Dutasteride reduces alcohol's sedative effects in men in a human laboratory setting and reduces drinking in the natural environment

Psychopharmacology

Volumn 231, Issue 17, 2014, Pages 3609-3618

  Covault, Jonathan ^a,e   Pond, Timothy ^b   Feinn, Richard ^c   Arias, Albert J ^d   Oncken, Cheryl ^a   Kranzler, Henry R ^b  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c New York   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

5 Reductase; Human subjects; Neuroactive steroids

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR ALPHA2; ANDROSTANEDIOL GLUCURONIDE; DUTASTERIDE; GLUCURONIDE; PLACEBO; STEROID 5ALPHA REDUCTASE; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; ANDROSTANEDIOL; AZASTEROID; CENTRAL DEPRESSANT AGENT; GABRA2 PROTEIN, HUMAN; STEROID 5ALPHA REDUCTASE INHIBITOR;

ADULT; ALCOHOL CONSUMPTION; ALCOHOL SENSATION SCALE; ALCOHOL USE DISORDER; ARTICLE; BIPHASIC ALCOHOL EFFECTS SCALE; CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG ELIMINATION; DRUG SAFETY; DRUG TOLERABILITY; ENZYME ACTIVITY; ENZYME INHIBITION; GABRA2 GENE; GENETIC POLYMORPHISM; GENOTYPE; HEART RATE; HORMONE DETERMINATION; HUMAN; LOADING DRUG DOSE; MALE; PRIORITY JOURNAL; RATING SCALE; SELF REPORT; STOMACH DISCOMFORT; ANTAGONISTS AND INHIBITORS; BLOOD; DOSE RESPONSE; DRINKING BEHAVIOR; DRUG THERAPY; ENVIRONMENT; GENETICS; MIDDLE AGED; PSYCHOLOGY; RANDOMIZED CONTROLLED TRIAL; YOUNG ADULT;

5-ALPHA REDUCTASE INHIBITORS; ADULT; ALCOHOL DRINKING; ANDROSTANE-3,17-DIOL; AZASTEROIDS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DUTASTERIDE; ENVIRONMENT; ETHANOL; HUMANS; MALE; MIDDLE AGED; RECEPTORS, GABA-A; YOUNG ADULT;

EID: 84906940653     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-014-3487-4     Document Type: Article

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