Metabolome analysis based on capillary electrophoresis-mass spectrometry

TrAC - Trends in Analytical Chemistry

Volumn 61, Issue , 2014, Pages 215-222

  Hirayama, Akiyoshi ^a   Wakayama, Masataka ^a   Soga, Tomoyoshi ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Capillary electrophoresis; CE MS; Energy metabolism; Mass spectrometry; Metabolite identification; Metabolome analysis; Metabolomics; Sample pretreatment; Separation; Sheathless interface

Indexed keywords

CAPILLARY ELECTROPHORESIS; DATA HANDLING; METABOLISM; METABOLITES; SEPARATION;

ENERGY METABOLISM; METABOLITE IDENTIFICATION; METABOLOME ANALYSIS; METABOLOMICS; SAMPLE PRETREATMENT;

MASS SPECTROMETRY;

PROTEOME;

CAPILLARY ELECTROPHORESIS; CHEMICAL ANALYSIS; ELECTROOSMOSIS; ELECTROSPRAY; GAS CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; INFRARED SPECTROSCOPY; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; MASS SPECTROMETRY; METABOLOME; METABOLOMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REVIEW; SOLID PHASE EXTRACTION;

EID: 84907016229     PISSN: 01659936     EISSN: 18793142     Source Type: Journal    
DOI: 10.1016/j.trac.2014.05.005     Document Type: Review

References (76)

