Axial distribution of nitric oxide airway production in asthma patients

Respiratory Physiology and Neurobiology

Volumn 185, Issue 2, 2013, Pages 313-318

  Van Muylem, Alain ^a   Kerckx, Yannick ^a   Michils, Alain ^a  

^a ERASME HOSPITAL   (Belgium)

Author keywords

AMP challenge; Asthma; Exhaled nitric oxide; Methacholine challenge

Indexed keywords

ADENOSINE PHOSPHATE; METHACHOLINE; NITRIC OXIDE;

ADULT; AIRWAY CONDUCTANCE; ARTICLE; ASTHMA; BREATHING; BRONCHOSPASM; CLINICAL ARTICLE; CLINICAL TRIAL; CROSSOVER PROCEDURE; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; MALE; PRIORITY JOURNAL; SINGLE BLIND PROCEDURE; SPIROMETRY;

ADENOSINE MONOPHOSPHATE; ADRENAL CORTEX HORMONES; ADULT; ASTHMA; BREATH TESTS; BRONCHI; BRONCHOCONSTRICTION; CROSS-OVER STUDIES; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; MALE; METHACHOLINE CHLORIDE; MIDDLE AGED; MUSCARINIC AGONISTS; NITRIC OXIDE; PULMONARY VENTILATION; SINGLE-BLIND METHOD; VITAL CAPACITY;

EID: 84871923374     PISSN: 15699048     EISSN: 18781519     Source Type: Journal    
DOI: 10.1016/j.resp.2012.09.011     Document Type: Article

References (41)

