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Volumn 88, Issue 19, 2014, Pages 11315-11326

High-risk human papillomavirus E6 protein promotes reprogramming of Fanconi anemia patient cells through repression of p53 but does not allow for sustained growth of induced pluripotent stem cells

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; CELL PROTEIN; PROTEIN E6; PROTEIN E7; PROTEIN P53; PROTEIN TRA 1 60; TRANSCRIPTION FACTOR NANOG; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; E6 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 16; HOMEODOMAIN PROTEIN; MEMBRANE ANTIGEN; NANOG PROTEIN, HUMAN; ONCOPROTEIN; PROTEOGLYCAN; REPRESSOR PROTEIN; SMALL INTERFERING RNA; TRA 1 60 ANTIGEN, HUMAN; TRA-1-60 ANTIGEN, HUMAN;

EID: 84906971678     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01533-14     Document Type: Article
Times cited : (26)

References (61)
  • 2
    • 78650748371 scopus 로고    scopus 로고
    • Persistence of human papillomavirus infection: keys to malignant progression
    • Bodily J, Laimins LA. 2011. Persistence of human papillomavirus infection: keys to malignant progression. Trends Microbiol. 19:33-39. http: //dx.doi.org/10.1016/j.tim.2010.10.002.
    • (2011) Trends Microbiol. , vol.19 , pp. 33-39
    • Bodily, J.1    Laimins, L.A.2
  • 3
    • 84884350609 scopus 로고    scopus 로고
    • Papillomavirus E6 oncoproteins
    • Vande Pol SB, Klingelhutz AJ. 2013. Papillomavirus E6 oncoproteins. Virology 445:115-137. http://dx.doi.org/10.1016/j.virol.2013.04.026.
    • (2013) Virology , vol.445 , pp. 115-137
    • Vande Pol, S.B.1    Klingelhutz, A.J.2
  • 4
    • 84884356554 scopus 로고    scopus 로고
    • The papillomavirus E7 proteins
    • Roman A, Munger K. 2013. The papillomavirus E7 proteins. Virology 445:138-168. http://dx.doi.org/10.1016/j.virol.2013.04.013.
    • (2013) Virology , vol.445 , pp. 138-168
    • Roman, A.1    Munger, K.2
  • 5
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. 2007. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861-872. http://dx.doi.org/10 .1016/j.cell.2007.11.019.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 6
    • 79960055909 scopus 로고    scopus 로고
    • Induced pluripotent stem cells: opportunities and challenges
    • Okita K, Yamanaka S. 2011. Induced pluripotent stem cells: opportunities and challenges. Philos. Trans. R. Soc. Lond. B Biol. Sci. 366:2198-2207. http://dx.doi.org/10.1098/rstb.2011.0016.
    • (2011) Philos. Trans. R. Soc. Lond. B Biol. Sci. , vol.366 , pp. 2198-2207
    • Okita, K.1    Yamanaka, S.2
  • 8
    • 77951878056 scopus 로고    scopus 로고
    • Induced pluripotent stem cells and senescence: learning the biology to improve the technology
    • Banito A, Gil J. 2010. Induced pluripotent stem cells and senescence: learning the biology to improve the technology. EMBO Rep. 11:353-359. http://dx.doi.org/10.1038/embor.2010.47.
    • (2010) EMBO Rep. , vol.11 , pp. 353-359
    • Banito, A.1    Gil, J.2
  • 13
    • 69349100179 scopus 로고    scopus 로고
    • Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
    • Hong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, Nakagawa M, Okita K, Yamanaka S. 2009. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460:1132-1135. http://dx.doi .org/10.1038/nature08235.
    • (2009) Nature , vol.460 , pp. 1132-1135
    • Hong, H.1    Takahashi, K.2    Ichisaka, T.3    Aoi, T.4    Kanagawa, O.5    Nakagawa, M.6    Okita, K.7    Yamanaka, S.8
  • 17
    • 78951484462 scopus 로고    scopus 로고
    • Homologous recombination conserves DNA sequence integrity throughout the cell cycle in embryonic stem cells
    • Serrano L, Liang L, Chang Y, Deng L, Maulion C, Nguyen S, Tischfield JA. 2011. Homologous recombination conserves DNA sequence integrity throughout the cell cycle in embryonic stem cells. Stem Cells Dev. 20:363-374. http://dx.doi.org/10.1089/scd.2010.0159.