1. Villas-BOˆas S.G., Mas S., A˚kesson M., Smedsgaard J., Nielsen J. Mass spectrometry in metabolome analysis. Mass Spectrom. Rev 2005, 24:613-646.
2. Wishart D.S., Jewison T., Guo A.C., Wilson M., Knox C., Liu Y., et al. HMDB 3.0 - the human metabolome database in 2013. Nucleic Acids Res 2013, 41:D801-D807.
3. Barbas C., Moraes E.P., Villasenor A. Capillary electrophoresis as a metabolomics tool for non-targeted fingerprinting of biological samples. J. Pharm. Biomed. Anal 2011, 55:823-831.
4. Scalbert A., Brennan L., Fiehn O., Hankemeier T., Kristal B.S., van Ommen B., et al. Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research. Metabolomics 2009, 5:435-458.
5. Becker S., Kortz L., Helmschrodt C., Thiery J., Ceglarek U. LC-MS-based metabolomics in the clinical laboratory. J. Chromatogr. B 2012, 883:68-75.
6. Harder U., Koletzko B., Peissner W. Quantification of 22 plasma amino acids combining derivatization and ion-pair LC-MS/MS. J. Chromatogr. B 2011, 879:495-504.
7. Cubbon S., Antonio C., Wilson J., Thomas-Oates J. Metabolomic applications of hilic-lc-ms. Mass Spectrom. Rev 2010, 29:671-684.
8. Kloepfer A., Quintana J.B., Reemtsma T. Operational options to reduce matrix effects in liquid chromatography-electrospray ionization-mass spectrometry analysis of aqueous environmental samples. J. Chromatogr. A 2005, 1067:153-160.
9. Monton M.R., Soga T. Metabolome analysis by capillary electrophoresis-mass spectrometry. J. Chromatogr. A 2007, 1168:237-246.
10. Kim H.K., Choi Y.H., Verpoorte R. NMR-based plant metabolomics: where do we stand, where do we go?. Trends Biotechnol 2011, 29:267-275.
11. Ramautar R., Mayboroda O.A., Somsen G.W., de Jong G.J. CE-MS for metabolomics: developments and applications in the period 2008-2010. Electrophoresis 2011, 32:52-65.
12. Ramautar R., Somsen G.W., de Jong G.J. CE-MS in metabolomics. Electrophoresis 2009, 30:276-291.
13. Ramautar R., Somsen G.W., de Jong G.J. CE-MS for metabolomics: developments and applications in the period 2010-2012. Electrophoresis 2013, 34:86-98.
14. Soga T., Heiger D.N. Amino acid analysis by capillary electrophoresis electrospray ionization mass spectrometry. Anal. Chem 2000, 72:1236-1241.
15. Sawada H., Nogami C. Capillary electrophoresis-electrospray ionization mass spectrometry using uncoated fused-silica capillaries and alkaline buffer solution for the analysis of small carboxylic acids. Anal. Chim. Acta 2004, 507:191-198.
16. Soga T., Ueno Y., Naraoka H., Ohashi Y., Tomita M., Nishioka T. Simultaneous determination of anionic intermediates for Bacillus subtilis metabolic pathways by capillary electrophoresis electrospray ionization mass spectrometry. Anal. Chem 2002, 74:2233-2239.
17. Harada K., Fukusaki E., Kobayashi A. Pressure-assisted capillary electrophoresis mass spectrometry using combination of polarity reversion and electroosmotic flow for metabolomics anion analysis. J. Biosci. Bioeng 2006, 101:403-409.
18. Huhn C., Ramautar R., Wuhrer M., Somsen G.W. Relevance and use of capillary coatings in capillary electrophoresis-mass spectrometry. Anal. Bioanal. Chem 2010, 396:297-314.
19. Soga T., Igarashi K., Ito C., Mizobuchi K., Zimmermann H.P., Tomita M. Metabolomic profiling of anionic metabolites by capillary electrophoresis mass spectrometry. Anal. Chem 2009, 81:6165-6174.
20. Hirayama A., Kami K., Sugimoto M., Sugawara M., Toki N., Onozuka H., et al. Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. Cancer Res 2009, 69:4918-4925.
21. Hirayama A., Nakashima E., Sugimoto M., Akiyama S.-I., Sato W., Maruyama S., et al. Metabolic profiling reveals new serum biomarkers for differentiating diabetic nephropathy. Anal. Bioanal. Chem 2012, 404:3101-3109.
22. Soga T., Baran R., Suematsu M., Ueno Y., Ikeda S., Sakurakawa T., et al. Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. J. Biol. Chem 2006, 281:16768-16776.
23. Soga T., Ohashi Y., Ueno Y., Naraoka H., Tomita M., Nishioka T. Quantitative metabolome analysis using capillary electrophoresis mass spectrometry. J. Proteome Res 2003, 2:488-494.
24. Ding J., Vouros P. Advances in CE/MS. Anal. Chem 1999, 71:378A-385A.
25. Ohnesorge J., Sanger-van de Griend C., Watzig H. Quantification in capillary electrophoresis-mass spectrometry: long- and short-term variance components and their compensation using internal standards. Electrophoresis 2005, 26:2360-2375.
26. Smith R.D., Barinaga C.J., Udseth H.R. Improved electrospray ionization interface for capillary zone electrophoresis-mass spectrometry. Anal. Chem 1988, 60:1948-1952.
27. Sanz-Nebot V., Benavente F., Balaguer E., Barbosa J. Capillary electrophoresis coupled to time of flight-mass spectrometry of therapeutic peptide hormones. Electrophoresis 2003, 24:883-891.
