The HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import

Journal of Biological Chemistry

Volumn 289, Issue 36, 2014, Pages 25351-25361

  De Houwer, Stéphanie ^a   Demeulemeester, Jonas ^a   Thys, Wannes ^a   Rocha, Susana ^a   Dirix, Lieve ^a   Gijsbers, Rik ^a   Christ, Frauke ^a   Debyser, Zeger ^a  

^a DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

DEFECTS; INTEGRATION; POLYMERASE CHAIN REACTION; PROTEINS; TRANSCRIPTION; VIRUSES;

ANTIVIRAL THERAPY; BINDING INTERFACE; HIV-1 INTEGRASE; INTERACTION INTERFACE; LONG TERMINAL REPEATS; PROTEIN-PROTEIN INTERACTIONS; QUANTITATIVE PCR; REVERSE TRANSCRIPTION;

DISEASES;

HIV 1 INTEGRASE; INTEGRASE; KARYOPHERIN; RALTEGRAVIR; TRANSPORTIN SR2; UNCLASSIFIED DRUG; KARYOPHERIN BETA; MUTANT PROTEIN; P31 INTEGRASE PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; PROTEIN BINDING;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; FLUORESCENCE ANALYSIS; GENE ACTIVITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LONG TERMINAL REPEAT; NONHUMAN; NUCLEAR IMPORT; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PROTEIN BINDING; PROTEIN DEFECT; PROTEIN PROTEIN INTERACTION; VIRUS MUTANT; VIRUS REPLICATION; ACTIVE TRANSPORT; BINDING COMPETITION; BINDING SITE; CELL NUCLEUS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENETICS; HELA CELL LINE; METABOLISM; MUTATION; PROTEIN TERTIARY STRUCTURE; VIROLOGY; WESTERN BLOTTING;

ACTIVE TRANSPORT, CELL NUCLEUS; BETA KARYOPHERINS; BINDING SITES; BINDING, COMPETITIVE; BLOTTING, WESTERN; CELL NUCLEUS; HELA CELLS; HIV INTEGRASE; HIV-1; HUMANS; MODELS, MOLECULAR; MUTANT PROTEINS; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; VIRUS REPLICATION;

EID: 84906966195     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.533281     Document Type: Article

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