Antibodies reactive with the protein core of MUC1 mucin are present in ovarian cancer patients and healthy women

Cancer Immunology Immunotherapy

Volumn 46, Issue 5, 1998, Pages 245-252

  Richards, Elizabeth R ^a   Devine, Peter L ^a   Quin, Rachel J ^a   Fontenot, J Darrell ^b   Ward, Bruce G ^a   McGuckin, Michael A ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b POPULATION COUNCIL   (United States)

Author keywords

Antibodies; Immune complexes; MUC1; Mucin; Ovarian cancer

Indexed keywords

ANTIBODY; MUCIN;

ADULT; ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; OVARY CANCER; PREGNANCY; PRIORITY JOURNAL; TANDEM REPEAT;

AMINO ACID SEQUENCE; ANTIBODIES; ANTIBODIES, NEOPLASM; ANTIBODY SPECIFICITY; ANTIGEN-ANTIBODY COMPLEX; ANTIGENS, NEOPLASM; CA-15-3 ANTIGEN; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; HUMANS; IMMUNOGLOBULIN M; MOLECULAR SEQUENCE DATA; OVARIAN DISEASES; OVARIAN NEOPLASMS; PREGNANCY; PROGNOSIS; REPETITIVE SEQUENCES, NUCLEIC ACID;

EID: 0031873942     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050484     Document Type: Article

References (28)

