Exhaled nitric oxide: A biomarker integrating both lung function and airway inflammation changes

Journal of Allergy and Clinical Immunology

Volumn 134, Issue 3, 2014, Pages 554-559

  Haccuria, Amaryllis ^a,b   Michils, Alain ^a   Michiels, Sébastien ^a   Van Muylem, Alain ^a  

^a ERASME HOSPITAL   (Belgium)

^b Centre Hospitalier Regional de Namur   (Belgium)

Author keywords

Allergen challenge; asthma; bronchoprovocation; fractional exhaled nitric oxide; house dust mite

Indexed keywords

BIOLOGICAL MARKER; HOUSE DUST ALLERGEN; NITRIC OXIDE;

ADULT; AIRWAY REMODELING; ANIMAL; ASTHMA; BREATH ANALYSIS; DISEASE COURSE; EXHALATION; FEMALE; HUMAN; IMMUNOLOGY; LUNG FUNCTION TEST; MALE; METABOLISM; PNEUMONIA; PROCEDURES; PROSPECTIVE STUDY; PYROGLYPHIDAE; RESPIRATORY SYSTEM;

ADULT; AIRWAY REMODELING; ANIMALS; ANTIGENS, DERMATOPHAGOIDES; ASTHMA; BIOLOGICAL MARKERS; BREATH TESTS; DISEASE PROGRESSION; EXHALATION; FEMALE; HUMANS; MALE; NITRIC OXIDE; PNEUMONIA; PROSPECTIVE STUDIES; PYROGLYPHIDAE; RESPIRATORY FUNCTION TESTS; RESPIRATORY SYSTEM;

EID: 84906944492     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.12.1070     Document Type: Article

References (41)

