Acinar effect of inhaled steroids evidenced by exhaled nitric oxide

Journal of Allergy and Clinical Immunology

Volumn 126, Issue 4, 2010, Pages

  Van Muylem, Alain ^a   Kerckx, Yannick ^a   Michils, Alain ^a  

^a ERASME HOSPITAL   (Belgium)

Author keywords

alveolar nitric oxide; asthma; Asthma Control Questionnaire; Exhaled nitric oxide; inhaled corticosteroids

Indexed keywords

BECLOMETASONE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; NITRIC OXIDE; STEROID;

ACINAR CELL; ADULT; AGED; AIRWAY OBSTRUCTION; ARTICLE; ASTHMA; BRONCHODILATATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE CONTROL; EXPIRED AIR; FEMALE; HUMAN; MALE; POWDER INHALER; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 77957770034     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2010.06.019     Document Type: Article

References (32)

1. N. Carroll, J. Elliot, A. Morton, and A. James The structure of large and small airways in nonfatal and fatal asthma Am Rev Respir Dis 147 1993 405 410
2. S. Balzar, S.E. Wenzel, and H.W. Chu Transbronchial biopsy as a tool to evaluate small airways in asthma Eur Respir J 20 2002 254 259
3. A.F. Gelb, T.C. Flynn, C.M. Shinar, C. Gutierrez, and N. Zamel Role of spirometry and exhaled nitric oxide to predict exacerbations in treated asthmatics Chest 129 2006 1492 1499
4. A.F. Gelb, C.F. Taylor, E. Nussbaum, C. Gutierrez, A. Schein, and C.M. Shinar Alveolar and airway sites of nitric oxide inflammation in treated asthma Am J Respir Crit Care Med 170 2004 737 741
5. E. Paraskakis, C. Brindicci, L. Fleming, R. Krol, S.A. Kharitonov, and N.M. Wilson Measurement of bronchial and alveolar nitric oxide production in normal children and children with asthma Am J Respir Crit Care Med 174 2006 260 267
6. I. van Veen, P.J. Sterk, R. Schot, S.A. Gauw, K.F. Rabe, and E.H. Bel Alveolar nitric oxide versus measures of peripheral airway dysfunction in severe asthma Eur Respir J 27 2006 951 956
7. C. Brindicci, K. Ito, P.J. Barnes, and S.A. Kharitonov Differential flow analysis of exhaled nitric oxide in patients with asthma of differing severity Chest 131 2007 1353 1362
8. M. Berry, B. Hargadon, A. Morgan, M. Shelley, J. Richter, and D. Shaw Alveolar nitric oxide in adults with asthma: evidence of distal lung inflammation in refractory asthma Eur Respir J 25 2005 986 991
9. S.A. Kharitonov, L.E. Donnelly, P. Montuschi, M. Corradi, J.V. Collins, and P.J. Barnes Dose-dependent onset and cessation of action of inhaled budesonide on exhaled nitric oxide and symptoms in mild asthma Thorax 57 2002 889 896
10. L. Lehtimäki, H. Kankaanranta, S. Saarelainen, V. Turjanmaa, and E. Moilanen Inhaled fluticasone decreases bronchial but not alveolar nitric oxide output in asthma Eur Respir J 18 2001 635 639
11. Y. Kerckx, A. Michils, and A. Van Muylem Airway contribution to alveolar nitric oxide in healthy subjects and stable asthma patients J Appl Physiol 104 2008 918 924
12. P. Condorelli, H.W. Shin, A.S. Aledia, P.E. Silkoff, and S.C. George A simple technique to characterize proximal and peripheral nitric oxide exchange using constant flow exhalations and an axial diffusion model J Appl Physiol 102 2007 417 425
13. H.W. Shin, and S.C. George Impact of axial diffusion on nitric oxide exchange in the lungs J Appl Physiol 93 2002 2070 2080
14. A. Van Muylem, C. Noel, and M. Paiva Modeling of impact of gas molecular diffusion on nitric oxide expired profile J Appl Physiol 94 2003 119 127
