencing technology: paving the way to personalized genomic medicine. Expert Rev Med Devices. 2013;10(1):1-6.
-
(2013)
Expert Rev Med Devices.
, vol.10
, Issue.1
, pp. 1-6
-
-
Ku, C.S.1
Roukos, D.H.2
-
55
-
-
84888641656
-
Effect of natural genetic variation on enhancer selection and function
-
Heinz S, Romanoski CE, Benner C, et al. Effect of natural genetic variation on enhancer selection and function. Nature. 2013; 503(7477):487-492.
-
(2013)
Nature.
, vol.503
, Issue.7477
, pp. 487-492
-
-
Heinz, S.1
Romanoski, C.E.2
Benner, C.3
-
56
-
-
67249117049
-
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
-
Hindorff LA, Sethupathy P, Junkins HA, et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A. 2009;106:9362-9367.
-
(2009)
Proc Natl Acad Sci U S A.
, vol.106
, pp. 9362-9367
-
-
Hindorff, L.A.1
Sethupathy, P.2
Junkins, H.A.3
-
57
-
-
84881101401
-
Mapping inherited and somatic variation in regulatory DNA: New roadmap for common disease clinical discoveries
-
Roukos DH, Baltogiannis GG, Baltogiannis G. Mapping inherited and somatic variation in regulatory DNA: new roadmap for common disease clinical discoveries. Expert Rev Mol Diagn. 2013;13(6):519-522.
-
(2013)
Expert Rev Mol Diagn.
, vol.13
, Issue.6
, pp. 519-522
-
-
Roukos, D.H.1
Baltogiannis, G.G.2
Baltogiannis, G.3
-
58
-
-
84865822182
-
Systematic localization of common disease-associated variation in regulatory DNA
-
Maurano MT, Humbert R, Rynes E, et al. Systematic localization of common disease-associated variation in regulatory DNA. Science. 2012; 337(6099):1190-1195.
-
(2012)
Science
, vol.337
, Issue.6099
, pp. 1190-1195
-
-
Maurano, M.T.1
Humbert, R.2
Rynes, E.3
-
59
-
-
84882276125
-
Cancer heterogeneity and signaling network-based drug target
-
Roukos DH. Cancer heterogeneity and signaling network-based drug target. Pharmacogenomics. 2013;14(11):1243-1246.
-
(2013)
Pharmacogenomics.
, vol.14
, Issue.11
, pp. 1243-1246
-
-
Roukos, D.H.1
-
60
-
-
84865739425
-
Architecture of the human regulatory network derived from ENCODE data
-
Gerstein MB, Kundaje A, Hariharan M, et al. Architecture of the human regulatory network derived from ENCODE data. Nature. 2012;489(7414):91-100.
-
(2012)
Nature.
, vol.489
, Issue.7414
, pp. 91-100
-
-
Gerstein, M.B.1
Kundaje, A.2
Hariharan, M.3
-
61
-
-
84866361701
-
Circuitry and dynamics of human transcription factor regulatory networks
-
Neph S, Stergachis AB, Reynolds A, Sandstrom R, Borenstein E, Stamatoyannopoulos JA. Circuitry and dynamics of human transcription factor regulatory networks. Cell. 2012;150(6):1274-1286.
-
(2012)
Cell.
, vol.150
, Issue.6
, pp. 1274-1286
-
-
Neph, S.1
Stergachis, A.B.2
Reynolds, A.3
Sandstrom, R.4
Borenstein, E.5
Stamatoyannopoulos, J.A.6
-
62
-
-
84865790047
-
An integrated encyclopedia of DNA elements in the human genome
-
ENCODE Project Consortium
-
ENCODE Project Consortium, Bernstein BE, Birney E, Dunham I, Green ED, Gunter C, Snyder M. An integrated encyclopedia of DNA elements in the human genome. Nature. 2012;489(7414):57-74.
-
(2012)
Nature.
, vol.489
, Issue.7414
, pp. 57-74
-
-
Bernstein, B.E.1
Birney, E.2
Dunham, I.3
Green, E.D.4
Gunter, C.5
Snyder, M.6
-
63
-
-
84865800494
-
The long-range interaction landscape of gene promoters
-
Sanyal A, Lajoie B, Jain G, Dekker J. The long-range interaction landscape of gene promoters. Nature. 2012;489(7414):109-113.
-
(2012)
Nature.
, vol.489
, Issue.7414
, pp. 109-113
-
-
Sanyal, A.1
Lajoie, B.2
Jain, G.3
Dekker, J.4
-
64
-
-
84876806691
-
Dynamic regulatory network controlling TH17 cell differentiation
-
Yosef N, Shalek AK, Gaublomme JT, et al. Dynamic regulatory network controlling TH17 cell differentiation. Nature. 2013;496(7446):461-468.
-
(2013)
Nature.
, vol.496
, Issue.7446
, pp. 461-468
-
-
Yosef, N.1
Shalek, A.K.2
Gaublomme, J.T.3
-
65
-
-
84870350993
-
Understanding cancer mechanisms through network dynamics
-
Cheng TM, Gulati S, Agius R, Bates PA. Understanding cancer mechanisms through network dynamics. Brief Funct Genomics. 2012; 11(6):543-560.
-
(2012)
Brief Funct Genomics.
, vol.11
, Issue.6
, pp. 543-560
-
-
Cheng, T.M.1
Gulati, S.2
Agius, R.3
Bates, P.A.4
-
66
-
-
84876802476
-
DNA: Celebrate the unknowns
-
Ball P. DNA: celebrate the unknowns. Nature. 2013;496(7446): 419-420.
-
(2013)
Nature.
, vol.496
, Issue.7446
, pp. 419-420
-
-
Ball, P.1
-
67
-
-
84894091641
-
Genome network medicine: New diagnostics and predictive tools
-
Roukos DH. Genome network medicine: new diagnostics and predictive tools. Expert Rev Mol Diagn. 2013;13(7):643-646.
-
(2013)
Expert Rev Mol Diagn.
, vol.13
, Issue.7
, pp. 643-646
-
-
Roukos, D.H.1
-
68
-
-
84863922124
-
Comprehensive molecular characterization of human colon and rectal cancer
-
The Cancer Genome Atlas Research Network
-
The Cancer Genome Atlas Research Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature. 2012;487:330-337.
-
(2012)
Nature.
, vol.487
, pp. 330-337
-
-
-
69
-
-
77951115122
-
International network of cancer genome projects
-
International Cancer Genome Consortium
-
International Cancer Genome Consortium, Hudson TJ, Anderson W, Artez A, et al. International network of cancer genome projects. Nature. 2010;464(7291):993-998.
-
(2010)
Nature.
, vol.464
, Issue.7291
, pp. 993-998
-
-
Hudson, T.J.1
Anderson, W.2
Artez, A.3
|