28. Krenkova J., Foret F. On-line CE/ESI/MS interfacing: recent developments and applications in proteomics. Proteomics 2012, 12:2978-2990.
29. Mokaddem M., Gareil P., Belgaied J., Varenne A. New insight into suction and dilution effects in CE coupled to MS via an ESI interface. II-Dilution effect. Electrophoresis 2009, 30:1692-1697.
30. Moini M. Capillary electrophoresis mass spectrometry and its application to the analysis of biological mixtures. Anal. Bioanal. Chem 2002, 373:466-480.
31. Maxwell E.J., Zhong X., Zhang H., van Zeijl N., Chen D.D. Decoupling CE and ESI for a more robust interface with MS. Electrophoresis 2010, 31:1130-1137.
32. Lindenburg P.W., Ramautar R., Jayo R.G., Chen D.D., Hankemeier T. Capillary electrophoresis-mass spectrometry using a flow-through microvial interface for cationic metabolome analysis. Electrophoresis 2014, 35:1308-1314.
33. Soliman L.C., Hui Y., Hewavitharana A.K., Chen D.D. Monitoring potential prostate cancer biomarkers in urine by capillary electrophoresis-tandem mass spectrometry. J. Chromatogr. A 2012, 1267:162-169.
34. Kele Z., Ferenc G., Klement E., Toth G.K., Janaky T. Design and performance of a sheathless capillary electrophoresis/mass spectrometry interface by combining fused-silica capillaries with gold-coated nanoelectrospray tips. Rapid Commun. Mass Spectrom 2005, 19:881-885.
35. Kriger M.S., Cook K.D., Ramsey R.S. Durable gold-coated fused silica capillaries for use in electrospray mass spectrometry. Anal. Chem 1995, 67:385-389.
36. Chen Y.R., Her G.R. A simple method for fabrication of silver-coated sheathless electrospray emitters. Rapid Commun. Mass Spectrom 2003, 17:437-441.
37. Zamfir A.D., Dinca N., Sisu E., Peter-Katalinic J. Copper-coated microsprayer interface for on-line sheathless capillary electrophoresis electrospray mass spectrometry of carbohydrates. J. Sep. Sci 2006, 29:414-422.
38. Sanz-Nebot V., Balaguer E., Benavente F., Barbosa J. Comparison of sheathless and sheath-flow electrospray interfaces for the capillary electrophoresis-electrospray ionization-mass spectrometry analysis of peptides. Electrophoresis 2005, 26:1457-1465.
39. Cao P., Moini M. A novel sheathless interface for capillary electrophoresis/electrospray ionization mass spectrometry using an in-capillary electrode. J. Am. Soc. Mass Spectrom 1997, 8:561-564.
40. Jeong J., Kim S., Park S. Capillary electrophoresis mass spectrometry with sheathless electrospray ionization for high sensitivity analysis of underivatized amino acids. Electrophoresis 2012, 33:2112-2121.
41. Shi L.H., Jin Y.X., Moon D.C., Kim S.K., Park S.R. A sheathless CE/ESI-MS interface with an ionophore membrane-packed electro-conduction channel. Electrophoresis 2009, 30:1661-1669.
42. Moini M. Simplifying CE-MS operation. 2. Interfacing low-flow separation techniques to mass spectrometry using a porous tip. Anal. Chem 2007, 79:4241-4246.
43. Faserl K., Sarg B., Kremser L., Lindner H. Optimization and evaluation of a sheathless capillary electrophoresis-electrospray ionization mass spectrometry platform for peptide analysis: comparison to liquid chromatography-electrospray ionization mass spectrometry. Anal. Chem 2011, 83:7297-7305.
44. Hirayama A., Tomita M., Soga T. Sheathless capillary electrophoresis-mass spectrometry with a high-sensitivity porous sprayer for cationic metabolome analysis. Analyst 2012, 137:5026-5033.
45. Ramautar R., Busnel J.-M., Deelder A.M., Mayboroda O.A. Enhancing the coverage of the urinary metabolome by sheathless capillary electrophoresis-mass spectrometry. Anal. Chem 2012, 84:885-892.
46. Ramautar R., Shyti R., Schoenmaker B., de Groote L., Derks R.J.E., Ferrari M.D., et al. Metabolic profiling of mouse cerebrospinal fluid by sheathless CE-MS. Anal. Bioanal. Chem 2012, 404:2895-2900.
47. Soga T., Kakazu Y., Robert M., Tomita M., Nishioka T. Qualitative and quantitative analysis of amino acids by capillary electrophoresis-electrospray ionization-tandem mass spectrometry. Electrophoresis 2004, 25:1964-1972.
48. Staub A., Schappler J., Rudaz S., Veuthey J. CE-TOF/MS: fundamental concepts, instrumental considerations and applications. Electrophoresis 2009, 30:1610-1623.
49. Bringmann G., Kajahn I., Neususs C., Pelzing M., Laug S., Unger M., et al. Analysis of the glucosinolate pattern of Arabidopsis thaliana seeds by capillary zone electrophoresis coupled to electrospray ionization-mass spectrometry. Electrophoresis 2005, 26:1513-1522.
50. Sancho J.V., Pozo O.J., Iba´ñez M., Herna´ndez F. Potential of liquid chromatography/time-of-flight mass spectrometry for the determination of pesticides and transformation products in water. Anal. Bioanal. Chem 2006, 386:987-997.
