Novel immunogenic antigens increase classification accuracy in meningioma to 93.84%

International Journal of Cancer

Volumn 128, Issue 6, 2011, Pages 1493-1501

  Ludwig, Nicole ^a   Keller, Andreas ^b   Heisel, Sabrina ^a   Leidinger, Petra ^a   Rheinheimer, Stefanie ^a   Andres, Claudia ^b   Stephan, Bernhard ^a   Steudel, Wolf Ingo ^a   Donauer, Erich ^c   Graf, Norbert ^a   Burgeth, Bernhard ^b   Weickert, Joachim ^b   Lenhof, Hans Peter ^b   Meese, Eckart ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c Department of Neurosurgery   (Germany)

Author keywords

antigens; brain tumor; diagnosis; meningioma; tumor marker

Indexed keywords

ANTIGEN; AUTOANTIBODY;

ADULT; AGED; ANTIGEN ANTIBODY REACTION; ANTIGEN DETECTION; ANTIGEN EXPRESSION; AREA UNDER THE CURVE; ARTICLE; CANCER CLASSIFICATION; CANCER SCREENING; CHILD; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; GLIOBLASTOMA; GLIOMA; HUMAN; IMMUNOGENICITY; MAJOR CLINICAL STUDY; MENINGIOMA; PRESCHOOL CHILD; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, NEOPLASM; AUTOANTIBODIES; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FEMALE; GENE LIBRARY; GLIOMA; HUMANS; MALE; MENINGEAL NEOPLASMS; MENINGIOMA; MIDDLE AGED; PROGNOSIS; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 79551505082     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25467     Document Type: Article

References (40)