1. ATS/ERS ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide. American Journal of Respiratory and Critical Care Medicine 2005, 171:912-930.
2. Global initiative for Asthma, 2006. http://www.ginaasthma.com/.
3. Bruce C.T., Zhao J., Yates D.H., Thomas P.S. AMP challenge induces a decrease in FE(NO) in asthmatic subjects modulated by nedocromil. European Journal of Clinical Investigation 2006, 36:899-905.
4. Condorelli P., Shin H.W., Aledia A.S., Silkoff P.E., George S.C. A simple technique to characterize proximal and peripheral nitric oxide exchange using constant flow exhalations and an axial diffusion model. Journal of Applied Physiology 2007, 102:417-425.
5. de Gouw H.W., Hendriks J., Woltman A.M., Twiss I.M., Sterk P.J. Exhaled nitric oxide (NO) is reduced shortly after bronchoconstriction to direct and indirect stimuli in asthma. American Journal of Respiratory and Critical Care Medicine 1998, 158:315-319.
6. Deykin A., Massaro A.F., Coulston E., Drazen J.M., Israel E. Exhaled nitric oxide following repeated spirometry or repeated plethysmography in healthy individuals. American Journal of Respiratory and Critical Care Medicine 2000, 161:1237-1240.
7. Dillon W.C., Hampl V., Shultz P.J., Rubins J.B., Archer S.L. Origins of breath nitric oxide in humans. Chest 1996, 110:930-938.
8. Dweik R.A., Laskowski D., bu-Soud H.M., Kaneko F., Hutte R., Stuehr D.J., Erzurum S.C. Nitric oxide synthesis in the lung. Regulation by oxygen through a kinetic mechanism. Journal of Clinical Investigation 1998, 101:660-666.
9. Estenne M., Van Muylem A., Knoop C., Antoine M. Detection of obliterative bronchiolitis after lung transplantation by indexes of ventilation distribution. American Journal of Respiratory and Critical Care Medicine 2000, 162:1047-1051.
10. Franklin P.J., Stick S.M., Le Souëf P.N., Ayres J.G., Turner S.W. Measuring exhaled nitric oxide levels in adults: the importance of atopy and airway responsiveness. Chest 2004, 126:1540-1545.
11. Gelb A.F., George S.C., Silkoff P.E., Krishnan A., Fraser C., Taylor C.F., Shinar C.M., Maginot T. Central and peripheral airway/alveolar sites of exhaled nitric oxide in acute asthma. Thorax 2010, 65:619-625.
12. Gelb A.F., Taylor C.F., Nussbaum E., Gutierrez C., Schein A., Shinar C.M., Schein M.J., Epstein J.D., Zamel N. Alveolar and airway sites of nitric oxide inflammation in treated asthma. American Journal of Respiratory and Critical Care Medicine 2004, 170:737-741.
13. Haefeli-Bleuer B., Weibel E.R. Morphometry of the human pulmonary acinus. Anatomical Record 1988, 220:401-414.
14. Ho L.P., Wood F.T., Robson A., Innes J.A., Greening A.P. The current single exhalation method of measuring exhales nitric oxide is affected by airway calibre. European Respiratory Journal 2000, 15:1009-1013.
15. Holgate S.T. Pathogenesis of asthma. Clinical and Experimental Allergy 2008, 38:872-897.
16. Jiang J., Malavia N., Suresh V., George S.C. Nitric oxide gas phase release in human small airway epithelial cells. Respiratory Research 2009, 10:3.
17. Joos G.F., O'Connor B., Anderson S.D., Chung F., Cockcroft D.W., Dahlen B., DiMaria G., Foresi A., Hargreave F.E., Holgate S.T., Inman M., Lotvall J., Magnussen H., Polosa R., Postma D.S., Riedler J. Indirect airway challenges. European Respiratory Journal 2003, 21:1050-1068.
18. Jorens P.G., Vermeire P.A., Hew M. l-arginine-dependent nitric oxide synthase: a new metabolic pathway in the lung and airways. European Respiratory Journal 1993, 6:258-266.
19. Kerckx Y., Michils A., Van Muylem A. Airway contribution to alveolar nitric oxide in healthy subjects and stable asthma patients. Journal of Applied Physiology 2008, 104:918-924.
20. Kerckx Y., Van Muylem A. Axial distribution heterogeneity of nitric oxide airway production in healthy adults. Journal of Applied Physiology 2009, 106:1832-1839.
21. Kharitonov S.A., Chung K.F., Evans D., O'Connor B.J., Barnes P.J. Increased exhaled nitric oxide in asthma is mainly derived from the lower respiratory tract. American Journal of Respiratory and Critical Care Medicine 1996, 153:1773-1780.
22. Massaro A.F., Mehta S., Lilly C.M., Kobzik L., Reilly J.J., Drazen J.M. Elevated nitric oxide concentrations in isolated lower airway gas of asthmatic subjects. American Journal of Respiratory and Critical Care Medicine 1996, 153:1510-1514.
23. Michils A., Elkrim Y., Haccuria A., Van Muylem A. Adenosine 5'-monophosphate challenge elicits a more peripheral airway response than methacholine challenge. Journal of Applied Physiology 2011, 110:1241-1247.
24. Moncada S., Higgs A. The l-arginine-nitric oxide pathway. The New England Journal of Medicine 1993, 329:2002-2012.
25. Paiva M., Engel L.A. Theoretical studies of gas mixing and ventilation distribution in the lung. Physiological Reviews 1987, 67:750-796.
26. Paiva M., Van Muylem A., Ravez P., Yernault J.C. Inspired volume dependence of the slope of the alveolar plateau. Respiration Physiology 1984, 56:309-325.
27. Paiva M., Verbanck S., Van Muylem A. Diffusion-dependent contribution to the slope of the alveolar plateau. Respiration Physiology 1988, 72:257-270.
28. Persson M.G., Wiklund N.P., Gustafsson L.E. Endogenous nitric oxide in single exhalations and the change during exercise. American Review of Respiratory Disease 1993, 148:1210-1214.
29. Piacentini G.L., Bodini A., Peroni D.G., Miraglia de Guidice M.J., Costella S., Boner A.L. Reduction in exhaled nitric oxide immediately after methacholine challenge in asthmatic children. Thorax 2002, 57:771-773.
30. Quanjer P.H., Tammeling G.J., Cotes J.E., Pedersen O.F., Peslin R., Yernault J.C. Lung volumes and forced ventilatory flows. Report Working Party. Standardization of Lung Function Tests. European Community for Steel and Coal. Official Statement of the European Respiratory Society. European Respiratory Journal 1993, 6(Suppl. 16):5-40.
31. Shelley D.A., Puckett J.L., George S.C. Quantifying proximal and distal sources of NO in asthma using a multicompartment model. Journal of Applied Physiology 2010, 108:821-829.
32. Shin H.W., Condorelli P., Rose-Gottron C.M., Cooper D.M., George S.C. Probing the impact of axial diffusion on nitric oxide exchange dynamics with heliox. Journal of Applied Physiology 2004, 97:874-882.
33. Silkoff P.E., McClean P.A., Caramori M., Slutsky A.S., Zamel N. A significant proportion of exhaled nitric oxide arises in large airways in normal subjects. Respiration Physiology 1998, 113:33-38.
34. Sterk P.J., Fabbri L.M., Quanjer P.H., Cockcroft D.W., O'Byrne P.M., Anderson S.D., Juniper E.F., Malo J.L. Airway responsiveness. Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. European Respiratory Journal 1993, (Suppl. 16):53-83.
35. Suresh V., Mih J.D., George S.C. Measurement of IL-13-induced iNOS-derived gas phase nitric oxide in human bronchial epithelial cells. American Journal of Respiratory Cell and Molecular Biology 2007, 37:97-104.
36. Tsoukias N.M., George S.C. A two-compartment model of pulmonary nitric oxide exchange dynamics. Journal of Applied Physiology 1998, 85:653-666.
37. Van Muylem A., De Vuyst P., Yernault J.C., Paiva M. Inert gas single-breath washout and structural alteration of respiratory bronchioles. American Review of Respiratory Disease 1992, 146:1167-1172.
38. Van Muylem A., Verbanck S., Estenne M. Monitoring the lung periphery of transplanted lungs. Respiratory Physiology & Neurobiology 2005, 148:141-151.
39. Verbanck S., Kerckx Y., Schuermans D., Vincken W., Paiva M., Van Muylem A. Effect of airways constriction on exhaled nitric oxide. Journal of Applied Physiology 2008, 104:925-930.
40. Weibel E.R. Morphometry of the Human Lung 1963, Academic Press, New York.
41. Yager D., Butler J.P., Bastacky J., Israel E., Smith G., Drazen J.M. Amplification of airway constriction due to liquid filling of airway interstices. Journal of Applied Physiology 1989, 66:2873-2884.