Antidiabetic property of Symplocos cochinchinensis is mediated by inhibition of alpha glucosidase and enhanced insulin sensitivity

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Antu, Kalathookunnel Antony ^a   Riya, Mariam Philip ^a   Mishra, Arvind ^b   Anilkumar, Karunakaran S ^b   Chandrakanth, Chandrasekharan K ^a   Tamrakar, Akhilesh K ^b   Srivastava, Arvind K ^b   Raghu, K Gopalan ^a  

^a Agroprocessing and Natural Products Division CSIR NIIST ^*  (India)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACARBOSE; ACETIC ACID ETHYL ESTER; ALCOHOL; ALPHA GLUCOSIDASE; ANTIDIABETIC AGENT; CALCIUM; DICHLOROMETHANE; DIPEPTIDYL PEPTIDASE IV; HEXANE; HYDROXYL RADICAL; MAGNESIUM; MANGANESE; METFORMIN; OLEANOLIC ACID; PHLORETIN 2' GLUCOSIDE; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; POTASSIUM; PROTEIN TYROSINE PHOSPHATASE 1B; REACTIVE OXYGEN METABOLITE; ROSIGLITAZONE; SITOSTEROL; SODIUM; SYMPLOCOS COCHINCHINENSIS EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ZINC; ADVANCED GLYCATION END PRODUCT; ANTIOXIDANT; BOVINE SERUM ALBUMIN; PTPN1 PROTEIN, RAT; STREPTOZOCIN;

ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; BARK; CELL PROLIFERATION; CELL REGENERATION; CHELATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DOSAGE FORM COMPARISON; DRUG MECHANISM; DRUG SCREENING; ENZYME INHIBITION; GLUCOSE TRANSPORT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERGLYCEMIA; IC50; IN VITRO STUDY; INSULIN SENSITIVITY; LIPID STORAGE; MALE; MEDICINAL PLANT; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PHYTOCHEMISTRY; PROTEIN GLYCOSYLATION; RAT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; SYMPLOCOS COCHINCHINENSIS; TOXICITY TESTING; ANGIOSPERM; ANIMAL; ANTAGONISTS AND INHIBITORS; AYURVEDA; BOVINE; CHEMICALLY INDUCED; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; HEPG2 CELL LINE; HUMAN; INSULIN RESISTANCE; ISOLATION AND PURIFICATION; METABOLISM; SACCHAROMYCES CEREVISIAE; SPRAGUE DAWLEY RAT;

SYMPLOCOS COCHINCHINENSIS;

ALPHA-GLUCOSIDASES; ANGIOSPERMS; ANIMALS; ANTIOXIDANTS; CATTLE; DIABETES MELLITUS, EXPERIMENTAL; DIPEPTIDYL PEPTIDASE 4; GLYCOSYLATION END PRODUCTS, ADVANCED; HEP G2 CELLS; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; MALE; MEDICINE, AYURVEDIC; PLANT BARK; PLANT EXTRACTS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RATS; RATS, SPRAGUE-DAWLEY; SACCHAROMYCES CEREVISIAE; SERUM ALBUMIN, BOVINE; STREPTOZOCIN;

EID: 84906985668     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0105829     Document Type: Article

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