Secretion and immunogenicity of the meningioma-associated antigen TXNDC16

Journal of Immunology

Volumn 193, Issue 6, 2014, Pages 3146-3154

  Harz, Christian ^a   Ludwig, Nicole ^a   Lang, Sven ^b   Werner, Tamara V ^a   Galata, Valentina ^a   Backes, Christina ^a   Schmitt, Katja ^a   Nickels, Ruth ^a   Krause, Elmar ^a   Jung, Martin ^a   Rettig, Jens ^a   Keller, Andreas ^a   Menger, Michael ^a   Zimmermann, Richard ^a   Meese, Eckart ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; EPITOPE; THIOREDOXIN DOMAIN CONTAINING 16 PROTEIN; TUMOR PROTEIN; UNCLASSIFIED DRUG; ANTIGEN ANTIBODY COMPLEX; MEMBRANE PROTEIN; TUMOR ANTIGEN; TXNDC16 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOSOL; EMBRYO; ENDOPLASMIC RETICULUM; EXOSOME; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOGENICITY; IN VITRO STUDY; MENINGIOMA; PROTEIN BLOOD LEVEL; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; BLOOD; HELA CELL LINE; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; SECRETION (PROCESS); TUMOR CELL LINE;

AMINO ACID SEQUENCE; ANTIGEN-ANTIBODY COMPLEX; ANTIGENS, NEOPLASM; AUTOANTIBODIES; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; EPITOPES; HELA CELLS; HUMANS; MEMBRANE GLYCOPROTEINS; MENINGIOMA; MOLECULAR SEQUENCE DATA;

EID: 84907081293     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1303098     Document Type: Article

References (52)

