Chlorogenic acid protects against atherosclerosis in ApoE-/-mice and promotes cholesterol efflux from RAW264.7 macrophages

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Wu, Chongming ^a   Luan, Hong ^a   Zhang, Xue ^a   Wang, Shuai ^a   Zhang, Xiaopo ^a   Sun, Xiaobo ^a   Guo, Peng ^a  

^a INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER G1; APOLIPOPROTEIN E; ATORVASTATIN; CAFFEIC ACID; CHLOROGENIC ACID; CHOLESTEROL; FERULIC ACID; GALLIC ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 6; INTERLEUKIN 8; LIPID; LIVER X RECEPTOR ALPHA; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; OXIDIZED LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; ABC TRANSPORTER; ABCA1 PROTEIN, MOUSE; ABCG1 PROTEIN, MOUSE; CAFFEIC ACID DERIVATIVE; COUMARIC ACID; HYPOCHOLESTEROLEMIC AGENT; LIPOPROTEIN; LIVER X RECEPTOR; LOW DENSITY LIPOPROTEIN; ORPHAN NUCLEAR RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; AORTA ROOT; AORTIC DILATATION; ARTICLE; ATHEROSCLEROSIS; BRACHIOCEPHALIC TRUNK; CELL MIGRATION; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DRUG METABOLISM; DRUG POTENCY; HEART DILATATION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LIPID BLOOD LEVEL; LIPID STORAGE; MACROPHAGE; MALE; METABOLITE; MOUSE; NONHUMAN; PATHOGENESIS; TRANSCRIPTION INITIATION; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; AORTA; BLOOD; CELL LINE; CHEMISTRY; DEFICIENCY; DRUG EFFECTS; GENE EXPRESSION; GENETICS; ISOLATION AND PURIFICATION; KNOCKOUT MOUSE; LIPID DIET; METABOLISM; PATHOLOGY; PLAQUE, ATHEROSCLEROTIC; TRANSPORT AT THE CELLULAR LEVEL; VASODILATATION;

MUS;

ANIMALS; ANTICHOLESTEREMIC AGENTS; AORTA; APOLIPOPROTEINS E; ATHEROSCLEROSIS; ATORVASTATIN CALCIUM; ATP BINDING CASSETTE TRANSPORTER 1; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CAFFEIC ACIDS; CELL LINE; CHLOROGENIC ACID; CHOLESTEROL; CHOLESTEROL, LDL; COUMARIC ACIDS; DIET, HIGH-FAT; GALLIC ACID; GENE EXPRESSION; LIPOPROTEINS; LIPOPROTEINS, LDL; MACROPHAGES; MICE; MICE, KNOCKOUT; ORPHAN NUCLEAR RECEPTORS; PLAQUE, ATHEROSCLEROTIC; PPAR GAMMA; TRIGLYCERIDES; VASODILATION;

EID: 84906991015     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0095452     Document Type: Article

References (45)

