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Volumn 24, Issue 18, 2014, Pages 4397-4401

The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Nav1.7

Author keywords

Benzenesulfonamide; Nav1.7; Pain; Sodium channel

Indexed keywords

BENZENESULFONAMIDE DERIVATIVE; CYTOCHROME; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL BLOCKING AGENT; VOLTAGE GATED SODIUM CHANNEL NAV1.7 INHIBITOR; BENZENESULFONAMIDE; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 3A; ENZYME INHIBITOR; SODIUM CHANNEL NAV1.7; SULFONAMIDE;

EID: 84906959754     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.08.017     Document Type: Article
Times cited : (32)

References (18)
  • 9
    • 66449112479 scopus 로고    scopus 로고
    • For recent reviews of the medicinal chemistry of sodium channel blockers, see
    • For recent reviews of the medicinal chemistry of sodium channel blockers, see: M.A. Matulenko, M.J. Scanio, and M.E. Kort Curr. Top. Med. Chem. 9 2009 362
    • (2009) Curr. Top. Med. Chem. , vol.9 , pp. 362
    • Matulenko, M.A.1    Scanio, M.J.2    Kort, M.E.3
  • 16
    • 0017332486 scopus 로고
    • v1.5). The voltage is then stepped back to a very negative (Vhold = 150 mV) voltage for 20 ms and then a test pulse is applied to quantify the compound block. The 20 ms brief repolarization was long enough for compound-free channels to completely recover from fast inactivation, but the compound-bound channels recovered more slowly such that negligible recovery could occur during this interval. The percent decrease in sodium current following wash-on of compound was taken as the percent block of sodium channels. All statistics in this study were given as mean ± SD.
    • (1977) J. Gen. Physiol. , vol.69 , pp. 497
    • Hille, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.