    • (2011) Stem Cells Dev. , vol.20 , pp. 363-374
    • Serrano, L.1    Liang, L.2    Chang, Y.3    Deng, L.4    Maulion, C.5    Nguyen, S.6    Tischfield, J.A.7
  • 18
    • 84876510977 scopus 로고    scopus 로고
    • Apoptotic susceptibility to DNA damage of pluripotent stem cells facilitates pharmacologic purging of teratoma risk
    • Smith AJ, Nelson NG, Oommen S, Hartjes KA, Folmes CD, Terzic A, Nelson TJ. 2012. Apoptotic susceptibility to DNA damage of pluripotent stem cells facilitates pharmacologic purging of teratoma risk. Stem Cells Transl. Med. 1:709-718. http://dx.doi.org/10.5966/sctm.2012-0066.
    • (2012) Stem Cells Transl. Med. , vol.1 , pp. 709-718
    • Smith, A.J.1    Nelson, N.G.2    Oommen, S.3    Hartjes, K.A.4    Folmes, C.D.5    Terzic, A.6    Nelson, T.J.7
  • 19
    • 79957501495 scopus 로고    scopus 로고
    • Repair at single targeted DNA doublestrand breaks in pluripotent and differentiated human cells
    • Fung H, Weinstock DM. 2011. Repair at single targeted DNA doublestrand breaks in pluripotent and differentiated human cells. PLoS One 6:e20514. http://dx.doi.org/10.1371/journal.pone.0020514.
    • (2011) PLoS One , vol.6 , pp. e20514
    • Fung, H.1    Weinstock, D.M.2
  • 20
    • 78149445840 scopus 로고    scopus 로고
    • DNAdamage responses in human induced pluripotent stem cells and embryonic stem cells
    • Momcilovic O, Knobloch L, Fornsaglio J, Varum S, Easley C, Schatten G. 2010.DNAdamage responses in human induced pluripotent stem cells and embryonic stem cells. PLoS One 5:e13410. http://dx.doi.org/10.1371 /journal.pone.0013410.
    • (2010) PLoS One , vol.5 , pp. e13410
    • Momcilovic, O.1    Knobloch, L.2    Fornsaglio, J.3    Varum, S.4    Easley, C.5    Schatten, G.6
  • 21
    • 84861989101 scopus 로고    scopus 로고
    • Human embryonic stem cells have constitutively active Bax at the Golgi and are primed to undergo rapid apoptosis
    • Dumitru R, Gama V, Fagan BM, Bower JJ, Swahari V, Pevny LH, Deshmukh M. 2012. Human embryonic stem cells have constitutively active Bax at the Golgi and are primed to undergo rapid apoptosis. Mol. Cell 46:573-583. http://dx.doi.org/10.1016/j.molcel.2012.04.002.
    • (2012) Mol. Cell , vol.46 , pp. 573-583
    • Dumitru, R.1    Gama, V.2    Fagan, B.M.3    Bower, J.J.4    Swahari, V.5    Pevny, L.H.6    Deshmukh, M.7
  • 22
    • 84877921677 scopus 로고    scopus 로고
    • The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma
    • Romick-Rosendale LE, Lui VWY, Grandis JR, Wells SI. 2013. The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma. Mutat. Res. 743-744:78-88. http://dx.doi.org /10.1016/j.mrfmmm.2013.01.001.
    • (2013) Mutat. Res. , vol.743-744 , pp. 78-88
    • Romick-Rosendale, L.E.1    Lui, V.W.Y.2    Grandis, J.R.3    Wells, S.I.4
  • 23
    • 77955889790 scopus 로고    scopus 로고
    • Expanded roles of the Fanconi anemia pathway in preserving genomic stability
    • Kee Y, D'Andrea AD. 2010. Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev. 24:1680-1694. http://dx .doi.org/10.1101/gad.1955310.
    • (2010) Genes Dev. , vol.24 , pp. 1680-1694
    • Kee, Y.1    D'Andrea, A.D.2
  • 24
    • 84872578210 scopus 로고    scopus 로고
    • Fanconi anaemia and the repair of Watson and Crick DNA crosslinks
    • Kottemann MC, Smogorzewska A. 2013. Fanconi anaemia and the repair of Watson and Crick DNA crosslinks. Nature 493:356-363. http://dx.doi .org/10.1038/nature11863.
    • (2013) Nature , vol.493 , pp. 356-363
    • Kottemann, M.C.1    Smogorzewska, A.2
  • 27
    • 84875805512 scopus 로고    scopus 로고
    • Homologous recombination DNA repair genes play a critical role in reprogramming to a pluripotent state
    • Gonzalez F, Georgieva D, Vanoli F, Shi Z-D, Stadtfeld M, Ludwig T, Jasin M, Huangfu D. 2013. Homologous recombination DNA repair genes play a critical role in reprogramming to a pluripotent state. Cell Rep. 3:651-660. http://dx.doi.org/10.1016/j.celrep.2013.02.005.