1. Dolecek, T. A., J. M. Propp, N. E. Stroup, and C. Kruchko. 2012. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005 -2009. Neuro-oncol. 14(Suppl 5): v1-v49
2. Kleihues, P., P. C. Burger, K. D. Aldape, D. J. Brat, W. Biernat, D. D. Bigner, Y. Nakazato, K. H. Pl ate, F. Giangaspero, A. von Deimlinge, et al. 2007. WHO Classificiation of Tumours of the Centra Nervous System. International Agency for Research on Cancer, Lyon
3. Comtesse, N., A. Zippel, S. Wall e, D. Monz, C. Backes, U. Fischer, J. Mayer, N. Ludwig, A. Hildebrandt, A. Keller, et al. 2005. Complex humoral immune response against a benign tumor: frequent antibody response against specific antigens as diagnostic targets. Proc. Natl. Acad. Sci. USA 102: 9601-9606.
4. Keller, A., N. Ludwig, N. Comtesse, A. Hildebrandt, E. Meese, and H. P. Lenhof. 2006. A minimally invasive multiple marker approach allows highly e fficient detection of meningioma tumors. BMC Bioinformatics 7: 539-548
5. Ludwig, N., A. Keller, S. Heisel, P. Leidinger, S. Rheinheimer, C. Andres, B. Stephan, W. I. Steudel, E. Donauer, N. Graf, et al. 2011. Novel immunogenic antigens increase classification accuracy in meningioma to 93.84%. Int. J. Cancer. 128: 1493-1501
6. Boon, T., P. G. Coulie, and B. Van den Eynde. 1997. Tumor antigens recognized by T cells. Immunol. Today 18: 267-268
7. Kirmiz, C., B. Li, H. J. An, B. H. Clowers, H. K. Chew, K. S. Lam, A. Ferrige, R. Alecio, A. D. Borowsky, S. Sulaimon, et al. 2007. A serum glycomics approach to breast cancer biomarkers. Mol. Cell. Proteomics 6: 43-55
8. Somasundaram, R., R. Swoboda, L. Caputo, L. Otvos, B. Weber, P. Volpe, P. van Belle, S. Hotz, D. E. Elder, F. M. Marincola, et al. 2006. Human leukocyte antigen-A2-restricted CTL responses to mutated BRAF peptides in melanoma patients. Cancer Res. 66: 3287-3293.
9. Uhlén M,E. Bjorling,C. Agaton,Szigyarto C.A.,B. Amini,E. Andersen,A.C. Andersson,P. Angelidou,A. Asplund,C. Asplund, et al, 2005. A human protein atlas for normal and cancer tissues based on antibody proteom ics. Mol. Cell. Proteomics 4, 1920-1932.
10. Barbe, L., E. Lundberg, P. Oksvold, A. Stenius, E. Lewin, E. Björling, A. Asplund, F. Pontén, H. Brismar, M. Uhlén, and H. Andersson-Svahn . 2008. Toward a confocal subcellular atlas of the human proteome. Mol. Cell. Proteomics 7: 499-508
11. Riemer, J., H. G. Hansen, C. Appenzeller-Herzog, L. Johansson, and L. Ellgaard. 2011. Identification of the PDI-family member ERp90 as an interaction partner of ERFAD. PLoS ONE 6: e17037
12. Zimmermann, R., S. Eyrisch, M. Ahmad, and V. Helms. 2011. Protein translocation across the ER membrane. Biochim. Biophys. Acta 1808: 912-924
13. Andres, D. A., I. M. Dickerson, and J. E. Dixon. 1990. Variants of the carboxylterminal KDEL sequence direct intracellular retention. J. Biol. Chem. 265: 5952-5955
14. Raykhel, I., H. Alanen, K. Salo, J. Jurvansuu, V. D. Nguyen, M. Latva-Ranta, and L. Ruddock. 2007. A molecular specificity code for the three mammalian KDEL receptors. J. Cell Biol. 179: 1193-1204
15. Lewis, M. J., and H. R. Pelham. 1990. A human homologue of the yeast HDEL receptor. Nature 348: 162-163
16. Lewis, M. J., and H. R. Pelham. 1992. Ligand-induced redistribution of a human KDEL receptor from the Golgi complex to the endoplasmic reticulum. Cell 68: 353-364
17. Orci, L., M. Stamnes, M. Ravazzola, M. Amherdt, A. Perrelet, T. H. Söllner, and J. E. Rothman. 1997. Bidirectional transport by distinct populations of COPIcoated vesicles. Cell 90: 335-349
18. Pelham, H. R. 1996. The dynamic organisation of the secretory pathway. Cell Struct. Funct. 21: 413-419
19. Gonzalez-Begne, M., B. Lu, X. Han, F. K. Hagen, A. R. Hand, J. E. Melvin, and J. R. Yates. 2009. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8: 1304-1314
20. Lotvall , J., and H. Valadi. 2007. Cell to cell signalling via exosomes through esRNA. Cell Adhes. Migr. 1: 156-158
21. Février, B., and G. Raposo. 2004. Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr. Opin. Cell Biol. 16: 415-421
22. Simpson, R. J., J. W. Lim, R. L. Moritz, and S. Mathivanan. 2009. Exosomes: proteomic insights and diagnostic potential. Expert Rev. Proteomics 6: 267-283
23. Nickel, W., and C. Rabouille. 2009. Mechanisms of regulated unconventional protein secretion. Nat. Rev. Mol. Cell Biol. 10: 148-155
24. Nickel, W., and M. Seedorf. 2008. Unconventional mechanisms of protein transport to the cell surface of eukaryotic cells. Annu. Rev. Cell Dev. Biol. 24: 287-308
25. Backes, C., N. Lud wig, P. Leidinger, C. Harz, J. Hoffmann, A. Keller, E. Meese, and H. P. Lenhof. 2011. Immunogenicity of autoantigens. BMC Genomics 12: 340-352
26. Daniels, T., J. Zhang, I. Gutierrez, M. L. Elliot, B. Yamada, M. J. Heeb, S. M. Sheets, X. Wu, and C. A. Casiano. 2005. Antinuclear autoantibodies in prostate cancer: immunity to LEDGF/p75, a survival protein highly expressed in prostate tumors and cleav ed during apoptosis. Prostate 62: 14-26
27. Keller, A., N. Ludwig, N. Comtesse, W. Henn, W. I. Steudel, H. P. Lenhof, and E. Meese. 2009. Combining gene expression signatures and autoantibody profiles in human meningioma. Gene Ther. 16: 184-189
