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Volumn 26, Issue 6, 2012, Pages 1407-1410

Dual inhibition of Jak2 and STAT5 enhances killing of myeloproliferative neoplasia cells

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN RECEPTOR; JANUS KINASE 2; JANUS KINASE 2 INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; PIMOZIDE; PROPIDIUM IODIDE; PROTEIN BCL XL; PROTEIN MCL 1; STAT5 PROTEIN;

EID: 84862000598     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2011.338     Document Type: Letter
Times cited : (36)

References (14)
  • 1
    • 55249095625 scopus 로고    scopus 로고
    • Myeloproliferative disorders
    • Levine RL, Gilliland DG. Myeloproliferative disorders. Blood 2008; 112: 2190-2198.
    • (2008) Blood , vol.112 , pp. 2190-2198
    • Levine, R.L.1    Gilliland, D.G.2
  • 3
    • 33744490974 scopus 로고    scopus 로고
    • Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model
    • DOI 10.1182/blood-2005-12-4824
    • Wernig G, Mercher T, Okabe R, Levine RL, Lee BH, Gilliland DG. Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model. Blood 2006; 107: 4274-4281. (Pubitemid 43801351)
    • (2006) Blood , vol.107 , Issue.11 , pp. 4274-4281
    • Wernig, G.1    Mercher, T.2    Okabe, R.3    Levine, R.L.4    Lee, B.H.5    Gilliland, D.G.6
  • 5
    • 70350123034 scopus 로고    scopus 로고
    • Chronic myeloproliferative diseases with and without the Ph chromosome: Some unresolved issues
    • Goldman JM, Green AR, Holyoake T, Jamieson C, Mesa R, Mughal T et al. Chronic myeloproliferative diseases with and without the Ph chromosome: some unresolved issues. Leukemia 2009; 23: 1708-1715.
    • (2009) Leukemia , vol.23 , pp. 1708-1715
    • Goldman, J.M.1    Green, A.R.2    Holyoake, T.3    Jamieson, C.4    Mesa, R.5    Mughal, T.6
  • 6
    • 33746437130 scopus 로고    scopus 로고
    • MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
    • Pikman Y, Lee BH, Mercher T, McDowell E, Ebert BL, Gozo M et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med 2006; 3: e270.
    • (2006) PLoS Med , vol.3
    • Pikman, Y.1    Lee, B.H.2    Mercher, T.3    McDowell, E.4    Ebert, B.L.5    Gozo, M.6
  • 8
    • 84862005018 scopus 로고    scopus 로고
    • Developing pharmacological modulators of STAT signaling
    • Stephanou A (ed) Landes Bioscience: Austin
    • Nelson EA, Frank DA. Developing pharmacological modulators of STAT signaling. In: Stephanou A (ed). JAK-STAT Pathway in Disease. Landes Bioscience: Austin, 2009, pp 164-172.
    • (2009) JAK-STAT Pathway in Disease , pp. 164-172
    • Nelson, E.A.1    Frank, D.A.2
  • 9
    • 77949331464 scopus 로고    scopus 로고
    • STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant
    • Funakoshi-Tago M, Tago K, Abe M, Sonoda Y, Kasahara T. STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant. J Biol Chem 2010; 285: 5296-5307.
    • (2010) J Biol Chem , vol.285 , pp. 5296-5307
    • Funakoshi-Tago, M.1    Tago, K.2    Abe, M.3    Sonoda, Y.4    Kasahara, T.5
  • 10
    • 79953109597 scopus 로고    scopus 로고
    • The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors
    • Nelson EA, Walker SR, Weisberg E, Bar-Natan M, Barrett R, Gashin LB et al. The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood 2011; 117: 3421-3429.
    • (2011) Blood , vol.117 , pp. 3421-3429
    • Nelson, E.A.1    Walker, S.R.2    Weisberg, E.3    Bar-Natan, M.4    Barrett, R.5    Gashin, L.B.6
  • 12
    • 0034693871 scopus 로고    scopus 로고
    • Janus kinases: Components of multiple signaling pathways
    • Rane SG, Reddy EP. Janus kinases: components of multiple signaling pathways. Oncogene 2000; 19: 5662-5679.
    • (2000) Oncogene , vol.19 , pp. 5662-5679
    • Rane, S.G.1    Reddy, E.P.2
  • 13
    • 57749084579 scopus 로고    scopus 로고
    • Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2
    • Gozgit JM, Bebernitz G, Patil P, Ye M, Parmentier J, Wu J et al. Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2. J Biol Chem 2008; 283: 32334-32343.
    • (2008) J Biol Chem , vol.283 , pp. 32334-32343
    • Gozgit, J.M.1    Bebernitz, G.2    Patil, P.3    Ye, M.4    Parmentier, J.5    Wu, J.6
  • 14
    • 73949096431 scopus 로고    scopus 로고
    • FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation
    • Yoshimoto G, Miyamoto T, Jabbarzadeh-Tabrizi S, Iino T, Rocnik JL, Kikushige Y et al. FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation. Blood 2009; 114: 5034-5043.
    • (2009) Blood , vol.114 , pp. 5034-5043
    • Yoshimoto, G.1    Miyamoto, T.2    Jabbarzadeh-Tabrizi, S.3    Iino, T.4    Rocnik, J.L.5    Kikushige, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.