    • (2013) Cell Rep. , vol.3 , pp. 651-660
    • Gonzalez, F.1    Georgieva, D.2    Vanoli, F.3    Shi, Z.-D.4    Stadtfeld, M.5    Ludwig, T.6    Jasin, M.7    Huangfu, D.8
  • 28
    • 84876566569 scopus 로고    scopus 로고
    • Human pluripotent stem cell models of Fanconi anemia deficiency reveal an important role for Fanconi anemia proteins in cellular reprogramming and survival of haematopoietic progenitors
    • Yung SK, Tilgner K, Ledran MH, Habibollah S, Neganova I, Singhapol C, Saretzki GC, Stojkovic M, Armstrong L, Przyborski SA, Lako M. 2013. Human pluripotent stem cell models of Fanconi anemia deficiency reveal an important role for Fanconi anemia proteins in cellular reprogramming and survival of haematopoietic progenitors. Stem Cells 31: 1022-1029. http://dx.doi.org/10.1002/stem.1308.
    • (2013) Stem Cells , vol.31 , pp. 1022-1029
    • Yung, S.K.1    Tilgner, K.2    Ledran, M.H.3    Habibollah, S.4    Neganova, I.5    Singhapol, C.6    Saretzki, G.C.7    Stojkovic, M.8    Armstrong, L.9    Przyborski, S.A.10    Lako, M.11
  • 29
    • 0025932933 scopus 로고
    • A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18
    • Huibregtse JM, Scheffner M, Howley PM. 1991. A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. EMBO J. 10:4129-4135.
    • (1991) EMBO J. , vol.10 , pp. 4129-4135
    • Huibregtse, J.M.1    Scheffner, M.2    Howley, P.M.3
  • 30
    • 4444345089 scopus 로고    scopus 로고
    • Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex
    • Gewin L, Myers H, Kiyono T, Galloway DA. 2004. Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex. Genes Dev. 18:2269-2282. http://dx.doi.org /10.1101/gad.1214704.
    • (2004) Genes Dev. , vol.18 , pp. 2269-2282
    • Gewin, L.1    Myers, H.2    Kiyono, T.3    Galloway, D.A.4
  • 31
    • 73249151176 scopus 로고    scopus 로고
    • HPV E6 protein interacts physically and functionally with the cellular telomerase complex
    • Liu X, Dakic A, Zhang Y, Dai Y, Chen R, Schlegel R. 2009. HPV E6 protein interacts physically and functionally with the cellular telomerase complex. Proc. Natl. Acad. Sci. U. S. A. 106:18780-18785. http://dx.doi .org/10.1073/pnas.0906357106.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 18780-18785
    • Liu, X.1    Dakic, A.2    Zhang, Y.3    Dai, Y.4    Chen, R.5    Schlegel, R.6
  • 32
    • 0037478697 scopus 로고    scopus 로고
    • Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter
    • Veldman T, Liu X, Yuan H, Schlegel R. 2003. Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter. Proc. Natl. Acad. Sci. U. S. A. 100:8211-8216. http://dx.doi.org/10.1073/pnas.1435900100.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 8211-8216
    • Veldman, T.1    Liu, X.2    Yuan, H.3    Schlegel, R.4
  • 33
    • 0026639028 scopus 로고
    • Interactions of HPV E6 and E7 oncoproteins with tumour suppressor gene products
    • Munger K, Scheffner M, Huibregtse JM, Howley PM. 1992. Interactions of HPV E6 and E7 oncoproteins with tumour suppressor gene products. Cancer Surv. 12:197-217.
    • (1992) Cancer Surv. , vol.12 , pp. 197-217
    • Munger, K.1    Scheffner, M.2    Huibregtse, J.M.3    Howley, P.M.4
  • 34
    • 0030756473 scopus 로고    scopus 로고
    • The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2
    • Jones DL, Alani RM, Munger K. 1997. The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2. Genes Dev. 11:2101-2111. http://dx.doi.org/10.1101/gad.11.16.2101.
    • (1997) Genes Dev. , vol.11 , pp. 2101-2111
    • Jones, D.L.1    Alani, R.M.2    Munger, K.3
  • 35
    • 0030827303 scopus 로고    scopus 로고
    • Inhibition of CDK activity and PCNA-dependentDNAreplication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein
    • Funk JO, Waga S, Harry JB, Espling E, Stillman B, Galloway DA. 1997. Inhibition of CDK activity and PCNA-dependentDNAreplication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein. Genes Dev. 11:2090-2100. http://dx.doi.org/10.1101/gad.11.16.2090.