28. Schulman, S., B. Wang, W. Li, and T. A. Rapoport. 2010. Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners. Proc. Natl. Acad. Sci. USA 107: 15027-15032
29. Watts, C., W. Wickner, and R. Zimmermann. 1983. M13 procoat and a preimmunoglobulin share processing specificity but use different membrane receptor mechanisms. Proc. Natl. Acad. Sci. USA 80: 2809-2813
30. Tanudji, M., S. Hevi, and S. L. Chuck. 2002. Improperly folded green fluorescent protein is secreted via a non-classical pathway. J. Cell Sci. 115: 3849-3857.
31. Escola J.M.,M.J. Kleijmeer,W. Stoorvogel,J.M. Griffith,O. Yoshie,H.J. Geuze, 1998, Selective enrichment of tetraspan proteins on the internal vesicles of mul tivesicular endosomes and on exosomes secreted by human Blymphocytes, J. Biol. Chem, 273, 20121-20127.
32. Heijnen, H. F., A. E. Schiel, R. Fijnheer, H. J. Geuze, and J. J. Sixma. 1999. Activ ated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules. Blood 94: 3791-3799
33. Uhlen, M., P. Oksvold , L. Fagerberg, E. Lundberg, K. Jonasson, M. Forsberg, M. Zwahlen, C. Kampf, K. Wester, S. Hober, et al. 2010. Towards a knowledgebased Human Protein Atlas. Nat. Biotechnol. 28: 1248-1250
34. Yamazaki, T., Y. Miyazawa, A. Kobayashi, T. Moriwaki, N. Fujii, and H. Takahashi. 2012. MIZ1, an essential protein for root hydrotropism, is associated with the cytoplasmic face of the endoplasmic reticulum membrane in Arabidopsis root cells. FEBS Lett. 586: 398-402
35. Kaji, H., J. Kamiie, H. Kawakami, K. Kido, Y. Yamauchi, T. Shinkawa, M. Taoka, N. Takahashi, and T. Isobe. 2007. Proteomics re veals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins. Mol. Cell. Proteomics 6: 2100-2109
36. Kaji, H., Y. Yamauchi, N. Ta kahashi, and T. Isobe. 2006. Mass spectrometric identification of N-linked glycopeptides using lectin-mediated affinity capture and glycosylation site-specific stable isotope tagging. Nat. Protoc. 1: 3019-3027
37. Sato, Y., Y. Suzuki, E. Ito, S. Shimazaki, M. Ishida, T. Yamamoto, H. Yamamoto, T. Toda, M. Suzuki, A. Suzuki, and T. Endo. 2006. Identification and characterization of an increased glyco protein in aging: age-associated translocation of cathepsin D. Mech. Ageing Dev. 127: 771-778
38. Zhang, H., J. K. Kim, C. A. Edwards, Z. Xu, R. Taichman, and C. Y. Wang. 2005. Clusterin inhibits apoptosis by interacting with activated Bax. Nat. Cell Biol. 7: 909-915
39. Riemer, J., C. Appenzeller-Herzog, L. Johansson, B. Bodenmiller, R. Hartmann-Petersen, and L. Ellgaard. 2009. A luminal flavoprotein in endoplasmic reticulumassociated degradation. Proc. Natl. Acad. Sci. USA 106: 14831-14836
40. Bays, N. W., R. G. Gardner, L. P. Seelig, C. A. Joazeiro, and R. Y. Hampton. 2001. Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ERassociated degradation. Nat. Cell Biol. 3: 24-29
41. Chen, B., J. Mariano, Y. C. Tsai, A. H. Chan, M. Cohen, and A. M. Weissman. 2006. The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site. Proc. Natl. Acad. Sci. USA 103: 341-346
42. Grove, D. E., C. Y. Fan, H. Y. Ren, and D. M. Cyr. 2011. The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508. Mol. Biol. Cell 22: 301-314
43. Swanson, R., M. Locher, and M. Hochstrasser. 2001. A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ERassociated and Matalpha2 repressor degradatio n. Genes Dev. 15: 2660-2674
44. Brodsky, J. L. 2012. Cleaning up: ER-associated degradation to the rescue. Cell 151: 1163-1167
45. Hampton, R. Y., and T. Sommer. 2012. Finding the will and the way of ERAD substrate retrotranslocation. Curr. Opin. Cell Biol. 24: 460-466
46. Graner, M. W., O. Alzate, A. M. Dechkovskaia, J. D. Keene, J. H. Sampson, D. A. Mitchell, and D. D. Bigner. 2009. Proteomic and immunologic analyses of brain tumor exosomes. FASEB J. 23: 1541-1557
47. Valadi, H., K. Ekströ m, A. Bossios, M. Sjöstrand, J. J. Lee, and J. O. Lö tvall. 2007. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 9: 654-659
48. Rousselet, E., S. Benjannet, J. Hamelin, M. Canuel, and N. G. Seidah. 2011. The proprotein convertase PC7: unique zymogen activation and trafficking pathways. J. Biol. Chem. 286: 2728-2738
49. Hilgers, J., S. von Mensdorff-Pouilly, A. A. Verstraeten, and P. Kenemans. 1995. Quantitation of polymorphic epithelial mucin: a challenge for biochemists and immunologists. Scand. J. Clin. Lab. Invest. Suppl. 221: 81-86
50. Richards, E. R., P. L. Devine , R. J. Quin, J. D. Fontenot, B. G. Ward, and M. A. McGuckin. 1998. Antibodies reactive with the protein core of MUC1 mucin are present in ovarian cancer patients and healthy women. Cancer Immunol. Immunother. 46: 245-252
51. Plotz, P. H. 2003. The autoantibody repertoire: searching for order. Nat. Rev. Immunol. 3: 73-78.
52. Zeng G.,M. E. Aldridge,Y. Wang,A. J. Pantuck,A. Y. Wang,Y. X. Liu,Y. Han,Y. H. Yuan,P. F. Robbins,S. M. Dubinett,et al, 2005, Dominant B cell epitope from NY-ESO-1 recognized b y sera from a wide spectrum of cancer patients: implications as a potential biomarker, Int. J. Cancer,114, 268-273.