1. E.D. Bateman, S.S. Hurd, P.J. Barnes, J. Bousquet, J.M. Drazen, and M. FitzGerald et al. Global strategy for asthma management and prevention: GINA executive summary Eur Respir J 31 2008 143 178
2. R.H. Green, C.E. Brightling, S. McKenna, B. Hargadon, D. Parker, and P. Bradding et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial Lancet 360 2002 1715 1721
3. J.K. Sont, L.N. Willems, E.H. Bel, J.H. van Krieken, J.P. Vandenbroucke, and P.J. Sterk Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group Am J Respir Crit Care Med 159 1999 1043 1051
4. K. Alving, E. Weitzberg, and J.M. Lundberg Increased amount of nitric oxide in exhaled air of asthmatics Eur Respir J 6 1993 1368 1370
5. M.A. Berry, D.E. Shaw, R.H. Green, C.E. Brightling, A.J. Wardlaw, and I.D. Pavord The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma Clin Exp Allergy 35 2005 1175 1179
6. S. Moncada, and A. Higgs The L-arginine-nitric oxide pathway N Engl J Med 329 1993 2002 2012
7. R.A. Dweik, P.B. Boggs, S.C. Erzurum, C.G. Irvin, M.W. Leigh, and J.O. Lundberg et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications Am J Respir Crit Care Med 84 2011 602 615
8. A. Van Muylem, Y. Kerckx, and A. Michils Axial distribution of exhaled nitric oxide production in asthma Respir Physiol Neurobiol 185 2013 313 318
9. L.P. Ho, F.T. Wood, A. Robson, J.A. Innes, and A.P. Greening The current single exhalation method of measuring exhales nitric oxide is affected by airway calibre Eur Respir J 15 2000 1009 1013
10. H.W. de Gouw, J. Hendriks, A.M. Woltman, I.M. Twiss, and P.J. Sterk Exhaled nitric oxide (NO) is reduced shortly after bronchoconstriction to direct and indirect stimuli in asthma Am J Respir Crit Care Med 158 1998 315 319
11. S. Verbanck, Y. Kerckx, D. Schuermans, W. Vincken, M. Paiva, and A. Van Muylem Effect of airways constriction on exhaled nitric oxide J Appl Physiol 104 2008 925 930
12. P.J. Sterk, L.M. Fabbri, P.H. Quanjer, D.W. Cockcroft, P.M. O'Byrne, and S.D. Anderson et al. Airway responsiveness. Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society Eur Respir J Suppl 16 1993 53 83
13. A.P. Pietropaoli, I.B. Perillo, A. Torres, P.T. Perkins, L.M. Frasier, and M.J. Utell et al. Simultaneous measurement of nitric oxide production by conducting and alveolar airways of humans J Appl Physiol 87 1999 1532 1542
14. Y. Kerckx, A. Michils, and A. Van Muylem Airway contribution to alveolar nitric oxide in healthy subjects and stable asthma patients J Appl Physiol 104 2008 918 924
15. P.H. Quanjer, G.J. Tammeling, J.E. Cotes, O.F. Pedersen, R. Peslin, and J.C. Yernault Lung volumes and forced ventilatory flows. Report Working Party. Standardization of Lung Function Tests. European Community for Steel and Coal. Official Statement of the European Respiratory Society Eur Respir J 6 Suppl 16 1993 5 40
16. A. Michils, Y. Elkrim, A. Haccuria, and A. Van Muylem Adenosine 5′-monophosphate challenge elicits a more peripheral airway response than methacholine challenge J Appl Physiol 110 2011 1241 1247
17. S. Holms A simple sequentially rejective multiple test procedure Scand J Stat 6 1979 65 70
18. R Core TeamR: a language and environment for statistical computing. Vienna: R Foundation for Statistical Computing. Available at: http://www.R-project.org/.
19. S. Nakagawa, and H. Schielzeth A general and simple method for obtaining R2 from generalized linear mixed-effects models Methods Ecol Evol 4 2013 133 142
20. F. Faul, E. Erdfelder, A.G. Lang, and A. Buchner G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences Behav Res Methods 39 2007 175 191
21. P. Garnier, I. Fajac, J.F. Dessanges, J. Dall'Ava-Santucci, A. Lockhart, and A.T. Dinh-Xuan Exhaled nitric oxide during acute changes of airways calibre in asthma Eur Respir J 9 2013 1134 1138
22. G.M. Gauvreau, R.M. Watson, and P.M. O'Byrne Kinetics of allergen-induced airway eosinophilic cytokine production and airway inflammation Am J Respir Crit Care Med 160 1999 640 647
23. Z. Diamant, G.M. Gauvreau, D.W. Cockcroft, L.P. Boulet, P.J. Sterk, and F.H. De Jongh et al. Inhaled allergen bronchoprovocation tests J Allergy Clin Immunol 132 2013 1045 1055
24. O.P. Twentyman, and S.T. Holgate Reversibility of the allergen-provoked late asthmatic response by an inhaled beta 2-adrenoceptor agonist Clin Exp Allergy 24 1994 245 249
25. D.W. Cockcroft, and K.Y. Murdock Comparative effects of inhaled salbutamol, sodium cromoglycate, and beclomethasone dipropionate on allergen-induced early asthmatic responses, late asthmatic responses, and increased bronchial responsiveness to histamine J Allergy Clin Immunol 79 1987 734 740
26. J. Jiang, N. Malavia, V. Suresh, and S.C. George Nitric oxide gas phase release in human small airway epithelial cells Respir Res 10 2009 3
27. P.G. Gibson Using fractional exhaled nitric oxide to guide asthma therapy: design and methodological issues for ASthma TReatment ALgorithm studies Clin Exp Allergy 39 2009 478 490
28. S.J. Szefler, H. Mitchell, C.A. Sorkness, P.J. Gergen, G.T. O'Connor, and W.J. Morgan et al. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial Lancet 372 2008 1065 1072
29. A.D. Smith, J.O. Cowan, K.P. Brassett, G.P. Herbison, and D.R. Taylor Use of exhaled nitric oxide measurements to guide treatment in chronic asthma N Engl J Med 352 2005 2163 2173
30. D.E. Shaw, M.A. Berry, M. Thomas, R.H. Green, C.E. Brightling, and A.J. Wardlaw et al. The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial Am J Respir Crit Care Med 176 2007 231 237
31. A. Michils, S. Baldassarre, and A. Van Muylem Exhaled nitric oxide and asthma control: a longitudinal study in unselected patients Eur Respir J 31 2008 539 546
32. A. Van Muylem, P. De Vuyst, J.C. Yernault, and M. Paiva Inert gas single-breath washout and structural alteration of respiratory bronchioles Am Rev Respir Dis 146 1992 1167 1172
33. M. Paiva, and L.A. Engel Theoretical studies of gas mixing and ventilation distribution in the lung Physiol Rev 67 1987 750 796
34. B. Haefeli-Bleuer, and E.R. Weibel Morphometry of the human pulmonary acinus Anat Rec 220 1988 401 414
35. M. Estenne, A. Van Muylem, C. Knoop, and M. Antoine Detection of obliterative bronchiolitis after lung transplantation by indexes of ventilation distribution Am J Respir Crit Care Med 162 2000 1047 1051
36. H.K. Ljungberg, and P.M. Gustafsson Peripheral airway function in childhood asthma, assessed by single-breath He and SF6 washout Pediatr Pulmonol 36 2003 339 347
37. P.M. Gustafsson, H.K. Ljungberg, and B. Kjellman Peripheral airway involvement in asthma assessed by single-breath SF6 and He washout Eur Respir J 21 2003 1033 1039
38. N.G. Carroll, S. Mutavdzic, and A.L. James Distribution and degranulation of airway mast cells in normal and asthmatic subjects Eur Respir J 19 2002 879 885
39. P.M. O'Byrne, and G.M. Gauvreau Interaction between haemopoietic regulation and airway inflammation Clin Exp Immunol 29 1999 27 32
40. A.F. Gelb, C.F. Taylor, E. Nussbaum, C. Gutierrez, A. Schein, and C.M. Shinar et al. Alveolar and airway sites of nitric oxide inflammation in treated asthma Am J Respir Crit Care Med 170 2004 737 741
41. A. Van Muylem, Y. Kerckx, and A. Michils Acinar effect of inhaled steroids evidenced by exhaled nitric oxide J Allergy Clin Immunol 126 2010 730 735