51. Forcisi S., Moritz F., Kanawati B., Tziotis D., Lehmann R., Schmitt-Kopplin P. Liquid chromatography-mass spectrometry in metabolomics research: mass analyzers in Ultra High Pressure Liquid Chromatography coupling. J. Chromatogr. A 2013, 1292:51-65.
52. Himmelsbach M. 10 years of MS instrumental developments-Impact on LC-MS/MS in clinical chemistry. J. Chromatogr. B 2012, 883:3-17.
53. Wojcik R., Li Y., MacCoss M.J., Dovichi N.J. Capillary electrophoresis with Orbitrap-Velos mass spectrometry detection. Talanta 2012, 88:324-329.
54. Bligh E., Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol 1959, 37:911-917.
55. Seip K.F., Gjelstad A., Pedersen-Bjergaard S. Electromembrane extraction from aqueous samples containing polar organic solvents. J. Chromatogr. A 2013, 1308:37-44.
56. Raterink R.J., Lindenburg P.W., Vreeken R.J., Hankemeier T. Three-phase electroextraction: a new (online) sample purification and enrichment method for bioanalysis. Anal. Chem 2013, 85:7762-7768.
57. Zhou B., Xiao J.F., Tuli L., Ressom H.W. LC-MS-based metabolomics. Mol. Biosyst 2012, 8:470-481.
58. Sugimoto M., Hirayama A., Ishikawa T., Robert M., Baran R., Uehara K., et al. Differential metabolomics software for capillary electrophoresis-mass spectrometry data analysis. Metabolomics 2010, 6:27-41.
59. De Vos R.C., Moco S., Lommen A., Keurentjes J.J., Bino R.J., Hall R.D. Untargeted large-scale plant metabolomics using liquid chromatography coupled to mass spectrometry. Nat. Protoc 2007, 2:778-791.
60. Katajamaa M., Oresic M. Processing methods for differential analysis of LC/MS profile data. BMC Bioinformatics 2005, 6:179.
61. Nordstrom A., O'Maille G., Qin C., Siuzdak G. Nonlinear data alignment for UPLC-MS and HPLC-MS based metabolomics: quantitative analysis of endogenous and exogenous metabolites in human serum. Anal. Chem 2006, 78:3289-3295.
62. Smith C.A., Want E.J., O'Maille G., Abagyan R., Siuzdak G. XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Anal. Chem 2006, 78:779-787.
63. Xia J., Wishart D.S. Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst. Nat. Protoc 2011, 6:743-760.
64. Pluskal T., Castillo S., Villar-Briones A., Oresˇicˇ M. MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data. BMC Bioinformatics 2010, 11:395.
65. Iba´ñez C., Simo´ C., Garci´a-Cañas V., Cifuentes A., Castro-Puyana M. Metabolomics, peptidomics and proteomics applications of capillary electrophoresis-mass spectrometry in Foodomics: a review. Anal. Chim. Acta 2013, 802:1-13.
66. Sugimoto M., Wong D.T., Hirayama A., Soga T., Tomita M. Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics 2010, 6:78-95.
67. Sugimoto M., Kikuchi S., Arita M., Soga T., Nishioka T., Tomita M. Large-scale prediction of cationic metabolite identity and migration time in capillary electrophoresis mass spectrometry using artificial neural networks. Anal. Chem 2005, 77:78-84.
68. Sugimoto M., Hirayama A., Robert M., Abe S., Soga T., Tomita M. Prediction of metabolite identity from accurate mass, migration time prediction and isotopic pattern information in CE-TOFMS data. Electrophoresis 2010, 31:2311-2318.
69. Lee R., Ptolemy A.S., Niewczas L., Britz-McKibbin P. Integrative metabolomics for characterizing unknown low-abundance metabolites by capillary electrophoresis-mass spectrometry with computer simulations. Anal. Chem 2007, 79:403-415.
70. Nemes P., Rubakhin S.S., Aerts J.T., Sweedler J.V. Qualitative and quantitative metabolomic investigation of single neurons by capillary electrophoresis electrospray ionization mass spectrometry. Nat. Protoc 2013, 8:783-799.
71. Knolhoff A.M., Nautiyal K.M., Nemes P., Kalachikov S., Morozova I., Silver R., et al. Combining small-volume metabolomic and transcriptomic approaches for assessing brain chemistry. Anal. Chem 2013, 85:3136-3143.
72. Kitagawa F., Otsuka K. Recent applications of on-line sample preconcentration techniques in capillary electrophoresis. J. Chromatogr. A 2014, 1335:43-60.
73. Bragg W., Shamsi S.A. Development of a fritless packed column for capillary electrochromatography-mass spectrometry. J. Chromatogr. A 2011, 1218:8691-8700.
74. Zheng J., Bragg W., Hou J., Lin N., Chandrasekaran S., Shamsi S.A. Sulfated and sulfonated polysaccharide as chiral stationary phases for capillary electrochromatography and capillary electrochromatography-mass spectrometry. J. Chromatogr. A 2009, 1216:857-872.
75. Wuethrich A., Haddad P.R., Quirino J.P. Chiral capillary electromigration techniques-mass spectrometry-hope and promise. Electrophoresis 2014, 35:2-11.
76. Kraly J.R., Holcomb R.E., Guan Q., Henry C.S. Review: microfluidic applications in metabolomics and metabolic profiling. Anal. Chim. Acta 2009, 653:23-35.