Adenosine 5′-monophosphate challenge elicits a more peripheral airway response than methacholine challenge

Journal of Applied Physiology

Volumn 110, Issue 5, 2011, Pages 1241-1247

  Michils, Alain ^a   Elkrim, Yvon ^a   Haccuria, Amaryllis ^b   Van Muylem, Alain ^a  

^a ERASME HOSPITAL   (Belgium)

^b Centre Hospitalier Regional de Namur   (Belgium)

Author keywords

Airway hyperresponsiveness; Asthma; Helium; Hexafluorosulfur; Methacholine; Ventilation distribution

Indexed keywords

ADENOSINE PHOSPHATE; DIAGNOSTIC AGENT; METHACHOLINE CHLORIDE;

ADULT; ARTICLE; ASTHMA; COMPARATIVE STUDY; DRUG EFFECT; FEMALE; HUMAN; LUNG; LUNG FUNCTION TEST; LUNG VENTILATION; MALE; METHODOLOGY; PATHOPHYSIOLOGY;

ADENOSINE MONOPHOSPHATE; ADULT; ASTHMA; FEMALE; HUMANS; LUNG; MALE; METHACHOLINE CHLORIDE; PULMONARY VENTILATION; RESPIRATORY FUNCTION TESTS;

EID: 79956117921     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01401.2010     Document Type: Article

References (40)