1. Perry A, Louis DN, Scheithauer BW, Budka H, von Deimling A,. Meningiomas. In:, Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, eds. WHO Classification of Tumors of the Central Nervous System. Lyon: IARC press, 2007; 164-172.
2. Harada T, Irving RM, Xuereb JH, Barton DE, Hardy DG, Moffat DA, Maher ER,. Molecular genetic investigation of the neurofibromatosis type 2 tumor suppressor gene in sporadic meningioma. J Neurosurg 1996; 84: 847-51.
3. Ruttledge MH, Sarrazin J, Rangaratnam S, Phelan CM, Twist E, Merel P, Delattre O, Thomas G, Nordenskjöld M, Collins VP, Dumanski JP, Rouleau GA,. Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomas. Nat Genet 1994: 6: 180-4.
4. Wellenreuther R, Kraus JA, Lenartz D, Menon AG, Schramm J, Louis DN, Ramesh V, Gusella JF, Wiestler OD, von Deimling A,. Analysis of the neurofibromatosis 2 gene reveals molecular variants of meningioma. Am J Pathol 1995: 146: 827-32.
5. Campbell BA, Jhamb A, Maguire JA, Toyota B, Ma R,. Meningiomas in 2009: controversies and future challenges. Am J Clin Oncol 2009; 32: 73-85.
6. Peyrard M, Fransson I, Xie YG, Han FY, Ruttledge MH, Swahn S, Collins JE, Dunham I, Collins VP, Dumanski JP,. Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene. Hum Mol Genet 1994; 3: 1393-9.
7. Peyrard M, Seroussi E, Sandberg-Nordqvist AC, Xie YG, Han FY, Fransson I, Collins J, Dunham I, Kost-Alimova M, Imreh S, Dumanski JP,. The human LARGE gene from 22q12.3-q13.1 is a new, distinct member of the glycosyltransferase gene family. Proc Natl Acad Sci USA 1999; 96: 598-603.
8. Schmitz U, Mueller W, Weber M, Sévenet N, Delattre O, von Deimling A,. INI1 mutations in meningiomas at a potential hotspot in exon 9. Br J Cancer 2001; 84: 199-201.
9. Lekanne Deprez RH, Riegman PH, Groen NA, Warringa UL, van Biezen NA, Molijn AC, Bootsma D, de Jong PJ, Menon AG, Kley NA, et al. Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma. Oncogene 1995; 10: 1521-8.
10. Perry A, Gutmann DH, Reifenberger G,. Molecular pathogenesis of meningiomas. J Neurooncol 2004; 70: 183-202.
11. Perry A, Banerjee R, Lohse CM, Kleinschmidt-DeMasters BK, Scheithauer BW,. A role for chromosome 9p21 deletions in the malignant progression of meningiomas and the prognosis of anaplastic meningiomas. Brain Pathol 2002; 12: 183-90.
12. Boström J, Meyer-Puttlitz B, Wolter M, Blaschke B, Weber RG, Lichter P, Ichimura K, Collins VP, Reifenberger G,. Alterations of the tumor suppressor genes CDKN2A (p16(INK4a)), p14(ARF), CDKN2B, (p15(INK4b)), and CDKN2C (p18(INK4c)) in atypical and anaplastic meningiomas. Am J Pathol 2001; 159: 661-9.
13. Korshunov A, Shishkina L, Golanov A,. Immunohistochemical analysis of p16INK4a, p14ARF, p18INK4c, p21CIP1, p27KIP1 and p73 expression in 271 meningiomas correlation with tumor grade and clinical outcome. Int J Cancer 2003; 104: 728-34.
14. Zhang X, Gejman R, Mahta A, Zhong Y, Rice KA, Zhou Y, Cheunsuchon P, Louis DN, Klibanski A,. Maternally expressed gene 3, an imprinted noncoding RNA gene, is associated with meningioma pathogenesis and progression. Cancer Res 2010; 70: 2350-8.
15. Casiano CA, Mediavilla-Varela M, Tan EM,. Tumor-associated antigen arrays for the serological diagnosis of cancer. Mol Cell Proteomics 2006; 5: 1745-59.
16. Sahin U, Tureci O, Schmitt H,. Human neoplasms elicit multiple specific immune responses in the autologous host. Proc Natl Acad Sci USA 1995; 92: 11810-3.
17. Bonnycastle LLC, Mehroke JS, Rashed M, Gong X, Scott JK,. Probing the basis of antibody reactivity with a panel of constrained peptide libraries displayed by filamentous phage. J Mol Biol 1996; 258: 747-62.
18. Wang X, Yu J, Sreekumar A, Varambally S, Shen R, Giacherio D, Mehra R, Montie JE, Pienta KJ, Sanda MG, Kantoff PW, Rubin MA, et al. Autoantibody signatures in prostate cancer. N Engl J Med 2005; 353: 1224-35.
19. Chen G, Wang X, Yu J, Varambally S, Yu J, Thomas DG, Lin MY, Vishnu P, Wang Z, Wang R, Fielhauer J, Ghosh D, et al. Autoantibody profiles reveal ubiquitin 1 as a humoral immune response target in lung adenocarcinoma. Cancer Res 2007; 67: 3461-7.
20. Zhong L, Hidalgo GE, Stromberg AJ, Khattar NH, Jett JR, Hirschowitz EA,. Using protein microarray as a diagnostic assay for non-small cell lung cancer. Am J Respir Crit Care Med 2005; 172: 1308-14.