1. Sirimarco G, Amarenco P, Labreuche J, Touboul PJ, Alberts M, et al. (2013) Carotid atherosclerosis and risk of subsequent coronary event in outpatients with atherothrombosis. Stroke 44:373-379.
2. Frostegard J (2013) Immunity, atherosclerosis and cardiovascular disease. BMC Med 11:117.
3. Tall AR, Yvan-Charvet L, Terasaka N, Pagler T, Wang N (2008) HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosis. Cell Metab 7:365-375.
4. Goff DC Jr, Bertoni AG, Kramer H, Bonds D, Blumenthal RS, et al. (2006) Dyslipidemia prevalence, treatment, and control in the Multi-Ethnic Study of Atherosclerosis (MESA): gender, ethnicity, and coronary artery calcium. Circulation 113:647-656.
5. Working Group on the Summit on Combination Therapy for CVD (2014) Combination pharmacotherapy to prevent cardiovascular disease: present status and challenges. Eur Heart J 35:353-364.
6. Ding L, Biswas S, Morton RE, Smith JD, Hay N, et al. (2012) Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice. Cell Metab 15:861-872.
7. Moore KJ, Tabas I (2011) Macrophages in the pathogenesis of atherosclerosis. Cell 145:341-355.
8. Wang M, Wang D, Zhang Y, Wang X, Liu Y, et al. (2013) Adiponectin increases macrophages cholesterol efflux and suppresses foam cell formation in patients with type 2 diabetes mellitus. Atherosclerosis 229:62-70.
9. Lee TS, Pan CC, Peng CC, Kou YR, Chen CY, et al. (2010) Anti-atherogenic effect of berberine on LXRalpha-ABCA1-dependent cholesterol efflux in macrophages. J Cell Biochem 111:104-110.
10. Lee SM, Moon J, Cho Y, Chung JH, Shin MJ (2013) Quercetin up-regulates expressions of peroxisome proliferator-activated receptor gamma, liver X receptor alpha, and ATP binding cassette transporter A1 genes and increases cholesterol efflux in human macrophage cell line. Nutr Res 33:136-143.
11. Kennedy MA, Barrera GC, Nakamura K, Baldan A, Tarr P, et al. (2005) ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation. Cell Metab 1:121-131.
12. Chinetti G, Lestavel S, Bocher V, Remaley AT, Neve B, et al. (2001) PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat Med 7:53-58.
13. Wu ZH, Zhao SP (2009) Niacin promotes cholesterol efflux through stimulation of the PPARgamma-LXRalpha-ABCA1 pathway in 3T3-L1 adipocytes. Pharmacology 84:282-287.
14. Upadhyay R, Mohan Rao LJ (2013) An outlook on chlorogenic acidsoccurrence, chemistry, technology, and biological activities. Crit Rev Food Sci Nutr 53:968-984.
15. Ong KW, Hsu A, Tan BK (2012) Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes. PLoS One 7:e32718.
16. Suzuki A, Yamamoto N, Jokura H, Yamamoto M, Fujii A, et al. (2006) Chlorogenic acid attenuates hypertension and improves endothelial function in spontaneously hypertensive rats. J Hypertens 24:1065-1073.
17. Liu YJ, Zhou CY, Qiu CH, Lu XM, Wang YT (2013) Chlorogenic acid induced apoptosis and inhibition of proliferation in human acute promyelocytic leukemia HL60 cells. Mol Med Rep 8:1106-1110.
18. Wan CW, Wong CN, Pin WK, Wong MH, Kwok CY, et al. (2013) Chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by upregulating the gene expression of PPAR-alpha in hypercholesterolemic rats induced with a high-cholesterol diet. Phytother Res 27:545-551.
19. Ong KW, Hsu A, Tan BK (2013) Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation. Biochem Pharmacol 85:1341-1351.
20. Xu JG, Hu QP, Liu Y (2012) Antioxidant and DNA-protective activities of chlorogenic acid isomers. J Agric Food Chem 60:11625-11630.
21. Sato Y, Itagaki S, Kurokawa T, Ogura J, Kobayashi M, et al. (2011) In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid. Int J Pharm 403:136-138.
22. Shan J, Fu J, Zhao Z, Kong X, Huang H, et al. (2009) Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 cells through suppressing NF-kappaB and JNK/AP-1 activation. Int Immunopharmacol 9:1042-1048.
23. dos Santos MD, Almeida MC, Lopes NP, de Souza GE (2006) Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid. Biol Pharm Bull 29:2236-2240.
