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This paper presents a historical perspective and summarizes the current state of passive antibody therapy of infectious diseases, ••
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An anti-CD45RO immunotoxin kills HIV-latently infected cells from individuals on HAART with little effect on CD8 memory
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A study describes the targeting of certain subsets of CD45RO cells with a ricin A chain-armed antibody, •
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Saavedra-Lozano J, Cao Y, Callison J, Sarode R, Sodora D, Edgar J, Hatfield J, Picker L, Peterson D, Ramilo O, Vitetta ES: An anti-CD45RO immunotoxin kills HIV-latently infected cells from individuals on HAART with little effect on CD8 memory. Proc Natl Acad Sci USA (2004) 101(8):2494-2499. • A study describes the targeting of certain subsets of CD45RO cells with a ricin A chain-armed antibody.
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A study targeting viral envelope proteins on HIV-infected cells with antibodies armed with ricin A chain, •
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A study targeting viral envelope proteins on HIV-infected cells with antibodies armed with doxorubicin, •
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Johansson S, Goldenberg DM, Griffiths GL, Wahren B, Hinkula J: Elimination of HIV-1 infection by treatment with a doxorubicin-conjugated anti-envelope antibody. AIDS (2006) 20(15):1911-1915. • A study targeting viral envelope proteins on HIV-infected cells with antibodies armed with doxorubicin.
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Milenic DE, Brady ED, Brechbiel MW: Antibody-targeted radiation cancer therapy. Nat Rev Drug Discov (2004) 3(6):488-499. •• A detailed overview of the current status of cancer RIT.
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Milenic DE, Brady ED, Brechbiel MW: Antibody-targeted radiation cancer therapy. Nat Rev Drug Discov (2004) 3(6):488-499. •• A detailed overview of the current status of cancer RIT.
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Dadachova E, Casadevall A: Antibodies as delivery vehicles for radioimmunotherapy of infectious diseases. Expert Opin Drug Deliv (2005) 2(6):1075-1084. •• A detailed overview of the current status of RIT of infectious diseases.
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Dadachova E, Casadevall A: Antibodies as delivery vehicles for radioimmunotherapy of infectious diseases. Expert Opin Drug Deliv (2005) 2(6):1075-1084. •• A detailed overview of the current status of RIT of infectious diseases.
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Targeted killing of virally infected cells by radiolabeled antibodies to viral proteins
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A proof-of-principle study that established the utility of RIT against an experimental HIV-1 infection, ••
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Dadachova E, Patel MC, Toussi S, Apostolidis C, Morgenstern A, Brechbiel MW, Gorny MK, Zolla-Pazner S, Casadevall A, Goldstein H: Targeted killing of virally infected cells by radiolabeled antibodies to viral proteins. PLoS Med (2006) 3(11):e427. •• A proof-of-principle study that established the utility of RIT against an experimental HIV-1 infection.
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A proof-of-principle study showing the applicability of the RIT approach to the treatment of infectious diseases when microbes are targeted directly, ••
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Dadachova E, Nakouzi A, Bryan R, Casadevall A: Ionizing radiation delivered by specific antibody is therapeutic against a fungal infection. Proc Natl Acad Sci USA (2003) 100(19):10942-10947. •• A proof-of-principle study showing the applicability of the RIT approach to the treatment of infectious diseases when microbes are targeted directly.
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Dadachova E, Howell RW, Bryan RA, Frenkel A, Nosanchuk JD, Casadevall A: Susceptibility of the human pathogens fungi Cryptococcus neoformans and Histoplasma capsulatum to γ-radiation versus radioimmunotherapy with α- and β-emitting radioisotopes. J Nucl Med (2004) 45(2):313-320.
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The neutralizing antibody response to HIV-1: Viral evasion and escape from humoral immunity
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Targeting host cells harbouring viruses with radiolabeled antibodies
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Targeting the virus with radioimmunotherapy in virus-associated cancers
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•• A paper discussing the idea of treating virus-associated cancers with RIT directed to viral proteins expressed on cancer cells
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Dadachova E, Wang X-G, Casadevall A: Targeting the virus with radioimmunotherapy in virus-associated cancers. Cancer Biother Radiopharm (2007) 22(3):303-308. •• A paper discussing the idea of treating virus-associated cancers with RIT directed to viral proteins expressed on cancer cells.
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•• A proof-of-principle study demonstrating the feasibility of treating experimental virus-associated cancers with RIT directed to viral antigens expressed on cancer cells
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Wang X-G, Revskaya E, Bryan RA, Strickler HD, Burk RD, Casadevall A, Dadachova E: Treating cancer as an infectious disease - viral antigens as novel targets for treatment and potential prevention of tumors of viral etiology. PLOS One (2007) 2(10):e114. •• A proof-of-principle study demonstrating the feasibility of treating experimental virus-associated cancers with RIT directed to viral antigens expressed on cancer cells
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