    • (1997) Genes Dev. , vol.11 , pp. 2090-2100
    • Funk, J.O.1    Waga, S.2    Harry, J.B.3    Espling, E.4    Stillman, B.5    Galloway, D.A.6
  • 41
    • 0032816001 scopus 로고    scopus 로고
    • Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells
    • Liu Y, Chen JJ, Gao Q, Dalal S, Hong Y, Mansur CP, Band V, Androphy EJ. 1999. Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells. J. Virol. 73:7297-7307.
    • (1999) J. Virol. , vol.73 , pp. 7297-7307
    • Liu, Y.1    Chen, J.J.2    Gao, Q.3    Dalal, S.4    Hong, Y.5    Mansur, C.P.6    Band, V.7    Androphy, E.J.8
  • 42
    • 0032768483 scopus 로고    scopus 로고
    • The human papillomavirus type 16 E6 oncoprotein can down-regulate p53 activity by targeting the transcriptional coactivator CBP/p300
    • Zimmermann H, Degenkolbe R, Bernard H-U, O'Connor MJ. 1999. The human papillomavirus type 16 E6 oncoprotein can down-regulate p53 activity by targeting the transcriptional coactivator CBP/p300. J. Virol. 73:6209-6219.
    • (1999) J. Virol. , vol.73 , pp. 6209-6219
    • Zimmermann, H.1    Degenkolbe, R.2    Bernard, H.-U.3    O'Connor, M.J.4
  • 43
    • 0030008177 scopus 로고    scopus 로고
    • Telomerase activation by the E6 gene product of human papillomavirus type 16
    • Klingelhutz AJ, Foster SA, McDougall JK. 1996. Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature 380:79-82. http://dx.doi.org/10.1038/380079a0.
    • (1996) Nature , vol.380 , pp. 79-82
    • Klingelhutz, A.J.1    Foster, S.A.2    McDougall, J.K.3
  • 44
    • 0030050770 scopus 로고    scopus 로고
    • Mutational analysis of human papillomavirus type 16 E6 demonstrates that p53 degradation is necessary for immortalization of mammary epithelial cells
    • Dalal S, Gao Q, Androphy EJ, Band V. 1996. Mutational analysis of human papillomavirus type 16 E6 demonstrates that p53 degradation is necessary for immortalization of mammary epithelial cells. J. Virol. 70: 683-688.
    • (1996) J. Virol. , vol.70 , pp. 683-688
    • Dalal, S.1    Gao, Q.2    Androphy, E.J.3    Band, V.4
  • 45
    • 84880269308 scopus 로고    scopus 로고
    • Bone marrow cell transcripts from Fanconi anaemia patients reveal in vivo alterations in mitochondrial, redox and DNA repair pathways
    • Pagano G, Talamanca AA, Castello G, d'Ischia M, Pallardo FV, Petrovic S, Porto B, Tiano L, Zatterale A. 2013. Bone marrow cell transcripts from Fanconi anaemia patients reveal in vivo alterations in mitochondrial, redox and DNA repair pathways. Eur. J. Haematol. 91:141-151. http://dx .doi.org/10.1111/ejh.12131.
    • (2013) Eur. J. Haematol. , vol.91 , pp. 141-151
    • Pagano, G.1    Talamanca, A.A.2    Castello, G.3    d'Ischia, M.4    Pallardo, F.V.5    Petrovic, S.6    Porto, B.7    Tiano, L.8    Zatterale, A.9
  • 46
    • 84892142375 scopus 로고    scopus 로고
    • Evidence of mitochondrial dysfunction and impaired ROS detoxifying machinery in Fanconi anemia cells
    • Kumari U, Ya Jun W, Huat Bay B, Lyakhovich A. 2014. Evidence of mitochondrial dysfunction and impaired ROS detoxifying machinery in Fanconi anemia cells. Oncogene 33:165-172. http://dx.doi.org/10.1038 /onc.2012.583.
    • (2014) Oncogene , vol.33 , pp. 165-172
    • Kumari, U.1    Ya Jun, W.2    Huat Bay, B.3    Lyakhovich, A.4
  • 47
    • 84899881730 scopus 로고    scopus 로고
    • Damaged mitochondria and overproduction of ROS in Fanconi anemia cells
    • Lyakhovich A. 2013. Damaged mitochondria and overproduction of ROS in Fanconi anemia cells. Rare Dis. 1:e24048. http://dx.doi.org/10.4161 /rdis.24048.