1. Agrawal B, Reddish MA, Krantz MJ, Longenecker BM (1995) Does pregnancy immunize against breast cancer. Cancer Res 55:2257-2261
2. Apostolopoulos V, Karanikas V, Haurum JS, McKenzie IFC (1997) Induction of HLA-A2 resticted CTLs to the mucin 1 human breast cancer antigen. J Immunol 159:5211-5218
3. Devine PL, Yarker JY, Fong KM, McGuckin MA, Scells B, Ward BG, Thynne GS, Zimmerman PV (1994) Serum markers CASA, CEA, CYFRA 21-1, MSA, NSE, TPA and TPS in lung cancer. Int J Oncol 4:1129-1135
4. Domenech N, Henderson RA, Finn OJ (1995) Identification of an HLA-A11-restricted epitope from the tandem repeat domain of the epithelial tumor antigen mucin. J Immunol 155:4766-4774
5. Finn OJ, Jerome KR, Henderson RA, Pecher G, Domenech N, Barrattboyes SM (1995) MUC-1 epithelial tumor mucin-based immunity and cancer vaccines (review) Immunol Rev 145:61-89
6. Fontenot JD, Finn OJ, Dales N, Andrews PC, Montelaro RC (1993) Synthesis of large multideterminant peptide immunogens using a poly-proline β-turn helix motif. Peptide Res 6:330-336
7. Fontenot JD, Mariappan SVS, Catasti P, Domenech N, Finn OJ, Gupta G (1995) Structure of a tumor associated antigen containing a tandemly repeated immunodominant epitope. J Biomol Struct Dyn 13:245-260
8. Gendler SJ, Spicer AP, Lalani EN, Duhig T, Peat N, Burchell J, Pemberton L, Boshell M, Taylor-Papadimitriou J (1991) Structure and biology of a carcinoma-associated mucin, MUC1. Am Rev Respir Dis 144:S42-S47
9. Gourevitch MM, von Mensdorff-Pouilly S, Litvinov SV, Kenmans P, Vankamp GJ, Verstraeten M, Hilgers J (1995) Polymorphic epithelial mucin (MUC-1)-containing circulating immune complexes in carcinoma patients. Br J Cancer 72:934-938
10. Goydos JS, Elder E, Whiteside TL, Finn OJ, Lotze MT (1996) A phase I trial of a synthetic mucin peptide vaccine. Induction of specific immune reactivity in patients with adenocarcinoma. J Surg Res 63:298-304
11. Hilgers J, Mensdorff Pouilly S von, Verstraeten AA, Kenemans P (1995) Quantitation of polymorphic epithelial mucin: a challenge for biochemists and immunologists. Scand J Clin Lab Invest 55 [Suppl 221]:81-86
12. Ioannides CG, Fisk B, Jerome KR, Irimura T, Wharton JT, Finn OJ (1993) Cytotoxic T cells from ovarian malignant tumors can recognize polymorphic epithelial inucin core peptides. J Immunol 151:3693-3703
13. Kotera Y, Fontenot JD, Pecher G, Metzgar RS, Finn OJ (1994) Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients. Cancer Res 54:2856-2860
14. Longenecker BM, Reddish M, Koganty R, MacLean GD (1994) Specificity of the IgG response in mice and human breast cancer patients following immunization against synthetic sialyl-Tn, an epitope with possible functional significance in metastasis. Adv Exp Med Biol 353:105-124
15. MacLean GD, Reddish M, Koganty RR, Wong T, Gandhi S, Smolenski M, Samuel J, Nabholtz, JM, Longenecker BM (1993) Immunization of breast cancer patients using a synthetic sialyl-Tn glycoconjugate plus Detox adjuvant. Cancer Immunol Immunother 36:215-222
16. McGuckin MA, Ramm LE, Joy GJ, Devine PL, Ward BG (1993) Circulating tumour-associated mucin concentrations, determined by the CASA assay, in healthy women. Clin Chim Acta 214:139-151
17. McGuckin MA, Devine PL, Ramm LE, Ward BG (1994) Factors effecting the measurement of tumor-associated MUC1 mucins in serum. Tumor Biol 15:33-44
18. McGuckin MA, Hurst TG, Ward BG (1995) Heterogeneity in production, secretion and glycosylation of MUC1 epithelial mucin by primary cultures of ovarian carcinoma. Int J Cancer 63:412-418
19. Mensdorff-Pouilly S von, Gourevitch MM, Kenemans P, Verstraeten AA, Litvinov SV, van Kamp GJ, Meijer S, Vermorken J, Hilgers J (1996) Humoral immune response to polymorphic epithelial mucin (MUC-1) in patients with benign and malignant breast tumours. Eur J Cancer 32A:1325-1331
20. Rughetti A, Turchi V, Ghetti CA, Scambia G, Panici PB, Roncucci G, Mancuso S, Frati L, Nuti M (1993) Human B-cell immune response to the polymorphic epithelial mucin. Cancer Res 53:2457-2459
21. Sandrin MS, Vaughan HA, Xing PX, McKenzie IFC (1997) Natural human anti-Galα (1,3)Gal antibodies react with human mucin peptides. Glycoconj J 14:97-105
22. Wesseling J, Vandervalk SW, Vos HL, Sonnenberg A, Hilkens J (1995) Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components. J Cell Biol 129:255-265
23. Wesseling J, van der Valk SW, Hilkens J (1996) A mechanism for inhibition of E-cadherin-mediated cell-cell adhesion by the membrane-associated mucin episialin/MUC1. Mol Biol Cell 7:565-577
24. Wiel van Kemenade E van de, Ligtenberg MJ, Boer AJ de, Buijs F, Vos HL, Melief CJ, Hilkens J, Figdor CG (1993) Episialin (MUC1) inhibits cytotoxic lymphocyte-target cell interaction. J Immunol 151:767-776
25. Woods LK, Morgan RT, Quinn LA, Moore GE, Semple TU, Stedman KE (1979) Comparison of four new cell lines from patients with adenocarcinoma of the ovary. Cancer Res 39:4449-4459
26. Xing PX, Reynolds K, Tjandra JJ, Tang XL, McKenzie IF (1990) Synthetic peptides reactive with anti-human milk fat globule membrane monoclonal antibodies. Cancer Res 50:89-96
27. Xing PX, Michael M, Apostolopoulos V, Prenzoska J, Marshall C, Bishop J, McKenzie IFC (1995) Phase I study of synthetic muc1 peptides in breast cancer. Int J Oncol 6:1283-1289
28. Zotter S, Hageman PC, Lossnitzer A, Mooi WJ, Hilgers J (1988) Tissue and tumor distribution of human polymorphic epithelial mucin. Cancer Rev 11-12:55-101