Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity

Journal of Medicinal Chemistry

Volumn 55, Issue 3, 2012, Pages 1047-1055

  Page, Brent D G ^a   Khoury, Haytham ^b   Laister, Rob C ^b   Fletcher, Steven ^a   Vellozo, Megan ^b   Manzoli, Alessia ^b   Yue, Peibin ^c   Turkson, James ^c   Minden, Mark D ^b   Gunning, Patrick T ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 (4 CHLORO N METHYLPHENYLSULFONAMIDO) N (4 CYCLOHEXYLBENZYL)ACETAMIDO] 2 HYDROXYBENZOIC ACID; 4 [2 (N,4 DIMETHYLPHENYLSULFONAMIDO) N [[3' (METHOXYCARBONYL)TERPHENYL 4 YL]METHYL]ACETAMID] 2 HYDROXYBENZOIC ACID; 4 [N (4 CYCLOHEXYLBENZYL) 2 (N ,2, 4, 6 TETRAMETHYLPHENYLSULFONAMID)ACETAMIDO] 2 HYDROXYBENZOIC ACID; 4 [N (4 CYCLOHEXYLBENZYL) 2 (N METHYLBIPHENYL 4 YLSULFONAMID)ACETAMIDO] 2 HYDROXYBENZOIC ACID; 4 [N [4 [1 (4 CARBAMOYLPHENYL)PIPERIDIN 4 YL]BENZYL] 2 (N,4 DIMETHYL PHENYL SULFONAMID)ACETAMIDO] 2 HYDROXYBENZOIC ACID; 4 [N [4 [1 (4 CYANOPHENYL)PIPERIDIN 4 YL]BENZYL] 2 (N,4 DIMETHYLPHENYL SULFONAMID)ACETAMIDO] 2 HYDROXYBENZOIC ACID; 4 [N [[4'' CARBAMOYL (1,1':4',1'' TERPHENYL) 4 YL]METHYL] 2 (N,4 DIMETHYLPHENYL SULFONAMID)ACETAMIDO] 2 HYDROXYBENZOIC ACID; 4 [N BENZYL 2 [N (TERT BUTOXYCARBONYL) 4 METHYLPHENYLSULFONAMID]ACETAMIDO] 2 HYDROXYBENZOIC ACID; ANTILEUKEMIC AGENT; CYCLIN D1; CYCLIN D2; IMATINIB; MYC PROTEIN; PROTEIN MCL 1; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; UNCLASSIFIED DRUG;

ANTILEUKEMIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG SPECIFICITY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LEUKEMIA CELL; PROTEIN PHOSPHORYLATION;

AMINOSALICYLIC ACIDS; ANTINEOPLASTIC AGENTS; BINDING, COMPETITIVE; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LEUKEMIA, MYELOID, ACUTE; MODELS, MOLECULAR; PHOSPHORYLATION; PROTEIN ISOFORMS; SRC HOMOLOGY DOMAINS; STAT5 TRANSCRIPTION FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84856845674     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200720n     Document Type: Article

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