The current single exhalation method of measuring exhaled nitric oxide is affected by airway calibre

European Respiratory Journal

Volumn 15, Issue 6, 2000, Pages 1009-1013

  Ho, L P ^a   Wood, F T ^b   Robson, A ^b   Innes, J A ^b   Greening, A P ^b  

^a CHURCHILL HOSPITAL   (United Kingdom)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

Airway calibre; Exhaled nitric oxide

Indexed keywords

NITRIC OXIDE; SALBUTAMOL;

ADULT; AIRWAY RESISTANCE; ARTICLE; CHEMOLUMINESCENCE; CLINICAL ARTICLE; DRUG EFFECT; EXHALATION; FEMALE; FLOW RATE; FORCED EXPIRATORY VOLUME; HUMAN; LUNG FUNCTION; MALE; MEASUREMENT; PRIORITY JOURNAL; PROVOCATION TEST; SPIROMETRY;

ADULT; ASTHMA; BREATH TESTS; CROSS-SECTIONAL STUDIES; CYSTIC FIBROSIS; FORCED EXPIRATORY VOLUME; HISTAMINE; HUMANS; LONGITUDINAL STUDIES; NITRIC OXIDE; SPIROMETRY;

EID: 0034084633     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3003.2000.01506.x     Document Type: Article

References (17)

1. Moncada S. NO: mediator, modulator, and pathophysiologic entity. J Lab Clin Med 1992; 120: 187-191.
2. Gaston B, Drazen JM, Loscalzo J, Stamler JS. The biology of NO in the airways. Am J Respir Crit Care Med 1994; 149: 538-551.
3. Kharitonov SA, Yates D, Springall DR, et al. Increased NO in exhaled air of asthmatic patients. Lancet 1994; 343: 133-136.
4. Alving K, Witzberg E, Lundberg JM. Increased amount of NO in exhaled air of asthmatics. Eur Respir J 1993; 6: 1368-1370.
5. Kharitonov S, Alving K, Barnes PJ. Exhaled and nasal NO measurements: recommendations. Eur Respir J 1997; 10: 1683-1693.
6. American Thoracic Society. Standards for the diagnosis and care of patients with COPD and asthma. Am Rev Respir Dis 1987; 136: 225-244.
7. 2-agonist inhalation and spirometry in asthma. Am J Respir Crit Care Med 1999; 159: 940-944.
8. Deykin A, Halpern O, Massaro FA, Drazen JM, Israel E. Expired NO after bronchoprovocation and repeated spirometry in patients with asthma. Am J Respir Crit Care Med 1998; 157: 769-775.
9. Yates DH, Kharitonov SA, Barnes PJ. Effect of short and long acting inhaled beta 2 agonists on exhaled NO in asthmatic patients. Eur Respir J 1997; 10: 1483-1488.
10. Ho LP, Innes JA, Greening AP. Exhaled nitric oxide is not elevated in the inflammatory airways diseases of cystic fibrosis and bronchiectasis. Eur Respir J 1998; 12: 1290-1294.
11. de Gouw HWFM, Hendriks J, Woltman AM, Twiss IM, Sterk PJ. Exhaled NO is reduced shortly after broncho-constriction to direct and indirect stimuli in asthma. Am J Respir Crit Care Med 1998; 158: 315-319.
12. Granier P, Fajac JF, Dessanges JF, Dall'Ava-Santucci J, Lockhart A, Dinh-Xuan AT. Exhaled NO during acute changes of airway calibre in asthma. Eur Respir J 1996; 9: 1134-1138.
13. Silkoff PE, McClean PA, Slutsky AS, et al. Marked flow-dependence of exhaled nitric oxide using a new technique to exclude nasal nitric oxide. Am J Respir Crit Care Med 1997; 155: 260-267.
14. Ho LP, Innes JA, Greening AP. Nitrite levels in breath condensate are elevated in patients with cystic fibrosis in contrast to exhaled NO. Thorax 1998; 53: 680-684.
15. Watson DN, Peroni DJ, Basclain KA, Garlepp MJ, Thompson PJ. Expression and activity of NOS in human airway epithelium. Am J Respir Cell Mol Biol 1997; 16: 629-639.
16. Robbins RA, Barnes PJ, Springall DR, et al. Expression of iNOS in human lung epithelial cells. Biochem Biophys Res Commun 1994; 203: 209-218.
17. DuBois AB, Kelley PM, Douglas JS, Mohsenin V. NO production and absorption in trachea, bronchi, bronchioles and respiratory bronchioles of humans. J Appl Physiol 1999; 86: 159-167.