1. Abernathy EC, Hruban RH, Baumgartner WA, Reitz BA, Hutchins GM. The two forms of bronchiolitis obliterans in heart-lung transplant recipients. Hum Pathol 22: 1102-1110, 1991.
2. Anderson SD. Indirect challenge tests: airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest 138: 25S-30S, 2010.
3. Anonymous. Global Initiative for Asthma (Online). http://www.ginaasthma. com [revised 2006].
4. Barnes PJ, Basbaum CB, Nadel JA. Autoradiographic localization of autonomic receptors in airway smooth muscle. Marked differences between large and small airways. Am Rev Respir Dis 127: 758-762, 1983. (Pubitemid 13101560)
5. Bayat S, Stengell S, Porra L, Janosi TZ, Petak F, Suhonen H, Suortti P, Hantos Z, Sovijärvi AR, Habre W. Methacholine and ovalbumin challenges assessed by forced oscillations and synchrotron lung imaging. Am J Respir Crit Care Med 180: 296-303, 2009.
6. Carroll NG, Mutavdzic S, James AL. Distribution and degranulation of airway mast cells in normal and asthmatic subjects. Eur Respir J 19: 879-885, 2002. (Pubitemid 34567902)
7. Chai H, Farr RS, Froehlich LA, Mathison DA, McLean JA, Rosenthal RR, Sheffer AL, Spector SL, Townley RG. Standardization of bronchial inhalation challenge procedures. J Allergy Clin Immunol 56: 323-327, 1975.
8. Cockcroft DW. Direct challenge tests: airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest 138: 18S-24S, 2010.
9. Cohen J, Douma WR, Ten Hacken NH, Vonk JM, Oudkerk M, Postma DS. Ciclesonide improves measures of small airway involvement in asthma. Eur Respir J 31: 1213-1220, 2008.
10. Cohen J, Postma DS, Douma WR, Vonk JM, De Boer AH, Ten Hacken NH. Particle size matters: diagnostics and treatment of small airways involvement in asthma. Eur Respir J 37: 532-540, 2011.
11. de Lange EE, Altes TA, Patrie JT, Parmar J, Brookeman JR, Mugler JP III, Platts-Mills TA. The variability of regional airflow obstruction within the lungs of patients with asthma: assessment with hyperpolarized helium-3 magnetic resonance imaging. J Allergy Clin Immunol 119: 1072-1078, 2007. (Pubitemid 46667159)
12. De Meer G, Heederik D, Postma DS. Bronchial responsiveness to adenosine 5′-monophosphate (AMP) and methacholine differ in their relationship with airway allergy and baseline FEV(1). Am J Respir Crit Care Med 165: 327-331, 2002. (Pubitemid 34118503)
13. Dutrieue B, Vanholsbeeck F, Verbanck S, Paiva M. A human acinar structure for simulation of realistic alveolar plateau slopes. J Appl Physiol 89: 1859-1867, 2000.
14. Estenne M, Van Muylem A, Knoop C, Antoine M. Detection of obliterative bronchiolitis after lung transplantation by indexes of ventilation distribution. Am J Respir Crit Care Med 162: 1047-1051, 2000.
15. Gibbons WJ, Sharma A, Lougheed D, Macklem PT. Detection of excessive bronchoconstriction in asthma. Am J Respir Crit Care Med 153: 582-589, 1996. (Pubitemid 26051333)
16. Gustafsson PM, Ljungberg HK, Kjellman B. Peripheral airway involvement in asthma assessed by single-breath SF6 and He washout. Eur Respir J 21: 1033-1039, 2003. (Pubitemid 36675622)
17. Haefeli-Bleuer B, Weibel ER. Morphometry of the human pulmonary acinus. Anat Rec 220: 401-414, 1988.
18. Hargreave FE, Ryan G, Thomson NC, O'Byrne PM, Latimer K, Juniper EF, Dolovich J. Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance. J Allergy Clin Immunol 68: 347-355, 1981. (Pubitemid 12235137)
19. Joos GF, O'Connor B, Anderson SD, Chung F, Cockcroft DW, Dahlen B, DiMaria G, Foresi A, Hargreave FE, Holgate ST, Inman M, Lotvall J, Magnussen H, Polosa R, Postma DS, Riedler J. Indirect airway challenges. Eur Respir J 21: 1050-1068, 2003. (Pubitemid 36675625)
20. Kaczka DW, Ingenito EP, Israel E, Lutchen KR. Airway and lung tissue mechanics in asthma. Effects of albuterol. Am J Respir Crit Care Med 159: 169-178, 1999. (Pubitemid 29036521)
21. Ljungberg HK, Gustafsson PM. Peripheral airway function in childhood asthma, assessed by single-breath He and SF6 washout. Pediatr Pulmonol 36: 339-347, 2003. (Pubitemid 37129776)
22. Mak JC, Barnes PJ. Autoradiographic visualization of muscarinic receptor subtypes in human and guinea pig lung. Am J Respir Crit Care Med 141: 1559-1568, 1990. (Pubitemid 20201361)
23. Manrique HA, Gómez FP, Muñoz PA, Peña AM, Barberà JA, Roca J, Rodríguez-Roisin R. Adenosine 5′-monophosphate in asthma: gas exchange and sputum cellular responses. Eur Respir J 31: 1205-1212, 2008.
24. Paiva M. Gas transport in the human lung. J Appl Physiol 35: 401-410, 1973.
25. Paiva M, Van Muylem A, Ravez P, Yernault JC. Inspired volume dependence of the slope of the alveolar plateau. Respir Physiol 56: 309-325, 1984. (Pubitemid 14092510)
26. Paiva M, Verbanck S, Van Muylem A. Diffusion-dependent contribution to the slope of the alveolar plateau. Respir Physiol 72: 257-270, 1988.
27. Pellegrino R, Violante B, Crimi E, Brusasco V. Effects of aerosol methacholine and histamine on airways and lung parenchyma in healthy humans. J Appl Physiol 74: 2681-2686, 1993. (Pubitemid 23201291)
28. Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault JC. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests European Community for Steel and Coal Official Statement of the European Respiratory Society. Eur Respir J Suppl 16: 5-40, 1993.
29. Siddiqui S, Mistry V, Doe C, Roach K, Morgan A, Wardlaw A, Pavord ID, Bradding P, Brightling C. Airway hyperresponsiveness is dissociated from airway wall structural remodeling. J Allergy Clin Immunol 122: 335-341, 2008.
30. Sterk PJ, Fabbri LM, Quanjer PH, Cockcroft DW, O'Byrne PM, Anderson SD, Juniper EF, Malo JL. Airway responsiveness. Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal Official Statement of the European Respiratory Society. Eur Respir J Suppl 16: 53-83, 1993.
31. Tillie-Leblond I, de Blic J, Jaubert F, Wallaert B, Scheinmann P, Gosset P. Airway remodeling is correlated with obstruction in children with severe asthma. Allergy 63: 533-541, 2008. (Pubitemid 351490406)
32. van den Berge M, Kerstjens HA, Meijer RJ, de Reus DM, Koëter GH, Kauffman HF, Postma DS. Corticosteroid-induced improvement in the PC20 of adenosine monophosphate is more closely associated with reduction in airway inflammation than improvement in the PC20 of methacholine. Am J Respir Crit Care Med 164: 1127-1132, 2001. (Pubitemid 33052238)
33. van den Berge M, Meijer RJ, Kerstjens HA, de Reus DM, Koeter GH, Kauffman HF, Postma DS. PC(20) adenosine 5'-monophosphate is more closely associated with airway inflammation in asthma than PC(20) methacholine. Am J Respir Crit Care Med 163: 1546-1550, 2001. (Pubitemid 32578753)
34. Van Muylem A, Antoine M, Yernault JC, Paiva M, Estenne M. Inert gas single-breath washout after heart-lung transplantation. Am J Respir Crit Care Med 152: 947-952, 1995.
35. Van Muylem A, De Vuyst P, Yernault JC, Paiva M. Inert gas single-breath washout and structural alteration of respiratory bronchioles. Am Rev Respir Dis 146: 1167-1172, 1992.
36. Van Muylem A, Melot C, Antoine M, Knoop C, Estenne M. Role of pulmonary function in the detection of allograft dysfunction after heartlung transplantation. Thorax 52: 643-647, 1997. (Pubitemid 27342215)
37. Van Muylem A, Verbanck S, Estenne M. Monitoring the lung periphery of transplanted lungs. Respir Physiol Neurobiol 148: 141-151, 2005. (Pubitemid 41132755)
38. Van Schoor J, Joos GF, Pauwels RA. Indirect bronchial hyperresponsiveness in asthma: mechanisms, pharmacology and implications for clinical research. Eur Respir J 16: 514-533, 2000.
39. Ward C, Reid DW, Orsida BE, Feltis B, Ryan VA, Johns DP, Walters EH. Inter-relationships between airway inflammation, reticular basement membrane thickening and bronchial hyper-reactivity to methacholine in asthma; a systematic bronchoalveolar lavage and airway biopsy analysis. Clin Exp Allergy 35: 1565-1571, 2005.
40. Weibel ER. Morphometry of the Human Lung. New York: Academic, 1963.