Niacin promotes cholesterol efflux through stimulation of the PPARγ-LXRα-ABCA1 pathway in 3T3-L1 adipocytes

Pharmacology

Volumn 84, Issue 5, 2009, Pages 282-287

  Wu, Zhi Hong ^a   Zhao, Shui Ping ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

ABCA1; Adipocytes; Cholesterol efflux; High density lipoprotein; Niacin

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; ABC TRANSPORTER A1; APOLIPOPROTEIN A1; CHOLESTEROL; COMPLEMENTARY DNA; DEXAMETHASONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; ISOBUTYLMETHYLXANTHINE; MESSENGER RNA; NICOTINIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA ANTAGONIST; TRITIUM;

ADIPOCYTE; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CELL STRAIN 3T3; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; ANTICHOLESTEREMIC AGENTS; APOLIPOPROTEIN A-I; ATP-BINDING CASSETTE TRANSPORTERS; CELL DIFFERENTIATION; CELLS, CULTURED; CHOLESTEROL, HDL; GENE EXPRESSION REGULATION; MICE; NIACIN; ORPHAN NUCLEAR RECEPTORS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 70349595967     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000242999     Document Type: Article

References (21)

1. Gordon DJ, Probstfield JL, Garrison RJ, Neaton JD, Castelli WP, Knoke JD, Jacobs DR Jr, Bangdiwala S, Tyroler HA: High-density lipoprotein cholesterol and cardiovascular disease: four prospective American studies. Circulation 1989; 79: 8-15.
2. Tall AR: Cholesterol efflux pathways and other potential mechanisms involved in the athero-protective effect of high density lipoproteins. J Intern Med 2008; 263: 256-273.
3. Davidson MH, Toth PP: High-density lipoprotein metabolism: potential therapeutic targets. Am J Cardiol 2007; 100:n32-n40.
4. Carlson LA: Nicotinic acid and other therapies for raising high-density lipoprotein. Curr Opin Cardiol 2006; 21: 336-344.
5. Meyers CD, Kamanna VS, Kashyap ML: Niacin therapy in atherosclerosis. Curr Opin Lipidol 2004; 15: 659-665.
6. Krause BR, Hartman AD: Adipose tissue and cholesterol metabolism. J Lipid Res 1984; 25: 97-110.
7. Schreibman PH, Dell RB: Human adipocyte cholesterol: concentration, localization, synthesis, and turnover. J Clin Invest 1975; 55: 986-993.
8. Kovanen PT, Nikkila EA, Miettinen TA: Regulation of cholesterol synthesis and storage in fat cells. J Lipid Res 1975; 16: 211-223.
9. Le Lay S, Robichon C, Le Liepvre X, Dagher G, Ferre P, Dugail I: Regulation of ABCA1 expression and cholesterol efflux during adipose differentiation of 3T3-L1 cells. J Lipid Res 2003; 44: 1499-1507.
10. Bortnick AE, Rothblat GH, Stoudt G, Hoppe KL, Royer LJ, McNeish J, Francone OL: The correlation of ATP-binding cassette 1 mRNA levels with cholesterol efflux from various cell lines. J Biol Chem 2000; 275: 28634-28640.
11. Chawla A, Boisvert WA, Lee CH, Laffitte BA, Barak Y, Joseph SB, Liao D, Nagy L, Edwards PA, Curtiss LK, Evans RM, Tontonoz P: A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol Cell 2001; 7: 161-171.
12. Shepherd J, Packard CJ, Patsch JR, Gotto AM Jr, Taunton OD: Effects of nicotinic acid therapy on plasma high density lipoprotein subfraction distribution and composition and on apolipoprotein A metabolism. J Clin Invest 1979; 63: 858-867.
13. Jin FY, Kamanna VS, Kashyap ML: Niacin decreases removal of high-density lipoprotein apolipoprotein A-I but not cholesterol ester by Hep G2 cells: implication for reverse cholesterol transport. Arterioscler Thromb Vasc Biol 1997; 17: 2020-2028.
14. Zhang LH, Kamanna VS, Zhang MC, Kashyap ML: Niacin inhibits surface expression of ATP synthase beta chain in HepG2 cells: implications for raising HDL. J Lipid Res 2008; 49: 1195-1201.
15. Wise A, Foord SM, Fraser NJ, Barnes AA, Elshourbagy N, Eilert M, Ignar DM, Murdock PR, Steplewski K, Green A, Brown AJ, Dowell SJ, Szekeres PG, Hassall DG, Marshall FH, Wilson S, Pike NB: Molecular identification of high and low affinity receptors for nicotinic acid. J Biol Chem 2003; 278: 9869-9874.
16. Tunaru S, Kero J, Schaub A, Wufka C, Blaukat A, Pfeffer K, Offermanns S: PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat Med 2003; 9: 352-355.
17. Zhang Y, Schmidt RJ, Foxworthy P, Emkey R, Oler JK, Large TH, Wang H, Su EW, Mosior MK, Eacho PI, Cao G: Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74A. Biochem Biophys Res Commun 2005; 334: 729-732.
18. Oram JF, Lawn RM, Garvin MR, Wade DP: ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages. J Biol Chem 2000; 275: 34508-34511.
19. Takahashi Y, Miyata M, Zheng P, Imazato T, Horwitz A, Smith JD: Identification of cAMP analogue inducible genes in RAW264 macrophages. Biochim Biophys Acta 2000; 1492: 385-394.
20. Zhao SP, Yang J, Li J, Dong SZ, Wu ZH: Effect of niacin on LXRalpha and PPARgamma expression and HDL-induced cholesterol efflux in adipocytes of hypercholesterolemic rabbits. Int J Cardiol 2008; 124: 172-178.
21. Knowles HJ, te Poele RH, Workman P, Harris AL: Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways. Biochem Pharmacol 2006; 71: 646-656.