DNA methylation-mediated silencing of matricellular protein dermatopontin promotes hepatocellular carcinoma metastasis by a3β1 integrin-Rho GTPase signaling

Oncotarget

Volumn 5, Issue 16, 2014, Pages 6701-6715

  Fu, Ying ^a   Feng, Ming Xuan ^b   Yu, Jian ^a   Ma, Ming Ze ^a   Liu, Xiao Jin ^a,c   Li, Jun ^a   Yang, Xiao Mei ^a   Wang, Ya Hui ^a   Zhang, Yan Li ^a   Ao, Jun Ping ^a   Xue, Feng ^b   Qin, Wenxin ^a   Gu, Jianren ^a   Xia, Qiang ^b   Zhang, Zhi Gang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

Author keywords

a3 1 integrin; Dermatopontin; Hepatocellular carcinoma; Metastasis; Methylation; Patient prognosis

Indexed keywords

DERMATOPONTIN; FOCAL ADHESION KINASE; PROTEIN KINASE P60; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; TUMOR PROTEIN; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 3; DPT PROTEIN, HUMAN; PROTEOCHONDROITIN SULFATE; SCLEROPROTEIN;

ADOLESCENT; ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER PROGNOSIS; CANCER STAGING; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA METHYLATION; DOWN REGULATION; ENZYME PHOSPHORYLATION; EPIGENETICS; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; LIVER CELL CARCINOMA; LIVER METASTASIS; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR DIFFERENTIATION; TUMOR MICROENVIRONMENT; TUMOR PROMOTION; TUMOR VOLUME; ANIMAL; BAGG ALBINO MOUSE; CELL PROLIFERATION; GENETICS; LIVER TUMOR; METABOLISM; METASTASIS; MIDDLE AGED; NUDE MOUSE; PATHOLOGY; PHOSPHORYLATION; PROGNOSIS; TUMOR CELL LINE; XENOGRAFT; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; CHONDROITIN SULFATE PROTEOGLYCANS; DNA METHYLATION; EXTRACELLULAR MATRIX PROTEINS; HETEROGRAFTS; HUMANS; INTEGRIN ALPHA3BETA1; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MIDDLE AGED; NEOPLASM METASTASIS; PHOSPHORYLATION; PROGNOSIS; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; YOUNG ADULT;

EID: 84907064970     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2239     Document Type: Article

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