Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cells with new pimozide derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 18, 2014, Pages 4568-4574

  Rondanin, Riccardo ^a   Simoni, Daniele ^a   Romagnoli, Romeo ^a   Baruchello, Riccardo ^a   Marchetti, Paolo ^a   Costantini, Cristiana ^a   Fochi, Sara ^a   Padroni, Giacomo ^a   Grimaudo, Stefania ^b   Pipitone, Rosaria Maria ^b   Meli, Maria ^b   Tolomeo, Manlio ^b  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

Author keywords

Apoptosis; BCR ABL expressing leukemia; Cell growth inhibition; Pimozide; STAT5 inhibitors

Indexed keywords

BCR ABL PROTEIN; PIMOZIDE; STAT5 PROTEIN;

APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; COLONY FORMING UNIT GM; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CELL CYCLE; CELL LINE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GENETICS; K562 CELL LINE; METABOLISM; PHOSPHORYLATION; SYNTHESIS;

APOPTOSIS; CELL CYCLE; CELL LINE; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FUSION PROTEINS, BCR-ABL; HUMANS; K562 CELLS; MOLECULAR STRUCTURE; PHOSPHORYLATION; PIMOZIDE; STAT5 TRANSCRIPTION FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84906968007     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.07.069     Document Type: Article

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