    • (2013) Rare Dis. , vol.1 , pp. e24048
    • Lyakhovich, A.1
  • 49
  • 50
    • 84883237514 scopus 로고    scopus 로고
    • Changes in vimentin, lamin A/C and mitofilin induce aberrant cell organization in fibroblasts from Fanconi anemia complementation group A (FA-A) patients
    • Capanni C, Bruschi M, Columbaro M, Cuccarolo P, Ravera S, Dufour C, Candiano G, Petretto A, Degan P, Cappelli E. 2013. Changes in vimentin, lamin A/C and mitofilin induce aberrant cell organization in fibroblasts from Fanconi anemia complementation group A (FA-A) patients. Biochimie 95:1838-1847. http://dx.doi.org/10.1016/j.biochi.2013 .06.024.
    • (2013) Biochimie , vol.95 , pp. 1838-1847
    • Capanni, C.1    Bruschi, M.2    Columbaro, M.3    Cuccarolo, P.4    Ravera, S.5    Dufour, C.6    Candiano, G.7    Petretto, A.8    Degan, P.9    Cappelli, E.10
  • 54
    • 78649944103 scopus 로고    scopus 로고
    • Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer
    • Park JW, Pitot HC, Strati K, Spardy N, Duensing S, Grompe M, Lambert PF. 2010. Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer. Cancer Res. 70:9959-9968. http://dx.doi.org/10.1158/0008-5472 .CAN-10-1291.
    • (2010) Cancer Res. , vol.70 , pp. 9959-9968
    • Park, J.W.1    Pitot, H.C.2    Strati, K.3    Spardy, N.4    Duensing, S.5    Grompe, M.6    Lambert, P.F.7
  • 55
    • 84903607680 scopus 로고    scopus 로고
    • High incidence of female reproductive tract cancers in FA-deficient HPV16-transgenic mice correlates with E7's induction ofDNAdamage response, an activity mediated by E7's inactivation of pocket proteins
    • Park JW, Shin MK, Lambert PF. 2014. High incidence of female reproductive tract cancers in FA-deficient HPV16-transgenic mice correlates with E7's induction ofDNAdamage response, an activity mediated by E7's inactivation of pocket proteins. Oncogene 33:3383-3391. http://dx.doi .org/10.1038/onc.2013.327.
    • (2014) Oncogene , vol.33 , pp. 3383-3391
    • Park, J.W.1    Shin, M.K.2    Lambert, P.F.3
  • 56
    • 84884506632 scopus 로고    scopus 로고
    • High incidence of HPV-associated head and neck cancers in FA deficient mice is associated with E7's induction of DNA damage through its inactivation of pocket proteins
    • Park JW, Shin MK, Pitot HC, Lambert PF. 2013. High incidence of HPV-associated head and neck cancers in FA deficient mice is associated with E7's induction of DNA damage through its inactivation of pocket proteins. PLoS One 8:e75056. http://dx.doi.org/10.1371/journal.pone .0075056.
    • (2013) PLoS One , vol.8 , pp. e75056
    • Park, J.W.1    Shin, M.K.2    Pitot, H.C.3    Lambert, P.F.4
  • 58
    • 84879904684 scopus 로고    scopus 로고
    • Squamous cell carcinomas in patients with Fanconi anemia and dyskeratosis congenita: a search for human papillomavirus
    • Alter BP, Giri N, Savage SA, Quint WGV, de Koning MNC, Schiffman M. 2013. Squamous cell carcinomas in patients with Fanconi anemia and dyskeratosis congenita: a search for human papillomavirus. Int. J. Cancer 133:1513-1515. http://dx.doi.org/10.1002/ijc.28157.
    • (2013) Int. J. Cancer , vol.133 , pp. 1513-1515
    • Alter, B.P.1    Giri, N.2    Savage, S.A.3    Quint, W.G.V.4    de Koning, M.N.C.5    Schiffman, M.6
  • 61
    • 0142258073 scopus 로고    scopus 로고
    • The tumor-suppressive functions of the human INK4A locus
    • Voorhoeve PM, Agami R. 2003. The tumor-suppressive functions of the human INK4A locus. Cancer Cell 4:311-319. http://dx.doi.org/10.1016 /S1535-6108(03)00223-X.
    • (2003) Cancer Cell , vol.4 , pp. 311-319
    • Voorhoeve, P.M.1    Agami, R.2


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