24. Loke WM, Proudfoot JM, Hodgson JM, McKinley AJ, Hime N, et al. (2010) Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction. Arterioscler Thromb Vasc Biol 30:749-757.
25. de Haan W, de Vries-van der Weij J, van der Hoorn JW, Gautier T, van der Hoogt CC, et al. (2008) Torcetrapib does not reduce atherosclerosis beyond atorvastatin and induces more proinflammatory lesions than atorvastatin. Circulation 117:2515-2522.
26. Guo P, Kai Q, Gao J, Lian ZQ, Wu CM, et al. (2010) Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of AMP-activated protein kinase. J Pharmacol Sci 113:395-403.
27. Zhang X, Wu C, Wu H, Sheng L, Su Y, et al. (2013) Anti-hyperlipidemic effects and potential mechanisms of action of the caffeoylquinic acid-rich Pandanus tectorius fruit extract in hamsters fed a high fat-diet. PLoS One 8:e61922.
28. Jeong HW, Lee JW, Kim WS, Choe SS, Kim KH, et al. (2011) A newly identified CG301269 improves lipid and glucose metabolism without body weight gain through activation of peroxisome proliferator-activated receptor alpha and gamma. Diabetes 60:496-506.
29. Wu C, Feng J, Wang R, Liu H, Yang H, et al. (2012) HRS1 acts as a negative regulator of abscisic acid signaling to promote timely germination of Arabidopsis seeds. PLoS One 7:e35764.
30. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)) Method. Methods 25:402-408.
31. Shi H, Dong L, Jiang J, Zhao J, Zhao G, et al. (2013) Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway. Toxicology 303:107-114.
32. Gu L, Bai W, Li S, Zhang Y, Han Y, et al. (2013) Celastrol prevents atherosclerosis via inhibiting LOX-1 and oxidative stress. PLoS One 8:e65477.
33. Zhang J, Cai S, Peterson BR, Kris-Etherton PM, Heuvel JP (2011) Development of a cell-based, high-throughput screening assay for cholesterol efflux using a fluorescent mimic of cholesterol. Assay Drug Dev Technol 9:136-146.
34. Choi JM, Bothwell AL (2012) The nuclear receptor PPARs as important regulators of T-cell functions and autoimmune diseases. Mol Cells 33:217-222.
35. Erk T, Williamson G, Renouf M, Marmet C, Steiling H, et al. (2012) Dosedependent absorption of chlorogenic acids in the small intestine assessed by coffee consumption in ileostomists. Mol Nutr Food Res. 56:1488-1500.
36. Azuma K, Ippoushi K, Nakayama M, Ito H, Higashio H, et al. (2000) Absorption of chlorogenic acid and caffeic acid in rats after oral administration. J Agric Food Chem. 48:5496-5500.
37. Johnston KL, Clifford MN, Morgan LM (2003) Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. Am J Clin Nutr 78:728-733.
38. ∗3-Leiden. CETP mice. J Nutr Biochem 24:1423-1430.
39. Jain SK, Rains J, Croad J, Larson B, Jones K (2009) Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats. Antioxid Redox Signal 11:241-249.
40. Shi H, Dong L, Dang X, Liu Y, Jiang J, et al. (2013) Effect of chlorogenic acid on LPS-induced proinflammatory signaling in hepatic stellate cells. Inflamm Res 62:581-587.
41. Ohashi R, Mu H, Wang X, Yao Q, Chen C (2005) Reverse cholesterol transport and cholesterol efflux in atherosclerosis. QJM 98:845-856.
42. Ohnishi R, Ito H, Iguchi A, Shinomiya K, Kamei C, et al. (2006) Effects of chlorogenic acid and its metabolites on spontaneous locomotor activity in mice. Biosci Biotechnol Biochem 70:2560-2563.
43. Monteiro M, Farah A, Perrone D, Trugo LC, Donangelo C (2007) Chlorogenic acid compounds from coffee are differentially absorbed and metabolized in humans. J Nutr 137:2196-2201.
44. Uto-Kondo H, Ayaori M, Ogura M, Nakaya K, Ito M, et al. (2010) Coffee consumption enhances high-density lipoprotein-mediated cholesterol efflux in macrophages. Circ Res 106:779-787.
45. Park SH, Kim JL, Lee ES, Han SY, Gong JH, et al. (2011) Dietary ellagic acid attenuates oxidized LDL uptake and stimulates cholesterol efflux in murine macrophages. J Nutr 141:1931-1937.