21. Chatterjee M, Mohapatra S, Ionan A, Bawa G, Ali-Fehmi R, Wang X, Nowak J, Ye B, Nahhas FA, Lu K, Witkin SS, Fishman D, et al. Diagnostic markers of ovarian cancer by high-throughput antigen cloning and detection on arrays. Cancer Res 2006; 66: 1181-90.
22. Erkanli A, Taylor DD, Dean D, Eksir F, Egger D, Geyer J, Nelson BH, Stone B, Fritsche HA, Roden RB,. Application of Bayesian modeling of autologous antibody responses against ovarian tumor-associated antigens to cancer detection. Cancer Res 2006; 66: 1792-8.
23. Fischer U, Struss AK, Hemmer D, Pallasch CP, Steudel WI, Meese E,. Glioma-expressed antigen 2 (GLEA2): a novel protein that can elicit immune responses in glioblastoma patients and some controls. Clin Exp Immunol 2001; 126: 206-13.
24. Struss AK, Romeike BF, Munnia A, Nastainczyk W, Steudel WI, König J, Ohgaki H, Feiden W, Fischer U, Meese E,. PHF3-specific antibody responses in over 60% of patients with glioblastoma multiforme. Oncogene 2001; 12: 4107-14.
25. Comtesse N, Niedermayer I, Glass B, Heckel D, Maldener E, Nastainczyk W, Feiden W, Meese E,. MGEA6 is tumor-specific overexpressed and frequently recognized by patient-serum antibodies. Oncogene 2002; 21: 239-47.
26. Comtesse N, Zippel A, Walle S, Monz D, Backes C, Fischer U, Mayer J, Ludwig N, Hildebrandt A, Keller A, Steudel WI, Lenhof HP, et al. Complex humoral immune response against a benign tumor: Frequent antibody response against specific antigens as diagnostic targets. Proc Natl Acad Sci USA 2005; 102: 9601-6.
27. Bauer C, Diesinger I, Brass N, Steinhart H, Iro H, Meese EU,. Translation initiation factor eIF-4G is immunogenic, overexpressed, and amplified in patients with squamous cell lung carcinoma. Cancer 2001; 92: 822-9.
28. Keller A, Ludwig N, Comtesse N, Hildebrandt A, Meese E, Lenhof HP,. A minimally invasive multiple marker approach allows highly efficient detection of meningioma tumors. BMC Bioinformatics 2006; 7: 539.
29. Leidinger P, Keller A, Ludwig N, Rheinheimer S, Hamacher J, Huwer H, Stehle I, Lenhof HP, Meese E,. Toward an early diagnosis of lung cancer: an autoantibody signature for squamous cell lung carcinoma. Int J Cancer 2008; 123: 1631-6.
30. Ludwig N, Keller A, Comtesse N, Rheinheimer S, Pallasch C, Fischer U, Fassbender K, Steudel WI, Lenhof HP, Meese E,. Pattern of serum autoantibodies allows accurate distinction between a tumor and pathologies of the same organ. Clin Cancer Res 2008; 14: 4767-74.
31. Ludwig N, Keller A, Heisel S, Leidinger P, Klein V, Rheinheimer S, Andres C, Stephan B, Steudel WI, Graf N, Burgeth B, Weickert J, et al. Improving Seroreactivity-Based Detection of Glioma. Neoplasia 2009; 11: 1383-9.
32. Büssow K, Cahill D, Nietfeld W, Bancroft D, Scherzinger E, Lehrach H, Walter G,. A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. Nucleic Acids Res 1998; 26: 5007-8.
33. Leidinger P, Keller A, Heisel S, Ludwig N, Rheinheimer S, Klein V, Andres C, Hamacher J, Huwer H, Stephan B, Stehle I, Lenhof HP, et al. Novel autoantigens immunogenic in COPD patients. Respiratory Research 2009; 10: 20.
34. Soille P,. Morphological image analysis. New York: Springer, 2006.
35. Bolstad BM, Irizarry RA, Astrand M, Speed TP,. A Comparison of Normalization Methods for High Density Oligonucleotide Array Data Based on Bias and Variance. Bioinformatics 2003; 19: 185-93.
36. Heckel D, Brass N, Fischer U, Blin N, Steudel I, Türeci O, Fackler O, Zang KD, Meese E,. cDNA cloning and chromosomal mapping of a predicted coiled-coil proline-rich protein immunogenic in meningioma patients. Hum Mol Genet 1997; 6: 2031-41.
37. Heckel D, Comtesse N, Brass N, Blin N, Zang KD, Meese E,. Novel immunogenic antigen homologous to hyaluronidase in meningioma. Hum Mol Genet 1998; 7: 1859-72.
38. Comtesse N, Maldener E, Meese E,. Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase. Biochem Biophys Res Commun 2001; 283: 634-40.
39. Comtesse N, Heckel D, Rácz A, Brass N, Glass B, Meese E,. Five novel immunogenic antigens in meningioma: cloning, expression analysis, and chromosomal mapping. Clin Cancer Res 1999; 5: 3560-8.
40. Ramachandran N, Hainsworth E, Bhullar B, Eisenstein S, Rosen B, Lau AY, Walter JC, LaBaer J,. Self-assembling protein microarrays. Science 2004; 305: 86-90.