Metabolic profiling of mouse cerebrospinal fluid by sheathless CE-MS

Analytical and Bioanalytical Chemistry

Volumn 404, Issue 10, 2012, Pages 2895-2900

  Ramautar, Rawi ^a   Shyti, Reinald ^a   Schoenmaker, Bart ^a   De Groote, Lotte ^a   Derks, Rico J E ^a   Ferrari, Michel D ^a   Van Den Maagdenberg, Arn M J M ^a   Deelder, André M ^a   Mayboroda, Oleg A ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cerebrospinal fluid; Low volume samples; Mass spectrometry; Metabolic profiling; Sheathless interface; Urine

Indexed keywords

ACCURATE MASS; ANALYTICAL TECHNOLOGY; BIOLOGICAL SAMPLES; CEREBRO SPINAL FLUIDS; ELECTROSPRAY IONIZATION MASS SPECTROMETRY; EXPERIMENTAL ANIMALS; INJECTION VOLUME; LIMITS OF DETECTION; LOW-VOLUME SAMPLES; METABOLIC PROFILING; METHOD EVALUATION; MIGRATION TIME; MOLECULAR FEATURE; MOUSE PLASMA; NANOELECTROSPRAY; NON-TARGETED; URINE;

BIOMOLECULES; BRAIN; CAPILLARY ELECTROPHORESIS; CEREBROSPINAL FLUID; MASS SPECTROMETRY; METABOLISM; METABOLITES;

MAMMALS;

ANIMAL; ARTICLE; C57BL MOUSE; CAPILLARY ELECTROPHORESIS; CEREBROSPINAL FLUID; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; MALE; METABOLISM; METABOLOME; METABOLOMICS; METHODOLOGY; MOUSE;

ANIMALS; CEREBROSPINAL FLUID; ELECTROPHORESIS, CAPILLARY; MALE; METABOLOME; METABOLOMICS; MICE; MICE, INBRED C57BL; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

ANIMALIA; MUS;

EID: 84870947480     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-012-6431-7     Document Type: Article

References (19)

1. Lenz EM,Wilson ID (2007) Analytical strategies in metabolomics. J Proteome Res 6(2):443-458. doi:10.1021/pr0605217
2. Zhang A, Sun H, Wang P, Han Y, Wang X (2012) Modern analytical techniques in metabolomics analysis. Analyst 137(2):293-300. doi:10.1039/c1an15605e
3. Monton MR, Soga T (2007) Metabolome analysis by capillary electrophoresis-mass spectrometry. J Chromatogr A 1168(1- 2):237-246. doi:10.1016/j.chroma.2007.02.065, discussion 236
4. Lapainis T, Rubakhin SS, Sweedler JV (2009) Capillary electrophoresis with electrospray ionization mass spectrometric detection for single-cell metabolomics. Anal Chem 81(14):5858-5864. doi:10.1021/ac900936g
5. Chalcraft KR, Britz-McKibbin P (2009) Newborn screening of inborn errors of metabolism by capillary electrophoresis-electrospray ionization-mass spectrometry: a second-tier method with improved specificity and sensitivity. Anal Chem 81(1):307-314. doi:10.1021/ac8020455
6. Kennedy RT, Oates MD, Cooper BR, Nickerson B, Jorgenson JW (1989) Microcolumn separations and the analysis of single cells. Science 246(4926):57-63
7. Chiu DT, Lillard SJ, Scheller RH, Zare RN, Rodriguez-Cruz SE, Williams ER, Orwar O, Sandberg M, Lundqvist JA (1998) Probing single secretory vesicles with capillary electrophoresis. Science 279(5354):1190-1193
8. Powell PR, Ewing AG (2005) Recent advances in the application of capillary electrophoresis to neuroscience. Anal Bioanal Chem 382(3):581-591. doi:10.1007/s00216-005-3075-x
9. Moini M (2007) Simplifying CE-MS operation. 2. Interfacing lowflow separation techniques to mass spectrometry using a porous tip. Anal Chem 79(11):4241-4246. doi:10.1021/ac0704560
10. Ramautar R, Busnel JM, Deelder AM, Mayboroda OA (2012) Enhancing the coverage of the urinary metabolome by sheathless capillary electrophoresis-mass spectrometry. Anal Chem 84(2):885-892. doi:10.1021/ac202407v
11. Busnel JM, Schoenmaker B, Ramautar R, Carrasco-Pancorbo A, Ratnayake C, Feitelson JS, Chapman JD, Deelder AM, Mayboroda OA (2010) High capacity capillary electrophoresis-electrospray ionization mass spectrometry: coupling a porous sheathless interface with transient-isotachophoresis. Anal Chem 82(22):9476-9483. doi:10.1021/ac102159d
12. Nevedomskaya E, Ramautar R, Derks R, Westbroek I, Zondag G, van der Pluijm I, Deelder AM, Mayboroda OA (2010) CE-MS for metabolic profiling of volume-limited urine samples: application to accelerated aging TTD mice. J Proteome Res 9(9):4869-4874. doi:10.1021/pr100634d
13. Oshio K, Watanabe H, Song Y, Verkman AS, Manley GT (2005) Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1. FASEB J 19(1):76-78. doi:10.1096/fj.04- 1711fje
14. Gotz J, Ittner LM (2008) Animal models of Alzheimer's disease and frontotemporal dementia. Nat Rev Neurosci 9(7):532-544. doi:10.1038/nrn2420
15. van de Ven RC, Kaja S, Plomp JJ, Frants RR, van den Maagdenberg AM, FerrariMD(2007) Genetic models ofmigraine. Arch Neurol 64 (5):643-646. doi:10.1001/archneur.64.5.643
16. Sugimoto M, Ikeda S, Niigata K, Tomita M, Sato H, Soga T (2012) MMMDB: Mouse Multiple Tissue Metabolome Database. Nucleic Acids Res 40(Database issue):D809-D814. doi:10.1093/nar/gkr1170
17. Koek MM, Bakels F, Engel W, van den Maagdenberg A, Ferrari MD, Coulier L, Hankemeier T (2010) Metabolic profiling of ultrasmall sample volumes with GC/MS: from microliter to nanoliter samples. Anal Chem 82(1):156-162. doi:10.1021/ac9015787
18. Mandal R, Guo AC, Chaudhary KK, Liu P, Yallou FS, Dong E, Aziat F, Wishart DS (2012) Multi-platform characterization of the human cerebrospinal fluid metabolome: a comprehensive and quantitative update. Genome Med 4(4):38. doi:10.1186/gm337
19. Nicholson JK, Lindon JC, Holmes E (1999) 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29(11):1181-1189. doi:10.1080/004982599238047