15. S. Verbanck, Y. Kerckx, D. Schuermans, W. Vincken, M. Paiva, and A. Van Muylem Effect of airways constriction on exhaled nitric oxide J Appl Physiol 104 2008 925 930
16. Global initiative for Asthma. 2006. Available at: www.ginaasthma.com.
17. A.P. Pietropaoli, I.B. Perillo, A. Torres, P.T. Perkins, L.M. Frasier, and M.J. Utell Simultaneous measurement of nitric oxide production by conducting and alveolar airways of humans J Appl Physiol 87 1999 1532 1542 (Pubitemid 29483144)
18. N.M. Tsoukias, and S.C. George A two-compartment model of pulmonary nitric oxide exchange dynamics J Appl Physiol 85 1998 653 666
19. American Thoracic Society/European Respiratory Society recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005 Am J Respir Crit Care Med 171 2005 912 930
20. E.F. Juniper, K. Svensson, A.C. Mork, and E. Stahl Measurement properties and interpretation of three shortened versions of the asthma control questionnaire Respir Med 99 2005 553 558
21. E.F. Juniper, J. Bousquet, L. Abetz, and E.D. Bateman Identifying "well-controlled" and "not well-controlled" asthma using the Asthma Control Questionnaire Respir Med 100 2006 616 621
22. P.H. Quanjer, G.J. Tammeling, J.E. Cotes, O.F. Pedersen, R. Peslin, and J.C. Yernault Lung volumes and forced ventilatory flows. Report Working Party. Standardization of lung function tests. European Community for Steel and Coal. Official Statement of the European Respiratory Society Eur Respir J 6 suppl 16 1993 5 40
23. J. Travers, S. Marsh, S. Aldington, M. Williams, P. Shirtcliffe, and A. Pritchard Reference ranges for exhaled nitric oxide derived from a random community survey of adults Am J Respir Crit Care Med 176 2007 238 242
24. E.R. Weibel Morphometry of the human lung 1963 Academic Press New York
25. W.C. Moore, E.R. Bleecker, D. Curran-Everett, S.C. Erzurum, B.T. Ameredes, and L. Bacharier Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program J Allergy Clin Immunol 119 2007 405 413
26. L. Lehtimäki, H. Kankaanranta, S. Saarelainen, V. Turjanmaa, and E. Moilanen Peripheral inflammation in patients with asthmatic symptoms but normal lung function J Asthma 42 2005 605 609
27. L. Lehtimäki, H. Kankaanranta, S. Saarelainen, V. Turjanmaa, and E. Moilanen Increased alveolar nitric oxide concentration in asthmatic patients with nocturnal symptoms Eur Respir J 20 2002 841 845
28. S. Verbanck, D. Schuermans, M. Noppen, A. Van Muylem, M. Paiva, and W. Vincken Evidence of acinar airway involvement in asthma Am J Respir Crit Care Med 159 1999 1545 1550
29. G.P. Martin, H.B. MacRitchie, C. Marriott, and X.M. Zeng Characterisation of a carrier-free dry powder aerosol formulation using inertial impaction and laser diffraction Pharm Res 23 2006 2210 2219
30. L.J. Wood, R. Sehmi, G.M. Gauvreau, R.M. Watson, R. Foley, and J.A. Denburg An inhaled corticosteroid, budesonide, reduces baseline but not allergen-induced increases in bone marrow inflammatory cell progenitors in asthmatic subjects Am J Respir Crit Care Med 159 1999 1457 1463
31. Y. Kerckx, A. Michils, and A. Van Muylem Airway contribution to alveolar nitric oxide in healthy subjects and stable asthma patients J Appl Physiol 104 2008 918 924
32. A.V. Davison, and D.V. Hinkley Bootstrap methods and their applications 1997 Cambridge University Press Cambridge